| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WASATCH ADVISORS LP | 6,724,409 | 7,424,662 | +700,253 | 0.06 | 0.06 | -0.00 | buy |
| Lynx1 Capital Management LP | 7,098,133 | 7,098,133 | 0 | 4.07 | 2.93 | -1.14 | hold |
| Soleus Capital Management, L.P. | 6,978,942 | 6,978,942 | 0 | 0.88 | 0.69 | -0.19 | hold |
| ORBIMED ADVISORS LLC | 6,830,300 | 6,830,300 | 0 | 0.26 | 0.25 | -0.02 | hold |
| MORGAN STANLEY | 4,045,329 | 4,754,188 | +708,859 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 3,370,880 | 3,018,022 | -352,858 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,990,824 | 2,008,004 | +17,180 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 5,284,413 | 1,828,614 | -3,455,799 | 0.00 | 0.00 | -0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,111,910 | 1,111,910 | 0 | 0.26 | 0.20 | -0.06 | hold |
| MILLENNIUM MANAGEMENT LLC | 65,897 | 1,101,342 | +1,035,445 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 214,500 | 1,093,188 | +878,688 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 900,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 622,720 | 880,258 | +257,538 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 800,600 | 811,400 | +10,800 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,430,288 | 745,053 | -685,235 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 514,603 | 683,599 | +168,996 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 872,770 | 572,026 | -300,744 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 492,612 | +492,612 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 697,653 | 441,735 | -255,918 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 514,155 | 431,888 | -82,267 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 140,532 | 383,789 | +243,257 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 474,843 | 331,897 | -142,946 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,224,418 | 287,373 | -937,045 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 239,959 | +239,959 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 238,957 | +238,957 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 218,411 | 208,766 | -9,645 | 0.02 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 18,096 | 206,177 | +188,081 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,286,712 | 204,505 | -1,082,207 | 0.03 | 0.01 | -0.03 | sell |
| FMR LLC | 193,750 | 201,358 | +7,608 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,550,000 | 200,000 | -1,350,000 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 193,910 | 196,255 | +2,345 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 268,832 | 190,182 | -78,650 | 0.05 | 0.02 | -0.03 | sell |
| Invesco Ltd. | 139,486 | 155,017 | +15,531 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 143,687 | +143,687 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 27,675 | 139,723 | +112,048 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 499,768 | 139,673 | -360,095 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 24,203 | 136,219 | +112,016 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 180,372 | 132,765 | -47,607 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 126,900 | +126,900 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 40,100 | 108,278 | +68,178 | 0.00 | 0.01 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 129,900 | 104,900 | -25,000 | 0.01 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 79,275 | 89,475 | +10,200 | 0.00 | 0.00 | -0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.07 | 0.08 | +0.00 | hold |
| Man Group plc | 85,623 | 78,487 | -7,136 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 0 | 77,734 | +77,734 | 0.00 | 0.03 | +0.03 | buy |
| HRT FINANCIAL LP | 13,034 | 71,106 | +58,072 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 212,003 | 67,617 | -144,386 | 0.01 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 52,521 | +52,521 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 107,520 | 45,823 | -61,697 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 1 | 43,447 | +43,446 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 7,275 | 40,592 | +33,317 | 0.00 | 0.00 | +0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 40,000 | 40,000 | 0 | 0.10 | 0.06 | -0.03 | hold |
| R Squared Ltd | 0 | 30,587 | +30,587 | 0.00 | 0.02 | +0.02 | buy |
| Brookstone Capital Management | 0 | 29,325 | +29,325 | 0.00 | 0.00 | +0.00 | buy |
| Crestwood Advisors Group, LLC | 0 | 29,000 | +29,000 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 28,300 | +28,300 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | 28,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Savant Capital, LLC | 0 | 26,347 | +26,347 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 25,487 | 25,157 | -330 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 25,978 | 25,000 | -978 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 24,377 | +24,377 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 20,800 | 24,200 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 43,395 | 22,816 | -20,579 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 0 | 21,476 | +21,476 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,100 | 21,111 | -4,989 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 18,187 | 18,822 | +635 | 0.00 | 0.00 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 16,402 | 17,039 | +637 | 0.00 | 0.00 | -0.00 | buy |
| EWA, LLC | 0 | 16,643 | +16,643 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 16,095 | +16,095 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 15,836 | +15,836 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 0 | 15,164 | +15,164 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 19,595 | 14,720 | -4,875 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 14,239 | 14,261 | +22 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 16,009 | 13,547 | -2,462 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 12,745 | 12,695 | -50 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,143 | 12,400 | -25,743 | 0.00 | 0.00 | -0.00 | sell |
| B. Riley Wealth Advisors, Inc. | 11,000 | 11,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 11,600 | 11,000 | -600 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 43,941 | 10,963 | -32,978 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA SECURITIES, LLC | 0 | 10,589 | +10,589 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,418 | +10,418 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 10,225 | +10,225 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 14,429 | 10,156 | -4,273 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 0 | 3,953 | +3,953 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,375 | 2,743 | +368 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 89,633 | 2,716 | -86,917 | 0.00 | 0.00 | -0.00 | sell |
| SUMMIT SECURITIES GROUP LLC | 155 | 2,122 | +1,967 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,751 | 1,751 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SYNTAX RESEARCH, INC. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 163 | 430 | +267 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 325 | +325 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 33 | 310 | +277 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 295 | +295 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 150 | 150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 9 | 31 | +22 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 12,528 | 0 | -12,528 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 7,731 | 0 | -7,731 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 5,744 | 0 | -5,744 | 0.00 | 0.00 | -0.00 | sell |