| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 707,240 | 1,894,439 | +1,187,199 | 1.16 | 0.89 | -0.27 | buy |
| Nantahala Capital Management, LLC | 381,659 | 915,048 | +533,389 | 1.12 | 0.62 | -0.50 | buy |
| MANGROVE PARTNERS IM, LLC | 286,995 | 736,385 | +449,390 | 1.43 | 1.29 | -0.14 | buy |
| Holocene Advisors, LP | 843,110 | 1,199,990 | +356,880 | 0.20 | 0.06 | -0.14 | buy |
| Integral Health Asset Management, LLC | 200,000 | 450,000 | +250,000 | 1.31 | 0.61 | -0.70 | buy |
| Darwin Global Management, Ltd. | 1,523,732 | 1,687,135 | +163,403 | 7.20 | 2.53 | -4.67 | buy |
| Blue Owl Capital Holdings LP | 122,633 | 242,633 | +120,000 | 1.38 | 0.88 | -0.50 | buy |
| TWINBEECH CAPITAL LP | 15,378 | 129,553 | +114,175 | 0.02 | 0.04 | +0.02 | buy |
| Altium Capital Management LLC | 69,000 | 175,000 | +106,000 | 1.19 | 0.86 | -0.33 | buy |
| EMERALD ADVISERS, LLC | 155,545 | 244,633 | +89,088 | 0.35 | 0.15 | -0.20 | buy |
| Nebula Research & Development LLC | 13,439 | 71,710 | +58,271 | 0.09 | 0.13 | +0.04 | buy |
| DAFNA Capital Management LLC | 73,754 | 130,316 | +56,562 | 1.01 | 0.52 | -0.49 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 112,613 | 155,347 | +42,734 | 0.34 | 0.15 | -0.19 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 24,752 | 50,897 | +26,145 | 0.11 | 0.06 | 0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 4,603 | 25,523 | +20,920 | 0.01 | 0.02 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 6,144 | 22,213 | +16,069 | 0.08 | 0.06 | -0.02 | buy |
| Birchview Capital, LP | 7,000 | 15,000 | +8,000 | 0.35 | 0.19 | -0.16 | buy |
| NEOS Investment Management LLC | 27,778 | 35,663 | +7,885 | 0.05 | 0.01 | -0.04 | buy |
| Brevan Howard Capital Management LP | 5,718 | 11,186 | +5,468 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 27,905 | 32,756 | +4,851 | 0.01 | 0.00 | -0.01 | buy |
| Rafferty Asset Management, LLC | 41,112 | 45,801 | +4,689 | 0.01 | 0.00 | -0.01 | buy |
| PFM Health Sciences, LP | 101,050 | 104,323 | +3,273 | 0.33 | 0.10 | -0.23 | buy |
| VIRTUS ADVISERS, LLC | 1,859 | 3,857 | +1,998 | 0.05 | 0.02 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 7,217 | 8,589 | +1,372 | 0.05 | 0.01 | -0.03 | buy |
| J.Safra Asset Management Corp | 6 | 8 | +2 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 59,138 | 48,481 | -10,657 | 0.02 | 0.00 | -0.01 | sell |
| Avidity Partners Management LP | 293,200 | 210,000 | -83,200 | 0.87 | 0.33 | -0.54 | sell |
| Parkman Healthcare Partners LLC | 421,782 | 314,541 | -107,241 | 3.13 | 0.66 | -2.46 | sell |
| TCG Crossover Management, LLC | 879,344 | 550,000 | -329,344 | 4.33 | 0.85 | -3.48 | sell |
| Woodline Partners LP | 763,548 | 387,701 | -375,847 | 0.37 | 0.04 | -0.33 | sell |
| ADAR1 Capital Management, LLC | 445,068 | 23,246 | -421,822 | 4.33 | 0.08 | -4.26 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,897,601 | 1,101,000 | -796,601 | 0.19 | 0.04 | -0.15 | sell |