| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Jefferies Financial Group Inc. | 633,671 | 899,077 | +265,406 | 0.85 | 0.81 | -0.04 | buy |
| GOLDMAN SACHS GROUP INC | 258,368 | 521,447 | +263,079 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 737,379 | 982,209 | +244,830 | 1.57 | 1.41 | -0.17 | buy |
| VANGUARD GROUP INC | 1,545,758 | 1,757,120 | +211,362 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 338,243 | 548,916 | +210,673 | 6.11 | 5.05 | -1.06 | buy |
| D. E. Shaw & Co., Inc. | 18,874 | 175,695 | +156,821 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 209,700 | 343,200 | +133,500 | 0.49 | 0.67 | +0.17 | buy |
| Darwin Global Management, Ltd. | 1,435,950 | 1,525,902 | +89,952 | 12.65 | 8.00 | -4.65 | buy |
| Nantahala Capital Management, LLC | 293,997 | 378,807 | +84,810 | 1.91 | 1.74 | -0.17 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 595,846 | 679,580 | +83,734 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 25,512 | 88,636 | +63,124 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 238,806 | 298,170 | +59,364 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 91,858 | 150,462 | +58,604 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 337,663 | 392,956 | +55,293 | 0.02 | 0.01 | -0.00 | buy |
| Holocene Advisors, LP | 637,983 | 688,326 | +50,343 | 0.16 | 0.13 | -0.02 | buy |
| TWINBEECH CAPITAL LP | 0 | 48,988 | +48,988 | 0.00 | 0.04 | +0.04 | buy |
| MORGAN STANLEY | 289,157 | 335,669 | +46,512 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 40,000 | 85,000 | +45,000 | 0.26 | 0.39 | +0.13 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 33,828 | 74,288 | +40,460 | 1.48 | 4.28 | +2.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 190,000 | 230,000 | +40,000 | 0.02 | 0.02 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 38,061 | +38,061 | 0.00 | 0.10 | +0.10 | buy |
| PFM Health Sciences, LP | 0 | 33,355 | +33,355 | 0.00 | 0.08 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 17,135 | 48,281 | +31,146 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 30,102 | +30,102 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 2,262 | 31,235 | +28,973 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 19,379 | 44,897 | +25,518 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 24,459 | +24,459 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 178,335 | 198,627 | +20,292 | 1.45 | 1.24 | -0.21 | buy |
| Artia Global Partners LP | 0 | 20,000 | +20,000 | 0.00 | 0.23 | +0.23 | buy |
| ExodusPoint Capital Management, LP | 0 | 19,940 | +19,940 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 207,758 | 227,628 | +19,870 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 19,832 | +19,832 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 94,373 | 113,823 | +19,450 | 0.22 | 0.25 | +0.02 | buy |
| Bank of New York Mellon Corp | 99,633 | 118,388 | +18,755 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 17,540 | +17,540 | 0.00 | 0.07 | +0.07 | buy |
| Engineers Gate Manager LP | 32,459 | 47,806 | +15,347 | 0.06 | 0.05 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 761,700 | 775,845 | +14,145 | 0.47 | 0.34 | -0.13 | buy |
| Jump Financial, LLC | 0 | 13,681 | +13,681 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,931 | 31,758 | +12,827 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 11,633 | +11,633 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 24,822 | 36,279 | +11,457 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 11,943 | 22,738 | +10,795 | 0.07 | 0.09 | +0.02 | buy |
| Nebula Research & Development LLC | 0 | 8,254 | +8,254 | 0.00 | 0.06 | +0.06 | buy |
| NEOS Investment Management LLC | 14,264 | 21,904 | +7,640 | 0.06 | 0.04 | -0.02 | buy |
| RHUMBLINE ADVISERS | 34,527 | 41,638 | +7,111 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 49,900 | 56,800 | +6,900 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 172,477 | 178,994 | +6,517 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 6,355 | +6,355 | 0.00 | 0.05 | +0.05 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 17,053 | 22,453 | +5,400 | 0.03 | 0.03 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 5,167 | +5,167 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 4,996 | +4,996 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 20 | 4,809 | +4,789 | 0.00 | 0.03 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 9,832 | 14,307 | +4,475 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 895 | 4,923 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,143 | 17,071 | +3,928 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 25,455 | 29,115 | +3,660 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 14,300 | 17,800 | +3,500 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6,370 | 9,550 | +3,180 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,314 | 28,252 | +2,938 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 2,811 | +2,811 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 25,378 | 28,144 | +2,766 | 0.01 | 0.01 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,217 | 7,820 | +2,603 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,316 | 16,833 | +2,517 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,309 | 11,519 | +2,210 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 2,509 | 4,533 | +2,024 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 8,248 | 10,124 | +1,876 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 14,195 | 15,700 | +1,505 | 0.04 | 0.02 | -0.01 | buy |
| Handelsbanken Fonder AB | 6,700 | 8,000 | +1,300 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 6,947 | 8,077 | +1,130 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 235,638 | 236,488 | +850 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5,626 | 6,336 | +710 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,560 | 2,887 | +327 | 0.01 | 0.00 | -0.00 | buy |
| KBC Group NV | 766 | 831 | +65 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 124,072 | 124,113 | +41 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 867 | 901 | +34 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 41 | 62 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 15 | +10 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 42 | 44 | +2 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN FINANCIAL GROUP INC | 10,105 | 10,105 | 0 | 0.25 | 0.20 | -0.05 | hold |
| ORBIMED ADVISORS LLC | 1,268,734 | 1,268,734 | 0 | 1.54 | 1.15 | -0.39 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 1,598,907 | 1,598,907 | 0 | 0.58 | 0.37 | -0.21 | hold |
| HighVista Strategies LLC | 39,208 | 39,208 | 0 | 0.93 | 0.65 | -0.27 | hold |
| DAFNA Capital Management LLC | 67,754 | 67,754 | 0 | 1.02 | 0.74 | -0.28 | hold |
| Redmile Group, LLC | 552,506 | 552,506 | 0 | 1.34 | 1.53 | +0.18 | hold |
| Ensign Peak Advisors, Inc | 71,740 | 71,740 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SIGNATUREFD, LLC | 76 | 76 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 7,550 | 7,550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 133 | 133 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allianz Asset Management GmbH | 8,900 | 8,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 187,500 | 187,500 | 0 | 0.32 | 0.26 | -0.05 | hold |
| Opaleye Management Inc. | 367,500 | 367,500 | 0 | 5.30 | 3.84 | -1.46 | hold |
| Birchview Capital, LP | 7,000 | 7,000 | 0 | 0.38 | 0.30 | -0.08 | hold |
| Russell Investments Group, Ltd. | 82,352 | 82,352 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HighMark Wealth Management LLC | 75 | 75 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TCG Crossover Management, LLC | 879,344 | 879,344 | 0 | 4.60 | 4.19 | -0.41 | hold |