| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 0.89 | 1.12 | +0.23 | hold |
| Paradigm Biocapital Advisors LP | 0 | 4,216,084 | +4,216,084 | 0.00 | 2.49 | +2.49 | buy |
| TORONTO DOMINION BANK | 3,190,510 | 3,190,510 | 0 | 0.09 | 0.12 | +0.03 | hold |
| BlackRock, Inc. | 2,405,241 | 2,581,286 | +176,045 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,478,470 | 2,528,446 | +49,976 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,199,652 | 2,199,652 | 0 | 0.50 | 0.40 | -0.10 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,022,482 | 1,577,283 | -445,199 | 5.67 | 4.56 | -1.12 | sell |
| MILLENNIUM MANAGEMENT LLC | 594,031 | 1,468,737 | +874,706 | 0.01 | 0.02 | +0.02 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,259,749 | 1,259,749 | 0 | 11.29 | 12.76 | +1.47 | hold |
| SG Americas Securities, LLC | 1,149,081 | 1,157,383 | +8,302 | 0.07 | 0.08 | +0.02 | buy |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.09 | 0.12 | +0.03 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 1,000,000 | 0 | 0.69 | 0.77 | +0.08 | hold |
| D. E. Shaw & Co., Inc. | 27,432 | 888,933 | +861,501 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 807,638 | 819,446 | +11,808 | 0.00 | 0.00 | +0.00 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.13 | 0.17 | +0.04 | hold |
| TCG Crossover Management, LLC | 0 | 717,347 | +717,347 | 0.00 | 0.70 | +0.70 | buy |
| ORBIMED ADVISORS LLC | 478,400 | 689,000 | +210,600 | 0.16 | 0.33 | +0.16 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 687,475 | +687,475 | 0.00 | 0.05 | +0.05 | buy |
| Soleus Capital Management, L.P. | 2,185,000 | 679,000 | -1,506,000 | 2.07 | 0.72 | -1.34 | sell |
| CITADEL ADVISORS LLC | 543,196 | 602,277 | +59,081 | 0.01 | 0.01 | +0.00 | buy |
| Boxer Capital Management, LLC | 575,000 | 575,000 | 0 | 3.97 | 3.66 | -0.31 | hold |
| JPMORGAN CHASE & CO | 390,364 | 534,545 | +144,181 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 83,146 | 507,531 | +424,385 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 470,726 | 471,229 | +503 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 290,577 | 424,916 | +134,339 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 176,702 | 402,595 | +225,893 | 0.28 | 0.88 | +0.60 | buy |
| TWO SIGMA INVESTMENTS, LP | 189,412 | 386,203 | +196,791 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 361,441 | 356,615 | -4,826 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 147,280 | 328,419 | +181,139 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 71,921 | 308,328 | +236,407 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 306,724 | 306,371 | -353 | 0.02 | 0.03 | +0.01 | sell |
| VANGUARD GROUP INC | 254,971 | 303,785 | +48,814 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 218,500 | 297,851 | +79,351 | 0.02 | 0.04 | +0.02 | buy |
| Atom Investors LP | 317,596 | 291,962 | -25,634 | 0.39 | 0.44 | +0.06 | sell |
| Kynam Capital Management, LP | 656,573 | 282,412 | -374,161 | 0.97 | 0.52 | -0.45 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 38,200 | 275,100 | +236,900 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 267,718 | 261,401 | -6,317 | 0.00 | 0.00 | +0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 287,874 | 259,143 | -28,731 | 0.21 | 0.28 | +0.07 | sell |
| AQR CAPITAL MANAGEMENT LLC | 231,574 | 204,191 | -27,383 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 107,622 | 196,622 | +89,000 | 0.30 | 0.71 | +0.40 | buy |
| Walleye Capital LLC | 346,162 | 190,452 | -155,710 | 0.04 | 0.03 | -0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 261,785 | 184,382 | -77,403 | 0.02 | 0.01 | -0.00 | sell |
| UBS Group AG | 308,527 | 180,460 | -128,067 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 24,608 | 162,259 | +137,651 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 484,823 | 147,225 | -337,598 | 0.01 | 0.00 | -0.01 | sell |
| MPM BioImpact LLC | 0 | 135,000 | +135,000 | 0.00 | 0.44 | +0.44 | buy |
| HRT FINANCIAL LP | 104,226 | 133,674 | +29,448 | 0.01 | 0.01 | +0.00 | buy |
