| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,543,895 | 4,543,895 | 0 | 1.12 | 1.07 | -0.05 | hold |
| Paradigm Biocapital Advisors LP | 4,216,084 | 4,473,648 | +257,564 | 2.49 | 2.81 | +0.32 | buy |
| BlackRock, Inc. | 2,581,286 | 2,601,009 | +19,723 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,528,446 | 2,562,901 | +34,455 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,199,652 | 2,199,652 | 0 | 0.40 | 0.42 | +0.02 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,577,283 | 1,738,821 | +161,538 | 4.56 | 5.89 | +1.34 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,259,749 | 1,448,420 | +188,671 | 12.76 | 11.49 | -1.26 | buy |
| SG Americas Securities, LLC | 1,157,383 | 1,377,647 | +220,264 | 0.08 | 0.04 | -0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 1,358,812 | +1,358,812 | 0.00 | 0.02 | +0.02 | buy |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | 1,152,531 | 0 | 0.12 | 0.13 | +0.01 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 1,125,100 | +1,125,100 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 888,933 | 962,624 | +73,691 | 0.01 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 135,000 | 941,378 | +806,378 | 0.44 | 2.52 | +2.08 | buy |
| ORBIMED ADVISORS LLC | 689,000 | 875,487 | +186,487 | 0.33 | 0.42 | +0.09 | buy |
| STATE STREET CORP | 819,446 | 807,421 | -12,025 | 0.00 | 0.00 | +0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 781,620 | +781,620 | 0.00 | 0.19 | +0.19 | buy |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | 770,909 | 0 | 0.17 | 0.16 | -0.01 | hold |
| CITADEL ADVISORS LLC | 602,277 | 737,757 | +135,480 | 0.01 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 87,912 | 718,354 | +630,442 | 1.73 | 9.01 | +7.28 | buy |
| TCG Crossover Management, LLC | 717,347 | 717,347 | 0 | 0.70 | 0.56 | -0.15 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,468,737 | 618,952 | -849,785 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 356,615 | 616,606 | +259,991 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 513,303 | +513,303 | 0.00 | 0.47 | +0.47 | buy |
| Woodline Partners LP | 306,371 | 500,726 | +194,355 | 0.03 | 0.05 | +0.02 | buy |
| Boxer Capital Management, LLC | 575,000 | 500,000 | -75,000 | 3.66 | 2.56 | -1.09 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 471,229 | 475,212 | +3,983 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 424,916 | 459,722 | +34,806 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 303,785 | 439,751 | +135,966 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 687,475 | 435,490 | -251,985 | 0.05 | 0.04 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 162,259 | 366,680 | +204,421 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 350,000 | -650,000 | 0.77 | 0.40 | -0.36 | sell |
| Nuveen, LLC | 507,531 | 302,601 | -204,930 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 259,143 | 281,876 | +22,733 | 0.28 | 0.36 | +0.08 | buy |
| Opaleye Management Inc. | 0 | 268,423 | +268,423 | 0.00 | 0.83 | +0.83 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 275,100 | 244,300 | -30,800 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 386,203 | 241,213 | -144,990 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 261,401 | 237,457 | -23,944 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 180,460 | 235,040 | +54,580 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 291,962 | 234,423 | -57,539 | 0.44 | 0.44 | -0.01 | sell |
| Privium Fund Management B.V. | 196,622 | 214,622 | +18,000 | 0.71 | 0.93 | +0.22 | buy |
| Parkman Healthcare Partners LLC | 402,595 | 168,768 | -233,827 | 0.88 | 0.38 | -0.51 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,225 | 162,725 | +15,500 | 0.00 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 65,183 | 161,924 | +96,741 | 0.05 | 0.13 | +0.08 | buy |
| Informed Momentum Co LLC | 0 | 160,412 | +160,412 | 0.00 | 0.42 | +0.42 | buy |
| AQR CAPITAL MANAGEMENT LLC | 204,191 | 153,413 | -50,778 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 679,000 | 150,000 | -529,000 | 0.72 | 0.15 | -0.57 | sell |
