| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,187,910 | 1,514,505 | +326,595 | 0.01 | 0.01 | +0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,598,907 | 1,897,601 | +298,694 | 0.12 | 0.19 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 198,627 | 421,782 | +223,155 | 1.22 | 3.13 | +1.91 | buy |
| Holocene Advisors, LP | 688,326 | 843,110 | +154,784 | 0.13 | 0.20 | +0.07 | buy |
| Integral Health Asset Management, LLC | 85,000 | 200,000 | +115,000 | 0.37 | 1.31 | +0.94 | buy |
| PFM Health Sciences, LP | 33,355 | 101,050 | +67,695 | 0.08 | 0.33 | +0.26 | buy |
| Opaleye Management Inc. | 367,500 | 395,276 | +27,776 | 3.84 | 3.83 | -0.01 | buy |
| J. Goldman & Co LP | 30,102 | 54,236 | +24,134 | 0.04 | 0.09 | +0.05 | buy |
| Granahan Investment Management, LLC | 144,976 | 161,130 | +16,154 | 0.27 | 0.37 | +0.10 | buy |
| HighVista Strategies LLC | 39,208 | 52,107 | +12,899 | 0.65 | 1.04 | +0.39 | buy |
| FRED ALGER MANAGEMENT, LLC | 48,993 | 59,138 | +10,145 | 0.01 | 0.02 | +0.01 | buy |
| DAFNA Capital Management LLC | 67,754 | 73,754 | +6,000 | 0.74 | 1.01 | +0.27 | buy |
| NEOS Investment Management LLC | 21,904 | 27,778 | +5,874 | 0.04 | 0.05 | +0.01 | buy |
| ALGERT GLOBAL LLC | 15,700 | 10,080 | +5,620 | 0.02 | 0.02 | 0.00 | sell |
| Nebula Research & Development LLC | 8,254 | 13,439 | +5,185 | 0.06 | 0.09 | +0.03 | buy |
| BIT Capital GmbH | 22,738 | 26,237 | +3,499 | 0.08 | 0.14 | +0.06 | buy |
| Soleus Capital Management, L.P. | 221,600 | 224,600 | +3,000 | 0.89 | 1.08 | +0.19 | buy |
| China Universal Asset Management Co., Ltd. | 4,239 | 7,217 | +2,978 | 0.03 | 0.05 | +0.02 | buy |
| Nantahala Capital Management, LLC | 378,807 | 381,659 | +2,852 | 1.01 | 1.12 | +0.11 | buy |
| PROFUND ADVISORS LLC | 10,807 | 8,392 | +2,415 | 0.02 | 0.02 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,453 | 24,752 | +2,299 | 0.06 | 0.11 | 0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 2,811 | 3,844 | +1,033 | 0.03 | 0.04 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 1,829 | 1,859 | +30 | 0.04 | 0.05 | +0.01 | buy |
| ALPS ADVISORS INC | 28,144 | 27,905 | -239 | 0.01 | 0.01 | +0.00 | sell |
| Darwin Global Management, Ltd. | 1,525,902 | 1,523,732 | -2,170 | 8.00 | 7.20 | -0.81 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 116,544 | 113,860 | -2,684 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 775,845 | 763,548 | -12,297 | 0.34 | 0.37 | +0.03 | sell |
| Rafferty Asset Management, LLC | 57,555 | 41,112 | -16,443 | 0.01 | 0.01 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 48,988 | 15,378 | -33,610 | 0.04 | 0.02 | -0.03 | sell |
| Blue Owl Capital Holdings LP | 157,633 | 122,633 | -35,000 | 2.00 | 1.38 | -0.62 | sell |
| Avidity Partners Management LP | 343,200 | 293,200 | -50,000 | 0.67 | 0.87 | +0.20 | sell |
| Candriam S.C.A. | 441,855 | 345,384 | -96,471 | 0.12 | 0.12 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 548,916 | 445,068 | -103,848 | 5.05 | 4.33 | -0.72 | sell |
| READYSTATE ASSET MANAGEMENT LP | 113,823 | 4,603 | -109,220 | 0.25 | 0.01 | -0.23 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 499,208 | 380,000 | -119,208 | 0.39 | 0.38 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 1,268,734 | 1,018,734 | -250,000 | 1.15 | 1.08 | -0.07 | sell |
| BRAIDWELL LP | 982,209 | 707,240 | -274,969 | 1.41 | 1.16 | -0.24 | sell |