| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,300,000 | 3,735,741 | +435,741 | 0.10 | 0.08 | -0.02 | buy |
| Vestal Point Capital, LP | 0 | 400,000 | +400,000 | 0.00 | 0.40 | +0.40 | buy |
| MORGAN STANLEY | 1,838,706 | 2,181,464 | +342,758 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,160,899 | 1,499,201 | +338,302 | 0.02 | 0.02 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 280,345 | +280,345 | 0.00 | 2.25 | +2.25 | buy |
| STEMPOINT CAPITAL LP | 0 | 241,984 | +241,984 | 0.00 | 0.92 | +0.92 | buy |
| RTW INVESTMENTS, LP | 3,557,347 | 3,787,347 | +230,000 | 0.92 | 0.70 | -0.23 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,787 | 271,897 | +199,110 | 0.07 | 0.19 | +0.11 | buy |
| Trexquant Investment LP | 80,709 | 271,670 | +190,961 | 0.02 | 0.04 | +0.02 | buy |
| CITADEL ADVISORS LLC | 74,362 | 242,066 | +167,704 | 0.00 | 0.00 | +0.00 | buy |
| Epoch Investment Partners, Inc. | 0 | 136,872 | +136,872 | 0.00 | 0.01 | +0.01 | buy |
| AWM Investment Company, Inc. | 10,000 | 139,886 | +129,886 | 0.02 | 0.22 | +0.19 | buy |
| Squarepoint Ops LLC | 0 | 107,645 | +107,645 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 30,290 | 117,939 | +87,649 | 0.00 | 0.00 | +0.00 | buy |
| WESBANCO BANK INC | 0 | 74,400 | +74,400 | 0.00 | 0.03 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 274,465 | 347,541 | +73,076 | 0.63 | 0.56 | -0.06 | buy |
| NORTHERN TRUST CORP | 217,362 | 286,729 | +69,367 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 68,062 | +68,062 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 223,982 | 284,437 | +60,455 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 0 | 56,600 | +56,600 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 56,450 | +56,450 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 263,606 | 315,957 | +52,351 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 11,738 | 59,778 | +48,040 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 726,676 | 769,583 | +42,907 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 0 | 38,566 | +38,566 | 0.00 | 0.17 | +0.17 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 421,389 | 455,637 | +34,248 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 34,149 | +34,149 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 11,887 | 45,775 | +33,888 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 0 | 31,291 | +31,291 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 28,393 | +28,393 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,489 | 27,920 | +25,431 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 23,381 | +23,381 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,320,000 | 1,341,072 | +21,072 | 0.01 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 8,332 | 28,128 | +19,796 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,420 | 23,090 | +19,670 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 19,597 | +19,597 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 17,030 | +17,030 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 15,702 | +15,702 | 0.00 | 0.10 | +0.10 | buy |
| Monashee Investment Management LLC | 40,500 | 55,000 | +14,500 | 0.09 | 0.08 | -0.01 | buy |
| SG Americas Securities, LLC | 0 | 14,062 | +14,062 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 13,993 | +13,993 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 13,254 | +13,254 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,614 | 15,925 | +12,311 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,203 | +12,203 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 10,619 | 19,031 | +8,412 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82,917 | 90,493 | +7,576 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 12,745 | 20,140 | +7,395 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,643 | 20,698 | +6,055 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 31,565 | 37,595 | +6,030 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,656 | 8,546 | +5,890 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,289 | 19,347 | +5,058 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,244 | 8,100 | +3,856 | 0.01 | 0.01 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 38,500 | 40,500 | +2,000 | 0.16 | 0.13 | -0.03 | buy |
| Woodline Partners LP | 303,740 | 305,642 | +1,902 | 0.05 | 0.03 | -0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,948 | 12,839 | +1,891 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 18,481 | 20,225 | +1,744 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 76 | 1,611 | +1,535 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,663 | 12,822 | +1,159 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,816 | 3,832 | +1,016 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,079 | 1,523 | +444 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 66,086 | 66,489 | +403 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,302 | 13,480 | +178 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 161 | +161 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 138 | +138 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 48 | 160 | +112 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 75 | 167 | +92 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,618 | 11,667 | +49 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 36 | 81 | +45 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 6 | 12 | +6 | 0.00 | 0.00 | +0.00 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 10,750 | 10,750 | 0 | 0.05 | 0.04 | -0.01 | hold |
| CIBC Private Wealth Group LLC | 509 | 509 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.05 | 0.04 | -0.01 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 2,303,031 | 0 | 0.26 | 0.18 | -0.08 | hold |
| Migdal Insurance & Financial Holdings Ltd. | 686,472 | 686,472 | 0 | 0.19 | 0.14 | -0.05 | hold |
| MetLife Investment Management, LLC | 20,039 | 20,039 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 2.04 | 3.08 | +1.04 | hold |
| Arax Advisory Partners | 56 | 56 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.10 | 0.07 | -0.03 | hold |
| QUADRANT CAPITAL GROUP LLC | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivaldi Capital Management LP | 20,124 | 20,124 | 0 | 0.10 | 0.07 | -0.02 | hold |
| Russell Investments Group, Ltd. | 253 | 253 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 16,716 | 16,716 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Main Street Financial Solutions, LLC | 24,000 | 24,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Annandale Capital, LLC | 75,552 | 75,552 | 0 | 0.26 | 0.19 | -0.07 | hold |
| Activest Wealth Management | 1,001 | 1,001 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Ethos Financial Group, LLC | 10,500 | 10,500 | 0 | 0.03 | 0.02 | -0.01 | hold |
| De Lisle Partners LLP | 81,510 | 81,510 | 0 | 0.30 | 0.17 | -0.13 | hold |
| NBC SECURITIES, INC. | 647 | 647 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 943 | 943 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jefferies Financial Group Inc. | 965,000 | 965,000 | 0 | 0.32 | 0.20 | -0.12 | hold |
| TORONTO DOMINION BANK | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 215,841 | 215,739 | -102 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 45,075 | 44,965 | -110 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 497 | 380 | -117 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 170 | 47 | -123 | 0.00 | 0.00 | -0.00 | sell |
| Harel Insurance Investments & Financial Services Ltd. | 463,565 | 463,267 | -298 | 0.15 | 0.10 | -0.05 | sell |
| TWO SIGMA ADVISERS, LP | 24,900 | 24,500 | -400 | 0.00 | 0.00 | -0.00 | sell |