| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,096,387 | 6,019,641 | -76,746 | 6.51 | 5.78 | -0.73 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,312,611 | 5,747,270 | +1,434,659 | 0.05 | 0.07 | +0.01 | buy |
| FMR LLC | 1,696,386 | 4,312,144 | +2,615,758 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,944,574 | 2,437,584 | -506,990 | 0.03 | 0.02 | -0.01 | sell |
| Rock Springs Capital Management LP | 2,661,507 | 2,367,816 | -293,691 | 4.49 | 3.91 | -0.58 | sell |
| Paradigm Biocapital Advisors LP | 1,453,883 | 1,787,176 | +333,293 | 4.66 | 4.09 | -0.57 | buy |
| BAKER BROS. ADVISORS LP | 2,520,731 | 1,515,318 | -1,005,413 | 1.96 | 1.24 | -0.72 | sell |
| GENERAL ATLANTIC, L.P. | 950,000 | 1,506,684 | +556,684 | 0.93 | 2.27 | +1.34 | buy |
| Bellevue Group AG | 976,054 | 972,254 | -3,800 | 1.02 | 0.96 | -0.06 | sell |
| Logos Global Management LP | 400,000 | 900,000 | +500,000 | 3.04 | 6.16 | +3.12 | buy |
| Fiera Capital Corp | 846,787 | 866,412 | +19,625 | 0.18 | 0.16 | -0.01 | buy |
| MORGAN STANLEY | 917,063 | 801,274 | -115,789 | 0.01 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 374,561 | 733,611 | +359,050 | 0.02 | 0.03 | +0.01 | buy |
| Pictet Asset Management Holding SA | 809,607 | 706,607 | -103,000 | 0.06 | 0.05 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 345,100 | 564,800 | +219,700 | 0.04 | 0.06 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 483,336 | 517,204 | +33,868 | 0.02 | 0.02 | -0.00 | buy |
| Polar Capital Holdings Plc | 501,300 | 501,300 | 0 | 0.21 | 0.17 | -0.04 | hold |
| TANG CAPITAL MANAGEMENT LLC | 405,600 | 405,600 | 0 | 2.56 | 2.74 | +0.18 | hold |
| First Turn Management, LLC | 343,079 | 394,674 | +51,595 | 3.37 | 3.84 | +0.47 | buy |
| BNP Paribas Asset Management Holding S.A. | 183,545 | 342,000 | +158,455 | 0.03 | 0.06 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 312,608 | 311,121 | -1,487 | 0.01 | 0.01 | -0.00 | sell |
| Avidity Partners Management LP | 300,200 | 286,400 | -13,800 | 0.78 | 0.66 | -0.12 | sell |
| Woodline Partners LP | 100,328 | 274,038 | +173,710 | 0.07 | 0.16 | +0.09 | buy |
| MILLENNIUM MANAGEMENT LLC | 59,998 | 267,787 | +207,789 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 176,332 | 257,080 | +80,748 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 244,439 | 248,468 | +4,029 | 0.02 | 0.02 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 63,825 | 218,892 | +155,067 | 0.02 | 0.05 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 217,951 | +217,951 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 346,930 | 215,014 | -131,916 | 0.02 | 0.01 | -0.01 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 211,831 | 213,990 | +2,159 | 0.03 | 0.03 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 157,082 | 203,949 | +46,867 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 144,006 | 189,006 | +45,000 | 0.07 | 0.08 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 312,000 | 164,000 | -148,000 | 0.57 | 0.28 | -0.28 | sell |
| D. E. Shaw & Co., Inc. | 84,653 | 140,094 | +55,441 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 161,957 | 135,649 | -26,308 | 0.03 | 0.02 | -0.01 | sell |
| Artisan Partners Limited Partnership | 126,610 | 126,610 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 119,265 | 116,295 | -2,970 | 0.01 | 0.01 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 293,000 | 115,000 | -178,000 | 3.41 | 1.16 | -2.25 | sell |
| ALLIANCEBERNSTEIN L.P. | 73,411 | 97,381 | +23,970 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 48,672 | 96,807 | +48,135 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 94,929 | 94,957 | +28 | 0.02 | 0.02 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 105,685 | 94,117 | -11,568 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 58,344 | 91,997 | +33,653 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 132,491 | 88,750 | -43,741 | 0.01 | 0.01 | -0.00 | sell |
| Pier Capital, LLC | 86,202 | 88,054 | +1,852 | 0.84 | 0.79 | -0.05 | buy |
| Allspring Global Investments Holdings, LLC | 85,784 | 87,614 | +1,830 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 87,400 | 86,600 | -800 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 84,143 | 86,096 | +1,953 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 84,278 | 79,778 | -4,500 | 0.58 | 0.49 | -0.08 | sell |
