| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 0 | 2,616,714 | +2,616,714 | 0.00 | 0.09 | +0.09 | buy |
| Kynam Capital Management, LP | 0 | 2,247,393 | +2,247,393 | 0.00 | 2.56 | +2.56 | buy |
| Opaleye Management Inc. | 268,423 | 1,430,000 | +1,161,577 | 0.83 | 3.39 | +2.56 | buy |
| Soleus Capital Management, L.P. | 150,000 | 727,000 | +577,000 | 0.15 | 0.53 | +0.38 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 781,620 | 1,314,112 | +532,492 | 0.19 | 0.24 | +0.05 | buy |
| J. Goldman & Co LP | 513,303 | 938,870 | +425,567 | 0.47 | 0.78 | +0.31 | buy |
| SG Americas Securities, LLC | 1,377,647 | 1,657,846 | +280,199 | 0.04 | 0.03 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,358,812 | 1,637,570 | +278,758 | 0.02 | 0.02 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 125,375 | 395,459 | +270,084 | 0.22 | 0.43 | +0.21 | buy |
| BlackRock, Inc. | 2,601,009 | 2,845,567 | +244,558 | 0.00 | 0.00 | -0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,448,420 | 1,673,420 | +225,000 | 11.49 | 8.55 | -2.94 | buy |
| Ally Bridge Group (NY) LLC | 0 | 202,124 | +202,124 | 0.00 | 3.61 | +3.61 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 158,111 | +158,111 | 0.00 | 0.02 | +0.02 | buy |
| Vestal Point Capital, LP | 0 | 139,079 | +139,079 | 0.00 | 0.07 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 459,722 | 598,528 | +138,806 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 168,768 | 275,000 | +106,232 | 0.38 | 0.51 | +0.14 | buy |
| Swiss National Bank | 0 | 77,800 | +77,800 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 26,972 | 102,949 | +75,977 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 0 | 73,905 | +73,905 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 807,421 | 874,176 | +66,755 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 962,624 | 1,023,159 | +60,535 | 0.02 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 475,212 | 523,831 | +48,619 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 403 | 47,419 | +47,016 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 237,457 | 275,938 | +38,481 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,272 | 38,750 | +36,478 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 35,393 | 70,240 | +34,847 | 0.01 | 0.01 | +0.00 | buy |
| BENDER ROBERT & ASSOCIATES | 0 | 34,701 | +34,701 | 0.00 | 0.15 | +0.15 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 32,116 | +32,116 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 25,671 | +25,671 | 0.00 | 0.08 | +0.08 | buy |
| Man Group plc | 0 | 25,395 | +25,395 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 74,055 | 98,055 | +24,000 | 0.01 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 214,622 | 238,122 | +23,500 | 0.93 | 0.89 | -0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 161,924 | 183,504 | +21,580 | 0.13 | 0.11 | -0.02 | buy |
| Legal & General Group Plc | 3,643 | 25,172 | +21,529 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 123,563 | 144,961 | +21,398 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 19,100 | +19,100 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 47,257 | 63,246 | +15,989 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 2 | 14,006 | +14,004 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 13,439 | +13,439 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 12,641 | +12,641 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 12,513 | +12,513 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 10,801 | +10,801 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4,666 | +4,666 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 4,124 | +4,124 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 281,876 | 285,834 | +3,958 | 0.36 | 0.29 | -0.08 | buy |
| RHUMBLINE ADVISERS | 45,760 | 49,407 | +3,647 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 941,378 | 943,803 | +2,425 | 2.52 | 1.31 | -1.21 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,154 | 18,866 | +1,712 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,469 | 3,069 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,402 | 4,943 | +1,541 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 21,810 | 23,155 | +1,345 | 0.30 | 0.17 | -0.13 | buy |
| KBC Group NV | 0 | 1,340 | +1,340 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 85,230 | 86,403 | +1,173 | 0.12 | 0.10 | -0.02 | buy |
| Invesco Ltd. | 27,066 | 28,080 | +1,014 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 22,445 | 23,326 | +881 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,627 | 8,307 | +680 | 0.01 | 0.01 | -0.00 | buy |
| Advisory Services Network, LLC | 0 | 553 | +553 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,246 | 9,520 | +274 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,275 | 2,442 | +167 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 8,391 | 8,546 | +155 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 919 | 1,045 | +126 | 0.00 | 0.00 | -0.00 | buy |
| TWIN PEAKS WEALTH ADVISORS, LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 98,829 | 98,942 | +113 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 140 | 244 | +104 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,576 | 10,676 | +100 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 352 | 439 | +87 | 0.00 | 0.00 | -0.00 | buy |
| Root Financial Partners, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 50 | 64 | +14 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 584 | 596 | +12 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 35 | 45 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 6 | +6 | 0.00 | 0.00 | 0.00 | buy |
| CWM, LLC | 3,889 | 3,894 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Hughes Financial Services, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 18 | 20 | +2 | 0.00 | 0.00 | -0.00 | buy |
| JPL Wealth Management, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 875,487 | 875,487 | 0 | 0.42 | 0.34 | -0.08 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,082 | 3,082 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHIKIAR ASSET MANAGEMENT INC | 10,750 | 10,750 | 0 | 0.06 | 0.06 | -0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 35,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 350,000 | 350,000 | 0 | 0.40 | 0.32 | -0.09 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.08 | 0.07 | -0.01 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.13 | 0.10 | -0.03 | hold |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.16 | 0.12 | -0.03 | hold |
| Parkside Financial Bank & Trust | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 1.07 | 0.81 | -0.25 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.10 | 0.08 | -0.02 | hold |
| IFP Advisors, Inc | 31 | 31 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 688 | 688 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.06 | 0.05 | -0.02 | hold |
| Vivaldi Capital Management LP | 15,661 | 15,661 | 0 | 0.05 | 0.04 | -0.01 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Pinnacle Wealth Planning Services, Inc. | 688 | 688 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 112 | 112 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Costello Asset Management, INC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Main Street Financial Solutions, LLC | 20,990 | 20,990 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Aisling Capital Management LP | 108,000 | 108,000 | 0 | 0.53 | 0.41 | -0.12 | hold |