| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,874,204 | 5,018,516 | +1,144,312 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 81,230 | 971,881 | +890,651 | 0.01 | 0.19 | +0.18 | buy |
| TCG Crossover Management, LLC | 0 | 879,344 | +879,344 | 0.00 | 4.60 | +4.60 | buy |
| Holocene Advisors, LP | 0 | 637,983 | +637,983 | 0.00 | 0.16 | +0.16 | buy |
| Jefferies Financial Group Inc. | 15,900 | 633,671 | +617,771 | 0.01 | 0.85 | +0.84 | buy |
| Redmile Group, LLC | 0 | 552,506 | +552,506 | 0.00 | 1.34 | +1.34 | buy |
| STATE STREET CORP | 1,054,367 | 1,562,895 | +508,528 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Global Management, Ltd. | 1,060,427 | 1,435,950 | +375,523 | 8.28 | 12.65 | +4.38 | buy |
| Soleus Capital Management, L.P. | 0 | 273,600 | +273,600 | 0.00 | 1.59 | +1.59 | buy |
| MARSHALL WACE, LLP | 49,472 | 272,971 | +223,499 | 0.00 | 0.03 | +0.03 | buy |
| Avidity Partners Management LP | 0 | 209,700 | +209,700 | 0.00 | 0.49 | +0.49 | buy |
| CIBC WORLD MARKETS CORP | 0 | 200,000 | +200,000 | 0.00 | 0.09 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 190,000 | +190,000 | 0.00 | 0.02 | +0.02 | buy |
| EcoR1 Capital, LLC | 0 | 187,500 | +187,500 | 0.00 | 0.32 | +0.32 | buy |
| Woodline Partners LP | 583,792 | 761,700 | +177,908 | 0.25 | 0.47 | +0.21 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,041,701 | 1,218,504 | +176,803 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 149,013 | +149,013 | 0.00 | 0.35 | +0.35 | buy |
| VANGUARD GROUP INC | 1,432,195 | 1,545,758 | +113,563 | 0.00 | 0.00 | +0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,498,907 | 1,598,907 | +100,000 | 0.39 | 0.58 | +0.19 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 580,000 | 680,000 | +100,000 | 0.38 | 0.71 | +0.33 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 94,373 | +94,373 | 0.00 | 0.22 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 510,211 | 595,846 | +85,635 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 9,980 | 88,683 | +78,703 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 71,740 | +71,740 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,120 | 91,858 | +70,738 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 65,880 | +65,880 | 0.00 | 0.02 | +0.02 | buy |
| Hudson Bay Capital Management LP | 0 | 65,438 | +65,438 | 0.00 | 0.04 | +0.04 | buy |
| Rafferty Asset Management, LLC | 65,281 | 119,511 | +54,230 | 0.01 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 205,099 | 258,368 | +53,269 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 46,419 | +46,419 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.26 | +0.26 | buy |
| HighVista Strategies LLC | 0 | 39,208 | +39,208 | 0.00 | 0.93 | +0.93 | buy |
| Engineers Gate Manager LP | 0 | 32,459 | +32,459 | 0.00 | 0.06 | +0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181,578 | 207,758 | +26,180 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,635 | 59,273 | +25,638 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 214,597 | 238,806 | +24,209 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 18,874 | +18,874 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 216,846 | 235,638 | +18,792 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 5,700 | 20,700 | +15,000 | 0.00 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 14,264 | +14,264 | 0.00 | 0.06 | +0.06 | buy |
| Opaleye Management Inc. | 357,500 | 367,500 | +10,000 | 3.78 | 5.30 | +1.52 | buy |
| Swiss National Bank | 40,900 | 49,900 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 8,900 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 8,480 | +8,480 | 0.00 | 0.05 | +0.05 | buy |
| FIRST TRUST ADVISORS LP | 0 | 8,248 | +8,248 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,847 | 18,661 | +7,814 | 0.02 | 0.05 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 17,715 | 25,512 | +7,797 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 7,593 | +7,593 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 9,443 | 17,003 | +7,560 | 0.01 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,293 | 17,122 | +6,829 | 0.00 | 0.00 | +0.00 | buy |
| Perpetual Ltd | 0 | 6,689 | +6,689 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 18,876 | 25,455 | +6,579 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 19,612 | 25,378 | +5,766 | 0.01 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 5,648 | +5,648 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 5,626 | +5,626 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 94,504 | 99,633 | +5,129 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 4,029 | +4,029 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 3,798 | +3,798 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 3,671 | +3,671 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 10,635 | 14,195 | +3,560 | 0.02 | 0.04 | +0.02 | buy |
| Pictet Asset Management Holding SA | 0 | 3,527 | +3,527 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 3,513 | +3,513 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,460 | 6,916 | +3,456 | 0.03 | 0.06 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 5,946 | 9,309 | +3,363 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,203 | 25,314 | +3,111 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 14,112 | 17,053 | +2,941 | 0.02 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,441 | 14,316 | +2,875 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 31,657 | 34,527 | +2,870 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,395 | 5,217 | +2,822 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 6,802 | 8,538 | +1,736 | 0.02 | 0.04 | +0.02 | buy |
| BIT Capital GmbH | 10,431 | 11,943 | +1,512 | 0.04 | 0.07 | +0.02 | buy |
| ProShare Advisors LLC | 5,640 | 7,136 | +1,496 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 11,188 | 12,653 | +1,465 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,885 | 13,143 | +1,258 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 5,805 | 6,947 | +1,142 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 766 | +766 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 6,489 | 7,063 | +574 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 560 | +560 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,236 | 2,560 | +324 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,077 | 3,378 | +301 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 12,898 | 13,149 | +251 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 347 | 395 | +48 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 111 | 133 | +22 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 20 | 41 | +21 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 9,817 | 9,832 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 37 | 42 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN FINANCIAL GROUP INC | 10,105 | 10,105 | 0 | 0.15 | 0.25 | +0.10 | hold |
| ORBIMED ADVISORS LLC | 1,268,734 | 1,268,734 | 0 | 1.01 | 1.54 | +0.53 | hold |
| Handelsbanken Fonder AB | 6,700 | 6,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 76 | 76 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 7,550 | 7,550 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 7,000 | 7,000 | 0 | 0.22 | 0.38 | +0.16 | hold |
| HighMark Wealth Management LLC | 75 | 75 | 0 | 0.00 | 0.00 | +0.00 | hold |
| B. Metzler seel. Sohn & Co. AG | 16,103 | 16,103 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sachetta, LLC | 488 | 488 | 0 | 0.01 | 0.01 | -0.00 | hold |