| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 2,886,455 | 3,250,927 | +364,472 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 876,671 | 1,195,878 | +319,207 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,604,550 | 1,856,221 | +251,671 | 0.00 | 0.00 | -0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 2,219,131 | 2,461,672 | +242,541 | 5.41 | 4.63 | -0.77 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 12,600 | 124,100 | +111,500 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 11,606 | 111,592 | +99,986 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 277,706 | 365,027 | +87,321 | 0.01 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 558,700 | 645,700 | +87,000 | 0.05 | 0.05 | +0.00 | buy |
| Walleye Capital LLC | 0 | 71,499 | +71,499 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 345,295 | 415,530 | +70,235 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 69,891 | 139,285 | +69,394 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 97,953 | 133,806 | +35,853 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 204,437 | 236,937 | +32,500 | 0.82 | 0.82 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 38,177 | 68,233 | +30,056 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 37,054 | 65,942 | +28,888 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 55,250 | 83,250 | +28,000 | 0.06 | 0.07 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 27,139 | +27,139 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 27,120 | +27,120 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 26,925 | +26,925 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 20,417 | 46,924 | +26,507 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 81,579 | 108,074 | +26,495 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 24,482 | +24,482 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 24,300 | +24,300 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 23,435 | +23,435 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 5,897 | 28,987 | +23,090 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 92,328 | 114,374 | +22,046 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 21,196 | +21,196 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 17,307 | +17,307 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 81,042 | 97,803 | +16,761 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 15,720 | +15,720 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,784 | 29,317 | +15,533 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 59,170 | 73,660 | +14,490 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,940 | 27,081 | +14,141 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 10,707 | +10,707 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 10,388 | +10,388 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 10,230 | +10,230 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 10,179 | +10,179 | 0.00 | 0.00 | +0.00 | buy |
| CAZ INVESTMENTS LP | 0 | 10,000 | +10,000 | 0.00 | 0.13 | +0.13 | buy |
| Invesco Ltd. | 411,372 | 420,575 | +9,203 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 29,873 | 38,539 | +8,666 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 67,708 | 75,604 | +7,896 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 7,690 | +7,690 | 0.00 | 0.00 | +0.00 | buy |
| FAS Wealth Partners, Inc. | 60,470 | 67,656 | +7,186 | 0.05 | 0.05 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 8,588 | 15,756 | +7,168 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,744 | 20,786 | +6,042 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 262,109 | 267,571 | +5,462 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,947 | 7,419 | +4,472 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 113,205 | 116,883 | +3,678 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 27,657 | 31,207 | +3,550 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,893 | +2,893 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,002 | 4,821 | +2,819 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,658 | 34,283 | +1,625 | 0.00 | 0.00 | -0.00 | buy |
| J.W. COLE ADVISORS, INC. | 13,900 | 15,400 | +1,500 | 0.01 | 0.01 | -0.00 | buy |
| Creative Planning | 32,362 | 32,956 | +594 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,084,922 | 1,085,318 | +396 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,600 | 5,691 | +91 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 37 | +37 | 0.00 | 0.00 | 0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,076 | 12,107 | +31 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 12 | +12 | 0.00 | 0.00 | 0.00 | buy |
| Avantax Planning Partners, Inc. | 32,174 | 32,174 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,077,927 | 11,077,927 | 0 | 1.97 | 1.57 | -0.40 | hold |
| ORBIMED ADVISORS LLC | 9,240,887 | 9,240,887 | 0 | 1.73 | 1.56 | -0.17 | hold |
| PERCEPTIVE ADVISORS LLC | 867,319 | 867,319 | 0 | 0.16 | 0.18 | +0.02 | hold |
| CIBC Private Wealth Group LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Janney Montgomery Scott LLC | 24,486 | 24,486 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 1.41 | 1.22 | -0.19 | hold |
| DAFNA Capital Management LLC | 239,194 | 239,194 | 0 | 0.56 | 0.49 | -0.07 | hold |
| SIGNATUREFD, LLC | 2,812 | 2,812 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 367 | 367 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PARK CIRCLE Co | 2,000 | 2,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Allworth Financial LP | 82 | 82 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 66,000 | 66,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 347 | 347 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rubric Capital Management LP | 639,203 | 639,203 | 0 | 0.19 | 0.14 | -0.05 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 11.26 | 10.69 | -0.57 | hold |
| US BANCORP \DE\ | 155 | 155 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 2,950,963 | 2,950,963 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AMALGAMATED BANK | 818 | 818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 100 | 76 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 516 | 485 | -31 | 0.00 | 0.00 | -0.00 | sell |
| C M BIDWELL & ASSOCIATES LTD | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 1,300 | 1,200 | -100 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 140 | 0 | -140 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 169 | 0 | -169 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 21,813 | 21,600 | -213 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 24,794 | 23,941 | -853 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 1,100 | 0 | -1,100 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 17,432 | 16,129 | -1,303 | 0.01 | 0.01 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 1,472 | 0 | -1,472 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,495 | 0 | -1,495 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| Salomon & Ludwin, LLC | 2,785 | 0 | -2,785 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 30,441 | 26,335 | -4,106 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,453 | 11,383 | -7,070 | 0.02 | 0.01 | -0.01 | sell |
| Paloma Partners Management Co | 10,093 | 0 | -10,093 | 0.01 | 0.00 | -0.01 | sell |
| MIRABELLA FINANCIAL SERVICES LLP | 10,117 | 0 | -10,117 | 0.01 | 0.00 | -0.01 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 63,808 | 52,814 | -10,994 | 0.00 | 0.00 | -0.00 | sell |