| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 9,072,400 | 8,867,338 | -205,062 | 0.00 | 0.00 | +0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | 8,000,000 | 0 | 0.22 | 0.32 | +0.10 | hold |
| BlackRock, Inc. | 2,048,526 | 7,896,718 | +5,848,192 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 6,998,902 | 7,326,691 | +327,789 | 2.91 | 3.95 | +1.04 | buy |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | 7,171,910 | 0 | 1.70 | 1.99 | +0.29 | hold |
| JPMORGAN CHASE & CO | 3,223,054 | 4,747,424 | +1,524,370 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,511,015 | 4,187,580 | +1,676,565 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 2,387,378 | 3,530,991 | +1,143,613 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 2,961,761 | 3,522,644 | +560,883 | 0.05 | 0.11 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 3,035,634 | 3,469,707 | +434,073 | 0.01 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 3,803,942 | 3,377,981 | -425,961 | 0.41 | 0.54 | +0.14 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,911,785 | 3,032,060 | +1,120,275 | 0.59 | 1.58 | +0.98 | buy |
| BANK OF AMERICA CORP /DE/ | 2,359,241 | 2,656,359 | +297,118 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 951,043 | 2,522,163 | +1,571,120 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 2,433,000 | +2,433,000 | 0.00 | 1.86 | +1.86 | buy |
| STATE STREET CORP | 382,973 | 2,115,621 | +1,732,648 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,890,914 | 1,806,199 | -84,715 | 0.01 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 0 | 1,796,937 | +1,796,937 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 1,060,331 | 1,740,989 | +680,658 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,286,840 | 1,732,210 | +445,370 | 0.00 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 0 | 1,608,815 | +1,608,815 | 0.00 | 1.16 | +1.16 | buy |
| HighVista Strategies LLC | 0 | 1,348,136 | +1,348,136 | 0.00 | 1.44 | +1.44 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,461,815 | 1,189,828 | -1,271,987 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 442,518 | 1,188,507 | +745,989 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 189,479 | 1,160,547 | +971,068 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 830,624 | 1,003,437 | +172,813 | 0.02 | 0.03 | +0.01 | buy |
| FMR LLC | 272,368 | 894,054 | +621,686 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 215,877 | 828,970 | +613,093 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 781,060 | +781,060 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 452,228 | 781,060 | +328,832 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 736,331 | +736,331 | 0.00 | 0.06 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 47,507 | 580,195 | +532,688 | 0.00 | 0.03 | +0.02 | buy |
| Velan Capital Investment Management LP | 0 | 570,000 | +570,000 | 0.00 | 1.63 | +1.63 | buy |
| STEMPOINT CAPITAL LP | 453,236 | 523,648 | +70,412 | 0.23 | 0.42 | +0.19 | buy |
| Rockefeller Capital Management L.P. | 0 | 495,817 | +495,817 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 484,010 | +484,010 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 867,911 | 452,701 | -415,210 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 256,468 | 408,648 | +152,180 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 384,766 | 384,766 | 0 | 0.26 | 0.44 | +0.19 | hold |
| Qube Research & Technologies Ltd | 752,114 | 370,554 | -381,560 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 136,047 | 364,351 | +228,304 | 0.03 | 0.15 | +0.13 | buy |
| Susquehanna Portfolio Strategies, LLC | 260,279 | 335,079 | +74,800 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 325,000 | +325,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 1,246,896 | 302,750 | -944,146 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 277,183 | 300,734 | +23,551 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 43,000 | 291,957 | +248,957 | 0.01 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 244,507 | 290,226 | +45,719 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 86,760 | 264,947 | +178,187 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 246,800 | 253,165 | +6,365 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 249,517 | +249,517 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 227,768 | +227,768 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 155,495 | 227,003 | +71,508 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,393,342 | 215,386 | -1,177,956 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 182,700 | +182,700 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 169,096 | 173,965 | +4,869 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 40,664 | 170,834 | +130,170 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 71,546 | 155,881 | +84,335 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 153,972 | +153,972 | 0.00 | 0.08 | +0.08 | buy |
| AMERICAN CENTURY COMPANIES INC | 85,444 | 150,681 | +65,237 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 47,151 | 135,438 | +88,287 | 0.00 | 0.01 | +0.01 | buy |
| Palumbo Wealth Management LLC | 0 | 132,417 | +132,417 | 0.00 | 0.13 | +0.13 | buy |
| RHUMBLINE ADVISERS | 2,716 | 131,877 | +129,161 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 131,100 | 131,100 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Walleye Capital LLC | 239,118 | 115,125 | -123,993 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 112,214 | +112,214 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 135,600 | 101,500 | -34,100 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 0 | 98,873 | +98,873 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 98,094 | +98,094 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 95,000 | +95,000 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.09 | 0.10 | +0.02 | hold |
| Aster Capital Management (DIFC) Ltd | 0 | 77,734 | +77,734 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 317,877 | 74,516 | -243,361 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 190,348 | 74,373 | -115,975 | 0.00 | 0.00 | -0.00 | sell |
| Crestwood Advisors Group, LLC | 66,536 | 66,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTREPID FAMILY OFFICE LLC | 60,000 | 65,000 | +5,000 | 0.14 | 0.28 | +0.14 | buy |
| CV Advisors LLC | 0 | 65,000 | +65,000 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 64,780 | +64,780 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 61,393 | +61,393 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 62,390 | 57,562 | -4,828 | 0.00 | 0.00 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 52,763 | +52,763 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 42,428 | 49,389 | +6,961 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 46,474 | +46,474 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 25,134 | 42,376 | +17,242 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 62,760 | 36,726 | -26,034 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.01 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 32,828 | +32,828 | 0.00 | 0.03 | +0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 15,950 | 31,235 | +15,285 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 29,893 | +29,893 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 27,513 | +27,513 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 264,620 | 25,111 | -239,509 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 24,100 | +24,100 | 0.00 | 0.00 | +0.00 | buy |
| StoneX Group Inc. | 0 | 22,420 | +22,420 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 21,773 | +21,773 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 21,260 | +21,260 | 0.00 | 0.08 | +0.08 | buy |
| Quantbot Technologies LP | 0 | 20,827 | +20,827 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 30,957 | 19,700 | -11,257 | 0.01 | 0.01 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,602 | +19,602 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 19,392 | +19,392 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 23,700 | 19,200 | -4,500 | 0.00 | 0.00 | +0.00 | sell |