| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 3,206,271 | +3,206,271 | 0.00 | 0.59 | +0.59 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,377,156 | 4,360,524 | +2,983,368 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 1,630,000 | 2,152,957 | +522,957 | 1.03 | 1.70 | +0.67 | buy |
| JPMORGAN CHASE & CO | 21,114 | 370,959 | +349,845 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 303,397 | +303,397 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,120,473 | 1,381,158 | +260,685 | 2.67 | 3.19 | +0.52 | buy |
| Atom Investors LP | 145,732 | 400,560 | +254,828 | 0.19 | 0.55 | +0.35 | buy |
| UBS Group AG | 922,698 | 1,173,088 | +250,390 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 233,322 | 410,607 | +177,285 | 0.02 | 0.03 | +0.01 | buy |
| SG Americas Securities, LLC | 20,269 | 162,514 | +142,245 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 72,472 | 196,802 | +124,330 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 301,206 | 423,632 | +122,426 | 2.82 | 5.59 | +2.77 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 686,472 | 786,472 | +100,000 | 0.10 | 0.12 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 92,877 | +92,877 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 767,300 | 857,727 | +90,427 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 25,489 | 114,066 | +88,577 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 870,000 | 950,000 | +80,000 | 4.99 | 5.12 | +0.13 | buy |
| Privium Fund Management B.V. | 27,691 | 107,622 | +79,931 | 0.07 | 0.31 | +0.24 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,133 | 92,025 | +51,892 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 140,148 | 185,790 | +45,642 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 19,541 | 62,809 | +43,268 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 36,271 | +36,271 | 0.00 | 0.06 | +0.06 | buy |
| DIADEMA PARTNERS LP | 50,000 | 76,220 | +26,220 | 0.60 | 0.67 | +0.07 | buy |
| Kynam Capital Management, LP | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 26,338 | 51,177 | +24,839 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 1,389 | 25,350 | +23,961 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 369,861 | 393,153 | +23,292 | 0.52 | 0.52 | -0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 17,571 | +17,571 | 0.00 | 0.17 | +0.17 | buy |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 0 | 15,384 | +15,384 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 13,291 | +13,291 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 12,567 | +12,567 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 61,165 | 73,704 | +12,539 | 0.05 | 0.07 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 461,902 | 473,330 | +11,428 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 324,324 | 333,400 | +9,076 | 2.79 | 3.59 | +0.80 | buy |
| Pale Fire Capital SE | 12,500 | 20,893 | +8,393 | 0.03 | 0.03 | -0.00 | buy |
| XTX Topco Ltd | 18,641 | 25,967 | +7,326 | 0.02 | 0.01 | -0.00 | buy |
| Epoch Investment Partners, Inc. | 125,688 | 132,439 | +6,751 | 0.01 | 0.01 | +0.00 | buy |
| CWM, LLC | 85 | 5,225 | +5,140 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 23,989 | 26,363 | +2,374 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 18,118 | 20,327 | +2,209 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 51,270 | 53,466 | +2,196 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 68,100 | 69,789 | +1,689 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,667 | 23,320 | +1,653 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 26 | 1,340 | +1,314 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 146,953 | 148,078 | +1,125 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 858 | +858 | 0.00 | 0.00 | +0.00 | buy |
| Rossby Financial, LCC | 0 | 770 | +770 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 305,642 | 306,371 | +729 | 0.02 | 0.02 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,486 | 38,182 | +696 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 647 | +647 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 107 | 678 | +571 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 943 | 1,335 | +392 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 332 | +332 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 274 | +274 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 16,716 | 16,987 | +271 | 0.00 | 0.00 | +0.00 | buy |
| Costello Asset Management, INC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 886 | 1,080 | +194 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 8 | 74 | +66 | 0.00 | 0.00 | +0.00 | buy |
| SouthState Corp | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,406 | 1,456 | +50 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,517 | 93,547 | +30 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,832 | 3,832 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 53,400 | 53,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SHIKIAR ASSET MANAGEMENT INC | 10,750 | 10,750 | 0 | 0.03 | 0.04 | +0.01 | hold |
| CIBC Private Wealth Group LLC | 509 | 509 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.04 | 0.05 | +0.01 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 2,303,031 | 0 | 0.15 | 0.17 | +0.01 | hold |
| DAFNA Capital Management LLC | 492,515 | 492,515 | 0 | 1.33 | 1.54 | +0.21 | hold |
| MEITAV INVESTMENT HOUSE LTD | 36,138 | 36,138 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Daiwa Securities Group Inc. | 160 | 160 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 3,834,794 | 3,834,794 | 0 | 0.62 | 0.65 | +0.03 | hold |
| MetLife Investment Management, LLC | 22,766 | 22,766 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 2.09 | 2.93 | +0.84 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Kovitz Investment Group Partners, LLC | 31,291 | 31,291 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivaldi Capital Management LP | 20,124 | 20,124 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Main Street Financial Solutions, LLC | 24,000 | 24,000 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Annandale Capital, LLC | 75,552 | 75,552 | 0 | 0.16 | 0.16 | -0.00 | hold |
| SBI Securities Co., Ltd. | 67 | 67 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 1,001 | 1,001 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ethos Financial Group, LLC | 10,500 | 10,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| De Lisle Partners LLP | 81,510 | 81,510 | 0 | 0.13 | 0.15 | +0.02 | hold |
| Police & Firemen's Retirement System of New Jersey | 9,023 | 9,023 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,516,303 | 1,516,303 | 0 | 8.69 | 11.18 | +2.49 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,837 | 7,837 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WESBANCO BANK INC | 74,400 | 74,400 | 0 | 0.03 | 0.03 | +0.00 | hold |
| TORONTO DOMINION BANK | 1,749,142 | 1,749,142 | 0 | 0.04 | 0.05 | +0.01 | hold |
| NISA INVESTMENT ADVISORS, LLC | 30 | 28 | -2 | 0.00 | 0.00 | +0.00 | sell |
| IFP Advisors, Inc | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 12 | 1 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 47 | 0 | -47 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 80 | 25 | -55 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 317 | 195 | -122 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,585 | 1,320 | -265 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 19,237 | 18,955 | -282 | 0.00 | 0.00 | +0.00 | sell |