| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| K2 PRINCIPAL FUND, L.P. | 2,552,062 | 3,054,333 | +502,271 | 2.89 | 3.92 | +1.03 | buy |
| Nantahala Capital Management, LLC | 1,099,075 | 1,596,504 | +497,429 | 0.53 | 0.88 | +0.35 | buy |
| DAFNA Capital Management LLC | 0 | 311,169 | +311,169 | 0.00 | 0.41 | +0.41 | buy |
| FRANKLIN RESOURCES INC | 3,868,509 | 4,098,497 | +229,988 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 115,344 | +115,344 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 98,598 | +98,598 | 0.00 | 0.00 | +0.00 | buy |
| DENALI ADVISORS LLC | 0 | 87,500 | +87,500 | 0.00 | 0.15 | +0.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 175,543 | 253,416 | +77,873 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 77,162 | +77,162 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 21,452 | 88,165 | +66,713 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 63,803 | +63,803 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 803,341 | 864,869 | +61,528 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 26,151 | 68,157 | +42,006 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 536,160 | 576,980 | +40,820 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 31,803 | +31,803 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 11,030 | 38,022 | +26,992 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 17,777 | 40,374 | +22,597 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 20,117 | +20,117 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 17,439 | +17,439 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 16,500 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 15,252 | +15,252 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,197 | +10,197 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 463,700 | 473,700 | +10,000 | 0.02 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 52,847 | 61,725 | +8,878 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,453 | 11,105 | +8,652 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 7,498 | +7,498 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 25 | 5,600 | +5,575 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 324,403 | 329,550 | +5,147 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,767 | 5,239 | +3,472 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 27,931 | 31,201 | +3,270 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 3,096 | +3,096 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 249 | 2,812 | +2,563 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,857 | 14,555 | +1,698 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 83,924 | 84,358 | +434 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 34,280 | 34,649 | +369 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 347 | +347 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 155 | +155 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 16,382 | 16,534 | +152 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 12,101 | 12,202 | +101 | 0.00 | 0.00 | -0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Avantax Planning Partners, Inc. | 32,174 | 32,174 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,077,927 | 11,077,927 | 0 | 0.92 | 1.12 | +0.20 | hold |
| ORBIMED ADVISORS LLC | 9,240,887 | 9,240,887 | 0 | 0.75 | 1.01 | +0.26 | hold |
| Ameritas Investment Partners, Inc. | 2,002 | 2,002 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 62,790 | 62,790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 409,463 | 409,463 | 0 | 0.22 | 0.21 | -0.01 | hold |
| BAKER BROS. ADVISORS LP | 2,006,451 | 2,006,451 | 0 | 0.04 | 0.13 | +0.08 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 36,000 | 36,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,459,678 | 9,459,678 | 0 | 0.70 | 0.81 | +0.11 | hold |
| Daiwa Securities Group Inc. | 367 | 367 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 1,105,911 | 1,105,911 | 0 | 1.29 | 1.56 | +0.27 | hold |
| MetLife Investment Management, LLC | 13,784 | 13,784 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PARK CIRCLE Co | 2,000 | 2,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| FAS Wealth Partners, Inc. | 45,970 | 45,970 | 0 | 0.02 | 0.02 | +0.01 | hold |
| Rubric Capital Management LP | 639,203 | 639,203 | 0 | 0.10 | 0.13 | +0.03 | hold |
| Steward Partners Investment Advisory, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Salomon & Ludwin, LLC | 2,785 | 2,785 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 7.77 | 9.23 | +1.46 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,428 | 1,428 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 28,157 | 28,157 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,940 | 12,940 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 18 | 0 | -18 | 0.00 | 0.00 | 0.00 | sell |
| RHUMBLINE ADVISERS | 36,355 | 36,328 | -27 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,153 | 12,112 | -41 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 21,883 | 21,809 | -74 | 0.00 | 0.00 | +0.00 | sell |
| Parallel Advisors, LLC | 151 | 0 | -151 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,650 | 2,407 | -243 | 0.00 | 0.00 | +0.00 | sell |
| Janney Montgomery Scott LLC | 24,072 | 23,605 | -467 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 707 | 0 | -707 | 0.00 | 0.00 | -0.00 | sell |
| Brendel Financial Advisors LLC | 19,125 | 18,281 | -844 | 0.11 | 0.07 | -0.04 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,761 | 4,693 | -1,068 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,250 | 30,806 | -1,444 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 261,140 | 259,681 | -1,459 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 51,521 | 48,449 | -3,072 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 70,500 | 66,396 | -4,104 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,865 | 33,803 | -5,062 | 0.00 | 0.00 | +0.00 | sell |
| Belvedere Trading LLC | 6,143 | 0 | -6,143 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 111,071 | 104,067 | -7,004 | 0.02 | 0.02 | +0.00 | sell |
| HighTower Advisors, LLC | 22,779 | 15,139 | -7,640 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 10,042 | 0 | -10,042 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 10,117 | 0 | -10,117 | 0.01 | 0.00 | -0.01 | sell |
| Dynamic Technology Lab Private Ltd | 10,371 | 0 | -10,371 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,760 | 0 | -10,760 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 10,794 | 0 | -10,794 | 0.00 | 0.00 | -0.00 | sell |
| StoneX Group Inc. | 11,280 | 0 | -11,280 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 64,000 | 52,250 | -11,750 | 0.03 | 0.03 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 13,835 | 0 | -13,835 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,121,289 | 2,106,486 | -14,803 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 82,300 | 66,000 | -16,300 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 35,646 | 7,065 | -28,581 | 0.00 | 0.00 | -0.00 | sell |
| Tejara Capital Ltd | 103,739 | 73,739 | -30,000 | 0.22 | 0.17 | -0.05 | sell |
| DIMENSIONAL FUND ADVISORS LP | 373,738 | 324,726 | -49,012 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 154,511 | 76,290 | -78,221 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 80,816 | 0 | -80,816 | 0.03 | 0.00 | -0.03 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 137,700 | 52,000 | -85,700 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 239,448 | 141,101 | -98,347 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,307,340 | 1,202,315 | -105,025 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 150,000 | 0 | -150,000 | 0.06 | 0.00 | -0.06 | sell |
| Woodline Partners LP | 847,054 | 661,414 | -185,640 | 0.04 | 0.04 | +0.00 | sell |
| Charles Schwab Trust Co | 4,246,071 | 3,996,071 | -250,000 | 1.81 | 2.16 | +0.35 | sell |