| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 519,376 | 1,411,402 | +892,026 | 0.57 | 1.36 | +0.78 | buy |
| BAKER BROS. ADVISORS LP | 1,515,318 | 2,322,656 | +807,338 | 0.48 | 0.76 | +0.29 | buy |
| Kynam Capital Management, LP | 1,225,576 | 1,695,576 | +470,000 | 2.38 | 4.30 | +1.92 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,555,600 | 1,915,708 | +360,108 | 3.04 | 3.14 | +0.11 | buy |
| T. Rowe Price Investment Management, Inc. | 6,700,208 | 7,051,818 | +351,610 | 0.12 | 0.14 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 108,762 | 301,170 | +192,408 | 0.13 | 0.41 | +0.28 | buy |
| Fiera Capital Corp | 779,964 | 805,150 | +25,186 | 0.07 | 0.09 | +0.01 | buy |
| Bellevue Group AG | 1,205,464 | 1,221,794 | +16,330 | 0.68 | 0.81 | +0.13 | buy |
| Hennion & Walsh Asset Management, Inc. | 49,608 | 62,555 | +12,947 | 0.07 | 0.08 | +0.02 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,668,550 | 2,678,650 | +10,100 | 0.06 | 0.07 | +0.00 | buy |
| NEOS Investment Management LLC | 11,194 | 15,428 | +4,234 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 11,194 | 15,428 | +4,234 | 0.14 | 0.14 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 459,045 | 460,751 | +1,706 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 10,298 | 10,853 | +555 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 328,059 | 328,245 | +186 | 0.07 | 0.06 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 831 | 1,014 | +183 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,393 | 7,947 | -446 | 0.02 | 0.02 | -0.00 | sell |
| ALPS ADVISORS INC | 40,454 | 35,836 | -4,618 | 0.01 | 0.01 | -0.00 | sell |
| BIT Capital GmbH | 67,840 | 40,787 | -27,053 | 0.16 | 0.10 | -0.06 | sell |
| Rhenman & Partners Asset Management AB | 58,278 | 28,278 | -30,000 | 0.18 | 0.10 | -0.08 | sell |
| ARMISTICE CAPITAL, LLC | 1,200,000 | 978,000 | -222,000 | 0.48 | 0.43 | -0.05 | sell |