| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | 10,860,977 | 0 | 1.34 | 1.30 | -0.05 | hold |
| ORBIMED ADVISORS LLC | 8,288,510 | 8,288,510 | 0 | 2.00 | 1.98 | -0.02 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,503,812 | 7,503,812 | 0 | 1.16 | 1.12 | -0.04 | hold |
| Rubric Capital Management LP | 4,500,000 | 6,200,000 | +1,700,000 | 0.61 | 0.86 | +0.26 | buy |
| BlackRock, Inc. | 4,831,327 | 5,085,317 | +253,990 | 0.00 | 0.00 | +0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | 4,012,903 | 0 | 5.83 | 6.62 | +0.79 | hold |
| Aberdeen Group plc | 3,097,022 | 3,556,049 | +459,027 | 0.05 | 0.06 | +0.01 | buy |
| VANGUARD GROUP INC | 3,500,303 | 3,509,174 | +8,871 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,895,256 | 3,223,581 | +328,325 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 3,168,406 | +3,168,406 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 2,398,012 | 2,543,097 | +145,085 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 659,886 | 2,210,866 | +1,550,980 | 0.00 | 0.01 | +0.00 | buy |
| Tyro Capital Management LLC | 0 | 1,994,852 | +1,994,852 | 0.00 | 7.23 | +7.23 | buy |
| CITADEL ADVISORS LLC | 1,586,033 | 1,954,472 | +368,439 | 0.01 | 0.02 | +0.00 | buy |
| Casdin Capital, LLC | 1,600,000 | 1,600,000 | 0 | 1.34 | 1.16 | -0.18 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,505,617 | 1,552,870 | +47,253 | 0.00 | 0.00 | +0.00 | buy |
| Southpoint Capital Advisors LP | 1,500,000 | 1,500,000 | 0 | 0.40 | 0.41 | +0.01 | hold |
| Janney Montgomery Scott LLC | 1,213,020 | 1,287,832 | +74,812 | 0.03 | 0.03 | +0.01 | buy |
| BAMCO INC /NY/ | 1,268,532 | 1,268,532 | 0 | 0.03 | 0.04 | +0.01 | hold |
| GOLDMAN SACHS GROUP INC | 1,325,739 | 812,036 | -513,703 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 0 | 810,073 | +810,073 | 0.00 | 0.01 | +0.01 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 764,294 | 747,506 | -16,788 | 0.70 | 0.76 | +0.05 | sell |
| Nextech Invest, Ltd. | 660,703 | 660,703 | 0 | 1.01 | 0.74 | -0.27 | hold |
| BANK OF MONTREAL /CAN/ | 0 | 643,407 | +643,407 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 512,367 | 568,361 | +55,994 | 0.25 | 0.32 | +0.07 | buy |
| RAYMOND JAMES FINANCIAL INC | 756,347 | 566,056 | -190,291 | 0.00 | 0.00 | -0.00 | sell |
| GENERAL AMERICAN INVESTORS CO INC | 0 | 559,959 | +559,959 | 0.00 | 0.41 | +0.41 | buy |
| Third Point LLC | 0 | 556,237 | +556,237 | 0.00 | 0.09 | +0.09 | buy |
| MORGAN STANLEY | 700,414 | 552,364 | -148,050 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 520,758 | 550,932 | +30,174 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 531,503 | 521,009 | -10,494 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 272,026 | 482,084 | +210,058 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 455,766 | +455,766 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 390,092 | 418,883 | +28,791 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 35,059 | 417,090 | +382,031 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 742,508 | 398,959 | -343,549 | 0.00 | 0.00 | -0.00 | sell |
| Lisanti Capital Growth, LLC | 211,189 | 396,509 | +185,320 | 0.52 | 1.09 | +0.58 | buy |
| ADAR1 Capital Management, LLC | 59,230 | 369,569 | +310,339 | 0.06 | 0.32 | +0.26 | buy |
| Empire Life Investments Inc. | 355,686 | 352,602 | -3,084 | 0.21 | 0.23 | +0.02 | sell |
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV | 0 | 311,503 | +311,503 | 0.00 | 1.01 | +1.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 335,148 | 304,445 | -30,703 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 976,511 | 251,593 | -724,918 | 0.75 | 0.16 | -0.59 | sell |
| Steward Partners Investment Advisory, LLC | 146,692 | 216,296 | +69,604 | 0.01 | 0.01 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 0 | 207,051 | +207,051 | 0.00 | 0.02 | +0.02 | buy |
| FAS Wealth Partners, Inc. | 200,620 | 202,407 | +1,787 | 0.14 | 0.15 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 201,474 | +201,474 | 0.00 | 0.06 | +0.06 | buy |
| BARCLAYS PLC | 228,569 | 196,387 | -32,182 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 140,500 | 190,065 | +49,565 | 0.35 | 0.51 | +0.17 | buy |
| DIMENSIONAL FUND ADVISORS LP | 178,148 | 176,122 | -2,026 | 0.00 | 0.00 | +0.00 | sell |
