| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 1.30 | 0.92 | -0.37 | hold |
| ORBIMED ADVISORS LLC | 8,288,510 | 8,288,510 | 0 | 1.98 | 1.45 | -0.52 | hold |
| Rubric Capital Management LP | 6,200,000 | 8,000,000 | +1,800,000 | 0.86 | 0.79 | -0.08 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,503,812 | 7,503,812 | 0 | 1.12 | 0.71 | -0.41 | hold |
| MILLENNIUM MANAGEMENT LLC | 3,168,406 | 5,982,919 | +2,814,513 | 0.03 | 0.04 | +0.01 | buy |
| BlackRock, Inc. | 5,085,317 | 5,012,254 | -73,063 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 3,556,049 | 4,113,617 | +557,568 | 0.06 | 0.05 | -0.01 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 6.62 | 3.52 | -3.10 | hold |
| STATE STREET CORP | 3,223,581 | 3,644,966 | +421,385 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 2,543,097 | 3,278,549 | +735,452 | 0.01 | 0.01 | -0.00 | buy |
| Tyro Capital Management LLC | 1,994,852 | 2,968,599 | +973,747 | 7.23 | 6.03 | -1.20 | buy |
| UBS Group AG | 2,210,866 | 2,260,325 | +49,459 | 0.01 | 0.00 | -0.00 | buy |
| Janney Montgomery Scott LLC | 1,287,832 | 2,016,464 | +728,632 | 0.03 | 0.04 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,954,472 | 1,773,188 | -181,284 | 0.02 | 0.01 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,552,870 | 1,526,824 | -26,046 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 369,569 | 1,361,536 | +991,967 | 0.32 | 0.66 | +0.34 | buy |
| BAMCO INC /NY/ | 1,268,532 | 1,273,341 | +4,809 | 0.04 | 0.03 | -0.01 | buy |
| Third Point LLC | 556,237 | 1,000,000 | +443,763 | 0.09 | 0.39 | +0.30 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 559,959 | 727,154 | +167,195 | 0.41 | 0.39 | -0.02 | buy |
| GOLDMAN SACHS GROUP INC | 812,036 | 724,219 | -87,817 | 0.00 | 0.00 | -0.00 | sell |
| Nextech Invest, Ltd. | 660,703 | 610,703 | -50,000 | 0.74 | 0.35 | -0.40 | sell |
| K2 PRINCIPAL FUND, L.P. | 10,200 | 559,697 | +549,497 | 0.01 | 0.47 | +0.46 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 747,506 | 552,561 | -194,945 | 0.76 | 0.34 | -0.42 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 550,932 | 533,394 | -17,538 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 521,009 | 529,284 | +8,275 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 566,056 | 525,224 | -40,832 | 0.00 | 0.00 | -0.00 | sell |
| Empire Life Investments Inc. | 352,602 | 499,150 | +146,548 | 0.23 | 0.25 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 304,445 | 464,681 | +160,236 | 0.00 | 0.00 | +0.00 | buy |
| FIL Ltd | 810,073 | 455,575 | -354,498 | 0.01 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 455,766 | 428,599 | -27,167 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 422,038 | +422,038 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 417,090 | 382,801 | -34,289 | 0.00 | 0.00 | -0.00 | sell |
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV | 311,503 | 359,074 | +47,571 | 1.01 | 0.78 | -0.23 | buy |
| FMR LLC | 398,959 | 342,042 | -56,917 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 552,364 | 316,673 | -235,691 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 568,361 | 291,179 | -277,182 | 0.32 | 0.13 | -0.20 | sell |
| BANK OF AMERICA CORP /DE/ | 482,084 | 285,728 | -196,356 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 37,201 | 276,108 | +238,907 | 0.01 | 0.04 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 201,474 | 250,597 | +49,123 | 0.06 | 0.05 | -0.01 | buy |
| Tejara Capital Ltd | 0 | 210,400 | +210,400 | 0.00 | 0.56 | +0.56 | buy |
| FAS Wealth Partners, Inc. | 202,407 | 205,407 | +3,000 | 0.15 | 0.10 | -0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 176,122 | 172,339 | -3,783 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 168,789 | +168,789 | 0.00 | 0.09 | +0.09 | buy |
| Bank of New York Mellon Corp | 163,006 | 164,064 | +1,058 | 0.00 | 0.00 | -0.00 | buy |
| Quinn Opportunity Partners LLC | 155,000 | 155,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Nuveen, LLC | 149,597 | 150,696 | +1,099 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 216,296 | 146,453 | -69,843 | 0.01 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 190,065 | 139,285 | -50,780 | 0.51 | 0.25 | -0.26 | sell |
