| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 4,216,084 | +4,216,084 | 0.00 | 2.49 | +2.49 | buy |
| MILLENNIUM MANAGEMENT LLC | 594,031 | 1,468,737 | +874,706 | 0.01 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 27,432 | 888,933 | +861,501 | 0.00 | 0.01 | +0.01 | buy |
| TCG Crossover Management, LLC | 0 | 717,347 | +717,347 | 0.00 | 0.70 | +0.70 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 687,475 | +687,475 | 0.00 | 0.05 | +0.05 | buy |
| Nuveen, LLC | 83,146 | 507,531 | +424,385 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 38,200 | 275,100 | +236,900 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 71,921 | 308,328 | +236,407 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 176,702 | 402,595 | +225,893 | 0.28 | 0.88 | +0.60 | buy |
| ORBIMED ADVISORS LLC | 478,400 | 689,000 | +210,600 | 0.16 | 0.33 | +0.16 | buy |
| TWO SIGMA INVESTMENTS, LP | 189,412 | 386,203 | +196,791 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 147,280 | 328,419 | +181,139 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 2,405,241 | 2,581,286 | +176,045 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 390,364 | 534,545 | +144,181 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,608 | 162,259 | +137,651 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 135,000 | +135,000 | 0.00 | 0.44 | +0.44 | buy |
| GOLDMAN SACHS GROUP INC | 290,577 | 424,916 | +134,339 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 116,436 | +116,436 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 111,600 | +111,600 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 103,866 | +103,866 | 0.00 | 0.03 | +0.03 | buy |
| Verition Fund Management LLC | 0 | 89,028 | +89,028 | 0.00 | 0.01 | +0.01 | buy |
| Privium Fund Management B.V. | 107,622 | 196,622 | +89,000 | 0.30 | 0.71 | +0.40 | buy |
| Schonfeld Strategic Advisors LLC | 218,500 | 297,851 | +79,351 | 0.02 | 0.04 | +0.02 | buy |
| FMR LLC | 2,390 | 73,116 | +70,726 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 543,196 | 602,277 | +59,081 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 50,458 | +50,458 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 50,458 | +50,458 | 0.00 | 0.08 | +0.08 | buy |
| MORGAN STANLEY | 2,478,470 | 2,528,446 | +49,976 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 48,964 | +48,964 | 0.00 | 0.08 | +0.08 | buy |
| VANGUARD GROUP INC | 254,971 | 303,785 | +48,814 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 30,850 | 72,286 | +41,436 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 31,886 | +31,886 | 0.00 | 0.16 | +0.16 | buy |
| HRT FINANCIAL LP | 104,226 | 133,674 | +29,448 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 29,302 | +29,302 | 0.00 | 0.03 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 38,355 | 65,183 | +26,828 | 0.02 | 0.05 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 35,000 | +25,000 | 0.02 | 0.07 | +0.05 | buy |
| Graham Capital Management, L.P. | 0 | 23,571 | +23,571 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 60,314 | 83,611 | +23,297 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 21,376 | +21,376 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 17,714 | +17,714 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 70,570 | 87,507 | +16,937 | 0.07 | 0.11 | +0.04 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,902 | +16,902 | 0.00 | 0.05 | +0.05 | buy |
| ExodusPoint Capital Management, LP | 0 | 16,543 | +16,543 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 14,890 | +14,890 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 12,379 | +12,379 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 807,638 | 819,446 | +11,808 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 11,008 | +11,008 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 10,444 | +10,444 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,741 | 22,355 | +9,614 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 1,149,081 | 1,157,383 | +8,302 | 0.07 | 0.08 | +0.02 | buy |
| Allianz Asset Management GmbH | 14,800 | 22,000 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| Main Street Financial Solutions, LLC | 25,968 | 32,190 | +6,222 | 0.03 | 0.04 | +0.02 | buy |
| Cetera Investment Advisers | 26,370 | 32,096 | +5,726 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,800 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 3,301 | +3,301 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 196 | 3,321 | +3,125 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 123,359 | 125,969 | +2,610 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 93,430 | 95,353 | +1,923 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,023 | 10,469 | +1,446 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 688 | +688 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 3,621 | 4,271 | +650 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 18 | 652 | +634 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 470,726 | 471,229 | +503 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 282 | +282 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 304 | 524 | +220 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 647 | 816 | +169 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 13,732 | 13,881 | +149 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 13 | 149 | +136 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 132 | +132 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1 | 45 | +44 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 336 | 374 | +38 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,781 | 1,789 | +8 | 0.00 | 0.00 | +0.00 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 10,750 | 10,750 | 0 | 0.04 | 0.05 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 35,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 1,000,000 | 0 | 0.69 | 0.77 | +0.08 | hold |
| CIBC Private Wealth Group LLC | 509 | 509 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.07 | 0.09 | +0.02 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.09 | 0.12 | +0.03 | hold |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.13 | 0.17 | +0.04 | hold |
| Parkside Financial Bank & Trust | 45 | 45 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 160 | 160 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 0.89 | 1.12 | +0.23 | hold |
| MetLife Investment Management, LLC | 22,766 | 22,766 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.07 | 0.09 | +0.02 | hold |
| Kovitz Investment Group Partners, LLC | 34,802 | 34,802 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.04 | 0.06 | +0.01 | hold |
| Vivaldi Capital Management LP | 15,661 | 15,661 | 0 | 0.03 | 0.04 | +0.01 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.01 | 0.01 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 589 | 589 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Costello Asset Management, INC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cresset Asset Management, LLC | 16,716 | 16,716 | 0 | 0.00 | 0.00 | +0.00 | hold |