| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 1,525,549 | +1,525,549 | 0.00 | 0.09 | +0.09 | buy |
| SG Americas Securities, LLC | 1,657,846 | 2,052,906 | +395,060 | 0.03 | 0.04 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,023,159 | 1,145,819 | +122,660 | 0.01 | 0.03 | +0.01 | buy |
| Soleus Capital Management, L.P. | 727,000 | 829,810 | +102,810 | 0.53 | 1.05 | +0.52 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 523,831 | 610,364 | +86,533 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 79,271 | +79,271 | 0.00 | 0.26 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 70,300 | +70,300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,520 | 43,599 | +34,079 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 63,246 | 94,596 | +31,350 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 29,615 | +29,615 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 43,498 | 71,260 | +27,762 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 17,585 | +17,585 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 16,487 | +16,487 | 0.00 | 0.28 | +0.28 | buy |
| Engineers Gate Manager LP | 0 | 16,378 | +16,378 | 0.00 | 0.01 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 285,834 | 300,650 | +14,816 | 0.29 | 0.54 | +0.25 | buy |
| LPL Financial LLC | 0 | 14,457 | +14,457 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 98,942 | 113,028 | +14,086 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 18,990 | 32,350 | +13,360 | 0.01 | 0.01 | +0.01 | buy |
| Arax Advisory Partners | 0 | 11,739 | +11,739 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 11,699 | +11,699 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,430,000 | 1,439,996 | +9,996 | 3.39 | 4.80 | +1.41 | buy |
| Cresset Asset Management, LLC | 0 | 9,966 | +9,966 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 9,660 | +9,660 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 9,505 | +9,505 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 9,397 | +9,397 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 43,710 | +8,670 | 0.00 | 0.00 | -0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 8,000 | +8,000 | 0.00 | 0.02 | +0.02 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 7,642 | +7,642 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 7,623 | +7,623 | 0.00 | 0.00 | +0.00 | buy |
| Kathmere Capital Management, LLC | 0 | 7,360 | +7,360 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 7,179 | +7,179 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 6,975 | +6,975 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 325 | 7,212 | +6,887 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,750 | 44,949 | +6,199 | 0.00 | 0.00 | +0.00 | buy |
| Brookstone Capital Management | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,513 | 18,398 | +5,885 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,407 | 54,922 | +5,515 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 0 | 5,462 | +5,462 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 144,060 | 149,228 | +5,168 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 8,546 | 11,060 | +2,514 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 86,403 | 88,591 | +2,188 | 0.10 | 0.18 | +0.08 | buy |
| Quantbot Technologies LP | 0 | 2,133 | +2,133 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,326 | 24,865 | +1,539 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,676 | 12,075 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 958 | +958 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,082 | 3,867 | +785 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,866 | 19,536 | +670 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 244 | 485 | +241 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 45 | 241 | +196 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 14,006 | 14,163 | +157 | 0.00 | 0.00 | +0.00 | buy |
| Altshuler Shaham Ltd | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 10 | 16 | +6 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.07 | 0.12 | +0.06 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.10 | 0.17 | +0.07 | hold |
| KBC Group NV | 1,340 | 1,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.12 | 0.18 | +0.06 | hold |
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 0.81 | 1.43 | +0.61 | hold |
| Allianz Asset Management GmbH | 10,100 | 10,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 387,074 | 387,074 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Swiss National Bank | 77,800 | 77,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 31 | 31 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.05 | 0.08 | +0.04 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Pinnacle Wealth Planning Services, Inc. | 688 | 688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 112 | 112 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Costello Asset Management, INC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aisling Capital Management LP | 108,000 | 108,000 | 0 | 0.41 | 0.84 | +0.44 | hold |
| Woodline Partners LP | 500,726 | 500,726 | 0 | 0.03 | 0.06 | +0.02 | hold |
| EverSource Wealth Advisors, LLC | 596 | 584 | -12 | 0.00 | 0.00 | +0.00 | sell |
| Arizona State Retirement System | 10,801 | 10,746 | -55 | 0.00 | 0.00 | +0.00 | sell |
| Cetera Investment Advisers | 29,096 | 28,952 | -144 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 455 | 247 | -208 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,442 | 2,179 | -263 | 0.00 | 0.00 | +0.00 | sell |
| Sound Income Strategies, LLC | 388 | 0 | -388 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 553 | 0 | -553 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 13,474 | 12,906 | -568 | 0.00 | 0.00 | +0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 688 | 0 | -688 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,069 | 2,251 | -818 | 0.00 | 0.00 | +0.00 | sell |
| State of New Jersey Common Pension Fund D | 13,439 | 12,593 | -846 | 0.00 | 0.00 | +0.00 | sell |
| Integrated Wealth Concepts LLC | 12,641 | 11,741 | -900 | 0.00 | 0.00 | +0.00 | sell |
| Focus Partners Wealth | 34,038 | 33,061 | -977 | 0.00 | 0.00 | +0.00 | sell |
| Tidal Investments LLC | 102,949 | 101,837 | -1,112 | 0.01 | 0.01 | +0.00 | sell |
| HighVista Strategies LLC | 26,510 | 24,968 | -1,542 | 0.13 | 0.21 | +0.08 | sell |
| Quantinno Capital Management LP | 20,176 | 18,252 | -1,924 | 0.00 | 0.00 | +0.00 | sell |
| SHIKIAR ASSET MANAGEMENT INC | 10,750 | 8,750 | -2,000 | 0.06 | 0.08 | +0.03 | sell |
| KLP KAPITALFORVALTNING AS | 14,300 | 10,200 | -4,100 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 4,124 | 0 | -4,124 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 8,066 | 1,105 | -6,961 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 943,803 | 933,415 | -10,388 | 1.31 | 2.09 | +0.78 | sell |
| Main Street Financial Solutions, LLC | 20,990 | 8,190 | -12,800 | 0.03 | 0.02 | -0.01 | sell |
| ARK Investment Management LLC | 115,545 | 101,508 | -14,037 | 0.02 | 0.02 | +0.01 | sell |
| Vivaldi Capital Management LP | 15,661 | 0 | -15,661 | 0.04 | 0.00 | -0.04 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 25,671 | 7,957 | -17,714 | 0.08 | 0.05 | -0.03 | sell |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 0 | -21,823 | 0.08 | 0.00 | -0.08 | sell |
| MEITAV INVESTMENT HOUSE LTD | 22,223 | 0 | -22,223 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 25,395 | 0 | -25,395 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 238,122 | 210,000 | -28,122 | 0.89 | 1.42 | +0.53 | sell |
| TWO SIGMA INVESTMENTS, LP | 177,901 | 148,963 | -28,938 | 0.00 | 0.00 | +0.00 | sell |