| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 3.19 | 1.34 | -1.85 | hold |
| ORBIMED ADVISORS LLC | 8,288,510 | 8,288,510 | 0 | 3.64 | 2.00 | -1.64 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,724,508 | 7,503,812 | -2,220,696 | 3.08 | 1.16 | -1.92 | sell |
| BlackRock, Inc. | 4,423,464 | 4,831,327 | +407,863 | 0.00 | 0.00 | -0.00 | buy |
| Rubric Capital Management LP | 1,294,878 | 4,500,000 | +3,205,122 | 0.36 | 0.61 | +0.24 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 15.18 | 5.83 | -9.34 | hold |
| VANGUARD GROUP INC | 3,262,673 | 3,500,303 | +237,630 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 1,502,575 | 3,097,022 | +1,594,447 | 0.04 | 0.05 | +0.00 | buy |
| STATE STREET CORP | 2,194,493 | 2,895,256 | +700,763 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 3,825,793 | 2,642,111 | -1,183,682 | 0.02 | 0.01 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 1,828,755 | 2,398,012 | +569,257 | 0.01 | 0.01 | -0.00 | buy |
| Casdin Capital, LLC | 0 | 1,600,000 | +1,600,000 | 0.00 | 1.34 | +1.34 | buy |
| CITADEL ADVISORS LLC | 2,242,176 | 1,586,033 | -656,143 | 0.03 | 0.01 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,342,387 | 1,505,617 | +163,230 | 0.00 | 0.00 | -0.00 | buy |
| Southpoint Capital Advisors LP | 1,709,069 | 1,500,000 | -209,069 | 0.75 | 0.40 | -0.36 | sell |
| GOLDMAN SACHS GROUP INC | 1,464,312 | 1,325,739 | -138,573 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,303,399 | 1,303,399 | 0 | 3.94 | 2.14 | -1.80 | hold |
| BAMCO INC /NY/ | 40,000 | 1,268,532 | +1,228,532 | 0.00 | 0.03 | +0.03 | buy |
| Janney Montgomery Scott LLC | 591,425 | 1,213,020 | +621,595 | 0.03 | 0.03 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 1,034,798 | +1,034,798 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 0 | 976,511 | +976,511 | 0.00 | 0.75 | +0.75 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 289,147 | 764,294 | +475,147 | 0.50 | 0.70 | +0.21 | buy |
| RAYMOND JAMES FINANCIAL INC | 673,370 | 756,347 | +82,977 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,567,010 | 742,508 | -824,502 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 383,616 | 700,414 | +316,798 | 0.00 | 0.00 | -0.00 | buy |
| Nextech Invest, Ltd. | 741,729 | 660,703 | -81,026 | 2.45 | 1.01 | -1.44 | sell |
| UBS Group AG | 866,935 | 659,886 | -207,049 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 631,720 | +631,720 | 0.00 | 0.07 | +0.07 | buy |
| K2 PRINCIPAL FUND, L.P. | 317,126 | 621,807 | +304,681 | 1.01 | 0.66 | -0.36 | buy |
| NORTHERN TRUST CORP | 485,014 | 531,503 | +46,489 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 442,202 | 520,758 | +78,556 | 0.00 | 0.00 | -0.00 | buy |
| CenterBook Partners LP | 0 | 512,367 | +512,367 | 0.00 | 0.25 | +0.25 | buy |
| Alyeska Investment Group, L.P. | 290,092 | 390,092 | +100,000 | 0.02 | 0.01 | -0.01 | buy |
| Empire Life Investments Inc. | 0 | 355,686 | +355,686 | 0.00 | 0.21 | +0.21 | buy |
| FIRST TRUST ADVISORS LP | 340,119 | 352,943 | +12,824 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 325,645 | 335,148 | +9,503 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 325,352 | 272,026 | -53,326 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 329,073 | 246,170 | -82,903 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 0 | 242,037 | +242,037 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 622,235 | 228,569 | -393,666 | 0.00 | 0.00 | -0.00 | sell |
| Lisanti Capital Growth, LLC | 420,075 | 211,189 | -208,886 | 2.03 | 0.52 | -1.51 | sell |
| FAS Wealth Partners, Inc. | 149,160 | 200,620 | +51,460 | 0.19 | 0.14 | -0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 199,153 | +199,153 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 39,914 | 197,320 | +157,406 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 234,841 | 186,726 | -48,115 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 180,492 | 178,148 | -2,344 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 382,555 | 168,238 | -214,317 | 1.86 | 0.51 | -1.35 | sell |
| Bank of New York Mellon Corp | 145,117 | 154,604 | +9,487 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Grove Partners LP | 0 | 152,197 | +152,197 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 300,419 | 150,936 | -149,483 | 0.03 | 0.01 | -0.02 | sell |
