| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 9,439,328 | +9,439,328 | 0.00 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 4,972,032 | 8,981,662 | +4,009,630 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 8,000,000 | +8,000,000 | 0.00 | 0.16 | +0.16 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,111,910 | 7,171,910 | +6,060,000 | 0.16 | 1.05 | +0.89 | buy |
| Lynx1 Capital Management LP | 7,098,133 | 7,098,133 | 0 | 3.21 | 2.74 | -0.46 | hold |
| VANGUARD GROUP INC | 3,191,557 | 4,379,815 | +1,188,258 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 4,852,741 | 4,344,918 | -507,823 | 0.06 | 0.05 | -0.01 | sell |
| Soleus Capital Management, L.P. | 7,053,942 | 3,803,942 | -3,250,000 | 0.84 | 0.31 | -0.53 | sell |
| BANK OF AMERICA CORP /DE/ | 2,053,162 | 2,387,586 | +334,424 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,897,383 | 1,994,224 | +96,841 | 0.61 | 0.55 | -0.06 | buy |
| BlackRock, Inc. | 1,595,639 | 1,969,814 | +374,175 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 515,437 | 1,775,783 | +1,260,346 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 936,950 | 1,602,580 | +665,630 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 834,726 | 1,509,603 | +674,877 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 5,235,146 | 1,404,902 | -3,830,244 | 0.28 | 0.05 | -0.22 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,934,225 | 1,188,969 | -745,256 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 459,893 | 1,089,020 | +629,127 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 763,100 | 1,068,200 | +305,100 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 725,304 | 988,878 | +263,574 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 203,568 | 874,794 | +671,226 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 809,260 | +809,260 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 128,108 | 657,173 | +529,065 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 350,606 | 449,432 | +98,826 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 481,449 | 447,808 | -33,641 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 443,341 | +443,341 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.06 | +0.06 | buy |
| STATE STREET CORP | 287,373 | 342,773 | +55,400 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 349,289 | 296,480 | -52,809 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 115,973 | 290,234 | +174,261 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 272,053 | 272,053 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Invesco Ltd. | 191,820 | 268,350 | +76,530 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 106,275 | 265,027 | +158,752 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 211,348 | 254,406 | +43,058 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 200,930 | 243,305 | +42,375 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 205,033 | 237,137 | +32,104 | 0.02 | 0.02 | -0.00 | buy |
| BARCLAYS PLC | 43,062 | 219,204 | +176,142 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 204,505 | 204,505 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NORTHERN TRUST CORP | 138,319 | 166,207 | +27,888 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 90,278 | 156,098 | +65,820 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 10,099 | 136,054 | +125,955 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 133,112 | +133,112 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 79,900 | 131,100 | +51,200 | 0.00 | 0.01 | +0.00 | buy |
| Mariner, LLC | 128,237 | 128,050 | -187 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 0 | 117,700 | +117,700 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 111,551 | +111,551 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 104,964 | +104,964 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 149,962 | 104,458 | -45,504 | 0.02 | 0.01 | -0.01 | sell |
| Graham Capital Management, L.P. | 40,628 | 102,198 | +61,570 | 0.00 | 0.01 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.11 | 0.08 | -0.03 | hold |
| AMERICAN CENTURY COMPANIES INC | 24,248 | 68,245 | +43,997 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 67,617 | 67,617 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Crestwood Advisors Group, LLC | 66,536 | 66,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 62,165 | +62,165 | 0.00 | 0.00 | +0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 70,000 | 55,000 | -15,000 | 0.14 | 0.10 | -0.04 | sell |
| D. E. Shaw & Co., Inc. | 11,863 | 52,879 | +41,016 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,264 | 49,840 | +46,576 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 42,500 | 42,500 | 0 | 0.01 | 0.02 | +0.00 | hold |
| GROUP ONE TRADING LLC | 12,432 | 38,994 | +26,562 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 38,187 | +38,187 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 37,721 | +37,721 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 38,200 | 35,340 | -2,860 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 0 | 33,660 | +33,660 | 0.00 | 0.00 | +0.00 | buy |
| Callan Family Office, LLC | 0 | 31,743 | +31,743 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,836 | 30,658 | +22,822 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 29,500 | +29,500 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | 28,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 8,414 | 25,980 | +17,566 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 16,286 | 24,416 | +8,130 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 22,702 | 21,387 | -1,315 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 20,655 | +20,655 | 0.00 | 0.00 | +0.00 | buy |
| Delta Investment Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| EWA, LLC | 19,510 | 16,889 | -2,621 | 0.01 | 0.01 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,475 | 15,792 | +3,317 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 14,574 | 15,224 | +650 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 14,300 | 15,050 | +750 | 0.00 | 0.00 | -0.00 | buy |
| R Squared Ltd | 17,880 | 13,674 | -4,206 | 0.02 | 0.01 | -0.00 | sell |
| HSBC HOLDINGS PLC | 13,629 | 13,629 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jain Global LLC | 0 | 12,762 | +12,762 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,400 | 12,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NINE MASTS CAPITAL Ltd | 0 | 11,472 | +11,472 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 10,508 | 10,278 | -230 | 0.00 | 0.00 | -0.00 | sell |
| Simplicity Wealth,LLC | 10,213 | 10,202 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Abel Hall, LLC | 10,140 | 10,140 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bronte Capital Management Pty Ltd. | 0 | 10,033 | +10,033 | 0.00 | 0.00 | +0.00 | buy |
| Blackston Financial Advisory Group, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,751 | 4,709 | +1,958 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 2,716 | 2,716 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 80,806 | 2,161 | -78,645 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,463 | 1,903 | +440 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| OPTIMA CAPITAL LLC | 0 | 226 | +226 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 156 | 156 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 152 | 100 | -52 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 55 | 19 | -36 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 182,640 | 0 | -182,640 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 13,043 | 0 | -13,043 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 0 | -900,000 | 0.08 | 0.00 | -0.08 | sell |
| ALGERT GLOBAL LLC | 106,300 | 0 | -106,300 | 0.00 | 0.00 | -0.00 | sell |