| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 2.28 | 3.19 | +0.91 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 10,514,657 | 9,724,508 | -790,149 | 2.62 | 3.08 | +0.46 | sell |
| ORBIMED ADVISORS LLC | 8,288,510 | 8,288,510 | 0 | 2.50 | 3.64 | +1.13 | hold |
| BlackRock, Inc. | 4,298,988 | 4,423,464 | +124,476 | 0.00 | 0.00 | +0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 12.97 | 15.18 | +2.21 | hold |
| ALLIANCEBERNSTEIN L.P. | 3,922,805 | 3,825,793 | -97,012 | 0.02 | 0.02 | +0.00 | sell |
| VANGUARD GROUP INC | 3,488,293 | 3,262,673 | -225,620 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 801,290 | 2,242,176 | +1,440,886 | 0.01 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 2,031,234 | 2,194,493 | +163,259 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,857,544 | 1,828,755 | -28,789 | 0.01 | 0.01 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,728,000 | +1,728,000 | 0.00 | 0.05 | +0.05 | buy |
| Southpoint Capital Advisors LP | 0 | 1,709,069 | +1,709,069 | 0.00 | 0.75 | +0.75 | buy |
| FMR LLC | 990,860 | 1,567,010 | +576,150 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,002,659 | 1,502,575 | +499,916 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 717,953 | 1,464,312 | +746,359 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 131,776 | 1,433,187 | +1,301,411 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 625,000 | 1,350,000 | +725,000 | 1.07 | 5.17 | +4.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,260,477 | 1,342,387 | +81,910 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,313,104 | 1,303,399 | -9,705 | 2.84 | 3.94 | +1.10 | sell |
| Rubric Capital Management LP | 1,029,101 | 1,294,878 | +265,777 | 0.23 | 0.36 | +0.13 | buy |
| Cormorant Asset Management, LP | 1,600,000 | 1,100,000 | -500,000 | 1.52 | 1.43 | -0.09 | sell |
| MILLENNIUM MANAGEMENT LLC | 807,036 | 878,157 | +71,121 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 591,182 | 866,935 | +275,753 | 0.00 | 0.00 | +0.00 | buy |
| Nextech Invest, Ltd. | 936,729 | 741,729 | -195,000 | 2.74 | 2.45 | -0.29 | sell |
| RAYMOND JAMES FINANCIAL INC | 706,787 | 673,370 | -33,417 | 0.00 | 0.00 | +0.00 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 622,823 | +622,823 | 0.00 | 0.84 | +0.84 | buy |
| BARCLAYS PLC | 132,035 | 622,235 | +490,200 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 448,669 | 591,425 | +142,756 | 0.02 | 0.03 | +0.01 | buy |
| NORTHERN TRUST CORP | 487,043 | 485,014 | -2,029 | 0.00 | 0.00 | +0.00 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 325,000 | 475,000 | +150,000 | 0.95 | 1.35 | +0.41 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 464,030 | +464,030 | 0.00 | 0.06 | +0.06 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 501,821 | 456,979 | -44,842 | 0.21 | 0.24 | +0.03 | sell |
| First Turn Management, LLC | 669,010 | 455,953 | -213,057 | 1.70 | 1.48 | -0.21 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 416,657 | 442,202 | +25,545 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 193,830 | 420,075 | +226,245 | 0.73 | 2.03 | +1.31 | buy |
| MORGAN STANLEY | 442,514 | 383,616 | -58,898 | 0.00 | 0.00 | +0.00 | sell |
| WEXFORD CAPITAL LP | 408,551 | 382,555 | -25,996 | 1.34 | 1.86 | +0.53 | sell |
| AMERIPRISE FINANCIAL INC | 104,110 | 345,055 | +240,945 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 340,119 | +340,119 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 171,124 | 329,073 | +157,949 | 0.01 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 279,840 | 325,645 | +45,805 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 444,703 | 325,352 | -119,351 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 317,347 | 324,877 | +7,530 | 0.00 | 0.00 | +0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 485,355 | 317,126 | -168,229 | 0.93 | 1.01 | +0.08 | sell |
| Woodline Partners LP | 600,322 | 300,419 | -299,903 | 0.05 | 0.03 | -0.02 | sell |
| Allspring Global Investments Holdings, LLC | 368,556 | 294,111 | -74,445 | 0.01 | 0.01 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 290,092 | 290,092 | 0 | 0.01 | 0.02 | +0.00 | hold |
