| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 737,379 | 982,209 | +244,830 | 1.57 | 1.41 | -0.17 | buy |
| ADAR1 Capital Management, LLC | 338,243 | 548,916 | +210,673 | 6.11 | 5.05 | -1.06 | buy |
| Avidity Partners Management LP | 209,700 | 343,200 | +133,500 | 0.49 | 0.67 | +0.17 | buy |
| Darwin Global Management, Ltd. | 1,435,950 | 1,525,902 | +89,952 | 12.65 | 8.00 | -4.65 | buy |
| Nantahala Capital Management, LLC | 293,997 | 378,807 | +84,810 | 1.11 | 1.01 | -0.10 | buy |
| Holocene Advisors, LP | 637,983 | 688,326 | +50,343 | 0.16 | 0.13 | -0.02 | buy |
| Integral Health Asset Management, LLC | 40,000 | 85,000 | +45,000 | 0.26 | 0.39 | +0.13 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 33,828 | 74,288 | +40,460 | 1.48 | 4.28 | +2.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 190,000 | 230,000 | +40,000 | 0.02 | 0.02 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 178,335 | 198,627 | +20,292 | 1.45 | 1.24 | -0.21 | buy |
| READYSTATE ASSET MANAGEMENT LP | 94,373 | 113,823 | +19,450 | 0.22 | 0.25 | +0.02 | buy |
| Woodline Partners LP | 761,700 | 775,845 | +14,145 | 0.47 | 0.34 | -0.13 | buy |
| BIT Capital GmbH | 11,943 | 22,738 | +10,795 | 0.06 | 0.08 | +0.02 | buy |
| PROFUND ADVISORS LLC | 18,661 | 10,807 | +7,854 | 0.05 | 0.02 | 0.00 | sell |
| NEOS Investment Management LLC | 14,264 | 21,904 | +7,640 | 0.06 | 0.04 | -0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 17,053 | 22,453 | +5,400 | 0.08 | 0.06 | 0.00 | buy |
| ALPS ADVISORS INC | 25,378 | 28,144 | +2,766 | 0.01 | 0.01 | -0.00 | buy |
| ALGERT GLOBAL LLC | 14,195 | 15,700 | +1,505 | 0.04 | 0.02 | 0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 117,030 | 116,544 | -486 | 0.02 | 0.01 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 2,567 | 1,829 | -738 | 0.09 | 0.04 | -0.05 | sell |
| China Universal Asset Management Co., Ltd. | 6,916 | 4,239 | -2,677 | 0.06 | 0.03 | -0.03 | sell |
| Granahan Investment Management, LLC | 149,013 | 144,976 | -4,037 | 0.35 | 0.27 | -0.08 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 34,715 | 20,293 | -14,422 | 0.09 | 0.04 | -0.06 | sell |
| Blue Owl Capital Holdings LP | 172,633 | 157,633 | -15,000 | 2.28 | 2.00 | -0.28 | sell |
| FRED ALGER MANAGEMENT, LLC | 65,880 | 48,993 | -16,887 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,218,504 | 1,187,910 | -30,594 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 65,438 | 30,038 | -35,400 | 0.02 | 0.01 | -0.02 | sell |
| Soleus Capital Management, L.P. | 273,600 | 221,600 | -52,000 | 1.59 | 0.89 | -0.70 | sell |
| Rafferty Asset Management, LLC | 119,511 | 57,555 | -61,956 | 0.03 | 0.01 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 680,000 | 499,208 | -180,792 | 0.71 | 0.39 | -0.32 | sell |
| Candriam S.C.A. | 651,999 | 441,855 | -210,144 | 0.28 | 0.12 | -0.15 | sell |