| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 0.92 | 0.76 | -0.17 | hold |
| Rubric Capital Management LP | 8,000,000 | 8,540,861 | +540,861 | 0.79 | 0.63 | -0.16 | buy |
| ORBIMED ADVISORS LLC | 8,288,510 | 8,288,510 | 0 | 1.45 | 1.26 | -0.19 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,503,812 | 7,503,812 | 0 | 0.71 | 0.63 | -0.08 | hold |
| BlackRock, Inc. | 5,012,254 | 5,311,319 | +299,065 | 0.00 | 0.00 | -0.00 | buy |
| Tyro Capital Management LLC | 2,968,599 | 4,459,337 | +1,490,738 | 6.03 | 8.01 | +1.98 | buy |
| Aberdeen Group plc | 4,113,617 | 4,170,629 | +57,012 | 0.05 | 0.05 | -0.01 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 3.52 | 3.09 | -0.43 | hold |
| STATE STREET CORP | 3,644,966 | 3,730,623 | +85,657 | 0.00 | 0.00 | -0.00 | buy |
| Capital World Investors | 0 | 2,754,931 | +2,754,931 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 5,982,919 | 2,400,937 | -3,581,982 | 0.04 | 0.01 | -0.02 | sell |
| Janney Montgomery Scott LLC | 2,016,464 | 2,064,498 | +48,034 | 0.04 | 0.03 | -0.01 | buy |
| UBS Group AG | 2,260,325 | 1,939,654 | -320,671 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,526,824 | 1,699,017 | +172,193 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 250,597 | 1,601,504 | +1,350,907 | 0.05 | 0.24 | +0.19 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 727,154 | 1,133,046 | +405,892 | 0.39 | 0.55 | +0.16 | buy |
| Third Point LLC | 1,000,000 | 1,000,000 | 0 | 0.39 | 0.17 | -0.21 | hold |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 672,139 | +672,139 | 0.00 | 0.17 | +0.17 | buy |
| Tejara Capital Ltd | 210,400 | 607,039 | +396,639 | 0.56 | 2.00 | +1.44 | buy |
| ADAR1 Capital Management, LLC | 1,361,536 | 600,999 | -760,537 | 0.66 | 0.23 | -0.43 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 551,416 | +551,416 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 533,394 | 551,416 | +18,022 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 529,284 | 549,064 | +19,780 | 0.00 | 0.00 | -0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 552,561 | 548,965 | -3,596 | 0.34 | 0.30 | -0.04 | sell |
| CITADEL ADVISORS LLC | 1,773,188 | 531,063 | -1,242,125 | 0.01 | 0.00 | -0.01 | sell |
| Empire Life Investments Inc. | 499,150 | 471,856 | -27,294 | 0.25 | 0.21 | -0.04 | sell |
| BANK OF AMERICA CORP /DE/ | 285,728 | 463,256 | +177,528 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 464,681 | 461,384 | -3,297 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 455,575 | 455,575 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 724,219 | 380,770 | -343,449 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 136,235 | 377,007 | +240,772 | 0.07 | 0.16 | +0.09 | buy |
| K2 PRINCIPAL FUND, L.P. | 559,697 | 375,132 | -184,565 | 0.47 | 0.28 | -0.20 | sell |
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV | 359,074 | 373,491 | +14,417 | 0.78 | 0.76 | -0.02 | buy |
| JPMORGAN CHASE & CO | 382,801 | 363,316 | -19,485 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 342,042 | 349,164 | +7,122 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 525,224 | 318,583 | -206,641 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 286,733 | +286,733 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 255,200 | +255,200 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 316,673 | 229,100 | -87,573 | 0.00 | 0.00 | -0.00 | sell |
| FAS Wealth Partners, Inc. | 205,407 | 214,507 | +9,100 | 0.10 | 0.09 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 175,614 | +175,614 | 0.00 | 0.04 | +0.04 | buy |
| Quinn Opportunity Partners LLC | 155,000 | 175,000 | +20,000 | 0.07 | 0.07 | +0.00 | buy |
| Bank of New York Mellon Corp | 164,064 | 168,136 | +4,072 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 139,285 | 164,285 | +25,000 | 0.25 | 0.25 | -0.00 | buy |
| Nuveen, LLC | 150,696 | 161,342 | +10,646 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 47,256 | 139,419 | +92,163 | 0.00 | 0.01 | +0.01 | buy |
| Steward Partners Investment Advisory, LLC | 146,453 | 128,600 | -17,853 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 84,169 | 126,261 | +42,092 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN ASSETS INC | 7,000 | 125,000 | +118,000 | 0.57 | 0.30 | -0.27 | buy |
