| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 135,000 | 941,378 | +806,378 | 0.44 | 2.52 | +2.08 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 87,912 | 718,354 | +630,442 | 1.73 | 9.01 | +7.28 | buy |
| Paradigm Biocapital Advisors LP | 4,216,084 | 4,473,648 | +257,564 | 2.49 | 2.81 | +0.32 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,259,749 | 1,448,420 | +188,671 | 12.76 | 11.49 | -1.26 | buy |
| ORBIMED ADVISORS LLC | 689,000 | 875,487 | +186,487 | 0.33 | 0.42 | +0.09 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,577,283 | 1,738,821 | +161,538 | 4.56 | 5.89 | +1.34 | buy |
| Hennion & Walsh Asset Management, Inc. | 65,183 | 161,924 | +96,741 | 0.05 | 0.13 | +0.08 | buy |
| ADAR1 Capital Management, LLC | 35,000 | 125,375 | +90,375 | 0.07 | 0.22 | +0.15 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 259,143 | 281,876 | +22,733 | 0.28 | 0.36 | +0.08 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 21,376 | 39,383 | +18,007 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 196,622 | 214,622 | +18,000 | 0.71 | 0.93 | +0.22 | buy |
| MEITAV INVESTMENT HOUSE LTD | 31,513 | 35,517 | +4,004 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 50,458 | 53,576 | +3,118 | 0.01 | 0.01 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 31,157 | 31,569 | +412 | 0.00 | 0.00 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 995 | 919 | -76 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,109 | 7,627 | -482 | 0.01 | 0.01 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 87,507 | 85,230 | -2,277 | 0.11 | 0.12 | +0.01 | sell |
| HighVista Strategies LLC | 31,886 | 28,005 | -3,881 | 0.16 | 0.17 | +0.01 | sell |
| ARK Investment Management LLC | 126,720 | 121,484 | -5,236 | 0.02 | 0.02 | +0.00 | sell |
| Persistent Asset Partners Ltd | 20,726 | 12,806 | -7,920 | 0.30 | 0.14 | -0.16 | sell |
| Annandale Capital, LLC | 70,552 | 60,552 | -10,000 | 0.25 | 0.23 | -0.02 | sell |
| Main Street Financial Solutions, LLC | 32,190 | 20,990 | -11,200 | 0.04 | 0.04 | -0.00 | sell |
| Atom Investors LP | 291,962 | 234,423 | -57,539 | 0.44 | 0.44 | -0.01 | sell |
| DIADEMA PARTNERS LP | 90,000 | 21,810 | -68,190 | 1.25 | 0.30 | -0.95 | sell |
| Boxer Capital Management, LLC | 575,000 | 500,000 | -75,000 | 3.66 | 2.56 | -1.09 | sell |
| Parkman Healthcare Partners LLC | 402,595 | 168,768 | -233,827 | 0.88 | 0.38 | -0.51 | sell |
| Soleus Capital Management, L.P. | 679,000 | 150,000 | -529,000 | 0.72 | 0.15 | -0.57 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 350,000 | -650,000 | 0.77 | 0.40 | -0.36 | sell |