| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,018,516 | 4,719,760 | -298,756 | 0.02 | 0.01 | -0.01 | sell |
| VANGUARD GROUP INC | 1,545,758 | 1,757,120 | +211,362 | 0.00 | 0.00 | -0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,598,907 | 1,598,907 | 0 | 0.58 | 0.37 | -0.21 | hold |
| Darwin Global Management, Ltd. | 1,435,950 | 1,525,902 | +89,952 | 12.65 | 8.00 | -4.65 | buy |
| ORBIMED ADVISORS LLC | 1,268,734 | 1,268,734 | 0 | 1.54 | 1.15 | -0.39 | hold |
| STATE STREET CORP | 1,562,895 | 1,221,376 | -341,519 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,218,504 | 1,187,910 | -30,594 | 0.01 | 0.01 | -0.00 | sell |
| BRAIDWELL LP | 737,379 | 982,209 | +244,830 | 1.57 | 1.41 | -0.17 | buy |
| Jefferies Financial Group Inc. | 633,671 | 899,077 | +265,406 | 0.85 | 0.81 | -0.04 | buy |
| TCG Crossover Management, LLC | 879,344 | 879,344 | 0 | 4.60 | 4.19 | -0.41 | hold |
| Woodline Partners LP | 761,700 | 775,845 | +14,145 | 0.47 | 0.34 | -0.13 | buy |
| Holocene Advisors, LP | 637,983 | 688,326 | +50,343 | 0.16 | 0.13 | -0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 595,846 | 679,580 | +83,734 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 552,506 | 552,506 | 0 | 1.34 | 1.53 | +0.18 | hold |
| ADAR1 Capital Management, LLC | 338,243 | 548,916 | +210,673 | 6.11 | 5.05 | -1.06 | buy |
| GOLDMAN SACHS GROUP INC | 258,368 | 521,447 | +263,079 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 680,000 | 499,208 | -180,792 | 0.71 | 0.39 | -0.32 | sell |
| Candriam S.C.A. | 651,999 | 441,855 | -210,144 | 0.28 | 0.12 | -0.15 | sell |
| CITADEL ADVISORS LLC | 450,278 | 410,484 | -39,794 | 0.03 | 0.02 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 632,049 | 400,214 | -231,835 | 0.01 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 337,663 | 392,956 | +55,293 | 0.02 | 0.01 | -0.00 | buy |
| Nantahala Capital Management, LLC | 293,997 | 378,807 | +84,810 | 1.91 | 1.74 | -0.17 | buy |
| Point72 Asset Management, L.P. | 971,881 | 370,350 | -601,531 | 0.19 | 0.05 | -0.13 | sell |
| Opaleye Management Inc. | 367,500 | 367,500 | 0 | 5.30 | 3.84 | -1.46 | hold |
| Avidity Partners Management LP | 209,700 | 343,200 | +133,500 | 0.49 | 0.67 | +0.17 | buy |
| MORGAN STANLEY | 289,157 | 335,669 | +46,512 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 238,806 | 298,170 | +59,364 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 235,638 | 236,488 | +850 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 190,000 | 230,000 | +40,000 | 0.02 | 0.02 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 207,758 | 227,628 | +19,870 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 273,600 | 221,600 | -52,000 | 1.59 | 0.89 | -0.70 | sell |
| Parkman Healthcare Partners LLC | 178,335 | 198,627 | +20,292 | 1.45 | 1.24 | -0.21 | buy |
| EcoR1 Capital, LLC | 187,500 | 187,500 | 0 | 0.32 | 0.26 | -0.05 | hold |
| BANK OF AMERICA CORP /DE/ | 172,477 | 178,994 | +6,517 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 18,874 | 175,695 | +156,821 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 165,406 | 161,715 | -3,691 | 0.00 | 0.00 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 172,633 | 157,633 | -15,000 | 2.28 | 2.00 | -0.28 | sell |
| ALLIANCEBERNSTEIN L.P. | 91,858 | 150,462 | +58,604 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 149,013 | 144,976 | -4,037 | 0.35 | 0.27 | -0.08 | sell |
| DEUTSCHE BANK AG\ | 124,072 | 124,113 | +41 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 99,633 | 118,388 | +18,755 | 0.00 | 0.00 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 117,030 | 116,544 | -486 | 0.02 | 0.01 | -0.01 | sell |
| READYSTATE ASSET MANAGEMENT LP | 94,373 | 113,823 | +19,450 | 0.22 | 0.25 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 25,512 | 88,636 | +63,124 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 40,000 | 85,000 | +45,000 | 0.26 | 0.39 | +0.13 | buy |
| Russell Investments Group, Ltd. | 82,352 | 82,352 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 33,828 | 74,288 | +40,460 | 1.48 | 4.28 | +2.80 | buy |
| Ensign Peak Advisors, Inc | 71,740 | 71,740 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DAFNA Capital Management LLC | 67,754 | 67,754 | 0 | 1.02 | 0.74 | -0.28 | hold |
