| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,787,347 | 3,834,794 | +47,447 | 0.70 | 0.62 | -0.08 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,735,741 | 2,928,086 | -807,655 | 0.08 | 0.05 | -0.03 | sell |
| BlackRock, Inc. | 2,497,943 | 2,467,211 | -30,732 | 0.00 | 0.00 | -0.00 | sell |
| MENORA MIVTACHIM HOLDINGS LTD. | 2,303,031 | 2,303,031 | 0 | 0.18 | 0.15 | -0.03 | hold |
| TORONTO DOMINION BANK | 0 | 1,749,142 | +1,749,142 | 0.00 | 0.04 | +0.04 | buy |
| Vestal Point Capital, LP | 400,000 | 1,630,000 | +1,230,000 | 0.40 | 1.03 | +0.63 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,341,072 | 1,377,156 | +36,084 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 1,371,638 | +1,371,638 | 0.00 | 1.02 | +1.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 901,129 | 1,120,473 | +219,344 | 2.58 | 2.67 | +0.09 | buy |
| Jefferies Financial Group Inc. | 965,000 | 965,929 | +929 | 0.20 | 0.11 | -0.08 | buy |
| UBS Group AG | 45,775 | 922,698 | +876,923 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 870,000 | +870,000 | 0.00 | 4.99 | +4.99 | buy |
| STATE STREET CORP | 769,583 | 808,053 | +38,470 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 2,181,464 | 767,300 | -1,414,164 | 0.00 | 0.00 | -0.00 | sell |
| Migdal Insurance & Financial Holdings Ltd. | 686,472 | 686,472 | 0 | 0.14 | 0.10 | -0.04 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,499,201 | 645,785 | -853,416 | 0.02 | 0.01 | -0.01 | sell |
| Wildcat Capital Management, LLC | 495,606 | 495,606 | 0 | 3.08 | 2.09 | -0.99 | hold |
| DAFNA Capital Management LLC | 458,915 | 492,515 | +33,600 | 1.38 | 1.33 | -0.04 | buy |
| Harel Insurance Investments & Financial Services Ltd. | 463,267 | 463,267 | 0 | 0.10 | 0.08 | -0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 455,637 | 461,902 | +6,265 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,839 | 393,984 | +381,145 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 347,541 | 369,861 | +22,320 | 0.56 | 0.52 | -0.04 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 360,000 | +360,000 | 0.00 | 0.14 | +0.14 | buy |
| Stonepine Capital Management, LLC | 280,345 | 324,324 | +43,979 | 2.25 | 2.79 | +0.54 | buy |
| GOLDMAN SACHS GROUP INC | 315,957 | 317,522 | +1,565 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 1,506,646 | 317,114 | -1,189,532 | 0.07 | 0.01 | -0.06 | sell |
| NORTHERN TRUST CORP | 286,729 | 310,074 | +23,345 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 305,642 | 305,642 | 0 | 0.03 | 0.02 | -0.01 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 301,206 | +301,206 | 0.00 | 2.82 | +2.82 | buy |
| Cormorant Asset Management, LP | 1,550,000 | 300,000 | -1,250,000 | 1.04 | 0.18 | -0.87 | sell |
| VANGUARD GROUP INC | 284,437 | 297,354 | +12,917 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 271,897 | 264,031 | -7,866 | 0.19 | 0.15 | -0.03 | sell |
| Hudson Bay Capital Management LP | 0 | 233,322 | +233,322 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 242,066 | 228,785 | -13,281 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 215,739 | 221,540 | +5,801 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 404,100 | 220,000 | -184,100 | 0.86 | 0.41 | -0.45 | sell |
| ALLIANCEBERNSTEIN L.P. | 23,400 | 199,259 | +175,859 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 758,786 | 187,843 | -570,943 | 2.91 | 0.94 | -1.96 | sell |
| Trexquant Investment LP | 271,670 | 172,551 | -99,119 | 0.04 | 0.02 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 137,300 | 146,953 | +9,653 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 0 | 145,732 | +145,732 | 0.00 | 0.19 | +0.19 | buy |
| ARK Investment Management LLC | 121,634 | 140,148 | +18,514 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 138,200 | +138,200 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 136,491 | +136,491 | 0.00 | 0.00 | +0.00 | buy |
| Epoch Investment Partners, Inc. | 136,872 | 125,688 | -11,184 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 87,567 | 93,997 | +6,430 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 90,493 | 93,517 | +3,024 | 0.00 | 0.00 | -0.00 | buy |
