| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,077,927 | 11,077,927 | 0 | 1.12 | 1.97 | +0.85 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,459,678 | 10,860,977 | +1,401,299 | 0.81 | 1.41 | +0.60 | buy |
| ORBIMED ADVISORS LLC | 9,240,887 | 9,240,887 | 0 | 1.01 | 1.73 | +0.72 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 9.23 | 11.26 | +2.03 | hold |
| FRANKLIN RESOURCES INC | 4,098,497 | 2,950,963 | -1,147,534 | 0.01 | 0.01 | -0.00 | sell |
| VANGUARD GROUP INC | 2,106,486 | 2,886,455 | +779,969 | 0.00 | 0.00 | +0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 3,054,333 | 2,219,131 | -835,202 | 3.92 | 5.41 | +1.48 | sell |
| STATE STREET CORP | 576,980 | 1,604,550 | +1,027,570 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,202,315 | 1,084,922 | -117,393 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 864,869 | 876,671 | +11,802 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 867,319 | +867,319 | 0.00 | 0.16 | +0.16 | buy |
| Rubric Capital Management LP | 639,203 | 639,203 | 0 | 0.13 | 0.19 | +0.06 | hold |
| ROYCE & ASSOCIATES LP | 473,700 | 558,700 | +85,000 | 0.02 | 0.05 | +0.03 | buy |
| Sio Capital Management, LLC | 1,105,911 | 536,163 | -569,748 | 1.56 | 1.91 | +0.35 | sell |
| GOLDMAN SACHS GROUP INC | 141,101 | 462,716 | +321,615 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 14,555 | 411,372 | +396,817 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 661,414 | 401,788 | -259,626 | 0.04 | 0.04 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,550 | 345,295 | +15,745 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 20,117 | 277,706 | +257,589 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 324,726 | 275,289 | -49,437 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 259,681 | 262,109 | +2,428 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 311,169 | 239,194 | -71,975 | 0.41 | 0.56 | +0.15 | sell |
| SECTORAL ASSET MANAGEMENT INC | 354,641 | 204,437 | -150,204 | 0.84 | 0.82 | -0.02 | sell |
| GSA CAPITAL PARTNERS LLP | 115,344 | 128,889 | +13,545 | 0.05 | 0.10 | +0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 113,205 | +113,205 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 31,803 | 112,065 | +80,262 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 111,559 | +111,559 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 104,441 | +104,441 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.13 | +0.13 | buy |
| MORGAN STANLEY | 0 | 97,953 | +97,953 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,239 | 97,462 | +92,223 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 88,165 | 92,328 | +4,163 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 98,598 | 81,579 | -17,019 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 48,449 | 81,042 | +32,593 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 253,416 | 80,845 | -172,571 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 80,798 | +80,798 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 72,322 | +72,322 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 84,358 | 69,891 | -14,467 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 66,396 | 67,708 | +1,312 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 66,000 | 66,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 63,803 | 63,808 | +5 | 0.00 | 0.00 | +0.00 | buy |
| FAS Wealth Partners, Inc. | 45,970 | 60,470 | +14,500 | 0.02 | 0.05 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,790 | 59,170 | -3,620 | 0.00 | 0.00 | +0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 52,250 | 55,250 | +3,000 | 0.03 | 0.06 | +0.03 | buy |
| JPMORGAN CHASE & CO | 34,649 | 50,183 | +15,534 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,806 | 41,425 | +10,619 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 38,177 | +38,177 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 36,328 | 37,054 | +726 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 36,000 | 36,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 76,290 | 34,570 | -41,720 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,803 | 32,658 | -1,145 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 31,201 | 32,362 | +1,161 | 0.00 | 0.00 | +0.00 | buy |
| Avantax Planning Partners, Inc. | 32,174 | 32,174 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 17,439 | 30,441 | +13,002 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 40,374 | 29,873 | -10,501 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 28,157 | 27,657 | -500 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 27,120 | +27,120 | 0.00 | 0.01 | +0.01 | buy |
| HighTower Advisors, LLC | 15,139 | 24,794 | +9,655 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 23,605 | 24,486 | +881 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 21,809 | 21,813 | +4 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 61,725 | 20,417 | -41,308 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 20,201 | +20,201 | 0.00 | 0.02 | +0.02 | buy |
| CIBC Private Wealth Group LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,105 | 18,453 | +7,348 | 0.01 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 17,432 | +17,432 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 16,800 | +16,800 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,252 | 14,744 | -508 | 0.00 | 0.00 | +0.00 | sell |
| J.W. COLE ADVISORS, INC. | 0 | 13,900 | +13,900 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 13,784 | 13,784 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,940 | 12,940 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 0 | 12,633 | +12,633 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 52,000 | 12,600 | -39,400 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 12,202 | 12,099 | -103 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,112 | 12,076 | -36 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 11,606 | +11,606 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,197 | 11,139 | +942 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 10,117 | +10,117 | 0.00 | 0.01 | +0.01 | buy |
| Paloma Partners Management Co | 0 | 10,093 | +10,093 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 7,498 | 8,588 | +1,090 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 5,897 | +5,897 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,600 | 5,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,693 | 2,947 | -1,746 | 0.00 | 0.00 | +0.00 | sell |
| SIGNATUREFD, LLC | 2,812 | 2,812 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Salomon & Ludwin, LLC | 2,785 | 2,785 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantbot Technologies LP | 0 | 2,100 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,002 | 2,002 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PARK CIRCLE Co | 2,000 | 2,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,428 | 1,495 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 3,096 | 1,472 | -1,624 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aquatic Capital Management LLC | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,407 | 818 | -1,589 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 0 | 516 | +516 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 367 | 367 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 347 | 347 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 0 | 169 | +169 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 155 | 155 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 76 | 100 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 82 | +82 | 0.00 | 0.00 | +0.00 | buy |