| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 707,240 | 1,894,439 | +1,187,199 | 1.16 | 0.89 | -0.27 | buy |
| FMR LLC | 4,899,134 | 5,543,308 | +644,174 | 0.02 | 0.01 | -0.01 | buy |
| Lynx1 Capital Management LP | 0 | 544,001 | +544,001 | 0.00 | 3.23 | +3.23 | buy |
| Nantahala Capital Management, LLC | 381,659 | 915,048 | +533,389 | 1.86 | 1.01 | -0.85 | buy |
| MANGROVE PARTNERS IM, LLC | 286,995 | 736,385 | +449,390 | 1.43 | 1.29 | -0.14 | buy |
| Holocene Advisors, LP | 843,110 | 1,199,990 | +356,880 | 0.20 | 0.06 | -0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 572,990 | 878,159 | +305,169 | 0.03 | 0.01 | -0.02 | buy |
| MORGAN STANLEY | 365,297 | 656,801 | +291,504 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 200,000 | 450,000 | +250,000 | 1.37 | 0.63 | -0.74 | buy |
| Verition Fund Management LLC | 0 | 216,103 | +216,103 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,048 | 211,309 | +202,261 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 197,666 | +197,666 | 0.00 | 0.03 | +0.03 | buy |
| Clearbridge Investments, LLC | 0 | 190,064 | +190,064 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 31,117 | 213,431 | +182,314 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 355,664 | 535,584 | +179,920 | 0.00 | 0.00 | -0.00 | buy |
| Darwin Global Management, Ltd. | 1,523,732 | 1,687,135 | +163,403 | 7.20 | 2.53 | -4.67 | buy |
| FEDERATED HERMES, INC. | 0 | 124,620 | +124,620 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 122,633 | 242,633 | +120,000 | 1.38 | 0.88 | -0.50 | buy |
| UBS Group AG | 55,907 | 174,941 | +119,034 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 15,378 | 129,553 | +114,175 | 0.02 | 0.04 | +0.02 | buy |
| Altium Capital Management LLC | 69,000 | 175,000 | +106,000 | 1.19 | 0.86 | -0.33 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 103,408 | +103,408 | 0.00 | 0.30 | +0.30 | buy |
| TFG Asset Management GP Ltd | 0 | 103,000 | +103,000 | 0.00 | 0.53 | +0.53 | buy |
| VANGUARD GROUP INC | 1,856,418 | 1,957,109 | +100,691 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 2,632,608 | 2,729,278 | +96,670 | 0.00 | 0.00 | -0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 95,375 | +95,375 | 0.00 | 0.11 | +0.11 | buy |
| STATE STREET CORP | 1,113,590 | 1,203,383 | +89,793 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 155,545 | 244,633 | +89,088 | 0.35 | 0.15 | -0.20 | buy |
| CITADEL ADVISORS LLC | 704,923 | 791,109 | +86,186 | 0.04 | 0.01 | -0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 3,694 | 74,255 | +70,561 | 0.01 | 0.08 | +0.07 | buy |
| NORGES BANK | 0 | 64,900 | +64,900 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 61,200 | +61,200 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 39,669 | 100,017 | +60,348 | 0.04 | 0.03 | -0.02 | buy |
| Nebula Research & Development LLC | 13,439 | 71,710 | +58,271 | 0.09 | 0.13 | +0.04 | buy |
| DAFNA Capital Management LLC | 73,754 | 130,316 | +56,562 | 1.01 | 0.52 | -0.49 | buy |
| TD ASSET MANAGEMENT INC | 0 | 51,600 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 60,014 | 107,542 | +47,528 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 46,110 | +46,110 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 112,613 | 155,347 | +42,734 | 0.34 | 0.15 | -0.19 | buy |
| JANE STREET GROUP, LLC | 60,178 | 101,112 | +40,934 | 0.01 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 725,621 | 765,436 | +39,815 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 297,669 | 328,920 | +31,251 | 0.01 | 0.00 | -0.01 | buy |
| CITIGROUP INC | 23,381 | 54,423 | +31,042 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 266,356 | 296,467 | +30,111 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 29,146 | +29,146 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 24,752 | 50,897 | +26,145 | 0.04 | 0.02 | -0.02 | buy |
| SG Americas Securities, LLC | 0 | 24,493 | +24,493 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,806 | 40,356 | +23,550 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,322 | 33,664 | +23,342 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,839 | 22,984 | +21,145 | 0.00 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 4,603 | 25,523 | +20,920 | 0.01 | 0.02 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 260,120 | 279,682 | +19,562 | 0.00 | 0.00 | -0.00 | buy |
| F/m Investments LLC | 0 | 17,061 | +17,061 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,720 | 44,434 | +16,714 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 6,144 | 22,213 | +16,069 | 0.08 | 0.06 | -0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 50,552 | 64,416 | +13,864 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 6,900 | 20,700 | +13,800 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 11,535 | +11,535 | 0.00 | 0.08 | +0.08 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 11,158 | +11,158 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,392 | 18,881 | +8,489 | 0.01 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 18,510 | 26,957 | +8,447 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 7,000 | 15,000 | +8,000 | 0.35 | 0.19 | -0.16 | buy |
| NEOS Investment Management LLC | 27,778 | 35,663 | +7,885 | 0.05 | 0.01 | -0.04 | buy |
| SIMPLEX TRADING, LLC | 0 | 7,387 | +7,387 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,726 | 11,256 | +6,530 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 6,242 | +6,242 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 5,718 | 11,186 | +5,468 | 0.02 | 0.00 | -0.01 | buy |
| CANADA LIFE ASSURANCE Co | 2,395 | 7,371 | +4,976 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 27,905 | 32,756 | +4,851 | 0.01 | 0.00 | -0.01 | buy |
| Rafferty Asset Management, LLC | 41,112 | 45,801 | +4,689 | 0.01 | 0.00 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 11,055 | 15,208 | +4,153 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 101,050 | 104,323 | +3,273 | 0.34 | 0.13 | -0.21 | buy |
| AlphaQuest LLC | 632 | 3,596 | +2,964 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 29,115 | 31,970 | +2,855 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 7,785 | 10,549 | +2,764 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 152,436 | 155,163 | +2,727 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 56,300 | 59,000 | +2,700 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 10,080 | 12,697 | +2,617 | 0.02 | 0.00 | -0.01 | buy |
| Bank of New York Mellon Corp | 95,416 | 97,878 | +2,462 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,371 | 7,449 | +2,078 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,859 | 3,857 | +1,998 | 0.05 | 0.02 | -0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,798 | 19,184 | +1,386 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,217 | 8,589 | +1,372 | 0.05 | 0.01 | -0.03 | buy |
| Covestor Ltd | 2 | 1,282 | +1,280 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 1,210 | +1,210 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 9,700 | 10,800 | +1,100 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,071 | 18,098 | +1,027 | 0.01 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,354 | 28,121 | +767 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 12,163 | 12,616 | +453 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 40,476 | 40,867 | +391 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 380 | +380 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 1,263 | 1,622 | +359 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 288,234 | 288,428 | +194 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 86 | 170 | +84 | 0.00 | 0.00 | -0.00 | buy |
| PRIVATE TRUST CO NA | 0 | 81 | +81 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 6 | 8 | +2 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |