| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Candriam S.C.A. | 741,061 | 819,062 | +78,001 | 0.17 | 0.22 | +0.06 | buy |
| Parkman Healthcare Partners LLC | 298,475 | 360,467 | +61,992 | 1.74 | 2.03 | +0.28 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 97,542 | 154,664 | +57,122 | 0.01 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 60,341 | 14,112 | +46,229 | 0.05 | 0.04 | 0.00 | sell |
| DAFNA Capital Management LLC | 65,961 | 74,361 | +8,400 | 0.65 | 0.71 | +0.05 | buy |
| Rafferty Asset Management, LLC | 58,189 | 65,281 | +7,092 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 6,962 | 10,431 | +3,469 | 0.03 | 0.04 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 758 | 3,460 | +2,702 | 0.01 | 0.03 | +0.02 | buy |
| B. Metzler seel. Sohn & Co. AG | 14,151 | 16,103 | +1,952 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,021 | 10,847 | +826 | 0.02 | 0.02 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,561 | 2,743 | +182 | 0.05 | 0.07 | +0.02 | buy |
| ALPS ADVISORS INC | 21,893 | 19,612 | -2,281 | 0.01 | 0.01 | +0.00 | sell |
| Opaleye Management Inc. | 360,400 | 357,500 | -2,900 | 3.74 | 3.78 | +0.04 | sell |
| Nantahala Capital Management, LLC | 328,781 | 310,141 | -18,640 | 0.90 | 0.74 | -0.16 | sell |
| Woodline Partners LP | 718,423 | 583,792 | -134,631 | 0.27 | 0.25 | -0.02 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,676,522 | 1,498,907 | -177,615 | 0.10 | 0.13 | +0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,267,232 | 1,041,701 | -225,531 | 0.01 | 0.01 | -0.00 | sell |
| BRAIDWELL LP | 1,357,309 | 1,118,961 | -238,348 | 1.37 | 1.63 | +0.27 | sell |
| ORBIMED ADVISORS LLC | 1,514,734 | 1,268,734 | -246,000 | 1.04 | 1.01 | -0.03 | sell |