| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 519,376 | 1,411,402 | +892,026 | 0.57 | 1.36 | +0.78 | buy |
| BAKER BROS. ADVISORS LP | 1,515,318 | 2,322,656 | +807,338 | 0.48 | 0.76 | +0.29 | buy |
| Kynam Capital Management, LP | 1,225,576 | 1,695,576 | +470,000 | 2.38 | 4.30 | +1.92 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,555,600 | 1,915,708 | +360,108 | 3.04 | 3.14 | +0.11 | buy |
| T. Rowe Price Investment Management, Inc. | 6,700,208 | 7,051,818 | +351,610 | 0.12 | 0.14 | +0.02 | buy |
| Point72 Asset Management, L.P. | 403,304 | 628,292 | +224,988 | 0.03 | 0.05 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 108,762 | 301,170 | +192,408 | 0.13 | 0.41 | +0.28 | buy |
| BANK OF AMERICA CORP /DE/ | 189,577 | 295,408 | +105,831 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 100,000 | +100,000 | 0.00 | 0.11 | +0.11 | buy |
| DIADEMA PARTNERS LP | 0 | 96,984 | +96,984 | 0.00 | 2.30 | +2.30 | buy |
| BARCLAYS PLC | 20,625 | 107,090 | +86,465 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 325,300 | 395,334 | +70,034 | 0.06 | 0.07 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 54,493 | +54,493 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 130,641 | 173,861 | +43,220 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 140,706 | 176,132 | +35,426 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 29,393 | +29,393 | 0.00 | 0.04 | +0.04 | buy |
| Fiera Capital Corp | 779,964 | 805,150 | +25,186 | 0.07 | 0.09 | +0.01 | buy |
| FMR LLC | 4,817,699 | 4,840,496 | +22,797 | 0.01 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 22,330 | +22,330 | 0.00 | 0.58 | +0.58 | buy |
| Bellevue Group AG | 1,205,464 | 1,221,794 | +16,330 | 0.68 | 0.81 | +0.13 | buy |
| ROYAL BANK OF CANADA | 30,322 | 44,011 | +13,689 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 49,608 | 62,555 | +12,947 | 0.07 | 0.08 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 0 | 11,847 | +11,847 | 0.00 | 0.10 | +0.10 | buy |
| WELLS FARGO & COMPANY/MN | 71,935 | 83,670 | +11,735 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 10,736 | +10,736 | 0.00 | 0.00 | +0.00 | buy |
| Banque Transatlantique SA | 0 | 10,150 | +10,150 | 0.00 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,668,550 | 2,678,650 | +10,100 | 0.06 | 0.07 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 13,017 | 22,934 | +9,917 | 0.00 | 0.01 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 9,011 | +9,011 | 0.00 | 0.15 | +0.15 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 7,574 | +7,574 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 632,944 | 639,288 | +6,344 | 0.02 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 136,875 | 141,675 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 11,194 | 15,428 | +4,234 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 11,194 | 15,428 | +4,234 | 0.14 | 0.14 | -0.00 | buy |
| STATE STREET CORP | 77,265 | 81,159 | +3,894 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 2,900 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 459,045 | 460,751 | +1,706 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 35,492 | 37,124 | +1,632 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 32,171 | 33,710 | +1,539 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 686 | 2,086 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 1,400 | 2,709 | +1,309 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 15,721 | 16,890 | +1,169 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 876 | +876 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 66,524 | 67,259 | +735 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 10,298 | 10,853 | +555 | 0.00 | 0.00 | +0.00 | buy |
| Lowe Wealth Advisors, LLC | 0 | 330 | +330 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 328,059 | 328,245 | +186 | 0.07 | 0.06 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 831 | 1,014 | +183 | 0.00 | 0.00 | +0.00 | buy |
| Crossmark Global Holdings, Inc. | 38,020 | 38,147 | +127 | 0.02 | 0.02 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 96 | +96 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 559 | 644 | +85 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 415 | 476 | +61 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 7,367 | 7,411 | +44 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Park Place Capital Corp | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 350 | 357 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,319 | 1,326 | +7 | 0.00 | 0.00 | +0.00 | buy |
| PALISADE CAPITAL MANAGEMENT, LP | 0 | 0 | 0 | 0.00 | 0.01 | +0.01 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 0 | 0 | 0.00 | 0.50 | +0.50 | hold |
| GENERAL ATLANTIC, L.P. | 1,261,684 | 1,261,684 | 0 | 1.32 | 1.26 | -0.07 | hold |
| GROUPAMA ASSET MANAGMENT | 0 | 0 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 65,539 | 65,539 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 0.01 | +0.01 | hold |
| PRINCIPAL SECURITIES, INC. | 96 | 96 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 56 | 56 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LINDEN ADVISORS LP | 0 | 0 | 0 | 0.00 | 0.26 | +0.26 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 0.53 | +0.53 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.00 | 1.63 | +1.63 | hold |
| Kohlberg Kravis Roberts & Co. L.P. | 0 | 0 | 0 | 0.00 | 0.43 | +0.43 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 17,200 | 17,200 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.17 | 2.21 | +0.04 | hold |
| BNP Paribas Asset Management Holding S.A. | 161,292 | 161,292 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Wellesley Asset Management | 0 | 0 | 0 | 0.00 | 0.10 | +0.10 | hold |
| Candriam S.C.A. | 134,785 | 134,785 | 0 | 0.02 | 0.03 | +0.00 | hold |
| First Horizon Advisors, Inc. | 607 | 607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 1,006 | 1,006 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 112 | 112 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Larson Financial Group LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| M&G Plc | 0 | 0 | 0 | 0.00 | 0.03 | +0.03 | hold |
| Jump Financial, LLC | 0 | 0 | 0 | 0.00 | 0.10 | +0.10 | hold |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.33 | 0.36 | +0.02 | hold |
| Continuum Advisory, LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 109 | 109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blue Trust, Inc. | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 2,658 | 2,658 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Bell Investment Advisors, Inc | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| READYSTATE ASSET MANAGEMENT LP | 0 | 0 | 0 | 0.00 | 0.55 | +0.55 | hold |
| BRAIDWELL LP | 0 | 0 | 0 | 0.00 | 1.54 | +1.54 | hold |
| JPMORGAN CHASE & CO | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BlackRock, Inc. | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Northwest & Ethical Investments L.P. | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 310 | 310 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 0 | 0 | 0 | 0.00 | 0.01 | +0.01 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 202,806 | 202,806 | 0 | 0.01 | 0.01 | +0.00 | hold |