| Eversept Partners, LP | 251,593 | 136,235 | -115,358 | 0.16 | 0.07 | -0.09 | sell |
| WEXFORD CAPITAL LP | 165,313 | 130,313 | -35,000 | 0.50 | 0.17 | -0.32 | sell |
| Knights of Columbus Asset Advisors LLC | 130,729 | 130,032 | -697 | 0.09 | 0.06 | -0.03 | sell |
| Rafferty Asset Management, LLC | 115,564 | 117,635 | +2,071 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 114,273 | +114,273 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 107,200 | 107,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 79,214 | 105,006 | +25,792 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 53,113 | 101,412 | +48,299 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 96,093 | +96,093 | 0.00 | 0.01 | +0.01 | buy |
| SIT INVESTMENT ASSOCIATES INC | 92,875 | 92,875 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Cambridge Investment Research Advisors, Inc. | 87,161 | 87,161 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 196,387 | 84,169 | -112,218 | 0.00 | 0.00 | -0.00 | sell |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | 83,225 | 0 | 0.28 | 0.20 | -0.08 | hold |
| Corient Private Wealth LLC | 0 | 80,943 | +80,943 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 81,168 | 80,830 | -338 | 0.01 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 29,803 | 79,150 | +49,347 | 0.28 | 0.56 | +0.28 | buy |
| AssuredPartners Investment Advisors, LLC | 75,779 | 76,210 | +431 | 0.13 | 0.07 | -0.06 | buy |
| RHUMBLINE ADVISERS | 73,293 | 72,257 | -1,036 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 71,627 | +71,627 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 55,561 | 67,229 | +11,668 | 0.29 | 0.23 | -0.06 | buy |
| AXQ CAPITAL, LP | 0 | 64,304 | +64,304 | 0.00 | 0.07 | +0.07 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 61,752 | +61,752 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 60,537 | +60,537 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 34,128 | 58,373 | +24,245 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 53,830 | 55,730 | +1,900 | 0.05 | 0.03 | -0.02 | buy |
| DEUTSCHE BANK AG\ | 48,727 | 54,491 | +5,764 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 207,051 | 54,024 | -153,027 | 0.02 | 0.00 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,098 | 53,658 | -440 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 42,808 | 52,328 | +9,520 | 0.02 | 0.02 | +0.00 | buy |
| SCHULHOFF & CO INC | 51,150 | 51,150 | 0 | 0.25 | 0.17 | -0.08 | hold |
| Headlands Technologies LLC | 0 | 48,206 | +48,206 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 58,368 | 47,885 | -10,483 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 47,256 | +47,256 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 46,558 | +46,558 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 43,665 | +43,665 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 60,120 | 41,980 | -18,140 | 0.00 | 0.00 | -0.00 | sell |
| Kestra Advisory Services, LLC | 3,470 | 40,920 | +37,450 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,788 | 40,779 | +6,991 | 0.00 | 0.00 | -0.00 | buy |
| Norman Fields, Gottscho Capital Management, LLC | 0 | 39,850 | +39,850 | 0.00 | 0.11 | +0.11 | buy |
| Belpointe Asset Management LLC | 25,468 | 38,445 | +12,977 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 37,230 | 38,186 | +956 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,100 | 35,867 | +1,767 | 0.00 | 0.00 | -0.00 | buy |
| Permanent Capital Management, LP | 52,306 | 35,115 | -17,191 | 0.12 | 0.05 | -0.07 | sell |
| MetLife Investment Management, LLC | 34,338 | 34,338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIKER MANAGEMENT LLC | 33,508 | 33,508 | 0 | 0.30 | 0.24 | -0.06 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 33,032 | +33,032 | 0.00 | 0.00 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 21,614 | 31,568 | +9,954 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 74,256 | 30,385 | -43,871 | 0.00 | 0.00 | -0.00 | sell |
| Private Advisor Group, LLC | 31,460 | 30,242 | -1,218 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 30,152 | 30,152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,600 | 29,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 0 | 25,877 | +25,877 | 0.00 | 0.00 | +0.00 | buy |