| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 0.81 | 1.43 | +0.61 | hold |
| BlackRock, Inc. | 2,845,567 | 3,201,461 | +355,894 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,560,038 | 2,576,363 | +16,325 | 0.00 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 2,247,393 | 2,434,207 | +186,814 | 2.56 | 4.95 | +2.39 | buy |
| Jefferies Financial Group Inc. | 2,199,652 | 2,199,652 | 0 | 0.48 | 0.74 | +0.26 | hold |
| SG Americas Securities, LLC | 1,657,846 | 2,052,906 | +395,060 | 0.03 | 0.04 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,637,570 | 1,685,719 | +48,149 | 0.02 | 0.03 | +0.01 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,673,420 | 1,673,420 | 0 | 8.55 | 16.80 | +8.25 | hold |
| Point72 Asset Management, L.P. | 0 | 1,525,549 | +1,525,549 | 0.00 | 0.09 | +0.09 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,314,112 | 1,508,547 | +194,435 | 0.24 | 0.52 | +0.27 | buy |
| Opaleye Management Inc. | 1,430,000 | 1,439,996 | +9,996 | 3.39 | 4.80 | +1.41 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,503,045 | 1,301,979 | -201,066 | 3.18 | 5.33 | +2.15 | sell |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.10 | 0.17 | +0.07 | hold |
| D. E. Shaw & Co., Inc. | 1,023,159 | 1,145,819 | +122,660 | 0.01 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 874,176 | 1,003,071 | +128,895 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 943,803 | 933,415 | -10,388 | 1.31 | 2.09 | +0.78 | sell |
| Soleus Capital Management, L.P. | 727,000 | 829,810 | +102,810 | 0.53 | 1.05 | +0.52 | buy |
| GOLDMAN SACHS GROUP INC | 598,528 | 819,834 | +221,306 | 0.00 | 0.00 | +0.00 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.12 | 0.18 | +0.06 | hold |
| ORBIMED ADVISORS LLC | 875,487 | 676,187 | -199,300 | 0.34 | 0.47 | +0.13 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 523,831 | 610,364 | +86,533 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,726 | 500,726 | 0 | 0.03 | 0.06 | +0.02 | hold |
| Boxer Capital Management, LLC | 500,000 | 500,000 | 0 | 1.18 | 1.39 | +0.21 | hold |
| BANK OF AMERICA CORP /DE/ | 126,783 | 475,702 | +348,919 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 387,074 | 387,074 | 0 | 0.01 | 0.02 | +0.01 | hold |
| NORTHERN TRUST CORP | 275,938 | 304,570 | +28,632 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 285,834 | 300,650 | +14,816 | 0.29 | 0.54 | +0.25 | buy |
| Hennion & Walsh Asset Management, Inc. | 183,504 | 276,696 | +93,192 | 0.11 | 0.29 | +0.18 | buy |
| ADAR1 Capital Management, LLC | 395,459 | 252,395 | -143,064 | 0.43 | 0.44 | +0.01 | sell |
| J. Goldman & Co LP | 938,870 | 212,775 | -726,095 | 0.78 | 0.28 | -0.51 | sell |
| Privium Fund Management B.V. | 238,122 | 210,000 | -28,122 | 0.89 | 1.42 | +0.53 | sell |
| FMR LLC | 144,961 | 197,098 | +52,137 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 387,371 | 191,313 | -196,058 | 4.98 | 4.45 | -0.53 | sell |
| Parkman Healthcare Partners LLC | 275,000 | 174,064 | -100,936 | 0.51 | 0.66 | +0.15 | sell |
| AQR CAPITAL MANAGEMENT LLC | 144,060 | 149,228 | +5,168 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 177,901 | 148,963 | -28,938 | 0.00 | 0.00 | +0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 128,370 | +128,370 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,466 | 128,370 | +39,904 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 159,658 | 121,461 | -38,197 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 100,215 | 115,362 | +15,147 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 98,942 | 113,028 | +14,086 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 230,630 | 111,141 | -119,489 | 0.02 | 0.02 | +0.00 | sell |
| Aisling Capital Management LP | 108,000 | 108,000 | 0 | 0.41 | 0.84 | +0.44 | hold |
| MILLENNIUM MANAGEMENT LLC | 370,898 | 106,692 | -264,206 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 102,949 | 101,837 | -1,112 | 0.01 | 0.01 | +0.00 | sell |
| ARK Investment Management LLC | 115,545 | 101,508 | -14,037 | 0.02 | 0.02 | +0.01 | sell |
