| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 1.07 | 0.81 | -0.25 | hold |
| BlackRock, Inc. | 2,601,009 | 2,845,567 | +244,558 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 0 | 2,616,714 | +2,616,714 | 0.00 | 0.09 | +0.09 | buy |
| MORGAN STANLEY | 2,562,901 | 2,560,038 | -2,863 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 0 | 2,247,393 | +2,247,393 | 0.00 | 2.56 | +2.56 | buy |
| Jefferies Financial Group Inc. | 2,199,652 | 2,199,652 | 0 | 0.42 | 0.48 | +0.06 | hold |
| Paradigm Biocapital Advisors LP | 4,473,648 | 1,703,949 | -2,769,699 | 2.81 | 0.63 | -2.18 | sell |
| ACORN CAPITAL ADVISORS, LLC | 1,448,420 | 1,673,420 | +225,000 | 11.49 | 8.55 | -2.94 | buy |
| SG Americas Securities, LLC | 1,377,647 | 1,657,846 | +280,199 | 0.04 | 0.03 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,358,812 | 1,637,570 | +278,758 | 0.02 | 0.02 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,738,821 | 1,503,045 | -235,776 | 5.89 | 3.18 | -2.71 | sell |
| Opaleye Management Inc. | 268,423 | 1,430,000 | +1,161,577 | 0.83 | 3.39 | +2.56 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 781,620 | 1,314,112 | +532,492 | 0.19 | 0.24 | +0.05 | buy |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.13 | 0.10 | -0.03 | hold |
| D. E. Shaw & Co., Inc. | 962,624 | 1,023,159 | +60,535 | 0.02 | 0.01 | -0.00 | buy |
| MPM BioImpact LLC | 941,378 | 943,803 | +2,425 | 2.52 | 1.31 | -1.21 | buy |
| J. Goldman & Co LP | 513,303 | 938,870 | +425,567 | 0.47 | 0.78 | +0.31 | buy |
| ORBIMED ADVISORS LLC | 875,487 | 875,487 | 0 | 0.42 | 0.34 | -0.08 | hold |
| STATE STREET CORP | 807,421 | 874,176 | +66,755 | 0.00 | 0.00 | -0.00 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.16 | 0.12 | -0.03 | hold |
| Soleus Capital Management, L.P. | 150,000 | 727,000 | +577,000 | 0.15 | 0.53 | +0.38 | buy |
| GOLDMAN SACHS GROUP INC | 459,722 | 598,528 | +138,806 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 475,212 | 523,831 | +48,619 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 500,726 | 500,726 | 0 | 0.05 | 0.03 | -0.01 | hold |
| Boxer Capital Management, LLC | 500,000 | 500,000 | 0 | 2.56 | 1.18 | -1.38 | hold |
| TCG Crossover Management, LLC | 717,347 | 405,365 | -311,982 | 0.56 | 0.21 | -0.35 | sell |
| ADAR1 Capital Management, LLC | 125,375 | 395,459 | +270,084 | 0.22 | 0.43 | +0.21 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 718,354 | 387,371 | -330,983 | 9.01 | 4.98 | -4.03 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1,125,100 | 387,074 | -738,026 | 0.04 | 0.01 | -0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 618,952 | 370,898 | -248,054 | 0.01 | 0.00 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 350,000 | 350,000 | 0 | 0.40 | 0.32 | -0.09 | hold |
| RICE HALL JAMES & ASSOCIATES, LLC | 281,876 | 285,834 | +3,958 | 0.36 | 0.29 | -0.08 | buy |
| NORTHERN TRUST CORP | 237,457 | 275,938 | +38,481 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 168,768 | 275,000 | +106,232 | 0.38 | 0.51 | +0.14 | buy |
| CITADEL ADVISORS LLC | 737,757 | 267,996 | -469,761 | 0.01 | 0.00 | -0.01 | sell |
| Privium Fund Management B.V. | 214,622 | 238,122 | +23,500 | 0.93 | 0.89 | -0.03 | buy |
| DEUTSCHE BANK AG\ | 366,680 | 236,192 | -130,488 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 435,490 | 230,630 | -204,860 | 0.04 | 0.02 | -0.02 | sell |
| Ally Bridge Group (NY) LLC | 0 | 202,124 | +202,124 | 0.00 | 3.61 | +3.61 | buy |
| Hennion & Walsh Asset Management, Inc. | 161,924 | 183,504 | +21,580 | 0.13 | 0.11 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 241,213 | 177,901 | -63,312 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 235,040 | 159,658 | -75,382 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 158,111 | +158,111 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 234,423 | 145,342 | -89,081 | 0.44 | 0.19 | -0.25 | sell |
| FMR LLC | 123,563 | 144,961 | +21,398 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 153,413 | 144,060 | -9,353 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 139,079 | +139,079 | 0.00 | 0.07 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 128,630 | 126,783 | -1,847 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 121,484 | 115,545 | -5,939 | 0.02 | 0.02 | -0.00 | sell |
