| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 400,000 | 1,630,000 | +1,230,000 | 0.40 | 1.03 | +0.63 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 901,129 | 1,120,473 | +219,344 | 2.58 | 2.67 | +0.09 | buy |
| RTW INVESTMENTS, LP | 3,787,347 | 3,834,794 | +47,447 | 0.70 | 0.62 | -0.08 | buy |
| Stonepine Capital Management, LLC | 280,345 | 324,324 | +43,979 | 2.25 | 2.79 | +0.54 | buy |
| DAFNA Capital Management LLC | 458,915 | 492,515 | +33,600 | 1.38 | 1.33 | -0.04 | buy |
| Parkman Healthcare Partners LLC | 347,541 | 369,861 | +22,320 | 0.56 | 0.52 | -0.04 | buy |
| ARK Investment Management LLC | 121,634 | 140,148 | +18,514 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,100 | 8,948 | +848 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 34,149 | 34,121 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Coastal Bridge Advisors, LLC | 40,500 | 39,000 | -1,500 | 0.13 | 0.10 | -0.02 | sell |
| Corton Capital Inc. | 15,702 | 13,861 | -1,841 | 0.10 | 0.08 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 271,897 | 264,031 | -7,866 | 0.19 | 0.15 | -0.03 | sell |
| Epoch Investment Partners, Inc. | 136,872 | 125,688 | -11,184 | 0.01 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 76,799 | 61,165 | -15,634 | 0.09 | 0.05 | -0.03 | sell |
| Opaleye Management Inc. | 404,100 | 220,000 | -184,100 | 0.86 | 0.41 | -0.45 | sell |
| GREAT POINT PARTNERS LLC | 758,786 | 187,843 | -570,943 | 2.84 | 0.94 | -1.89 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,735,741 | 2,928,086 | -807,655 | 0.08 | 0.05 | -0.03 | sell |
| Cormorant Asset Management, LP | 1,550,000 | 300,000 | -1,250,000 | 1.04 | 0.18 | -0.87 | sell |