| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 733,611 | 2,992,273 | +2,258,662 | 0.03 | 0.06 | +0.03 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 49,500 | 1,951,070 | +1,901,570 | 0.00 | 0.05 | +0.05 | buy |
| ARMISTICE CAPITAL, LLC | 164,000 | 976,000 | +812,000 | 0.14 | 0.42 | +0.27 | buy |
| LOOMIS SAYLES & CO L P | 18,998 | 301,815 | +282,817 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 972,254 | 1,154,654 | +182,400 | 0.96 | 0.64 | -0.33 | buy |
| Candriam S.C.A. | 189,006 | 313,423 | +124,417 | 0.08 | 0.06 | -0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 311,121 | 390,565 | +79,444 | 0.01 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 342,000 | 397,463 | +55,463 | 0.06 | 0.03 | -0.02 | buy |
| BIT Capital GmbH | 13,904 | 32,749 | +18,845 | 0.07 | 0.09 | +0.02 | buy |
| Fiera Capital Corp | 866,412 | 875,593 | +9,181 | 0.16 | 0.09 | -0.07 | buy |
| NEOS Investment Management LLC | 3,944 | 9,454 | +5,510 | 0.02 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 35,135 | 38,060 | +2,925 | 0.02 | 0.01 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 5,962 | 8,298 | +2,336 | 0.21 | 0.14 | -0.07 | buy |
| DnB Asset Management AS | 5,343 | 7,211 | +1,868 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 21,232 | 22,622 | +1,390 | 0.07 | 0.04 | -0.03 | buy |
| Polar Capital Holdings Plc | 501,300 | 502,570 | +1,270 | 0.17 | 0.10 | -0.07 | buy |
| China Universal Asset Management Co., Ltd. | 6,621 | 4,380 | -2,241 | 0.05 | 0.02 | -0.03 | sell |
| Pier Capital, LLC | 88,054 | 81,306 | -6,748 | 0.79 | 0.41 | -0.38 | sell |
| Atle Fund Management AB | 40,899 | 23,778 | -17,121 | 1.62 | 0.49 | -1.13 | sell |
| Rhenman & Partners Asset Management AB | 79,778 | 58,278 | -21,500 | 0.49 | 0.19 | -0.30 | sell |
| Robeco Institutional Asset Management B.V. | 72,841 | 19,869 | -52,972 | 0.01 | 0.00 | -0.01 | sell |
| Avidity Partners Management LP | 286,400 | 200,000 | -86,400 | 0.66 | 0.29 | -0.37 | sell |
| First Turn Management, LLC | 394,674 | 291,086 | -103,588 | 3.84 | 1.60 | -2.23 | sell |
| GENERAL ATLANTIC, L.P. | 1,506,684 | 1,261,684 | -245,000 | 2.27 | 1.34 | -0.93 | sell |
| RTW INVESTMENTS, LP | 6,019,641 | 4,869,798 | -1,149,843 | 5.78 | 2.56 | -3.22 | sell |
| Rock Springs Capital Management LP | 2,367,816 | 419,030 | -1,948,786 | 3.91 | 0.43 | -3.48 | sell |