| JPMORGAN CHASE & CO | 534,545 | 146,271 | -388,274 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 30,484 | 136,019 | +105,535 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 133,674 | 130,899 | -2,775 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 108,454 | 128,630 | +20,176 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 125,298 | 126,034 | +736 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 35,000 | 125,375 | +90,375 | 0.07 | 0.22 | +0.15 | buy |
| FMR LLC | 73,116 | 123,563 | +50,447 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 126,720 | 121,484 | -5,236 | 0.02 | 0.02 | +0.00 | sell |
| Aisling Capital Management LP | 0 | 108,000 | +108,000 | 0.00 | 0.53 | +0.53 | buy |
| Bank of New York Mellon Corp | 95,353 | 98,829 | +3,476 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91,059 | 90,989 | -70 | 0.00 | 0.00 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 87,507 | 85,230 | -2,277 | 0.11 | 0.12 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 125,969 | 84,158 | -41,811 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 44,000 | 80,188 | +36,188 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 83,611 | 76,762 | -6,849 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 184,382 | 74,055 | -110,327 | 0.01 | 0.01 | -0.01 | sell |
| TRUIST FINANCIAL CORP | 72,286 | 72,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 0 | 65,935 | +65,935 | 0.00 | 0.02 | +0.02 | buy |
| Annandale Capital, LLC | 70,552 | 60,552 | -10,000 | 0.25 | 0.23 | -0.02 | sell |
| BARCLAYS PLC | 55,619 | 57,744 | +2,125 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,937 | 55,686 | +19,749 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 50,458 | 53,576 | +3,118 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 3,321 | 47,257 | +43,936 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 50,953 | 45,760 | -5,193 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 21,376 | 39,383 | +18,007 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 37,000 | 37,000 | 0 | 0.06 | 0.06 | +0.01 | hold |
| MEITAV INVESTMENT HOUSE LTD | 31,513 | 35,517 | +4,004 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 16,543 | 35,393 | +18,850 | 0.00 | 0.01 | +0.00 | buy |
| Focus Partners Wealth | 0 | 35,277 | +35,277 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,040 | 35,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 31,157 | 31,569 | +412 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 31,516 | +31,516 | 0.00 | 0.03 | +0.03 | buy |
| Cetera Investment Advisers | 32,096 | 30,096 | -2,000 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 31,886 | 28,005 | -3,881 | 0.16 | 0.17 | +0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 27,380 | +27,380 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 22,355 | 27,066 | +4,711 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 26,972 | +26,972 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 24,500 | 24,500 | 0 | 0.09 | 0.08 | -0.01 | hold |
| MML INVESTORS SERVICES, LLC | 0 | 24,363 | +24,363 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 20,309 | 23,514 | +3,205 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 22,831 | +22,831 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 29,302 | 22,491 | -6,811 | 0.03 | 0.01 | -0.02 | sell |
| MetLife Investment Management, LLC | 22,766 | 22,445 | -321 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 15,227 | 22,210 | +6,983 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 22,109 | +22,109 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 22,000 | 22,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | 21,823 | 0 | 0.09 | 0.10 | +0.01 | hold |
| DIADEMA PARTNERS LP | 90,000 | 21,810 | -68,190 | 1.25 | 0.30 | -0.95 | sell |
| Main Street Financial Solutions, LLC | 32,190 | 20,990 | -11,200 | 0.04 | 0.04 | -0.00 | sell |
| Jump Financial, LLC | 103,866 | 17,900 | -85,966 | 0.03 | 0.01 | -0.03 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,017 | 17,154 | +137 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 16,991 | +16,991 | 0.00 | 0.02 | +0.02 | buy |
| OPPENHEIMER & CO INC | 0 | 16,962 | +16,962 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 0 | 16,961 | +16,961 | 0.00 | 0.00 | +0.00 | buy |