| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,483,697 | 3,083,430 | +1,599,733 | 0.41 | 0.72 | +0.31 | buy |
| RTW INVESTMENTS, LP | 857,464 | 1,726,808 | +869,344 | 0.25 | 0.40 | +0.15 | buy |
| MORGAN STANLEY | 111,127 | 455,124 | +343,997 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 275,785 | 426,506 | +150,721 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 6,996 | 143,879 | +136,883 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 125,226 | +125,226 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 219,127 | 312,516 | +93,389 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 53,647 | 114,221 | +60,574 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 59,690 | +59,690 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 111,834 | 170,599 | +58,765 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 177,391 | 235,236 | +57,845 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 15,660 | 60,165 | +44,505 | 0.05 | 0.16 | +0.11 | buy |
| D. E. Shaw & Co., Inc. | 33,633 | 77,873 | +44,240 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 454,104 | 490,831 | +36,727 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 70,063 | 104,600 | +34,537 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,421 | 37,367 | +33,946 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 145,311 | 175,500 | +30,189 | 0.37 | 0.37 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 43,338 | 71,664 | +28,326 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 27,218 | +27,218 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 18,383 | +18,383 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 406 | 18,684 | +18,278 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 508,883 | 525,404 | +16,521 | 2.66 | 2.43 | -0.23 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,394 | 62,880 | +16,486 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 29,766 | 45,977 | +16,211 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 13,610 | +13,610 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 57,806 | 70,104 | +12,298 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,080 | +11,080 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,716 | +10,716 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 120,214 | 130,755 | +10,541 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 8,707 | +8,707 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,864 | 34,706 | +7,842 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,379 | 22,996 | +6,617 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,175 | 26,728 | +6,553 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 10,057 | 16,609 | +6,552 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 19,219 | 25,069 | +5,850 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 19,043 | 23,944 | +4,901 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,403 | 14,626 | +4,223 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,765 | 13,521 | +3,756 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 29,600 | 33,320 | +3,720 | 0.02 | 0.02 | +0.00 | buy |
| ROYAL BANK OF CANADA | 17,016 | 20,623 | +3,607 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 3,150 | 6,651 | +3,501 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 774 | 3,575 | +2,801 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 216,533 | 219,081 | +2,548 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 26,821 | 28,552 | +1,731 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 130,200 | 131,900 | +1,700 | 0.02 | 0.02 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,616 | 2,816 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 3,764 | 4,955 | +1,191 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,130 | 2,868 | +738 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 80 | 616 | +536 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,078 | 1,586 | +508 | 0.00 | 0.00 | +0.00 | buy |
| FIRST MANHATTAN CO. LLC. | 1,000 | 1,500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,772 | 3,238 | +466 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,317 | 4,477 | +160 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 11,288 | 11,348 | +60 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 10,055 | 10,102 | +47 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 33,250 | 33,250 | 0 | 0.16 | 0.15 | -0.01 | hold |
| GREAT POINT PARTNERS LLC | 2,620,545 | 2,620,545 | 0 | 6.91 | 6.70 | -0.21 | hold |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.03 | 0.03 | +0.00 | hold |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 2,303,031 | 0 | 0.29 | 0.29 | -0.00 | hold |
| MEITAV INVESTMENT HOUSE LTD | 91,456 | 91,456 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Migdal Insurance & Financial Holdings Ltd. | 648,302 | 648,302 | 0 | 0.19 | 0.20 | +0.00 | hold |
| Daiwa Securities Group Inc. | 48 | 48 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 2.79 | 2.57 | -0.22 | hold |
| Opaleye Management Inc. | 320,000 | 320,000 | 0 | 1.46 | 1.28 | -0.18 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.07 | 0.06 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 56 | 56 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivaldi Capital Management LP | 16,461 | 16,461 | 0 | 0.08 | 0.09 | +0.02 | hold |
| Russell Investments Group, Ltd. | 253 | 253 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 15,384 | 15,384 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Cresset Asset Management, LLC | 16,716 | 16,716 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Annandale Capital, LLC | 81,831 | 81,831 | 0 | 0.34 | 0.29 | -0.06 | hold |
| Ethos Financial Group, LLC | 10,500 | 10,500 | 0 | 0.04 | 0.03 | -0.00 | hold |
| BENDER ROBERT & ASSOCIATES | 34,701 | 34,701 | 0 | 0.14 | 0.13 | -0.01 | hold |
| TORONTO DOMINION BANK | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,600 | 8,563 | -37 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 4,919 | 4,880 | -39 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 10,514 | 10,368 | -146 | 0.00 | 0.00 | -0.00 | sell |
| Harel Insurance Investments & Financial Services Ltd. | 870,194 | 870,045 | -149 | 0.24 | 0.23 | -0.01 | sell |
| Carmel Capital Partners, LLC | 259 | 0 | -259 | 0.00 | 0.00 | -0.00 | sell |
| West Tower Group, LLC | 354 | 0 | -354 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 18,900 | 18,300 | -600 | 0.00 | 0.00 | -0.00 | sell |
| Coastal Bridge Advisors, LLC | 38,500 | 37,750 | -750 | 0.14 | 0.15 | +0.00 | sell |
| FEDERATED HERMES, INC. | 13,130 | 11,709 | -1,421 | 0.00 | 0.00 | -0.00 | sell |
| Blue Trust, Inc. | 1,567 | 0 | -1,567 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 2,048 | 0 | -2,048 | 0.01 | 0.00 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 3,311 | 354 | -2,957 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 4,563 | 0 | -4,563 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 75,180 | 69,892 | -5,288 | 0.07 | 0.06 | -0.01 | sell |
| Point72 Middle East FZE | 5,941 | 0 | -5,941 | 0.01 | 0.00 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 10,390 | 1,691 | -8,699 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 11,259 | 1,400 | -9,859 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 10,189 | 0 | -10,189 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 86,109 | 72,961 | -13,148 | 0.00 | 0.00 | -0.00 | sell |
| DENALI ADVISORS LLC | 14,300 | 0 | -14,300 | 0.07 | 0.00 | -0.07 | sell |
| Verition Fund Management LLC | 17,017 | 0 | -17,017 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 215,272 | 161,525 | -53,747 | 0.02 | 0.01 | -0.01 | sell |