| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,834,794 | 4,543,895 | +709,101 | 0.65 | 0.89 | +0.24 | buy |
| TORONTO DOMINION BANK | 1,749,142 | 3,190,510 | +1,441,368 | 0.05 | 0.09 | +0.04 | buy |
| MORGAN STANLEY | 857,727 | 2,478,470 | +1,620,743 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,423,463 | 2,405,241 | -18,222 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 815,000 | 2,199,652 | +1,384,652 | 0.16 | 0.50 | +0.34 | buy |
| Soleus Capital Management, L.P. | 0 | 2,185,000 | +2,185,000 | 0.00 | 2.07 | +2.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,381,158 | 2,022,482 | +641,324 | 3.19 | 5.67 | +2.48 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,516,303 | 1,259,749 | -256,554 | 11.18 | 11.29 | +0.10 | sell |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 1,152,531 | -1,150,500 | 0.17 | 0.09 | -0.07 | sell |
| SG Americas Securities, LLC | 162,514 | 1,149,081 | +986,567 | 0.01 | 0.07 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.69 | +0.69 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,277,000 | 830,000 | -447,000 | 0.03 | 0.02 | -0.01 | sell |
| STATE STREET CORP | 795,012 | 807,638 | +12,626 | 0.00 | 0.00 | +0.00 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 786,472 | 770,909 | -15,563 | 0.12 | 0.13 | +0.00 | sell |
| Kynam Capital Management, LP | 25,000 | 656,573 | +631,573 | 0.02 | 0.97 | +0.94 | buy |
| MILLENNIUM MANAGEMENT LLC | 423,585 | 594,031 | +170,446 | 0.00 | 0.01 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 575,000 | +575,000 | 0.00 | 3.97 | +3.97 | buy |
| CITADEL ADVISORS LLC | 189,677 | 543,196 | +353,519 | 0.00 | 0.01 | +0.00 | buy |
| Rosalind Advisors, Inc. | 950,000 | 542,366 | -407,634 | 5.12 | 3.60 | -1.52 | sell |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 2.93 | 4.03 | +1.11 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 92,025 | 484,823 | +392,798 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 478,400 | +478,400 | 0.00 | 0.16 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 473,330 | 470,726 | -2,604 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 370,959 | 390,364 | +19,405 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,277 | 384,891 | +355,614 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 368,654 | 361,441 | -7,213 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 492,515 | 349,515 | -143,000 | 1.54 | 1.32 | -0.22 | sell |
| Walleye Capital LLC | 0 | 346,162 | +346,162 | 0.00 | 0.04 | +0.04 | buy |
| Atom Investors LP | 400,560 | 317,596 | -82,964 | 0.55 | 0.39 | -0.16 | sell |
| UBS Group AG | 1,173,088 | 308,527 | -864,561 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 306,371 | 306,724 | +353 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 284,334 | 290,577 | +6,243 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 255,791 | 287,874 | +32,083 | 0.17 | 0.21 | +0.05 | buy |
| NORTHERN TRUST CORP | 285,614 | 267,718 | -17,896 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 196,802 | 265,117 | +68,315 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 92,877 | 261,785 | +168,908 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 250,429 | 254,971 | +4,542 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 114,066 | 231,574 | +117,508 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 218,837 | +218,837 | 0.00 | 0.03 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 69,789 | 218,500 | +148,711 | 0.01 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 17,288 | 189,412 | +172,124 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 332 | 185,030 | +184,698 | 0.00 | 0.07 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 393,153 | 176,702 | -216,451 | 0.52 | 0.28 | -0.24 | sell |
| Point72 Asset Management, L.P. | 236,006 | 168,779 | -67,227 | 0.01 | 0.01 | -0.00 | sell |
| ARK Investment Management LLC | 185,790 | 166,094 | -19,696 | 0.02 | 0.02 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 148,078 | 158,052 | +9,974 | 0.00 | 0.00 | +0.00 | buy |
| Harel Insurance Investments & Financial Services Ltd. | 373,982 | 157,772 | -216,210 | 0.05 | 0.02 | -0.03 | sell |
