| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 1,060,427 | 1,435,950 | +375,523 | 8.28 | 12.65 | +4.38 | buy |
| Woodline Partners LP | 583,792 | 761,700 | +177,908 | 0.25 | 0.47 | +0.21 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,041,701 | 1,218,504 | +176,803 | 0.01 | 0.01 | +0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,498,907 | 1,598,907 | +100,000 | 0.13 | 0.18 | +0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 580,000 | 680,000 | +100,000 | 0.38 | 0.71 | +0.33 | buy |
| Rafferty Asset Management, LLC | 65,281 | 119,511 | +54,230 | 0.01 | 0.03 | +0.02 | buy |
| Erste Asset Management GmbH | 5,700 | 20,700 | +15,000 | 0.00 | 0.02 | +0.01 | buy |
| Opaleye Management Inc. | 357,500 | 367,500 | +10,000 | 3.78 | 5.30 | +1.52 | buy |
| PROFUND ADVISORS LLC | 10,847 | 18,661 | +7,814 | 0.02 | 0.05 | 0.00 | buy |
| ALPS ADVISORS INC | 19,612 | 25,378 | +5,766 | 0.01 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 10,635 | 14,195 | +3,560 | 0.02 | 0.04 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,460 | 6,916 | +3,456 | 0.03 | 0.06 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 14,112 | 17,053 | +2,941 | 0.04 | 0.08 | 0.00 | buy |
| BIT Capital GmbH | 10,431 | 11,943 | +1,512 | 0.04 | 0.06 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 2,743 | 2,567 | -176 | 0.07 | 0.09 | +0.02 | sell |
| DAFNA Capital Management LLC | 74,361 | 67,754 | -6,607 | 0.71 | 1.02 | +0.31 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 48,883 | 34,715 | -14,168 | 0.08 | 0.09 | +0.01 | sell |
| Nantahala Capital Management, LLC | 310,141 | 293,997 | -16,144 | 0.74 | 1.11 | +0.37 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 154,664 | 117,030 | -37,634 | 0.02 | 0.02 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 74,649 | 33,828 | -40,821 | 2.12 | 1.48 | -0.64 | sell |
| Candriam S.C.A. | 819,062 | 651,999 | -167,063 | 0.22 | 0.28 | +0.05 | sell |
| Blue Owl Capital Holdings LP | 352,633 | 172,633 | -180,000 | 3.35 | 2.28 | -1.07 | sell |
| Parkman Healthcare Partners LLC | 360,467 | 178,335 | -182,132 | 2.03 | 1.45 | -0.58 | sell |
| ADAR1 Capital Management, LLC | 688,316 | 338,243 | -350,073 | 12.24 | 6.11 | -6.13 | sell |
| BRAIDWELL LP | 1,118,961 | 737,379 | -381,582 | 1.63 | 1.57 | -0.06 | sell |