| Nuveen, LLC | 139,133 | 149,597 | +10,464 | 0.00 | 0.00 | -0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 105,000 | 147,000 | +42,000 | 0.42 | 0.32 | -0.10 | buy |
| Steward Partners Investment Advisory, LLC | 128,180 | 146,692 | +18,512 | 0.02 | 0.01 | -0.01 | buy |
| XTX Topco Ltd | 17,093 | 143,636 | +126,543 | 0.01 | 0.07 | +0.06 | buy |
| DAFNA Capital Management LLC | 0 | 140,500 | +140,500 | 0.00 | 0.35 | +0.35 | buy |
| Knights of Columbus Asset Advisors LLC | 68,094 | 134,476 | +66,382 | 0.07 | 0.08 | +0.01 | buy |
| Quinn Opportunity Partners LLC | 45,000 | 125,000 | +80,000 | 0.07 | 0.09 | +0.02 | buy |
| Rafferty Asset Management, LLC | 80,846 | 122,410 | +41,564 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 166,184 | 114,853 | -51,331 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 48,688 | 105,751 | +57,063 | 0.02 | 0.02 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 87,025 | 91,675 | +4,650 | 0.13 | 0.07 | -0.06 | buy |
| Epoch Investment Partners, Inc. | 72,780 | 89,980 | +17,200 | 0.01 | 0.00 | -0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 87,162 | 87,161 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 84,300 | 84,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | 83,225 | 0 | 0.47 | 0.24 | -0.22 | hold |
| SECTORAL ASSET MANAGEMENT INC | 65,785 | 81,785 | +16,000 | 0.76 | 0.51 | -0.25 | buy |
| RHUMBLINE ADVISERS | 81,261 | 81,204 | -57 | 0.00 | 0.00 | -0.00 | sell |
| Sculptor Capital LP | 0 | 77,100 | +77,100 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 55,446 | 76,884 | +21,438 | 0.00 | 0.00 | -0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 40,350 | 74,525 | +34,175 | 0.02 | 0.02 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 61,106 | 73,842 | +12,736 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 72,177 | +72,177 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 67,212 | +67,212 | 0.00 | 0.01 | +0.01 | buy |
| CastleKnight Management LP | 65,300 | 65,300 | 0 | 0.08 | 0.04 | -0.04 | hold |
| Campbell & CO Investment Adviser LLC | 0 | 60,525 | +60,525 | 0.00 | 0.05 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 0 | 59,230 | +59,230 | 0.00 | 0.06 | +0.06 | buy |
| Matisse Capital | 56,714 | 57,791 | +1,077 | 0.47 | 0.26 | -0.21 | buy |
| AssuredPartners Investment Advisors, LLC | 56,969 | 57,785 | +816 | 0.24 | 0.13 | -0.11 | buy |
| Legal & General Group Plc | 54,825 | 55,243 | +418 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN ASSETS INC | 0 | 55,000 | +55,000 | 0.00 | 0.18 | +0.18 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 17,557 | 53,402 | +35,845 | 0.00 | 0.00 | +0.00 | buy |
| Permanent Capital Management, LP | 0 | 53,341 | +53,341 | 0.00 | 0.10 | +0.10 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 50,940 | +50,940 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 53,000 | 49,600 | -3,400 | 0.01 | 0.00 | -0.00 | sell |
| Kestra Advisory Services, LLC | 33,760 | 49,199 | +15,439 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 85,082 | 48,112 | -36,970 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 23,536 | 45,819 | +22,283 | 0.04 | 0.03 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,988 | 44,388 | +7,400 | 0.00 | 0.00 | -0.00 | buy |
| DIKER MANAGEMENT LLC | 41,000 | 43,508 | +2,508 | 0.67 | 0.35 | -0.32 | buy |
| SCHULHOFF & CO INC | 43,500 | 43,500 | 0 | 0.34 | 0.19 | -0.15 | hold |
| DEUTSCHE BANK AG\ | 37,013 | 41,951 | +4,938 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 40,472 | +40,472 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 117,500 | 40,109 | -77,391 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 102,791 | 38,116 | -64,675 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 36,862 | +36,862 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 35,856 | +35,856 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 35,742 | +35,742 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 34,560 | 35,059 | +499 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 32,777 | 34,338 | +1,561 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 57,449 | 34,219 | -23,230 | 0.00 | 0.00 | -0.00 | sell |