| UBS Group AG | 124,185 | 65,555 | -58,630 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 119,511 | 57,555 | -61,956 | 0.03 | 0.01 | -0.02 | sell |
| Swiss National Bank | 49,900 | 56,800 | +6,900 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 59,273 | 56,097 | -3,176 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 65,880 | 48,993 | -16,887 | 0.02 | 0.01 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 0 | 48,988 | +48,988 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 17,135 | 48,281 | +31,146 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 32,459 | 47,806 | +15,347 | 0.06 | 0.05 | -0.01 | buy |
| JANE STREET GROUP, LLC | 19,379 | 44,897 | +25,518 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 34,527 | 41,638 | +7,111 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 39,208 | 39,208 | 0 | 0.93 | 0.65 | -0.27 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 38,061 | +38,061 | 0.00 | 0.10 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 24,822 | 36,279 | +11,457 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 60,405 | 34,113 | -26,292 | 0.03 | 0.01 | -0.02 | sell |
| PFM Health Sciences, LP | 0 | 33,355 | +33,355 | 0.00 | 0.08 | +0.08 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,931 | 31,758 | +12,827 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 2,262 | 31,235 | +28,973 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 55,410 | 30,695 | -24,715 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 30,102 | +30,102 | 0.00 | 0.05 | +0.05 | buy |
| Hudson Bay Capital Management LP | 65,438 | 30,038 | -35,400 | 0.04 | 0.01 | -0.03 | sell |
| Legal & General Group Plc | 25,455 | 29,115 | +3,660 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,314 | 28,252 | +2,938 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 25,378 | 28,144 | +2,766 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 69,656 | 24,992 | -44,664 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 0 | 24,459 | +24,459 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 11,943 | 22,738 | +10,795 | 0.07 | 0.09 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 17,053 | 22,453 | +5,400 | 0.03 | 0.03 | -0.00 | buy |
| MARSHALL WACE, LLP | 272,971 | 22,377 | -250,594 | 0.03 | 0.00 | -0.03 | sell |
| NEOS Investment Management LLC | 14,264 | 21,904 | +7,640 | 0.06 | 0.04 | -0.02 | buy |
| Erste Asset Management GmbH | 20,700 | 20,700 | 0 | 0.02 | 0.01 | -0.01 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 34,715 | 20,293 | -14,422 | 0.09 | 0.04 | -0.06 | sell |
| Artia Global Partners LP | 0 | 20,000 | +20,000 | 0.00 | 0.23 | +0.23 | buy |
| ExodusPoint Capital Management, LP | 0 | 19,940 | +19,940 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 19,832 | +19,832 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 14,300 | 17,800 | +3,500 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 17,540 | +17,540 | 0.00 | 0.07 | +0.07 | buy |
| MetLife Investment Management, LLC | 13,143 | 17,071 | +3,928 | 0.01 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,316 | 16,833 | +2,517 | 0.00 | 0.00 | -0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 16,103 | 16,103 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALGERT GLOBAL LLC | 14,195 | 15,700 | +1,505 | 0.04 | 0.02 | -0.01 | buy |
| JANUS HENDERSON GROUP PLC | 9,832 | 14,307 | +4,475 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 13,681 | +13,681 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,122 | 12,616 | -4,506 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 117,456 | 12,583 | -104,873 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 88,683 | 11,865 | -76,818 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 11,633 | +11,633 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,309 | 11,519 | +2,210 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 18,661 | 10,807 | -7,854 | 0.05 | 0.02 | -0.03 | sell |
| TUDOR INVESTMENT CORP ET AL | 17,003 | 10,357 | -6,646 | 0.01 | 0.01 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 8,248 | 10,124 | +1,876 | 0.00 | 0.00 | -0.00 | buy |