| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 4,706,168 | 5,721,945 | +1,015,777 | 0.03 | 0.03 | +0.00 | buy |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 1.46 | 1.32 | -0.14 | hold |
| FMR LLC | 4,829,154 | 4,307,246 | -521,908 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,693,241 | 3,638,241 | -55,000 | 0.09 | 0.07 | -0.02 | sell |
| Bellevue Group AG | 2,796,803 | 2,788,245 | -8,558 | 2.01 | 1.86 | -0.14 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,649,368 | 2,649,368 | 0 | 4.06 | 3.82 | -0.24 | hold |
| Vestal Point Capital, LP | 2,766,868 | 1,800,000 | -966,868 | 2.33 | 1.34 | -1.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,021,265 | 1,648,983 | +627,718 | 0.03 | 0.04 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,237,403 | 1,597,037 | +359,634 | 0.03 | 0.03 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 1,188,000 | 1,428,000 | +240,000 | 1.18 | 1.25 | +0.07 | buy |
| Caligan Partners LP | 0 | 1,381,317 | +1,381,317 | 0.00 | 2.12 | +2.12 | buy |
| Kynam Capital Management, LP | 884,937 | 1,375,000 | +490,063 | 1.69 | 2.41 | +0.72 | buy |
| BVF INC/IL | 1,294,463 | 1,294,463 | 0 | 1.24 | 1.05 | -0.19 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 501,091 | 1,209,894 | +708,803 | 0.02 | 0.05 | +0.02 | buy |
| BlackRock, Inc. | 656,309 | 1,004,598 | +348,289 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,102,271 | 990,280 | -111,991 | 0.06 | 0.05 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 919,332 | 831,068 | -88,264 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 1,500,000 | 600,000 | -900,000 | 2.33 | 0.82 | -1.51 | sell |
| MARSHALL WACE, LLP | 180,340 | 590,941 | +410,601 | 0.01 | 0.02 | +0.01 | buy |
| Hudson Bay Capital Management LP | 633,174 | 590,000 | -43,174 | 0.11 | 0.09 | -0.03 | sell |
| CITADEL ADVISORS LLC | 230,399 | 566,761 | +336,362 | 0.00 | 0.01 | +0.01 | buy |
| BRAIDWELL LP | 0 | 521,327 | +521,327 | 0.00 | 0.61 | +0.61 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 519,130 | 485,789 | -33,341 | 0.01 | 0.01 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 484,782 | 484,782 | 0 | 0.38 | 0.34 | -0.04 | hold |
| Fulcrum Asset Management LLP | 0 | 470,025 | +470,025 | 0.00 | 1.43 | +1.43 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 407,373 | 407,219 | -154 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 335,191 | 405,116 | +69,925 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 269,729 | 373,046 | +103,317 | 0.04 | 0.05 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 250,211 | 340,100 | +89,889 | 0.27 | 0.21 | -0.06 | buy |
| Woodline Partners LP | 316,762 | 316,762 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Deep Track Capital, LP | 1,931,884 | 311,218 | -1,620,666 | 1.20 | 0.15 | -1.06 | sell |
| Legal & General Group Plc | 156,143 | 299,670 | +143,527 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 295,546 | +295,546 | 0.00 | 0.17 | +0.17 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 197,308 | 274,663 | +77,355 | 0.22 | 0.20 | -0.02 | buy |
| DIADEMA PARTNERS LP | 193,189 | 254,863 | +61,674 | 2.41 | 2.86 | +0.45 | buy |
| JANE STREET GROUP, LLC | 204,368 | 233,348 | +28,980 | 0.01 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 223,124 | +223,124 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 323,606 | 187,850 | -135,756 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 661,786 | 172,503 | -489,283 | 0.95 | 0.19 | -0.76 | sell |
| Catalio Capital Management, LP | 84,352 | 148,045 | +63,693 | 0.53 | 0.88 | +0.35 | buy |
| GOLDMAN SACHS GROUP INC | 119,497 | 137,326 | +17,829 | 0.00 | 0.00 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 134,165 | +134,165 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 38,498 | 131,949 | +93,451 | 0.02 | 0.04 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 34,927 | 126,652 | +91,725 | 0.02 | 0.08 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 206,866 | 116,144 | -90,722 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 96,106 | 116,135 | +20,029 | 0.05 | 0.05 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 135,828 | 103,558 | -32,270 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 164,000 | 102,400 | -61,600 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 97,940 | 98,229 | +289 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 94,936 | 90,949 | -3,987 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 19,254 | 73,928 | +54,674 | 0.01 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 20,685 | 72,846 | +52,161 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 76,519 | 67,738 | -8,781 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 31,253 | 67,558 | +36,305 | 0.00 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 48,962 | 65,214 | +16,252 | 0.57 | 0.65 | +0.08 | buy |
