| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 11,000,000 | 6,500,000 | -4,500,000 | 0.05 | 0.03 | -0.02 | sell |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 1.69 | 1.46 | -0.23 | hold |
| FMR LLC | 4,539,225 | 4,829,154 | +289,929 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,693,643 | 4,706,168 | +12,525 | 0.03 | 0.03 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,961,880 | 3,693,241 | -268,639 | 0.10 | 0.09 | -0.02 | sell |
| Bellevue Group AG | 2,796,803 | 2,796,803 | 0 | 1.84 | 2.01 | +0.17 | hold |
| Vestal Point Capital, LP | 585,000 | 2,766,868 | +2,181,868 | 0.74 | 2.33 | +1.59 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,628,538 | 2,649,368 | +20,830 | 4.51 | 4.06 | -0.45 | buy |
| Deep Track Capital, LP | 2,003,978 | 1,931,884 | -72,094 | 1.59 | 1.20 | -0.38 | sell |
| T. Rowe Price Investment Management, Inc. | 5,961,227 | 1,891,600 | -4,069,627 | 0.13 | 0.04 | -0.09 | sell |
| Logos Global Management LP | 850,000 | 1,500,000 | +650,000 | 1.97 | 2.33 | +0.36 | buy |
| BVF INC/IL | 1,488,975 | 1,294,463 | -194,512 | 1.69 | 1.24 | -0.45 | sell |
| MILLENNIUM MANAGEMENT LLC | 911,597 | 1,237,403 | +325,806 | 0.02 | 0.03 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 1,098,000 | 1,188,000 | +90,000 | 0.93 | 1.18 | +0.25 | buy |
| Point72 Asset Management, L.P. | 504,151 | 1,102,271 | +598,120 | 0.03 | 0.06 | +0.03 | buy |
| Fiera Capital Corp | 1,044,831 | 1,080,099 | +35,268 | 0.12 | 0.11 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 359,293 | 1,021,265 | +661,972 | 0.02 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 968,784 | 919,332 | -49,452 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 856,462 | 884,937 | +28,475 | 1.94 | 1.69 | -0.24 | buy |
| BAKER BROS. ADVISORS LP | 2,322,656 | 734,397 | -1,588,259 | 0.47 | 0.13 | -0.34 | sell |
| Caption Management, LLC | 94,384 | 661,786 | +567,402 | 0.14 | 0.95 | +0.81 | buy |
| BlackRock, Inc. | 329,099 | 656,309 | +327,210 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 383,558 | 633,174 | +249,616 | 0.08 | 0.11 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 454,404 | 594,712 | +140,308 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 658,436 | 519,130 | -139,306 | 0.01 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 461,830 | 501,091 | +39,261 | 0.03 | 0.02 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 384,782 | 484,782 | +100,000 | 0.36 | 0.38 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 407,404 | 407,373 | -31 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 183,940 | 335,191 | +151,251 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 287,125 | 323,606 | +36,481 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 316,685 | 316,762 | +77 | 0.04 | 0.04 | -0.01 | buy |
| Candriam S.C.A. | 269,729 | 269,729 | 0 | 0.05 | 0.04 | -0.00 | hold |
| CANTOR FITZGERALD, L. P. | 0 | 250,211 | +250,211 | 0.00 | 0.27 | +0.27 | buy |
| CITADEL ADVISORS LLC | 234,268 | 230,399 | -3,869 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 211,140 | 211,140 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 234,737 | 206,866 | -27,871 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 100,940 | 204,368 | +103,428 | 0.00 | 0.01 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 197,308 | +197,308 | 0.00 | 0.22 | +0.22 | buy |
| DIADEMA PARTNERS LP | 70,300 | 193,189 | +122,889 | 1.45 | 2.41 | +0.95 | buy |
| MARSHALL WACE, LLP | 61,163 | 180,340 | +119,177 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 140,900 | 164,000 | +23,100 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 149,333 | 156,143 | +6,810 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 292,764 | 135,828 | -156,936 | 0.01 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 32,390 | 119,497 | +87,107 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 116,857 | +116,857 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 114,749 | +114,749 | 0.00 | 0.16 | +0.16 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 113,844 | +113,844 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 100,784 | +100,784 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.16 | +0.16 | buy |
