| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,257,347 | 3,557,347 | +300,000 | 0.72 | 0.92 | +0.20 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 3,300,000 | +2,000,000 | 0.04 | 0.10 | +0.07 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 3,083,430 | 3,083,430 | 0 | 0.59 | 0.68 | +0.10 | hold |
| GREAT POINT PARTNERS LLC | 2,620,545 | 2,906,259 | +285,714 | 6.13 | 9.34 | +3.22 | buy |
| Point72 Asset Management, L.P. | 1,112,020 | 2,449,277 | +1,337,257 | 0.05 | 0.13 | +0.08 | buy |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 2,303,031 | 0 | 0.26 | 0.26 | +0.00 | hold |
| MORGAN STANLEY | 390,549 | 1,838,706 | +1,448,157 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 1,650,000 | +1,650,000 | 0.00 | 1.61 | +1.61 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 1,320,000 | +1,320,000 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 41,880 | 1,160,899 | +1,119,019 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 508,587 | 1,102,000 | +593,413 | 2.14 | 4.57 | +2.43 | buy |
| Jefferies Financial Group Inc. | 840,000 | 965,000 | +125,000 | 0.25 | 0.32 | +0.06 | buy |
| STATE STREET CORP | 536,994 | 726,676 | +189,682 | 0.00 | 0.00 | +0.00 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 686,472 | 686,472 | 0 | 0.16 | 0.19 | +0.03 | hold |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 2.70 | 2.04 | -0.66 | hold |
| DAFNA Capital Management LLC | 0 | 469,000 | +469,000 | 0.00 | 1.88 | +1.88 | buy |
| Harel Insurance Investments & Financial Services Ltd. | 673,487 | 463,565 | -209,922 | 0.20 | 0.15 | -0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 323,952 | 421,389 | +97,437 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 270,000 | 412,000 | +142,000 | 0.88 | 1.58 | +0.70 | buy |
| Woodline Partners LP | 0 | 303,740 | +303,740 | 0.00 | 0.05 | +0.05 | buy |
| Parkman Healthcare Partners LLC | 184,184 | 274,465 | +90,281 | 0.34 | 0.63 | +0.29 | buy |
| GOLDMAN SACHS GROUP INC | 113,862 | 263,606 | +149,744 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 104,100 | 248,399 | +144,299 | 0.01 | 0.03 | +0.02 | buy |
| VANGUARD GROUP INC | 194,966 | 223,982 | +29,016 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 232,500 | 217,362 | -15,138 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 212,280 | 215,841 | +3,561 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 24,971 | 173,966 | +148,995 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 250,600 | 160,600 | -90,000 | 0.10 | 0.09 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 136,741 | 156,078 | +19,337 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 146,329 | 151,781 | +5,452 | 0.02 | 0.02 | +0.01 | buy |
| Atom Investors LP | 49,790 | 144,780 | +94,990 | 0.09 | 0.24 | +0.15 | buy |
| TWO SIGMA INVESTMENTS, LP | 80,497 | 100,422 | +19,925 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 68,219 | 96,619 | +28,400 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,411 | 96,345 | +68,934 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 62,880 | 82,917 | +20,037 | 0.00 | 0.00 | +0.00 | buy |
| De Lisle Partners LLP | 77,093 | 81,510 | +4,417 | 0.27 | 0.30 | +0.03 | buy |
| Trexquant Investment LP | 0 | 80,709 | +80,709 | 0.00 | 0.02 | +0.02 | buy |
| OAK RIDGE INVESTMENTS LLC | 61,204 | 79,929 | +18,725 | 0.09 | 0.13 | +0.04 | buy |
| Annandale Capital, LLC | 81,552 | 75,552 | -6,000 | 0.28 | 0.26 | -0.01 | sell |
| CITADEL ADVISORS LLC | 71,816 | 74,362 | +2,546 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 70,406 | 72,787 | +2,381 | 0.06 | 0.07 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 53,063 | 66,086 | +13,023 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 22,417 | 60,316 | +37,899 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 57,610 | +57,610 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 36,796 | 50,477 | +13,681 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 70,952 | 45,075 | -25,877 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 6,150 | 44,949 | +38,799 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 42,841 | +42,841 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 40,500 | +40,500 | 0.00 | 0.09 | +0.09 | buy |
| Coastal Bridge Advisors, LLC | 37,000 | 38,500 | +1,500 | 0.13 | 0.16 | +0.03 | buy |
| MEITAV INVESTMENT HOUSE LTD | 36,798 | 36,798 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 0 | 34,230 | +34,230 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 28,320 | 31,565 | +3,245 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 42,262 | 30,290 | -11,972 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 18,800 | 24,900 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Main Street Financial Solutions, LLC | 0 | 24,000 | +24,000 | 0.00 | 0.04 | +0.04 | buy |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Vivaldi Capital Management LP | 20,124 | 20,124 | 0 | 0.07 | 0.10 | +0.02 | hold |
| MetLife Investment Management, LLC | 14,626 | 20,039 | +5,413 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 19,323 | +19,323 | 0.00 | 0.01 | +0.01 | buy |
| Cresset Asset Management, LLC | 16,849 | 16,716 | -133 | 0.00 | 0.00 | -0.00 | sell |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 0 | 15,384 | +15,384 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,923 | 14,837 | +5,914 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,084 | 14,289 | +1,205 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,521 | 13,302 | -19,219 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 12,636 | 12,745 | +109 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 11,888 | +11,888 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 42,867 | 11,887 | -30,980 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 19,412 | 11,738 | -7,674 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 10,758 | 11,663 | +905 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,618 | +11,618 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 267,143 | 10,948 | -256,195 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 10,843 | +10,843 | 0.00 | 0.00 | +0.00 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 33,250 | 10,750 | -22,500 | 0.15 | 0.05 | -0.10 | sell |
| SIMPLEX TRADING, LLC | 2,805 | 10,619 | +7,814 | 0.00 | 0.01 | +0.00 | buy |
| Ethos Financial Group, LLC | 10,500 | 10,500 | 0 | 0.03 | 0.03 | +0.00 | hold |
| AWM Investment Company, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 0 | 9,289 | +9,289 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,838 | 8,332 | +3,494 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 4,963 | 5,298 | +335 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 11,625 | 5,261 | -6,364 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,903 | 4,244 | -1,659 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 2,785 | 3,614 | +829 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,231 | 3,420 | +189 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 187 | 3,368 | +3,181 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,816 | 2,816 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 39,795 | 2,656 | -37,139 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,788 | 2,489 | -299 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,079 | +1,079 | 0.00 | 0.00 | +0.00 | buy |
| Activest Wealth Management | 0 | 1,001 | +1,001 | 0.00 | 0.01 | +0.01 | buy |
| AMALGAMATED BANK | 943 | 943 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 437 | 647 | +210 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 509 | 509 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 650 | 497 | -153 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 253 | 253 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 134 | 170 | +36 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 41 | 76 | +35 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 17 | 75 | +58 | 0.00 | 0.00 | +0.00 | buy |