| LEVIN CAPITAL STRATEGIES, L.P. | 1,164,601 | 289,147 | -875,454 | 1.56 | 0.50 | -1.06 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 204,201 | 256,966 | +52,765 | 0.00 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 642,766 | 256,269 | -386,497 | 0.09 | 0.05 | -0.04 | sell |
| Nicholas Investment Partners, LP | 611,737 | 255,107 | -356,630 | 0.79 | 0.40 | -0.40 | sell |
| Pictet Asset Management Holding SA | 0 | 234,841 | +234,841 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 187,645 | 180,492 | -7,153 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 65,723 | 166,184 | +100,461 | 0.00 | 0.00 | +0.00 | buy |
| FAS Wealth Partners, Inc. | 139,535 | 149,160 | +9,625 | 0.14 | 0.19 | +0.05 | buy |
| Bank of New York Mellon Corp | 132,213 | 145,117 | +12,904 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 140,000 | +140,000 | 0.00 | 0.49 | +0.49 | buy |
| Nuveen, LLC | 154,456 | 139,133 | -15,323 | 0.00 | 0.00 | +0.00 | sell |
| Steward Partners Investment Advisory, LLC | 48,480 | 128,180 | +79,700 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 29,949 | 117,500 | +87,551 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 105,000 | +105,000 | 0.00 | 0.42 | +0.42 | buy |
| ROYAL BANK OF CANADA | 18,547 | 102,791 | +84,244 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 101,679 | +101,679 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 72,753 | 93,298 | +20,545 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 87,158 | 87,162 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 46,750 | 87,025 | +40,275 | 0.05 | 0.13 | +0.07 | buy |
| SEI INVESTMENTS CO | 95,034 | 85,082 | -9,952 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 75,700 | 84,300 | +8,600 | 0.00 | 0.00 | +0.00 | buy |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | 83,225 | 0 | 0.37 | 0.47 | +0.09 | hold |
| RHUMBLINE ADVISERS | 69,766 | 81,261 | +11,495 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 75,322 | 80,846 | +5,524 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 75,458 | +75,458 | 0.00 | 0.04 | +0.04 | buy |
| Epoch Investment Partners, Inc. | 118,982 | 72,780 | -46,202 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 21,600 | 69,479 | +47,879 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 43,144 | 68,094 | +24,950 | 0.04 | 0.07 | +0.03 | buy |
| SECTORAL ASSET MANAGEMENT INC | 100,205 | 65,785 | -34,420 | 0.98 | 0.76 | -0.22 | sell |
| CastleKnight Management LP | 65,300 | 65,300 | 0 | 0.09 | 0.08 | -0.01 | hold |
| WELLS FARGO & COMPANY/MN | 59,647 | 61,106 | +1,459 | 0.00 | 0.00 | +0.00 | buy |
| Harbour Capital Advisors, LLC | 28,650 | 57,950 | +29,300 | 0.09 | 0.20 | +0.11 | buy |
| D. E. Shaw & Co., Inc. | 33,797 | 57,449 | +23,652 | 0.00 | 0.00 | +0.00 | buy |
| AssuredPartners Investment Advisors, LLC | 69,111 | 56,969 | -12,142 | 0.17 | 0.24 | +0.08 | sell |
| Matisse Capital | 55,714 | 56,714 | +1,000 | 0.37 | 0.47 | +0.10 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 55,446 | +55,446 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 35,341 | 54,825 | +19,484 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 53,000 | +53,000 | 0.00 | 0.01 | +0.01 | buy |
| Miura Global Management, LLC | 75,000 | 50,000 | -25,000 | 1.40 | 0.94 | -0.46 | sell |
| Aquatic Capital Management LLC | 0 | 48,688 | +48,688 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 27,452 | 45,252 | +17,800 | 0.03 | 0.06 | +0.02 | buy |
| Quinn Opportunity Partners LLC | 111,628 | 45,000 | -66,628 | 0.10 | 0.07 | -0.03 | sell |
| SCHULHOFF & CO INC | 40,500 | 43,500 | +3,000 | 0.23 | 0.34 | +0.11 | buy |
| TWO SIGMA ADVISERS, LP | 40,900 | 41,200 | +300 | 0.00 | 0.00 | +0.00 | buy |
| DIKER MANAGEMENT LLC | 21,000 | 41,000 | +20,000 | 0.32 | 0.67 | +0.36 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 40,350 | +40,350 | 0.00 | 0.02 | +0.02 | buy |
| BAMCO INC /NY/ | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 156,635 | 39,914 | -116,721 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 37,973 | 39,713 | +1,740 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 33,119 | 37,604 | +4,485 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 95,210 | 37,583 | -57,627 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 39,103 | 37,013 | -2,090 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,988 | 36,988 | 0 | 0.00 | 0.00 | +0.00 | hold |