| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 1,513,058 | 4,377,900 | +2,864,842 | 0.14 | 0.46 | +0.32 | buy |
| Soleus Capital Management, L.P. | 4,051,996 | 6,603,996 | +2,552,000 | 1.65 | 3.13 | +1.48 | buy |
| MORGAN STANLEY | 1,137,938 | 2,326,134 | +1,188,196 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 278,580 | 1,201,848 | +923,268 | 0.00 | 0.02 | +0.02 | buy |
| WASATCH ADVISORS LP | 4,847,150 | 5,677,368 | +830,218 | 0.12 | 0.16 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 520,000 | +520,000 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 700,000 | +500,000 | 0.09 | 0.29 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 62,307 | 392,004 | +329,697 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 179,573 | 489,820 | +310,247 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,768,499 | 2,036,233 | +267,734 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 225,416 | +225,416 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 23,627 | 185,941 | +162,314 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 118,473 | 266,159 | +147,686 | 0.01 | 0.02 | +0.01 | buy |
| BIT Capital GmbH | 0 | 138,899 | +138,899 | 0.00 | 0.08 | +0.08 | buy |
| Squarepoint Ops LLC | 57,117 | 147,874 | +90,757 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 84,951 | +84,951 | 0.00 | 0.04 | +0.04 | buy |
| ArrowMark Colorado Holdings LLC | 1,244,358 | 1,319,484 | +75,126 | 0.07 | 0.10 | +0.03 | buy |
| CITIGROUP INC | 30,456 | 103,968 | +73,512 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 175,911 | 243,457 | +67,546 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 229,345 | 286,041 | +56,696 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 55,231 | +55,231 | 0.00 | 0.08 | +0.08 | buy |
| LMR Partners LLP | 0 | 51,000 | +51,000 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 142,832 | 192,364 | +49,532 | 0.03 | 0.05 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 0 | 43,400 | +43,400 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 22,100 | 62,175 | +40,075 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 38,956 | +38,956 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 42,101 | 80,499 | +38,398 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 19,300 | 54,116 | +34,816 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 34,383 | +34,383 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,993 | 37,837 | +30,844 | 0.00 | 0.00 | +0.00 | buy |
| Vestcor Inc | 0 | 29,500 | +29,500 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 27,126 | +27,126 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 25,779 | +25,779 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 24,941 | +24,941 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 22,813 | +22,813 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 21,168 | +21,168 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 15,477 | 35,455 | +19,978 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,918 | 41,664 | +18,746 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 95,441 | 113,907 | +18,466 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 14,344 | +14,344 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 110,075 | 122,373 | +12,298 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 11,620 | +11,620 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,079 | +11,079 | 0.00 | 0.00 | +0.00 | buy |
| Cynosure Group, LLC | 0 | 10,007 | +10,007 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 29,848 | 39,180 | +9,332 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 8,873 | +8,873 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,362,216 | 1,369,676 | +7,460 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,030 | 50,107 | +6,077 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 90,621 | 95,649 | +5,028 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 12,937 | 15,842 | +2,905 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 127,879 | 130,411 | +2,532 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 45,780 | 47,800 | +2,020 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 21,844 | 23,696 | +1,852 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN DEMPSEY CAPITAL MANAGEMENT LLC | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,761 | 26,917 | +1,156 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1,018 | +1,018 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 217 | +217 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 14,822 | 15,007 | +185 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 143 | +143 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 25 | 50 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,744 | 5,744 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,248 | 4,248 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 12,025 | 12,025 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUSSMAN STRATEGIC ADVISORS, INC. | 42,000 | 42,000 | 0 | 0.05 | 0.06 | +0.01 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,878,000 | 4,878,000 | 0 | 0.30 | 0.32 | +0.02 | hold |
| B. Riley Wealth Advisors, Inc. | 11,000 | 11,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 1,111,910 | 1,111,910 | 0 | 0.56 | 0.66 | +0.10 | hold |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 331 | 331 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Commodore Capital LP | 3,410,384 | 3,410,384 | 0 | 1.08 | 1.21 | +0.14 | hold |
| Lynx1 Capital Management LP | 6,880,527 | 6,880,527 | 0 | 11.49 | 13.90 | +2.41 | hold |
| Cape Investment Advisory, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corient Private Wealth LLC | 12,695 | 12,695 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SYNTAX RESEARCH, INC. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.15 | 0.21 | +0.05 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 5,063 | 5,063 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | 28,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 2,029 | 2,029 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Gradient Investments LLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 31,543 | 31,350 | -193 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 19,735 | 19,481 | -254 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 316 | 0 | -316 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 458 | 0 | -458 | 0.00 | 0.00 | -0.00 | sell |
| Piscataqua Savings Bank | 600 | 0 | -600 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 29,077 | 28,415 | -662 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 65,499 | 64,546 | -953 | 0.00 | 0.00 | +0.00 | sell |
| Pacer Advisors, Inc. | 1,056 | 0 | -1,056 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,735 | 0 | -1,735 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 38,097 | 35,170 | -2,927 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 34,149 | 28,436 | -5,713 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 488,958 | 482,929 | -6,029 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 23,268 | 15,446 | -7,822 | 0.01 | 0.01 | -0.00 | sell |
| Headlands Technologies LLC | 9,652 | 0 | -9,652 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 10,162 | 0 | -10,162 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 11,280 | 0 | -11,280 | 0.00 | 0.00 | -0.00 | sell |