| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 7,098,133 | 7,098,133 | 0 | 2.93 | 3.21 | +0.28 | hold |
| Soleus Capital Management, L.P. | 6,978,942 | 7,053,942 | +75,000 | 0.69 | 0.84 | +0.15 | buy |
| ORBIMED ADVISORS LLC | 6,830,300 | 5,235,146 | -1,595,154 | 0.25 | 0.28 | +0.03 | sell |
| MORGAN STANLEY | 4,754,188 | 4,972,032 | +217,844 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 7,424,662 | 4,852,741 | -2,571,921 | 0.06 | 0.06 | +0.00 | sell |
| VANGUARD GROUP INC | 3,018,022 | 3,191,557 | +173,535 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,008,004 | 2,053,162 | +45,158 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,101,342 | 1,934,225 | +832,883 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,897,383 | +1,897,383 | 0.00 | 0.61 | +0.61 | buy |
| BlackRock, Inc. | 1,828,614 | 1,595,639 | -232,975 | 0.00 | 0.00 | +0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,111,910 | 1,111,910 | 0 | 0.20 | 0.16 | -0.04 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,093,188 | 936,950 | -156,238 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 900,000 | 0 | 0.07 | 0.08 | +0.01 | hold |
| TWO SIGMA INVESTMENTS, LP | 683,599 | 834,726 | +151,127 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 811,400 | 763,100 | -48,300 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 745,053 | 725,304 | -19,749 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 515,437 | +515,437 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 441,735 | 503,145 | +61,410 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 481,449 | +481,449 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 880,258 | 459,893 | -420,365 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 0 | 420,000 | +420,000 | 0.00 | 0.17 | +0.17 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 331,897 | 350,606 | +18,709 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 431,888 | 349,289 | -82,599 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 287,373 | 287,373 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 126,900 | 272,053 | +145,153 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 201,358 | 211,348 | +9,990 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 208,766 | 205,033 | -3,733 | 0.01 | 0.02 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 204,505 | 204,505 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JANE STREET GROUP, LLC | 492,612 | 203,568 | -289,044 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 196,255 | 200,930 | +4,675 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 155,017 | 191,820 | +36,803 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 238,957 | 182,640 | -56,317 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 108,278 | 149,962 | +41,684 | 0.01 | 0.02 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 239,959 | 138,657 | -101,302 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 139,673 | 138,319 | -1,354 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 132,765 | 128,237 | -4,528 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 139,723 | 128,108 | -11,615 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 115,973 | +115,973 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 106,300 | +106,300 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 106,275 | +106,275 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 78,487 | 90,278 | +11,791 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.08 | 0.11 | +0.04 | hold |
| State of Wyoming | 0 | 82,509 | +82,509 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 206,177 | 80,806 | -125,371 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 104,900 | 79,900 | -25,000 | 0.00 | 0.00 | +0.00 | sell |
| INTREPID FAMILY OFFICE LLC | 40,000 | 70,000 | +30,000 | 0.06 | 0.14 | +0.08 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 67,617 | 67,617 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Crestwood Advisors Group, LLC | 29,000 | 66,536 | +37,536 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 45,823 | 43,062 | -2,761 | 0.00 | 0.00 | +0.00 | sell |
| Catalyst Funds Management Pty Ltd | 28,300 | 42,500 | +14,200 | 0.01 | 0.01 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 40,628 | +40,628 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 38,200 | +38,200 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 28,420 | +28,420 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | 28,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 0 | 24,248 | +24,248 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 12,695 | 22,702 | +10,007 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 43,447 | 21,708 | -21,739 | 0.01 | 0.01 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 21,111 | 20,510 | -601 | 0.00 | 0.00 | +0.00 | sell |
| EWA, LLC | 16,643 | 19,510 | +2,867 | 0.01 | 0.01 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 19,146 | +19,146 | 0.00 | 0.03 | +0.03 | buy |
| R Squared Ltd | 30,587 | 17,880 | -12,707 | 0.02 | 0.02 | -0.01 | sell |
| Engineers Gate Manager LP | 10,418 | 16,286 | +5,868 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 17,039 | 14,889 | -2,150 | 0.00 | 0.00 | +0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 14,720 | 14,574 | -146 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 25,157 | 13,629 | -11,528 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 0 | 13,043 | +13,043 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 12,710 | +12,710 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,261 | 12,475 | -1,786 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 15 | 12,432 | +12,417 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,400 | 12,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 89,475 | 11,863 | -77,612 | 0.00 | 0.00 | -0.00 | sell |
| B. Riley Wealth Advisors, Inc. | 11,000 | 11,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ethic Inc. | 15,164 | 10,508 | -4,656 | 0.00 | 0.00 | +0.00 | sell |
| Simplicity Wealth,LLC | 0 | 10,213 | +10,213 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 10,225 | 10,140 | -85 | 0.01 | 0.01 | +0.00 | sell |
| Squarepoint Ops LLC | 143,687 | 10,099 | -133,588 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 40,592 | 8,414 | -32,178 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 7,836 | +7,836 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 22,816 | 3,264 | -19,552 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,743 | 2,751 | +8 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 2,716 | 2,716 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,751 | 1,463 | -288 | 0.00 | 0.00 | +0.00 | sell |
| JFS WEALTH ADVISORS, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 3,953 | 234 | -3,719 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 430 | 156 | -274 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 150 | 152 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Wealthspire Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 34 | 17 | -17 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 0 | -200,000 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 383,789 | 0 | -383,789 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 10,963 | 0 | -10,963 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 16,095 | 0 | -16,095 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,589 | 0 | -10,589 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 71,106 | 0 | -71,106 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 15,836 | 0 | -15,836 | 0.00 | 0.00 | -0.00 | sell |
| Savant Capital, LLC | 26,347 | 0 | -26,347 | 0.00 | 0.00 | -0.00 | sell |