| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 850,000 | 1,500,000 | +650,000 | 1.97 | 2.33 | +0.36 | buy |
| Frazier Life Sciences Management, L.P. | 384,782 | 484,782 | +100,000 | 0.36 | 0.38 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 1,098,000 | 1,188,000 | +90,000 | 0.93 | 1.18 | +0.25 | buy |
| Fiera Capital Corp | 1,044,831 | 1,080,099 | +35,268 | 0.12 | 0.11 | -0.00 | buy |
| HighVista Strategies LLC | 32,998 | 58,697 | +25,699 | 0.29 | 0.49 | +0.19 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 42,000 | 63,000 | +21,000 | 0.35 | 0.41 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,628,538 | 2,649,368 | +20,830 | 4.51 | 4.06 | -0.45 | buy |
| Bridgewater Associates, LP | 9,952 | 18,930 | +8,978 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 75 | 227 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Elequin Capital, LP | 37 | 10 | -27 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 48,585 | 47,127 | -1,458 | 0.06 | 0.05 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 28,164 | 19,492 | -8,672 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 153,278 | 85,724 | -67,554 | 0.50 | 0.32 | -0.18 | sell |
| Deep Track Capital, LP | 2,003,978 | 1,931,884 | -72,094 | 1.59 | 1.20 | -0.38 | sell |
| BVF INC/IL | 1,488,975 | 1,294,463 | -194,512 | 1.69 | 1.24 | -0.45 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,961,880 | 3,693,241 | -268,639 | 0.10 | 0.09 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 2,322,656 | 734,397 | -1,588,259 | 0.47 | 0.13 | -0.34 | sell |
| T. Rowe Price Investment Management, Inc. | 5,961,227 | 1,891,600 | -4,069,627 | 0.13 | 0.04 | -0.09 | sell |
| Polar Capital Holdings Plc | 11,000,000 | 6,500,000 | -4,500,000 | 0.05 | 0.03 | -0.02 | sell |