| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 0 | 1,060,427 | +1,060,427 | 0.00 | 8.28 | +8.28 | buy |
| MORGAN STANLEY | 448,701 | 925,388 | +476,687 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 405,149 | 760,168 | +355,019 | 0.01 | 0.03 | +0.02 | buy |
| Blue Owl Capital Holdings LP | 0 | 352,633 | +352,633 | 0.00 | 3.35 | +3.35 | buy |
| DEUTSCHE BANK AG\ | 12,572 | 358,276 | +345,704 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 204,057 | 522,128 | +318,071 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 3,604,928 | 3,874,204 | +269,276 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 472,751 | 699,425 | +226,674 | 0.01 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 49,511 | 259,760 | +210,249 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 6,587 | 181,385 | +174,798 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 902,000 | 1,054,367 | +152,367 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 54,650 | 193,449 | +138,799 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 100,059 | 205,099 | +105,040 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 741,061 | 819,062 | +78,001 | 0.17 | 0.22 | +0.06 | buy |
| CITIGROUP INC | 98,109 | 169,391 | +71,282 | 0.00 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 298,475 | 360,467 | +61,992 | 1.74 | 2.03 | +0.28 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 97,542 | 154,664 | +57,122 | 0.01 | 0.02 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 49,472 | +49,472 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 48,883 | +48,883 | 0.00 | 0.08 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 31,572 | +31,572 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,406,431 | 1,432,195 | +25,764 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 8,958 | 34,542 | +25,584 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 486,001 | 510,211 | +24,210 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 75,875 | 94,557 | +18,682 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 77,800 | 95,338 | +17,538 | 0.02 | 0.03 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 15,900 | +15,900 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 15,532 | +15,532 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,122 | +13,122 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 53,069 | 62,644 | +9,575 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 9,443 | +9,443 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 10,606 | 19,417 | +8,811 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 65,961 | 74,361 | +8,400 | 0.65 | 0.71 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 637 | 8,262 | +7,625 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 58,189 | 65,281 | +7,092 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,085 | 17,135 | +6,050 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 5,805 | +5,805 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 5,802 | +5,802 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 5,640 | +5,640 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 5,205 | +5,205 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 176,953 | 181,578 | +4,625 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 212,899 | 216,846 | +3,947 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,123 | 8,927 | +3,804 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 6,962 | 10,431 | +3,469 | 0.03 | 0.04 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 758 | 3,460 | +2,702 | 0.01 | 0.03 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,708 | 28,891 | +2,183 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 14,151 | 16,103 | +1,952 | 0.01 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 969 | +969 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,021 | 10,847 | +826 | 0.02 | 0.02 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 214,074 | 214,597 | +523 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 411 | +411 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 12,494 | 12,898 | +404 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 347 | +347 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,561 | 2,743 | +182 | 0.05 | 0.07 | +0.02 | buy |
| SIGNATUREFD, LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 7 | +4 | 0.00 | 0.00 | 0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN FINANCIAL GROUP INC | 10,105 | 10,105 | 0 | 0.11 | 0.15 | +0.04 | hold |
| CANADA LIFE ASSURANCE Co | 2,395 | 2,395 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,236 | 2,236 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 21,120 | 21,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 10,635 | 10,635 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Handelsbanken Fonder AB | 6,700 | 6,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 580,000 | 580,000 | 0 | 0.33 | 0.38 | +0.04 | hold |
| DekaBank Deutsche Girozentrale | 7,550 | 7,550 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 111 | 111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 11,885 | 11,885 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 7,000 | 7,000 | 0 | 0.19 | 0.22 | +0.03 | hold |
| Chescapmanager LLC | 10,105 | 10,105 | 0 | 0.08 | 0.09 | +0.02 | hold |
| HighMark Wealth Management LLC | 75 | 75 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 5,700 | 5,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,424 | 1,424 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6,490 | 6,490 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 9,832 | 9,817 | -15 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 6,512 | 6,489 | -23 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,114 | 3,077 | -37 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,337 | 10,293 | -44 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 11,233 | 11,188 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 18,926 | 18,876 | -50 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 55 | 0 | -55 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 124 | 0 | -124 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,329 | 3,122 | -207 | 0.00 | 0.00 | +0.00 | sell |
| Tortoise Investment Management, LLC | 312 | 0 | -312 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 171,277 | 170,852 | -425 | 0.00 | 0.00 | +0.00 | sell |
| Cresset Asset Management, LLC | 7,682 | 7,176 | -506 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 32,543 | 31,657 | -886 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,267 | 22,203 | -1,064 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 21,893 | 19,612 | -2,281 | 0.01 | 0.01 | +0.00 | sell |
| Opaleye Management Inc. | 360,400 | 357,500 | -2,900 | 3.74 | 3.78 | +0.04 | sell |
| Swiss National Bank | 45,600 | 40,900 | -4,700 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 16,551 | 9,980 | -6,571 | 0.00 | 0.00 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 7,000 | 0 | -7,000 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 7,917 | 0 | -7,917 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 15,238 | 5,946 | -9,292 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 17,161 | 6,802 | -10,359 | 0.05 | 0.02 | -0.02 | sell |
| Allianz Asset Management GmbH | 12,200 | 0 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 12,700 | 0 | -12,700 | 0.04 | 0.00 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,874 | 11,441 | -18,433 | 0.00 | 0.00 | -0.00 | sell |