| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 279,701 | 718,423 | +438,722 | 0.13 | 0.27 | +0.14 | buy |
| BRAIDWELL LP | 1,143,865 | 1,357,309 | +213,444 | 1.50 | 1.37 | -0.13 | buy |
| Parkman Healthcare Partners LLC | 276,815 | 298,475 | +21,660 | 1.93 | 1.74 | -0.18 | buy |
| Candriam S.C.A. | 721,061 | 741,061 | +20,000 | 0.21 | 0.17 | -0.04 | buy |
| DAFNA Capital Management LLC | 47,661 | 65,961 | +18,300 | 0.52 | 0.65 | +0.13 | buy |
| Opaleye Management Inc. | 352,650 | 360,400 | +7,750 | 3.39 | 3.74 | +0.35 | buy |
| ALGERT GLOBAL LLC | 16,595 | 10,635 | +5,960 | 0.03 | 0.02 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 55,341 | 60,341 | +5,000 | 0.08 | 0.05 | 0.00 | buy |
| First Light Asset Management, LLC | 416,830 | 421,438 | +4,608 | 1.31 | 1.28 | -0.04 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 95,213 | 97,542 | +2,329 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 388 | 758 | +370 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 21,744 | 21,893 | +149 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,818 | 2,561 | -257 | 0.07 | 0.05 | -0.02 | sell |
| PROFUND ADVISORS LLC | 12,935 | 10,021 | -2,914 | 0.03 | 0.02 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,270,361 | 1,267,232 | -3,129 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 70,256 | 58,189 | -12,067 | 0.02 | 0.01 | -0.01 | sell |
| B. Metzler seel. Sohn & Co. AG | 26,256 | 14,151 | -12,105 | 0.01 | 0.01 | -0.01 | sell |
| Soleus Capital Management, L.P. | 70,800 | 12,700 | -58,100 | 0.32 | 0.04 | -0.28 | sell |
| Nantahala Capital Management, LLC | 497,161 | 328,781 | -168,380 | 2.42 | 1.33 | -1.09 | sell |