| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 1,726,808 | 3,257,347 | +1,530,539 | 0.40 | 0.72 | +0.32 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 126,000 | 1,112,020 | +986,020 | 0.01 | 0.05 | +0.04 | buy |
| Jefferies Financial Group Inc. | 0 | 840,000 | +840,000 | 0.00 | 0.25 | +0.25 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 267,143 | +267,143 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| OAK RIDGE INVESTMENTS LLC | 0 | 61,204 | +61,204 | 0.00 | 0.09 | +0.09 | buy |
| HSBC HOLDINGS PLC | 0 | 52,954 | +52,954 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 490,831 | 536,994 | +46,163 | 0.00 | 0.00 | +0.00 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 648,302 | 686,472 | +38,170 | 0.20 | 0.16 | -0.03 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 255,430 | 288,267 | +32,837 | 2.73 | 2.86 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 0 | 32,800 | +32,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 104,600 | 136,741 | +32,141 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 28,320 | +28,320 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 24,971 | +24,971 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 170,599 | 194,966 | +24,367 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 18,383 | 42,262 | +23,879 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,716 | 32,521 | +21,805 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 25,069 | 42,867 | +17,798 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 22,996 | 39,795 | +16,799 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 14,937 | +14,937 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 312,516 | 323,952 | +11,436 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 175,500 | 184,184 | +8,684 | 0.37 | 0.34 | -0.03 | buy |
| Cubist Systematic Strategies, LLC | 142 | 6,150 | +6,008 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 16,609 | 22,417 | +5,808 | 0.00 | 0.00 | +0.00 | buy |
| Vivaldi Capital Management LP | 16,461 | 20,124 | +3,663 | 0.09 | 0.07 | -0.02 | buy |
| Squarepoint Ops LLC | 59,690 | 63,039 | +3,349 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 10,368 | 13,084 | +2,716 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,575 | 5,903 | +2,328 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 34,706 | 36,796 | +2,090 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,728 | 27,411 | +683 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 10,102 | 10,758 | +656 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 69,892 | 70,406 | +514 | 0.06 | 0.06 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 509 | +509 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 18,300 | 18,800 | +500 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 437 | +437 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,563 | 8,923 | +360 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,521 | 13,664 | +143 | 0.00 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 16,716 | 16,849 | +133 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 616 | 650 | +34 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 4,955 | 4,963 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,816 | 2,816 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHIKIAR ASSET MANAGEMENT INC | 33,250 | 33,250 | 0 | 0.15 | 0.15 | -0.01 | hold |
| GREAT POINT PARTNERS LLC | 2,620,545 | 2,620,545 | 0 | 6.70 | 6.13 | -0.57 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.03 | 0.04 | +0.01 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,083,430 | 3,083,430 | 0 | 0.72 | 0.59 | -0.13 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 2,303,031 | 0 | 0.29 | 0.26 | -0.03 | hold |
| Laurion Capital Management LP | 250,600 | 250,600 | 0 | 0.13 | 0.10 | -0.03 | hold |
| Daiwa Securities Group Inc. | 48 | 48 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 14,626 | 14,626 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 2.57 | 2.70 | +0.13 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.06 | 0.09 | +0.02 | hold |
| Russell Investments Group, Ltd. | 253 | 253 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ethos Financial Group, LLC | 10,500 | 10,500 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Farther Finance Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,400 | 1,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 134 | 134 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,586 | 1,586 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 62,880 | 62,880 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BENDER ROBERT & ASSOCIATES | 34,701 | 34,701 | 0 | 0.13 | 0.12 | -0.01 | hold |
| TORONTO DOMINION BANK | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 56 | 26 | -30 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 57 | 0 | -57 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,868 | 2,785 | -83 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Annandale Capital, LLC | 81,831 | 81,552 | -279 | 0.29 | 0.28 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 354 | 0 | -354 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 114,221 | 113,862 | -359 | 0.00 | 0.00 | -0.00 | sell |
| Coastal Bridge Advisors, LLC | 37,750 | 37,000 | -750 | 0.15 | 0.13 | -0.02 | sell |
| Engineers Gate Manager LP | 13,610 | 12,636 | -974 | 0.01 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,691 | 187 | -1,504 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,880 | 3,231 | -1,649 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,477 | 2,788 | -1,689 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 70,104 | 68,219 | -1,885 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 72,961 | 70,952 | -2,009 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,238 | 943 | -2,295 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 235,236 | 232,500 | -2,736 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 6,651 | 2,805 | -3,846 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 23,944 | 17,666 | -6,278 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 219,081 | 212,280 | -6,801 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 8,707 | 0 | -8,707 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 20,623 | 11,625 | -8,998 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 60,165 | 49,790 | -10,375 | 0.16 | 0.09 | -0.07 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 11,080 | 0 | -11,080 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 11,348 | 0 | -11,348 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 11,709 | 0 | -11,709 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 33,320 | 21,573 | -11,747 | 0.02 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 18,684 | 4,838 | -13,846 | 0.00 | 0.00 | -0.00 | sell |
| SIERRA SUMMIT ADVISORS LLC | 14,515 | 0 | -14,515 | 0.06 | 0.00 | -0.06 | sell |
| ARK Investment Management LLC | 161,525 | 146,329 | -15,196 | 0.01 | 0.02 | +0.00 | sell |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 0 | -15,384 | 0.01 | 0.00 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 525,404 | 508,587 | -16,817 | 2.43 | 2.14 | -0.29 | sell |
| BARCLAYS PLC | 37,367 | 19,412 | -17,955 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 71,664 | 53,063 | -18,601 | 0.00 | 0.00 | -0.00 | sell |