| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GENERAL ATLANTIC, L.P. | 950,000 | 1,506,684 | +556,684 | 0.93 | 2.27 | +1.34 | buy |
| Logos Global Management LP | 400,000 | 900,000 | +500,000 | 3.04 | 6.16 | +3.12 | buy |
| T. Rowe Price Investment Management, Inc. | 374,561 | 733,611 | +359,050 | 0.02 | 0.03 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 1,453,883 | 1,787,176 | +333,293 | 4.66 | 4.09 | -0.57 | buy |
| Woodline Partners LP | 100,328 | 274,038 | +173,710 | 0.07 | 0.16 | +0.09 | buy |
| BNP Paribas Asset Management Holding S.A. | 183,545 | 342,000 | +158,455 | 0.03 | 0.06 | +0.02 | buy |
| First Turn Management, LLC | 343,079 | 394,674 | +51,595 | 3.37 | 3.84 | +0.47 | buy |
| Candriam S.C.A. | 144,006 | 189,006 | +45,000 | 0.07 | 0.08 | +0.01 | buy |
| Atle Fund Management AB | 7,823 | 40,899 | +33,076 | 0.42 | 1.62 | +1.20 | buy |
| Nicholas Investment Partners, LP | 52,159 | 77,455 | +25,296 | 0.42 | 0.52 | +0.10 | buy |
| Fiera Capital Corp | 846,787 | 866,412 | +19,625 | 0.18 | 0.16 | -0.01 | buy |
| BIT Capital GmbH | 4,003 | 13,904 | +9,901 | 0.03 | 0.07 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 12,384 | 21,232 | +8,848 | 0.05 | 0.07 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 6,207 | 9,479 | +3,272 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,900 | 6,621 | +2,721 | 0.05 | 0.05 | +0.00 | buy |
| Pier Capital, LLC | 86,202 | 88,054 | +1,852 | 0.84 | 0.79 | -0.05 | buy |
| ALPS ADVISORS INC | 33,390 | 35,135 | +1,745 | 0.02 | 0.02 | -0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 3,371 | 4,253 | +882 | 0.14 | 0.18 | +0.04 | buy |
| VIRTUS ADVISERS, LLC | 5,104 | 5,962 | +858 | 0.22 | 0.21 | -0.02 | buy |
| NEOS Investment Management LLC | 3,828 | 3,944 | +116 | 0.02 | 0.02 | -0.01 | buy |
| Robeco Institutional Asset Management B.V. | 74,127 | 72,841 | -1,286 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 312,608 | 311,121 | -1,487 | 0.01 | 0.01 | -0.00 | sell |
| Robertson Stephens Wealth Management, LLC | 13,780 | 11,030 | -2,750 | 0.06 | 0.04 | -0.02 | sell |
| Bellevue Group AG | 976,054 | 972,254 | -3,800 | 1.02 | 0.96 | -0.06 | sell |
| Rhenman & Partners Asset Management AB | 84,278 | 79,778 | -4,500 | 0.58 | 0.49 | -0.08 | sell |
| HighVista Strategies LLC | 41,627 | 34,762 | -6,865 | 1.03 | 0.81 | -0.23 | sell |
| Avidity Partners Management LP | 300,200 | 286,400 | -13,800 | 0.78 | 0.66 | -0.12 | sell |
| RTW INVESTMENTS, LP | 6,096,387 | 6,019,641 | -76,746 | 6.51 | 5.78 | -0.73 | sell |
| ARMISTICE CAPITAL, LLC | 312,000 | 164,000 | -148,000 | 0.29 | 0.14 | -0.15 | sell |
| GREAT POINT PARTNERS LLC | 293,000 | 115,000 | -178,000 | 3.41 | 1.16 | -2.25 | sell |
| Rock Springs Capital Management LP | 2,661,507 | 2,367,816 | -293,691 | 4.48 | 3.91 | -0.57 | sell |
| BAKER BROS. ADVISORS LP | 2,520,731 | 1,515,318 | -1,005,413 | 1.96 | 1.24 | -0.72 | sell |