| WEXFORD CAPITAL LP | 168,238 | 165,313 | -2,925 | 0.51 | 0.50 | -0.01 | sell |
| Bank of New York Mellon Corp | 154,604 | 163,006 | +8,402 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 125,000 | 155,000 | +30,000 | 0.09 | 0.08 | -0.01 | buy |
| Woodline Partners LP | 150,936 | 150,936 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Trexquant Investment LP | 631,720 | 150,100 | -481,620 | 0.07 | 0.02 | -0.05 | sell |
| Nuveen, LLC | 149,597 | 149,597 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knights of Columbus Asset Advisors LLC | 134,476 | 130,729 | -3,747 | 0.08 | 0.09 | +0.01 | sell |
| Rafferty Asset Management, LLC | 122,410 | 115,564 | -6,846 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 76,884 | 112,766 | +35,882 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 84,300 | 107,200 | +22,900 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 74,525 | 92,875 | +18,350 | 0.02 | 0.02 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 87,161 | 87,161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | 83,225 | 0 | 0.24 | 0.28 | +0.04 | hold |
| ALPS ADVISORS INC | 49,600 | 81,168 | +31,568 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 197,320 | 79,214 | -118,106 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,105 | 76,203 | +66,098 | 0.00 | 0.00 | +0.00 | buy |
| AssuredPartners Investment Advisors, LLC | 57,785 | 75,779 | +17,994 | 0.13 | 0.13 | +0.00 | buy |
| SEI INVESTMENTS CO | 48,112 | 74,807 | +26,695 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 73,842 | 74,256 | +414 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 81,204 | 73,293 | -7,911 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 0 | 68,645 | +68,645 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 65,746 | +65,746 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,642,111 | 60,120 | -2,581,991 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 55,243 | 58,368 | +3,125 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 57,791 | 55,561 | -2,230 | 0.26 | 0.29 | +0.03 | sell |
| AMERICAN ASSETS INC | 55,000 | 55,000 | 0 | 0.18 | 0.20 | +0.03 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,388 | 54,098 | +9,710 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 91,675 | 53,830 | -37,845 | 0.07 | 0.05 | -0.02 | sell |
| Quantinno Capital Management LP | 40,472 | 53,113 | +12,641 | 0.00 | 0.00 | +0.00 | buy |
| Permanent Capital Management, LP | 53,341 | 52,306 | -1,035 | 0.10 | 0.12 | +0.02 | sell |
| SCHULHOFF & CO INC | 43,500 | 51,150 | +7,650 | 0.19 | 0.25 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 41,951 | 48,727 | +6,776 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 26,330 | 42,808 | +16,478 | 0.01 | 0.02 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 38,587 | +38,587 | 0.00 | 0.07 | +0.07 | buy |
| Invesco Ltd. | 40,109 | 37,230 | -2,879 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 143,636 | 37,201 | -106,435 | 0.07 | 0.01 | -0.06 | sell |
| Aquatic Capital Management LLC | 105,751 | 36,037 | -69,714 | 0.02 | 0.01 | -0.01 | sell |
| MetLife Investment Management, LLC | 34,338 | 34,338 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 114,853 | 34,128 | -80,725 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,662 | 34,100 | +438 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,788 | 33,788 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIKER MANAGEMENT LLC | 43,508 | 33,508 | -10,000 | 0.35 | 0.30 | -0.05 | sell |
| AlphaQuest LLC | 45,819 | 32,970 | -12,849 | 0.03 | 0.02 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,473 | 32,058 | -415 | 0.00 | 0.00 | +0.00 | sell |
| Private Advisor Group, LLC | 20,582 | 31,460 | +10,878 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 30,152 | 30,152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 81,785 | 29,803 | -51,982 | 0.51 | 0.28 | -0.23 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 29,600 | +29,600 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 152,197 | 28,003 | -124,194 | 0.01 | 0.00 | -0.01 | sell |
| HighTower Advisors, LLC | 26,330 | 26,529 | +199 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 34,219 | 26,527 | -7,692 | 0.00 | 0.00 | -0.00 | sell |