| Engineers Gate Manager LP | 13,892 | 60,327 | +46,435 | 0.01 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 22,861 | 56,787 | +33,926 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 114,749 | 53,430 | -61,319 | 0.16 | 0.06 | -0.10 | sell |
| ALPS ADVISORS INC | 41,261 | 51,420 | +10,159 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 49,400 | +49,400 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 49,179 | +49,179 | 0.00 | 0.02 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 47,127 | 48,324 | +1,197 | 0.05 | 0.04 | -0.00 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.29 | 0.24 | -0.05 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 42,882 | 45,974 | +3,092 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 58,697 | 43,185 | -15,512 | 0.49 | 0.31 | -0.18 | sell |
| Virtus Investment Advisers, LLC | 22,940 | 40,155 | +17,215 | 0.19 | 0.30 | +0.11 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 31,674 | 39,532 | +7,858 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 61,260 | 39,213 | -22,047 | 0.00 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 18,930 | 36,707 | +17,777 | 0.00 | 0.00 | +0.00 | buy |
| Crossmark Global Holdings, Inc. | 36,457 | 36,416 | -41 | 0.02 | 0.01 | -0.00 | sell |
| Brevan Howard Capital Management LP | 16,420 | 34,450 | +18,030 | 0.00 | 0.02 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 27,663 | 34,275 | +6,612 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 34,170 | +34,170 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 211,140 | 33,982 | -177,158 | 0.01 | 0.00 | -0.01 | sell |
| Tidal Investments LLC | 30,651 | 30,849 | +198 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 30,909 | 29,517 | -1,392 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 0 | 22,815 | +22,815 | 0.00 | 0.18 | +0.18 | buy |
| Cinctive Capital Management LP | 0 | 21,904 | +21,904 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 4,517 | 21,514 | +16,997 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,936 | 18,999 | +2,063 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 1,122 | 17,583 | +16,461 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 17,039 | +17,039 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 16,968 | +16,968 | 0.00 | 0.02 | +0.02 | buy |
| Entropy Technologies, LP | 10,020 | 12,720 | +2,700 | 0.01 | 0.02 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 8,312 | 12,710 | +4,398 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 15,434 | 11,746 | -3,688 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 75,473 | 11,022 | -64,451 | 0.00 | 0.00 | -0.00 | sell |
| Banque Transatlantique SA | 0 | 10,150 | +10,150 | 0.00 | 0.01 | +0.01 | buy |
| Close Asset Management Ltd | 10,100 | 10,100 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Headlands Technologies LLC | 0 | 9,128 | +9,128 | 0.00 | 0.03 | +0.03 | buy |
| Scientech Research LLC | 0 | 8,854 | +8,854 | 0.00 | 0.23 | +0.23 | buy |
| China Universal Asset Management Co., Ltd. | 10,783 | 7,277 | -3,506 | 0.02 | 0.01 | -0.01 | sell |
| denkapparat Operations GmbH | 0 | 6,590 | +6,590 | 0.00 | 0.07 | +0.07 | buy |
| State of Tennessee, Department of Treasury | 0 | 6,399 | +6,399 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 3,097 | 3,541 | +444 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 28,387 | 3,213 | -25,174 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 2,822 | +2,822 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 2,749 | 2,749 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 2,658 | 2,658 | 0 | 0.01 | 0.01 | +0.00 | hold |
| GROUP ONE TRADING LLC | 100 | 2,019 | +1,919 | 0.00 | 0.00 | +0.00 | buy |