| DIADEMA PARTNERS LP | 76,220 | 150,000 | +73,780 | 0.67 | 1.28 | +0.60 | buy |
| JANE STREET GROUP, LLC | 51,177 | 147,280 | +96,103 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 216,478 | 123,359 | -93,119 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 107,622 | 107,622 | 0 | 0.31 | 0.30 | -0.01 | hold |
| HRT FINANCIAL LP | 0 | 104,226 | +104,226 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 32,764 | 94,309 | +61,545 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 93,490 | 93,430 | -60 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 93,396 | +93,396 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,547 | 92,898 | -649 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 423,632 | 87,912 | -335,720 | 5.59 | 1.50 | -4.09 | sell |
| Nuveen, LLC | 92,957 | 83,146 | -9,811 | 0.00 | 0.00 | +0.00 | sell |
| Annandale Capital, LLC | 75,552 | 75,552 | 0 | 0.16 | 0.19 | +0.03 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 2,418 | 71,921 | +69,503 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 73,704 | 70,570 | -3,134 | 0.07 | 0.07 | +0.00 | sell |
| BARCLAYS PLC | 44,540 | 70,154 | +25,614 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,092 | 60,314 | +50,222 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 53,400 | 53,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 53,466 | 51,293 | -2,173 | 0.00 | 0.00 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 0 | 38,355 | +38,355 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 90,600 | 38,200 | -52,400 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,182 | 37,476 | -706 | 0.00 | 0.00 | +0.00 | sell |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.04 | 0.04 | +0.01 | hold |
| MEITAV INVESTMENT HOUSE LTD | 36,138 | 36,138 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 70,417 | 35,040 | -35,377 | 0.00 | 0.00 | -0.00 | sell |
| Kovitz Investment Group Partners, LLC | 31,291 | 34,802 | +3,511 | 0.00 | 0.00 | +0.00 | buy |
| BENDER ROBERT & ASSOCIATES | 0 | 34,701 | +34,701 | 0.00 | 0.11 | +0.11 | buy |
| Persistent Asset Partners Ltd | 17,571 | 34,600 | +17,029 | 0.17 | 0.42 | +0.24 | buy |
| Virtu Financial LLC | 0 | 34,004 | +34,004 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 32,453 | +32,453 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 33,758 | 30,880 | -2,878 | 0.00 | 0.00 | +0.00 | sell |
| TRUIST FINANCIAL CORP | 0 | 30,850 | +30,850 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 27,432 | +27,432 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 26,370 | +26,370 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 26,166 | +26,166 | 0.00 | 0.09 | +0.09 | buy |
| Main Street Financial Solutions, LLC | 24,000 | 25,968 | +1,968 | 0.02 | 0.03 | +0.00 | buy |
| ALPS ADVISORS INC | 32,762 | 24,839 | -7,923 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 27,182 | 24,608 | -2,574 | 0.00 | 0.00 | +0.00 | sell |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.05 | 0.07 | +0.02 | hold |
| MetLife Investment Management, LLC | 22,766 | 22,766 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Quantinno Capital Management LP | 0 | 21,073 | +21,073 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 11,500 | 20,660 | +9,160 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,320 | 20,209 | -3,111 | 0.00 | 0.00 | -0.00 | sell |
| HAP Trading, LLC | 0 | 19,806 | +19,806 | 0.00 | 0.12 | +0.12 | buy |
| Entropy Technologies, LP | 0 | 19,379 | +19,379 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,363 | 18,902 | -7,461 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 0 | 16,747 | +16,747 | 0.00 | 0.10 | +0.10 | buy |
| Cresset Asset Management, LLC | 16,987 | 16,716 | -271 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 16,503 | +16,503 | 0.00 | 0.00 | +0.00 | buy |
| Vivaldi Capital Management LP | 20,124 | 15,661 | -4,463 | 0.04 | 0.03 | -0.00 | sell |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Allianz Asset Management GmbH | 0 | 14,800 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 14,285 | +14,285 | 0.00 | 0.00 | +0.00 | buy |