| Russell Investments Group, Ltd. | 63,246 | 94,596 | +31,350 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 87,522 | 92,102 | +4,580 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 86,403 | 88,591 | +2,188 | 0.10 | 0.18 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 55,757 | 80,234 | +24,477 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 79,271 | +79,271 | 0.00 | 0.26 | +0.26 | buy |
| Swiss National Bank | 77,800 | 77,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 98,055 | 74,024 | -24,031 | 0.01 | 0.01 | +0.00 | sell |
| TRUIST FINANCIAL CORP | 72,286 | 72,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 43,498 | 71,260 | +27,762 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 70,300 | +70,300 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 202,124 | 69,183 | -132,941 | 3.61 | 3.28 | -0.33 | sell |
| RHUMBLINE ADVISERS | 49,407 | 54,922 | +5,515 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 236,192 | 51,550 | -184,642 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 145,342 | 46,664 | -98,678 | 0.19 | 0.15 | -0.03 | sell |
| Annandale Capital, LLC | 58,552 | 45,425 | -13,127 | 0.17 | 0.25 | +0.07 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,750 | 44,949 | +6,199 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 43,710 | +8,670 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,520 | 43,599 | +34,079 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 21,122 | 39,544 | +18,422 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.05 | 0.08 | +0.04 | hold |
| Legal & General Group Plc | 25,172 | 35,830 | +10,658 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,116 | 35,054 | +2,938 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,454 | 35,003 | +6,549 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 34,038 | 33,061 | -977 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 158,111 | 32,459 | -125,652 | 0.02 | 0.01 | -0.02 | sell |
| ALGERT GLOBAL LLC | 18,990 | 32,350 | +13,360 | 0.01 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 30,166 | 31,668 | +1,502 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 29,615 | +29,615 | 0.00 | 0.01 | +0.01 | buy |
| Cetera Investment Advisers | 29,096 | 28,952 | -144 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 28,080 | 25,927 | -2,153 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 26,510 | 24,968 | -1,542 | 0.13 | 0.21 | +0.08 | sell |
| MetLife Investment Management, LLC | 23,326 | 24,865 | +1,539 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.07 | 0.12 | +0.06 | hold |
| CITIGROUP INC | 4,943 | 22,871 | +17,928 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 32,509 | 20,696 | -11,813 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,866 | 19,536 | +670 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 19,404 | 19,404 | 0 | 0.01 | 0.01 | +0.01 | hold |
| XTX Topco Ltd | 0 | 19,386 | +19,386 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 16,745 | 19,263 | +2,518 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,513 | 18,398 | +5,885 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 20,176 | 18,252 | -1,924 | 0.00 | 0.00 | +0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 17,585 | +17,585 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 16,487 | +16,487 | 0.00 | 0.28 | +0.28 | buy |
| Engineers Gate Manager LP | 0 | 16,378 | +16,378 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,737 | 15,737 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.01 | 0.02 | +0.01 | hold |
| LPL Financial LLC | 0 | 14,457 | +14,457 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 20,802 | 14,325 | -6,477 | 0.00 | 0.00 | +0.00 | sell |
| MAI Capital Management | 14,006 | 14,163 | +157 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 14,134 | +14,134 | 0.00 | 0.18 | +0.18 | buy |
| CITADEL ADVISORS LLC | 267,996 | 12,985 | -255,011 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 13,474 | 12,906 | -568 | 0.00 | 0.00 | +0.00 | sell |
| State of New Jersey Common Pension Fund D | 13,439 | 12,593 | -846 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 10,469 | 12,566 | +2,097 | 0.00 | 0.00 | +0.00 | buy |