| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 0 | 2,433,000 | +2,433,000 | 0.00 | 1.86 | +1.86 | buy |
| Candriam S.C.A. | 0 | 1,796,937 | +1,796,937 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 2,511,015 | 4,187,580 | +1,676,565 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 0 | 1,608,815 | +1,608,815 | 0.00 | 1.16 | +1.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 951,043 | 2,522,163 | +1,571,120 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 1,348,136 | +1,348,136 | 0.00 | 1.44 | +1.44 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,911,785 | 3,032,060 | +1,120,275 | 0.59 | 1.58 | +0.98 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 781,060 | +781,060 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 736,331 | +736,331 | 0.00 | 0.06 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 1,060,331 | 1,740,989 | +680,658 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 215,877 | 828,970 | +613,093 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 570,000 | +570,000 | 0.00 | 1.63 | +1.63 | buy |
| ExodusPoint Capital Management, LP | 47,507 | 580,195 | +532,688 | 0.00 | 0.03 | +0.02 | buy |
| Rockefeller Capital Management L.P. | 0 | 495,817 | +495,817 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 484,010 | +484,010 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,286,840 | 1,732,210 | +445,370 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 3,035,634 | 3,469,707 | +434,073 | 0.01 | 0.01 | +0.01 | buy |
| Lynx1 Capital Management LP | 6,998,902 | 7,326,691 | +327,789 | 2.91 | 3.95 | +1.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 325,000 | +325,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 249,517 | +249,517 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 43,000 | 291,957 | +248,957 | 0.01 | 0.06 | +0.06 | buy |
| Atom Investors LP | 136,047 | 364,351 | +228,304 | 0.03 | 0.15 | +0.13 | buy |
| Jump Financial, LLC | 0 | 182,700 | +182,700 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 0 | 153,972 | +153,972 | 0.00 | 0.08 | +0.08 | buy |
| Man Group plc | 256,468 | 408,648 | +152,180 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 132,417 | +132,417 | 0.00 | 0.13 | +0.13 | buy |
| Squarepoint Ops LLC | 40,664 | 170,834 | +130,170 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 2,716 | 131,877 | +129,161 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 112,214 | +112,214 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 98,094 | +98,094 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 95,000 | +95,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 47,151 | 135,438 | +88,287 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 155,495 | 227,003 | +71,508 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 453,236 | 523,648 | +70,412 | 0.23 | 0.42 | +0.19 | buy |
| CV Advisors LLC | 0 | 65,000 | +65,000 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 64,780 | +64,780 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 61,393 | +61,393 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 46,474 | +46,474 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.01 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 32,828 | +32,828 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 277,183 | 300,734 | +23,551 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 20,827 | +20,827 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,602 | +19,602 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 19,392 | +19,392 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 18,800 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 16,895 | +16,895 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 16,093 | +16,093 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 16,040 | +16,040 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,950 | 31,235 | +15,285 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 11,582 | +11,582 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 9,198 | +9,198 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 246,800 | 253,165 | +6,365 | 0.00 | 0.00 | +0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 60,000 | 65,000 | +5,000 | 0.14 | 0.28 | +0.14 | buy |
| Point72 Asset Management, L.P. | 169,096 | 173,965 | +4,869 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 2,043 | +2,043 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,396 | +1,396 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 829 | +829 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 358 | +358 | 0.00 | 0.00 | +0.00 | buy |
| Bronte Capital Management Pty Ltd. | 10,033 | 10,349 | +316 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,316 | 17,597 | +281 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 101 | 102 | +1 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,878 | 1,878 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 131,100 | 131,100 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 384,766 | 384,766 | 0 | 0.26 | 0.44 | +0.19 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | 8,000,000 | 0 | 0.22 | 0.32 | +0.10 | hold |
| Crestwood Advisors Group, LLC | 66,536 | 66,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | 7,171,910 | 0 | 1.70 | 1.99 | +0.29 | hold |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Callan Family Office, LLC | 19,146 | 19,146 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 435 | 435 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HANTZ FINANCIAL SERVICES, INC. | 3 | 0 | -3 | 0.00 | 0.00 | 0.00 | sell |
| Advisory Services Network, LLC | 74 | 0 | -74 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 5,090 | 4,945 | -145 | 0.00 | 0.00 | +0.00 | sell |
| Simplicity Wealth,LLC | 10,201 | 10,045 | -156 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 319 | 0 | -319 | 0.00 | 0.00 | -0.00 | sell |
| EWA, LLC | 14,572 | 14,129 | -443 | 0.01 | 0.01 | +0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 15,249 | 14,425 | -824 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,849 | 8,269 | -1,580 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 23,700 | 19,200 | -4,500 | 0.00 | 0.00 | +0.00 | sell |
| Blackston Financial Advisory Group, LLC | 10,000 | 0 | -10,000 | 0.02 | 0.00 | -0.02 | sell |
| Ethic Inc. | 10,131 | 0 | -10,131 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,203 | 0 | -10,203 | 0.00 | 0.00 | -0.00 | sell |
| CTC Alternative Strategies, Ltd. | 10,792 | 0 | -10,792 | 0.06 | 0.00 | -0.06 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 30,957 | 19,700 | -11,257 | 0.01 | 0.01 | +0.00 | sell |
| Corient Private Wealth LLC | 21,387 | 10,007 | -11,380 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 24,700 | 11,100 | -13,600 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 14,157 | 0 | -14,157 | 0.01 | 0.00 | -0.01 | sell |
| Graham Capital Management, L.P. | 23,733 | 0 | -23,733 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 23,944 | 0 | -23,944 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 25,740 | 0 | -25,740 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 62,760 | 36,726 | -26,034 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 135,600 | 101,500 | -34,100 | 0.00 | 0.00 | +0.00 | sell |
| Diametric Capital, LP | 34,594 | 0 | -34,594 | 0.02 | 0.00 | -0.02 | sell |
| Focus Partners Wealth | 38,187 | 0 | -38,187 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 49,586 | 0 | -49,586 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 59,700 | 0 | -59,700 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 86,278 | 10,745 | -75,533 | 0.03 | 0.01 | -0.02 | sell |
| HRT FINANCIAL LP | 87,400 | 11,400 | -76,000 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 92,647 | 0 | -92,647 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 190,348 | 74,373 | -115,975 | 0.00 | 0.00 | -0.00 | sell |