| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 3,300,000 | +2,000,000 | 0.04 | 0.10 | +0.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 508,587 | 1,102,000 | +593,413 | 2.14 | 4.57 | +2.43 | buy |
| RTW INVESTMENTS, LP | 3,257,347 | 3,557,347 | +300,000 | 0.72 | 0.92 | +0.20 | buy |
| GREAT POINT PARTNERS LLC | 2,620,545 | 2,906,259 | +285,714 | 6.13 | 9.34 | +3.22 | buy |
| Opaleye Management Inc. | 270,000 | 412,000 | +142,000 | 0.88 | 1.58 | +0.70 | buy |
| Atom Investors LP | 49,790 | 144,780 | +94,990 | 0.09 | 0.24 | +0.15 | buy |
| Parkman Healthcare Partners LLC | 184,184 | 274,465 | +90,281 | 0.34 | 0.63 | +0.29 | buy |
| OAK RIDGE INVESTMENTS LLC | 61,204 | 79,929 | +18,725 | 0.09 | 0.13 | +0.04 | buy |
| ARK Investment Management LLC | 146,329 | 151,781 | +5,452 | 0.02 | 0.02 | +0.01 | buy |
| De Lisle Partners LLP | 77,093 | 81,510 | +4,417 | 0.27 | 0.30 | +0.03 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 70,406 | 72,787 | +2,381 | 0.06 | 0.07 | +0.01 | buy |
| Coastal Bridge Advisors, LLC | 37,000 | 38,500 | +1,500 | 0.13 | 0.16 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 5,903 | 4,244 | -1,659 | 0.01 | 0.01 | -0.00 | sell |
| Annandale Capital, LLC | 81,552 | 75,552 | -6,000 | 0.28 | 0.26 | -0.01 | sell |
| SHIKIAR ASSET MANAGEMENT INC | 33,250 | 10,750 | -22,500 | 0.15 | 0.05 | -0.10 | sell |
| Laurion Capital Management LP | 250,600 | 160,600 | -90,000 | 0.03 | 0.03 | +0.00 | sell |
| Harel Insurance Investments & Financial Services Ltd. | 673,487 | 463,565 | -209,922 | 0.20 | 0.15 | -0.05 | sell |