| ARK Investment Management LLC | 166,094 | 126,720 | -39,374 | 0.02 | 0.02 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 123,359 | 125,969 | +2,610 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 158,052 | 125,298 | -32,754 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 116,436 | +116,436 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 111,600 | +111,600 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 265,117 | 108,454 | -156,663 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 103,866 | +103,866 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 93,430 | 95,353 | +1,923 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,898 | 91,059 | -1,839 | 0.00 | 0.00 | +0.00 | sell |
| DIADEMA PARTNERS LP | 150,000 | 90,000 | -60,000 | 1.28 | 1.25 | -0.03 | sell |
| Verition Fund Management LLC | 0 | 89,028 | +89,028 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 87,912 | 87,912 | 0 | 1.50 | 1.73 | +0.23 | hold |
| OAK RIDGE INVESTMENTS LLC | 70,570 | 87,507 | +16,937 | 0.07 | 0.11 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 60,314 | 83,611 | +23,297 | 0.00 | 0.00 | +0.00 | buy |
| Harel Insurance Investments & Financial Services Ltd. | 157,772 | 82,772 | -75,000 | 0.02 | 0.01 | -0.01 | sell |
| FMR LLC | 2,390 | 73,116 | +70,726 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 30,850 | 72,286 | +41,436 | 0.00 | 0.00 | +0.00 | buy |
| Annandale Capital, LLC | 75,552 | 70,552 | -5,000 | 0.19 | 0.25 | +0.06 | sell |
| Hennion & Walsh Asset Management, Inc. | 38,355 | 65,183 | +26,828 | 0.02 | 0.05 | +0.03 | buy |
| BARCLAYS PLC | 70,154 | 55,619 | -14,535 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 51,293 | 50,953 | -340 | 0.00 | 0.00 | +0.00 | sell |
| NEOS Investment Management LLC | 0 | 50,458 | +50,458 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 50,458 | +50,458 | 0.00 | 0.08 | +0.08 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 48,964 | +48,964 | 0.00 | 0.08 | +0.08 | buy |
| ROYAL BANK OF CANADA | 93,396 | 45,338 | -48,058 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 53,400 | 44,000 | -9,400 | 0.00 | 0.00 | +0.00 | sell |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.04 | 0.06 | +0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,476 | 35,937 | -1,539 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 35,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 10,000 | 35,000 | +25,000 | 0.02 | 0.07 | +0.05 | buy |
| Kovitz Investment Group Partners, LLC | 34,802 | 34,802 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BENDER ROBERT & ASSOCIATES | 34,701 | 34,701 | 0 | 0.11 | 0.15 | +0.04 | hold |
| Main Street Financial Solutions, LLC | 25,968 | 32,190 | +6,222 | 0.03 | 0.04 | +0.02 | buy |
| Cetera Investment Advisers | 26,370 | 32,096 | +5,726 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 31,886 | +31,886 | 0.00 | 0.16 | +0.16 | buy |
| MEITAV INVESTMENT HOUSE LTD | 36,138 | 31,513 | -4,625 | 0.01 | 0.01 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 32,453 | 31,157 | -1,296 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 30,880 | 30,484 | -396 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 0 | 29,302 | +29,302 | 0.00 | 0.03 | +0.03 | buy |
| DAFNA Capital Management LLC | 349,515 | 27,515 | -322,000 | 1.32 | 0.14 | -1.19 | sell |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.07 | 0.09 | +0.02 | hold |
| Graham Capital Management, L.P. | 0 | 23,571 | +23,571 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 22,766 | 22,766 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 12,741 | 22,355 | +9,614 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 14,800 | 22,000 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.07 | 0.09 | +0.02 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 21,376 | +21,376 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 34,600 | 20,726 | -13,874 | 0.42 | 0.30 | -0.12 | sell |
| Quantinno Capital Management LP | 21,073 | 20,309 | -764 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 20,660 | 18,675 | -1,985 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 0 | 17,714 | +17,714 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,209 | 17,017 | -3,192 | 0.00 | 0.00 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,902 | +16,902 | 0.00 | 0.05 | +0.05 | buy |