| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,878,000 | +4,878,000 | 0.00 | 0.43 | +0.43 | buy |
| Commodore Capital LP | 0 | 3,800,000 | +3,800,000 | 0.00 | 1.88 | +1.88 | buy |
| Lynx1 Capital Management LP | 1,019,230 | 3,134,396 | +2,115,166 | 1.25 | 6.96 | +5.71 | buy |
| Point72 Asset Management, L.P. | 16,021 | 1,961,359 | +1,945,338 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,704,269 | +1,704,269 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 1,675,097 | +1,675,097 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 1,123,061 | +1,123,061 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 6,247,141 | 7,138,949 | +891,808 | 0.07 | 0.22 | +0.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,863 | 1,002,513 | +840,650 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 56,391 | 692,082 | +635,691 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,186,459 | 2,558,480 | +372,021 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 68,147 | 311,377 | +243,230 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 0 | 205,341 | +205,341 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 198,671 | +198,671 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 159,765 | +159,765 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 28,014 | 169,416 | +141,402 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 102,379 | +102,379 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 95,020 | +95,020 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 0 | 94,400 | +94,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 57,894 | 135,473 | +77,579 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 76,800 | +76,800 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,924,856 | 1,999,401 | +74,545 | 0.00 | 0.00 | +0.00 | buy |
| Arete Wealth Advisors, LLC | 0 | 72,100 | +72,100 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 357,988 | 424,700 | +66,712 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 62,000 | +62,000 | 0.00 | 0.01 | +0.01 | buy |
| 683 Capital Management, LLC | 0 | 55,602 | +55,602 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 46,025 | +46,025 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 42,554 | +42,554 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 455,844 | 482,288 | +26,444 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 26,329 | +26,329 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 21,981 | +21,981 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 6,886 | 27,090 | +20,204 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 18,823 | +18,823 | 0.00 | 0.01 | +0.01 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 18,400 | +18,400 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 90,992 | 108,677 | +17,685 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 33,138 | 49,037 | +15,899 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 13,400 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 12,375 | +12,375 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 11,131 | +11,131 | 0.00 | 0.03 | +0.03 | buy |
| Shay Capital LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| FNY Investment Advisers, LLC | 0 | 8,800 | +8,800 | 0.00 | 0.05 | +0.05 | buy |
| Headlands Technologies LLC | 0 | 6,880 | +6,880 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 70,703 | 75,794 | +5,091 | 0.03 | 0.08 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 248,252 | 252,710 | +4,458 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 12,259 | 16,322 | +4,063 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 164,722 | 168,218 | +3,496 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 31,796 | 34,734 | +2,938 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 126,491 | 128,037 | +1,546 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,471 | 16,310 | +839 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 13,917 | 14,753 | +836 | 0.00 | 0.00 | +0.00 | buy |
| Avion Wealth | 0 | 331 | +331 | 0.00 | 0.00 | +0.00 | buy |
| FAIRFIELD, BUSH & CO. | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Coston, McIsaac & Partners | 0 | 19 | +19 | 0.00 | 0.00 | 0.00 | buy |
| BARCLAYS PLC | 43,614 | 43,615 | +1 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,791 | 1,791 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 1,642,210 | 1,642,210 | 0 | 0.34 | 0.89 | +0.55 | hold |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 1,276,574 | 1,276,574 | 0 | 0.35 | 0.80 | +0.45 | hold |
| Piscataqua Savings Bank | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corient Private Wealth LLC | 12,695 | 12,695 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SYNTAX RESEARCH, INC. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.07 | 0.22 | +0.15 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STATE STREET CORP | 155,373 | 155,373 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAPTRUST FINANCIAL ADVISORS | 14,855 | 14,822 | -33 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 110 | 0 | -110 | 0.00 | 0.00 | 0.00 | sell |
| Daiwa Securities Group Inc. | 142 | 0 | -142 | 0.00 | 0.00 | 0.00 | sell |
| Bank of New York Mellon Corp | 20,871 | 20,682 | -189 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 448 | 0 | -448 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 490 | 0 | -490 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 47,456 | 46,286 | -1,170 | 0.02 | 0.04 | +0.03 | sell |
| China Universal Asset Management Co., Ltd. | 1,269 | 0 | -1,269 | 0.00 | 0.00 | -0.00 | sell |
| M&T BANK CORP | 140,020 | 138,588 | -1,432 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 32,653 | 30,200 | -2,453 | 0.00 | 0.00 | +0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2,628 | 0 | -2,628 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 3,141 | 0 | -3,141 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 5,796 | 0 | -5,796 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 11,921 | 0 | -11,921 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 15,223 | 0 | -15,223 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 17,572 | 0 | -17,572 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 19,200 | 0 | -19,200 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 51,760 | 27,960 | -23,800 | 0.00 | 0.01 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 149,000 | 124,000 | -25,000 | 0.01 | 0.02 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,200 | 0 | -30,200 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 31,388 | 0 | -31,388 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 51,149 | 17,749 | -33,400 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 321,609 | 278,375 | -43,234 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 182,625 | 115,508 | -67,117 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 69,486 | 0 | -69,486 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 71,163 | 0 | -71,163 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 96,042 | 21,203 | -74,839 | 0.03 | 0.03 | -0.00 | sell |
| FMR LLC | 121,165 | 37,560 | -83,605 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 95,822 | 0 | -95,822 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 218,723 | 113,513 | -105,210 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 434,110 | 243,638 | -190,472 | 0.00 | 0.00 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 2,376,806 | 2,137,381 | -239,425 | 0.05 | 0.13 | +0.08 | sell |
| CITADEL ADVISORS LLC | 393,942 | 47,214 | -346,728 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 402,527 | 0 | -402,527 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,167,372 | 732,145 | -435,227 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 706,100 | 72,700 | -633,400 | 0.00 | 0.00 | -0.00 | sell |