| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,300,000 | 3,735,741 | +435,741 | 0.10 | 0.08 | -0.02 | buy |
| RTW INVESTMENTS, LP | 3,557,347 | 3,787,347 | +230,000 | 0.92 | 0.70 | -0.23 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,787 | 271,897 | +199,110 | 0.07 | 0.19 | +0.11 | buy |
| AWM Investment Company, Inc. | 10,000 | 139,886 | +129,886 | 0.02 | 0.22 | +0.19 | buy |
| Parkman Healthcare Partners LLC | 274,465 | 347,541 | +73,076 | 0.63 | 0.56 | -0.06 | buy |
| Monashee Investment Management LLC | 40,500 | 55,000 | +14,500 | 0.09 | 0.08 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 4,244 | 8,100 | +3,856 | 0.01 | 0.01 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 38,500 | 40,500 | +2,000 | 0.16 | 0.13 | -0.03 | buy |
| Woodline Partners LP | 303,740 | 305,642 | +1,902 | 0.05 | 0.03 | -0.02 | buy |
| Harel Insurance Investments & Financial Services Ltd. | 463,565 | 463,267 | -298 | 0.15 | 0.10 | -0.05 | sell |
| MEITAV INVESTMENT HOUSE LTD | 36,798 | 36,138 | -660 | 0.01 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 79,929 | 76,799 | -3,130 | 0.13 | 0.09 | -0.04 | sell |
| Opaleye Management Inc. | 412,000 | 404,100 | -7,900 | 1.58 | 0.86 | -0.72 | sell |
| DAFNA Capital Management LLC | 469,000 | 458,915 | -10,085 | 1.88 | 1.38 | -0.50 | sell |
| ARK Investment Management LLC | 151,781 | 121,634 | -30,147 | 0.02 | 0.01 | -0.01 | sell |
| Cormorant Asset Management, LP | 1,650,000 | 1,550,000 | -100,000 | 1.60 | 1.04 | -0.56 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,102,000 | 901,129 | -200,871 | 4.57 | 2.58 | -1.99 | sell |
| GREAT POINT PARTNERS LLC | 2,906,259 | 758,786 | -2,147,473 | 9.34 | 2.84 | -6.51 | sell |