| Aisling Capital Management LP | 108,000 | 108,000 | 0 | 0.53 | 0.41 | -0.12 | hold |
| Tidal Investments LLC | 26,972 | 102,949 | +75,977 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 126,034 | 100,215 | -25,819 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 98,829 | 98,942 | +113 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 74,055 | 98,055 | +24,000 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 90,989 | 88,466 | -2,523 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 302,601 | 87,522 | -215,079 | 0.00 | 0.00 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 85,230 | 86,403 | +1,173 | 0.12 | 0.10 | -0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 162,725 | 83,623 | -79,102 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 77,800 | +77,800 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 73,905 | +73,905 | 0.00 | 0.01 | +0.01 | buy |
| TRUIST FINANCIAL CORP | 72,286 | 72,286 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 35,393 | 70,240 | +34,847 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 47,257 | 63,246 | +15,989 | 0.00 | 0.00 | +0.00 | buy |
| Annandale Capital, LLC | 60,552 | 58,552 | -2,000 | 0.23 | 0.17 | -0.06 | sell |
| WELLS FARGO & COMPANY/MN | 84,158 | 55,757 | -28,401 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 45,760 | 49,407 | +3,647 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 130,899 | 49,363 | -81,536 | 0.01 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 403 | 47,419 | +47,016 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 76,762 | 43,498 | -33,264 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,272 | 38,750 | +36,478 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.06 | 0.05 | -0.02 | hold |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 35,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BENDER ROBERT & ASSOCIATES | 0 | 34,701 | +34,701 | 0.00 | 0.15 | +0.15 | buy |
| Focus Partners Wealth | 35,277 | 34,038 | -1,239 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39,383 | 32,509 | -6,874 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 32,116 | +32,116 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 136,019 | 30,166 | -105,853 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 30,096 | 29,096 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 616,606 | 28,454 | -588,152 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 27,066 | 28,080 | +1,014 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 28,005 | 26,510 | -1,495 | 0.17 | 0.13 | -0.04 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 25,671 | +25,671 | 0.00 | 0.08 | +0.08 | buy |
| Man Group plc | 0 | 25,395 | +25,395 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,643 | 25,172 | +21,529 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.08 | 0.07 | -0.01 | hold |
| MetLife Investment Management, LLC | 22,445 | 23,326 | +881 | 0.00 | 0.00 | -0.00 | buy |
| DIADEMA PARTNERS LP | 21,810 | 23,155 | +1,345 | 0.30 | 0.17 | -0.13 | buy |
| MEITAV INVESTMENT HOUSE LTD | 35,517 | 22,223 | -13,294 | 0.01 | 0.00 | -0.01 | sell |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.10 | 0.08 | -0.02 | hold |
| JPMORGAN CHASE & CO | 146,271 | 21,122 | -125,149 | 0.00 | 0.00 | -0.00 | sell |
| Main Street Financial Solutions, LLC | 20,990 | 20,990 | 0 | 0.04 | 0.03 | -0.01 | hold |
| MML INVESTORS SERVICES, LLC | 24,363 | 20,802 | -3,561 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 23,514 | 20,176 | -3,338 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 27,380 | 19,404 | -7,976 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 19,100 | +19,100 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 65,935 | 18,990 | -46,945 | 0.02 | 0.01 | -0.02 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,154 | 18,866 | +1,712 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 16,745 | 16,745 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivaldi Capital Management LP | 15,661 | 15,661 | 0 | 0.05 | 0.04 | -0.01 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.01 | 0.01 | -0.00 | hold |