| Nicholas Investment Partners, LP | 52,159 | 77,455 | +25,296 | 0.42 | 0.52 | +0.10 | buy |
| Robeco Institutional Asset Management B.V. | 74,127 | 72,841 | -1,286 | 0.01 | 0.01 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 68,574 | 69,965 | +1,391 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 64,419 | 65,784 | +1,365 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 240,356 | 62,025 | -178,331 | 0.02 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 18,728 | 57,630 | +38,902 | 0.02 | 0.04 | +0.03 | buy |
| Laurion Capital Management LP | 0 | 53,332 | +53,332 | 0.00 | 0.10 | +0.10 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 0 | 49,500 | +49,500 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.64 | 0.57 | -0.07 | hold |
| STATE STREET CORP | 43,526 | 45,446 | +1,920 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 42,224 | 42,297 | +73 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 7,823 | 40,899 | +33,076 | 0.42 | 1.62 | +1.20 | buy |
| Eschler Asset Management LLP | 40,000 | 40,000 | 0 | 2.17 | 1.68 | -0.49 | hold |
| NATIONAL BANK OF CANADA /FI/ | 0 | 37,400 | +37,400 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,295 | 36,045 | -250 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 33,390 | 35,135 | +1,745 | 0.02 | 0.02 | -0.00 | buy |
| HighVista Strategies LLC | 41,627 | 34,762 | -6,865 | 1.03 | 0.81 | -0.23 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 27,641 | 28,924 | +1,283 | 0.06 | 0.05 | -0.01 | buy |
| Jump Financial, LLC | 44,900 | 28,866 | -16,034 | 0.10 | 0.05 | -0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 26,029 | 27,045 | +1,016 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 26,679 | +26,679 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 23,642 | 24,866 | +1,224 | 0.00 | 0.00 | -0.00 | buy |
| Orion Porfolio Solutions, LLC | 17,301 | 23,127 | +5,826 | 0.01 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 4,139 | 22,495 | +18,356 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 17,980 | 21,646 | +3,666 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 12,384 | 21,232 | +8,848 | 0.05 | 0.07 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 18,238 | 19,643 | +1,405 | 0.00 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 18,998 | +18,998 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 18,870 | +18,870 | 0.00 | 0.02 | +0.02 | buy |
| CWM, LLC | 24,225 | 18,446 | -5,779 | 0.01 | 0.01 | -0.00 | sell |
| Allianz Asset Management GmbH | 15,800 | 15,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pentwater Capital Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OPPENHEIMER & CO INC | 19,230 | 14,072 | -5,158 | 0.02 | 0.02 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 96,785 | 14,000 | -82,785 | 0.01 | 0.00 | -0.01 | sell |
| BIT Capital GmbH | 4,003 | 13,904 | +9,901 | 0.03 | 0.08 | +0.05 | buy |
| UBS Group AG | 0 | 13,280 | +13,280 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 13,754 | 13,063 | -691 | 0.01 | 0.01 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 12,900 | +12,900 | 0.00 | 0.03 | +0.03 | buy |
| FORA Capital, LLC | 0 | 11,957 | +11,957 | 0.00 | 0.06 | +0.06 | buy |
| Robertson Stephens Wealth Management, LLC | 13,780 | 11,030 | -2,750 | 0.06 | 0.04 | -0.02 | sell |
| Dalton Investments, Inc. | 10,000 | 10,000 | 0 | 0.45 | 0.39 | -0.06 | hold |
| FRED ALGER MANAGEMENT, LLC | 6,207 | 9,479 | +3,272 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 9,212 | +9,212 | 0.00 | 0.07 | +0.07 | buy |
| SG Americas Securities, LLC | 12,569 | 8,151 | -4,418 | 0.01 | 0.00 | -0.01 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 8,251 | 8,120 | -131 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 7,581 | 7,748 | +167 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 101,082 | 7,708 | -93,374 | 0.00 | 0.00 | -0.00 | sell |
| Snowden Capital Advisors LLC | 7,537 | 7,495 | -42 | 0.02 | 0.02 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 7,322 | +7,322 | 0.00 | 0.04 | +0.04 | buy |
| Nan Fung Group Holdings Ltd | 0 | 6,750 | +6,750 | 0.00 | 0.41 | +0.41 | buy |