| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 1.82 | 1.52 | -0.29 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,077,927 | 10,514,657 | -563,270 | 2.40 | 2.11 | -0.29 | sell |
| ORBIMED ADVISORS LLC | 8,288,510 | 8,288,510 | 0 | 2.20 | 1.82 | -0.38 | hold |
| BlackRock, Inc. | 4,245,974 | 4,574,491 | +328,517 | 0.00 | 0.00 | -0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 11.67 | 10.32 | -1.34 | hold |
| ALLIANCEBERNSTEIN L.P. | 73,660 | 3,880,734 | +3,807,074 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 3,349,296 | 3,464,952 | +115,656 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,049,542 | 2,749,901 | +700,359 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 2,837,252 | 1,976,412 | -860,840 | 0.01 | 0.01 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 125,000 | 1,253,724 | +1,128,724 | 0.01 | 0.05 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,234,805 | 1,238,156 | +3,351 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 986,007 | 1,119,283 | +133,276 | 0.12 | 0.08 | -0.04 | buy |
| FMR LLC | 1,086,315 | 1,102,225 | +15,910 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 109,882 | 1,012,701 | +902,819 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 486,746 | 939,278 | +452,532 | 0.01 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 691,455 | 929,613 | +238,158 | 0.09 | 0.09 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 275,855 | 886,117 | +610,262 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 252,499 | 805,456 | +552,957 | 0.00 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 593,291 | 593,291 | 0 | 1.36 | 1.12 | -0.24 | hold |
| Cormorant Asset Management, LP | 0 | 500,000 | +500,000 | 0.00 | 0.29 | +0.29 | buy |
| NORTHERN TRUST CORP | 452,380 | 478,153 | +25,773 | 0.00 | 0.00 | -0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 269,426 | 467,627 | +198,201 | 0.38 | 0.47 | +0.09 | buy |
| MORGAN STANLEY | 638,622 | 432,603 | -206,019 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 423,947 | 427,477 | +3,530 | 0.00 | 0.00 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 423,561 | +423,561 | 0.00 | 0.13 | +0.13 | buy |
| WEXFORD CAPITAL LP | 248,347 | 369,497 | +121,150 | 0.86 | 1.00 | +0.14 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 22,518 | 344,941 | +322,423 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 178,221 | 344,171 | +165,950 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 340,591 | +340,591 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 245,935 | 286,846 | +40,911 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 234,537 | 247,314 | +12,777 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 192,448 | 196,458 | +4,010 | 0.00 | 0.00 | -0.00 | buy |
| Nicholas Investment Partners, LP | 201,771 | 172,018 | -29,753 | 0.27 | 0.16 | -0.11 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,291 | 171,385 | +24,094 | 0.00 | 0.00 | -0.00 | buy |
| Miura Global Management, LLC | 270,000 | 170,000 | -100,000 | 4.50 | 1.96 | -2.54 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 162,335 | 163,252 | +917 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 112,864 | 160,958 | +48,094 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 111,666 | 158,180 | +46,514 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 81,275 | 140,372 | +59,097 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 39,696 | 130,289 | +90,593 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 131,611 | 130,238 | -1,373 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 0 | 108,273 | +108,273 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 98,640 | 106,007 | +7,367 | 0.84 | 0.75 | -0.10 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 653,048 | 101,397 | -551,651 | 0.04 | 0.00 | -0.03 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,910 | 100,873 | +73,963 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 37,222 | 100,683 | +63,461 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 214,065 | 98,078 | -115,987 | 0.01 | 0.00 | -0.00 | sell |
| FAS Wealth Partners, Inc. | 84,855 | 94,705 | +9,850 | 0.10 | 0.08 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 98,449 | 93,037 | -5,412 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 148,294 | 88,790 | -59,504 | 0.51 | 0.24 | -0.27 | sell |
| Cambridge Investment Research Advisors, Inc. | 87,158 | 87,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | 83,225 | 0 | 0.42 | 0.30 | -0.12 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 77,208 | 80,641 | +3,433 | 0.01 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 80,548 | 76,732 | -3,816 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 75,700 | 75,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 32,448 | 69,376 | +36,928 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,896 | 67,277 | +19,381 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 63,339 | 65,163 | +1,824 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 57,624 | 60,294 | +2,670 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 85,295 | 56,563 | -28,732 | 0.02 | 0.01 | -0.01 | sell |
| MARSHALL WACE, LLP | 77,879 | 52,906 | -24,973 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 58,304 | 51,202 | -7,102 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,307 | 45,576 | +41,269 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 28,773 | 43,377 | +14,604 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 28,340 | 41,701 | +13,361 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 41,400 | 41,000 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 25,850 | 38,050 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,402 | 36,988 | -414 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 41,703 | 36,342 | -5,361 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 33,936 | 35,908 | +1,972 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 33,922 | 35,411 | +1,489 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,233 | 33,560 | +3,327 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 29,317 | 33,086 | +3,769 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 17,243 | 32,218 | +14,975 | 0.02 | 0.03 | +0.01 | buy |
| JPMORGAN CHASE & CO | 32,822 | 31,112 | -1,710 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 16,494 | 30,545 | +14,051 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 35,263 | 30,206 | -5,057 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 24,482 | 27,752 | +3,270 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 29,158 | 27,158 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 28,310 | 27,110 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 16,403 | 26,870 | +10,467 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 33,981 | 24,777 | -9,204 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 24,700 | 24,700 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 24,628 | +24,628 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 26,313 | 24,467 | -1,846 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 24,000 | 24,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 21,600 | 21,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LPL Financial LLC | 19,218 | 21,408 | +2,190 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 88,737 | 21,154 | -67,583 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 19,745 | 20,763 | +1,018 | 0.01 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,645 | 20,607 | +1,962 | 0.03 | 0.02 | -0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 20,515 | +20,515 | 0.00 | 0.04 | +0.04 | buy |
| CIBC Private Wealth Group LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 125,611 | 19,988 | -105,623 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 462,519 | 19,918 | -442,601 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,854 | 19,526 | -27,328 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 15,027 | 18,463 | +3,436 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 98,900 | 17,574 | -81,326 | 0.11 | 0.01 | -0.09 | sell |
| Engineers Gate Manager LP | 0 | 16,359 | +16,359 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 10,463 | 15,438 | +4,975 | 0.00 | 0.00 | -0.00 | buy |