| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 370,350 | 947,570 | +577,220 | 0.05 | 0.19 | +0.14 | buy |
| Paradigm Biocapital Advisors LP | 0 | 525,037 | +525,037 | 0.00 | 1.07 | +1.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,187,910 | 1,514,505 | +326,595 | 0.01 | 0.01 | +0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,598,907 | 1,897,601 | +298,694 | 0.37 | 0.60 | +0.23 | buy |
| CITADEL ADVISORS LLC | 410,484 | 704,923 | +294,439 | 0.02 | 0.04 | +0.02 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 287,484 | +287,484 | 0.00 | 0.16 | +0.16 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 286,995 | +286,995 | 0.00 | 1.43 | +1.43 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 88,636 | 325,434 | +236,798 | 0.01 | 0.05 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 198,627 | 421,782 | +223,155 | 1.24 | 3.13 | +1.89 | buy |
| Assenagon Asset Management S.A. | 24,459 | 223,704 | +199,245 | 0.00 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 392,956 | 572,990 | +180,034 | 0.01 | 0.03 | +0.01 | buy |
| FMR LLC | 4,719,760 | 4,899,134 | +179,374 | 0.01 | 0.02 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 34,113 | 199,354 | +165,241 | 0.01 | 0.09 | +0.08 | buy |
| EMERALD ADVISERS, LLC | 0 | 155,545 | +155,545 | 0.00 | 0.35 | +0.35 | buy |
| Holocene Advisors, LP | 688,326 | 843,110 | +154,784 | 0.13 | 0.20 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 56,097 | 175,294 | +119,197 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 85,000 | 200,000 | +115,000 | 0.39 | 1.37 | +0.98 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 112,613 | +112,613 | 0.00 | 0.34 | +0.34 | buy |
| VANGUARD GROUP INC | 1,757,120 | 1,856,418 | +99,298 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 86,930 | +86,930 | 0.00 | 1.51 | +1.51 | buy |
| JANUS HENDERSON GROUP PLC | 14,307 | 92,110 | +77,803 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 69,000 | +69,000 | 0.00 | 1.19 | +1.19 | buy |
| PFM Health Sciences, LP | 33,355 | 101,050 | +67,695 | 0.08 | 0.34 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 679,580 | 725,621 | +46,041 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 24,992 | 60,014 | +35,022 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 227,628 | 260,120 | +32,492 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 236,488 | 266,356 | +29,868 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 335,669 | 365,297 | +29,628 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 367,500 | 395,276 | +27,776 | 3.84 | 3.83 | -0.01 | buy |
| COMERICA BANK | 0 | 25,791 | +25,791 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 30,102 | 54,236 | +24,134 | 0.05 | 0.14 | +0.09 | buy |
| MARSHALL WACE, LLP | 22,377 | 43,500 | +21,123 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 82,352 | 102,316 | +19,964 | 0.01 | 0.01 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 17,674 | +17,674 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 144,976 | 161,130 | +16,154 | 0.27 | 0.37 | +0.10 | buy |
| JANE STREET GROUP, LLC | 44,897 | 60,178 | +15,281 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 14,949 | +14,949 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 10,124 | 24,130 | +14,006 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 39,208 | 52,107 | +12,899 | 0.65 | 1.04 | +0.39 | buy |
| CITIGROUP INC | 12,583 | 23,381 | +10,798 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 175,695 | 186,288 | +10,593 | 0.01 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,392 | +10,392 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 48,993 | 59,138 | +10,145 | 0.01 | 0.02 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 10,357 | 19,787 | +9,430 | 0.01 | 0.01 | +0.01 | buy |
| Valence8 US LP | 0 | 8,025 | +8,025 | 0.00 | 0.20 | +0.20 | buy |
| ALLIANCEBERNSTEIN L.P. | 150,462 | 158,205 | +7,743 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,144 | +6,144 | 0.00 | 0.08 | +0.08 | buy |
| DAFNA Capital Management LLC | 67,754 | 73,754 | +6,000 | 0.74 | 1.01 | +0.27 | buy |
| NEOS Investment Management LLC | 21,904 | 27,778 | +5,874 | 0.04 | 0.05 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 5,807 | +5,807 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 5,718 | +5,718 | 0.00 | 0.02 | +0.02 | buy |
| Nebula Research & Development LLC | 8,254 | 13,439 | +5,185 | 0.06 | 0.09 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 3,716 | +3,716 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 3,671 | +3,671 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 3,527 | +3,527 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 22,738 | 26,237 | +3,499 | 0.09 | 0.15 | +0.05 | buy |
| Soleus Capital Management, L.P. | 221,600 | 224,600 | +3,000 | 0.89 | 1.08 | +0.19 | buy |
| China Universal Asset Management Co., Ltd. | 4,239 | 7,217 | +2,978 | 0.03 | 0.05 | +0.02 | buy |
| Nantahala Capital Management, LLC | 378,807 | 381,659 | +2,852 | 1.74 | 1.86 | +0.13 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,183 | 17,798 | +2,615 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,453 | 24,752 | +2,299 | 0.03 | 0.04 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 48,281 | 50,552 | +2,271 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 5,667 | 7,785 | +2,118 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,058 | +2,058 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,377 | 5,371 | +1,994 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 13,681 | 15,503 | +1,822 | 0.01 | 0.02 | +0.01 | buy |
| Point72 (DIFC) Ltd | 17,540 | 19,255 | +1,715 | 0.07 | 0.09 | +0.02 | buy |
| Handelsbanken Fonder AB | 8,000 | 9,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 1,528 | +1,528 | 0.00 | 0.05 | +0.05 | buy |
| Allianz Asset Management GmbH | 8,900 | 10,400 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 2,811 | 3,844 | +1,033 | 0.03 | 0.04 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6,336 | 7,240 | +904 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,382 | 9,048 | +666 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 831 | 1,263 | +432 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 30,695 | 31,117 | +422 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,865 | 12,163 | +298 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,077 | 1,357 | +280 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 8,077 | 8,312 | +235 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,533 | 4,726 | +193 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 4,901 | 4,938 | +37 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,829 | 1,859 | +30 | 0.04 | 0.05 | +0.01 | buy |
| BESSEMER GROUP INC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 40 | +25 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 62 | 86 | +24 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 44 | 67 | +23 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 25 | 26 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1 | 2 | +1 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN FINANCIAL GROUP INC | 10,105 | 10,105 | 0 | 0.20 | 0.25 | +0.05 | hold |
| Ameritas Investment Partners, Inc. | 2,887 | 2,887 | 0 | 0.00 | 0.01 | +0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 20,293 | 20,293 | 0 | 0.04 | 0.05 | +0.02 | hold |
| Redmile Group, LLC | 552,506 | 552,506 | 0 | 1.53 | 1.89 | +0.36 | hold |
| Ensign Peak Advisors, Inc | 71,740 | 71,740 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SIGNATUREFD, LLC | 76 | 76 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 7,550 | 7,550 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 133 | 133 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 17,071 | 17,071 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Arax Advisory Partners | 16 | 16 | 0 | 0.00 | 0.00 | +0.00 | hold |