| STATE STREET CORP | 93,556 | 97,940 | +4,384 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 21,991 | 96,106 | +74,115 | 0.02 | 0.05 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 95,904 | 94,936 | -968 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 153,278 | 85,724 | -67,554 | 0.50 | 0.32 | -0.18 | sell |
| Catalio Capital Management, LP | 0 | 84,352 | +84,352 | 0.00 | 0.53 | +0.53 | buy |
| Eschler Asset Management LLP | 80,000 | 80,000 | 0 | 1.89 | 2.40 | +0.52 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 85,169 | 76,519 | -8,650 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 77,228 | 75,473 | -1,755 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 63,543 | +63,543 | 0.00 | 0.37 | +0.37 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 42,000 | 63,000 | +21,000 | 0.35 | 0.41 | +0.06 | buy |
| SEI INVESTMENTS CO | 50,337 | 61,260 | +10,923 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 32,998 | 58,697 | +25,699 | 0.29 | 0.49 | +0.19 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 55,190 | 56,825 | +1,635 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 27,932 | 48,962 | +21,030 | 0.47 | 0.57 | +0.11 | buy |
| Hennion & Walsh Asset Management, Inc. | 48,585 | 47,127 | -1,458 | 0.06 | 0.05 | -0.01 | sell |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.35 | 0.29 | -0.06 | hold |
| ROYAL BANK OF CANADA | 42,486 | 44,714 | +2,228 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 109,849 | 42,920 | -66,929 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 43,026 | 42,882 | -144 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 0 | 42,134 | +42,134 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 41,487 | 41,261 | -226 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 40,279 | +40,279 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 0 | 39,238 | +39,238 | 0.00 | 0.08 | +0.08 | buy |
| Jump Financial, LLC | 61,150 | 38,498 | -22,652 | 0.03 | 0.02 | -0.01 | sell |
| Crossmark Global Holdings, Inc. | 36,406 | 36,457 | +51 | 0.02 | 0.02 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 48,187 | 34,927 | -13,260 | 0.04 | 0.02 | -0.02 | sell |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 8,180 | 31,674 | +23,494 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 25,163 | 31,253 | +6,090 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 103,253 | 30,909 | -72,344 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 0 | 30,651 | +30,651 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 31,676 | 28,387 | -3,289 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 27,663 | 27,663 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtus Investment Advisers, LLC | 18,569 | 22,940 | +4,371 | 0.18 | 0.19 | +0.02 | buy |
| HRT FINANCIAL LP | 32,596 | 22,861 | -9,735 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 20,685 | +20,685 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 22,000 | 20,524 | -1,476 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 28,164 | 19,492 | -8,672 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 38,608 | 19,254 | -19,354 | 0.01 | 0.01 | -0.01 | sell |
| Bridgewater Associates, LP | 9,952 | 18,930 | +8,978 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 20,182 | 16,936 | -3,246 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 16,420 | +16,420 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 15,388 | 15,434 | +46 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 13,892 | +13,892 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 11,661 | 11,222 | -439 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 15,109 | 10,783 | -4,326 | 0.04 | 0.02 | -0.02 | sell |
| Close Asset Management Ltd | 0 | 10,100 | +10,100 | 0.00 | 0.01 | +0.01 | buy |
| Entropy Technologies, LP | 0 | 10,020 | +10,020 | 0.00 | 0.01 | +0.01 | buy |
| Federation des caisses Desjardins du Quebec | 5,478 | 8,312 | +2,834 | 0.00 | 0.00 | +0.00 | buy |
| Alta Wealth Advisors LLC | 0 | 8,255 | +8,255 | 0.00 | 0.08 | +0.08 | buy |
| Snowden Capital Advisors LLC | 6,970 | 7,430 | +460 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 8,659 | 7,078 | -1,581 | 0.00 | 0.00 | -0.00 | sell |