| Quantinno Capital Management LP | 101,412 | 124,429 | +23,017 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 105,006 | 123,714 | +18,708 | 0.00 | 0.00 | -0.00 | buy |
| CenterBook Partners LP | 291,179 | 123,624 | -167,555 | 0.13 | 0.05 | -0.08 | sell |
| DIMENSIONAL FUND ADVISORS LP | 172,339 | 115,523 | -56,816 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 12,983 | 104,643 | +91,660 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 102,700 | +102,700 | 0.00 | 0.08 | +0.08 | buy |
| Swiss National Bank | 107,200 | 94,600 | -12,600 | 0.00 | 0.00 | -0.00 | sell |
| SIT INVESTMENT ASSOCIATES INC | 92,875 | 92,875 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Corient Private Wealth LLC | 80,943 | 91,042 | +10,099 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 18,625 | 89,199 | +70,574 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 87,161 | 87,161 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | 83,225 | 0 | 0.20 | 0.17 | -0.03 | hold |
| RHUMBLINE ADVISERS | 72,257 | 75,989 | +3,732 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 48,206 | 75,279 | +27,073 | 0.04 | 0.06 | +0.02 | buy |
| AssuredPartners Investment Advisors, LLC | 76,210 | 73,260 | -2,950 | 0.07 | 0.06 | -0.01 | sell |
| XTX Topco Ltd | 276,108 | 73,187 | -202,921 | 0.04 | 0.01 | -0.03 | sell |
| Norman Fields, Gottscho Capital Management, LLC | 39,850 | 71,080 | +31,230 | 0.11 | 0.17 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 54,491 | 65,866 | +11,375 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 67,229 | 65,701 | -1,528 | 0.23 | 0.21 | -0.02 | sell |
| DIKER MANAGEMENT LLC | 33,508 | 65,508 | +32,000 | 0.24 | 0.40 | +0.16 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 61,752 | 64,658 | +2,906 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 117,635 | 63,574 | -54,061 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 30,385 | 62,995 | +32,610 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 58,373 | 60,110 | +1,737 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 41,980 | 59,490 | +17,510 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,537 | 58,413 | -2,124 | 0.00 | 0.00 | -0.00 | sell |
| Coastal Bridge Advisors, LLC | 55,730 | 55,838 | +108 | 0.03 | 0.03 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 54,024 | 54,024 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 52,400 | +52,400 | 0.00 | 0.00 | +0.00 | buy |
| SCHULHOFF & CO INC | 51,150 | 51,150 | 0 | 0.17 | 0.16 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 40,779 | 50,579 | +9,800 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,658 | 46,123 | -7,535 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 45,895 | +45,895 | 0.00 | 0.00 | +0.00 | buy |
| Permanent Capital Management, LP | 35,115 | 43,383 | +8,268 | 0.05 | 0.05 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 24,700 | 40,050 | +15,350 | 0.00 | 0.00 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 31,568 | 39,579 | +8,011 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 47,885 | 38,988 | -8,897 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 38,186 | 38,891 | +705 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 34,338 | 36,644 | +2,306 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,867 | 35,754 | -113 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 25,877 | 35,676 | +9,799 | 0.00 | 0.00 | +0.00 | buy |
| Everstar Asset Management, LLC | 20,000 | 33,732 | +13,732 | 0.09 | 0.13 | +0.04 | buy |
| WINTON GROUP Ltd | 0 | 32,900 | +32,900 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 52,328 | 32,199 | -20,129 | 0.02 | 0.01 | -0.01 | sell |
| Verition Fund Management LLC | 0 | 30,750 | +30,750 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 30,152 | 30,152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 79,150 | 29,900 | -49,250 | 0.56 | 0.17 | -0.39 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 29,727 | +29,727 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,600 | 29,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLSTATE CORP | 0 | 29,551 | +29,551 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 64,304 | 26,741 | -37,563 | 0.07 | 0.02 | -0.04 | sell |