| De Lisle Partners LLP | 81,510 | 81,510 | 0 | 0.17 | 0.13 | -0.04 | hold |
| Annandale Capital, LLC | 75,552 | 75,552 | 0 | 0.19 | 0.16 | -0.03 | hold |
| WESBANCO BANK INC | 74,400 | 74,400 | 0 | 0.03 | 0.03 | -0.01 | hold |
| BANK OF AMERICA CORP /DE/ | 66,489 | 72,472 | +5,983 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 59,778 | 69,325 | +9,547 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 124,300 | 68,100 | -56,200 | 0.01 | 0.00 | -0.01 | sell |
| OAK RIDGE INVESTMENTS LLC | 76,799 | 61,165 | -15,634 | 0.09 | 0.05 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 87,034 | 56,895 | -30,139 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 56,600 | 56,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 0 | 53,400 | +53,400 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,868 | 51,270 | +1,402 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 107,645 | 50,194 | -57,451 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 44,965 | 49,153 | +4,188 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,015 | 40,133 | +3,118 | 0.00 | 0.00 | -0.00 | buy |
| Coastal Bridge Advisors, LLC | 40,500 | 39,000 | -1,500 | 0.13 | 0.10 | -0.02 | sell |
| CITIGROUP INC | 28,128 | 38,010 | +9,882 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,480 | 37,486 | +24,006 | 0.00 | 0.00 | +0.00 | buy |
| MEITAV INVESTMENT HOUSE LTD | 36,138 | 36,138 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BENDER ROBERT & ASSOCIATES | 0 | 34,701 | +34,701 | 0.00 | 0.09 | +0.09 | buy |
| ALPS ADVISORS INC | 34,149 | 34,121 | -28 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 33,598 | +33,598 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 31,291 | 31,291 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 19,347 | 31,263 | +11,916 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 37,595 | 30,526 | -7,069 | 0.01 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 13,254 | 28,672 | +15,418 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,920 | 28,166 | +246 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 0 | 27,691 | +27,691 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 30,718 | 26,338 | -4,380 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 117,939 | 25,489 | -92,450 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.04 | 0.04 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 28,612 | 24,481 | -4,131 | 0.00 | 0.00 | -0.00 | sell |
| Main Street Financial Solutions, LLC | 24,000 | 24,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 12,203 | 23,989 | +11,786 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 20,039 | 22,766 | +2,727 | 0.00 | 0.00 | -0.00 | buy |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.07 | 0.06 | -0.01 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,698 | 21,667 | +969 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 68,062 | 21,114 | -46,948 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 14,062 | 20,269 | +6,207 | 0.00 | 0.00 | +0.00 | buy |
| Vivaldi Capital Management LP | 20,124 | 20,124 | 0 | 0.07 | 0.03 | -0.04 | hold |
| FMR LLC | 23,090 | 19,971 | -3,119 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 15,925 | 19,845 | +3,920 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 19,541 | +19,541 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 20,225 | 19,237 | -988 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 23,381 | 18,641 | -4,740 | 0.02 | 0.02 | -0.00 | sell |
| Engineers Gate Manager LP | 20,140 | 18,118 | -2,022 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 56,450 | 17,185 | -39,265 | 0.01 | 0.00 | -0.01 | sell |
| Cresset Asset Management, LLC | 16,716 | 16,716 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 15,702 | 13,861 | -1,841 | 0.10 | 0.08 | -0.01 | sell |
| Invesco Ltd. | 12,822 | 13,456 | +634 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 12,895 | +12,895 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 12,500 | +12,500 | 0.00 | 0.03 | +0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 11,893 | +11,893 | 0.00 | 0.00 | +0.00 | buy |