| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 5,747,270 | 6,380,451 | +633,181 | 0.07 | 0.04 | -0.03 | buy |
| RTW INVESTMENTS, LP | 6,019,641 | 4,869,798 | -1,149,843 | 5.78 | 2.56 | -3.22 | sell |
| FMR LLC | 4,312,144 | 4,812,604 | +500,460 | 0.02 | 0.01 | -0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 733,611 | 2,992,273 | +2,258,662 | 0.03 | 0.06 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,437,584 | 2,832,669 | +395,085 | 0.02 | 0.01 | -0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 49,500 | 1,951,070 | +1,901,570 | 0.00 | 0.05 | +0.05 | buy |
| BAKER BROS. ADVISORS LP | 1,515,318 | 1,515,318 | 0 | 1.24 | 0.66 | -0.58 | hold |
| GENERAL ATLANTIC, L.P. | 1,506,684 | 1,261,684 | -245,000 | 2.27 | 1.34 | -0.93 | sell |
| Bellevue Group AG | 972,254 | 1,154,654 | +182,400 | 0.96 | 0.64 | -0.33 | buy |
| ARMISTICE CAPITAL, LLC | 164,000 | 976,000 | +812,000 | 0.28 | 0.87 | +0.58 | buy |
| Fiera Capital Corp | 866,412 | 875,593 | +9,181 | 0.16 | 0.09 | -0.07 | buy |
| MORGAN STANLEY | 801,274 | 868,864 | +67,590 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 0 | 797,268 | +797,268 | 0.00 | 0.85 | +0.85 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 564,800 | 646,920 | +82,120 | 0.06 | 0.04 | -0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 267,787 | 600,954 | +333,167 | 0.01 | 0.02 | +0.00 | buy |
| Polar Capital Holdings Plc | 501,300 | 502,570 | +1,270 | 0.17 | 0.10 | -0.07 | buy |
| TWO SIGMA ADVISERS, LP | 86,600 | 457,500 | +370,900 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 135,649 | 439,453 | +303,804 | 0.02 | 0.04 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 517,204 | 437,112 | -80,092 | 0.02 | 0.01 | -0.01 | sell |
| Rock Springs Capital Management LP | 2,367,816 | 419,030 | -1,948,786 | 3.91 | 0.43 | -3.48 | sell |
| TANG CAPITAL MANAGEMENT LLC | 405,600 | 405,600 | 0 | 2.74 | 1.40 | -1.35 | hold |
| BNP Paribas Asset Management Holding S.A. | 342,000 | 397,463 | +55,463 | 0.06 | 0.03 | -0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 311,121 | 390,565 | +79,444 | 0.01 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 339,351 | +339,351 | 0.00 | 3.38 | +3.38 | buy |
| Candriam S.C.A. | 189,006 | 313,423 | +124,417 | 0.08 | 0.06 | -0.01 | buy |
| LOOMIS SAYLES & CO L P | 18,998 | 301,815 | +282,817 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 394,674 | 291,086 | -103,588 | 3.84 | 1.60 | -2.23 | sell |
| Woodline Partners LP | 274,038 | 274,038 | 0 | 0.16 | 0.09 | -0.08 | hold |
| TD ASSET MANAGEMENT INC | 215,014 | 264,896 | +49,882 | 0.01 | 0.01 | -0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 254,027 | +254,027 | 0.00 | 1.73 | +1.73 | buy |
| Qube Research & Technologies Ltd | 91,997 | 251,819 | +159,822 | 0.01 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 217,951 | 248,654 | +30,703 | 0.02 | 0.01 | -0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 248,468 | 232,594 | -15,874 | 0.02 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 62,025 | 228,952 | +166,927 | 0.00 | 0.01 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 213,990 | 205,243 | -8,747 | 0.03 | 0.01 | -0.01 | sell |
| Avidity Partners Management LP | 286,400 | 200,000 | -86,400 | 0.66 | 0.29 | -0.37 | sell |
| Hudson Bay Capital Management LP | 0 | 193,179 | +193,179 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 203,949 | 175,668 | -28,281 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 8,151 | 160,358 | +152,207 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 132,613 | +132,613 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 88,750 | 121,753 | +33,003 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 36,045 | 120,517 | +84,472 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 108,762 | +108,762 | 0.00 | 0.17 | +0.17 | buy |
| AXA S.A. | 94,957 | 95,012 | +55 | 0.02 | 0.01 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 96,807 | 90,184 | -6,623 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 231 | 89,208 | +88,977 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 86,096 | 81,782 | -4,314 | 0.00 | 0.00 | -0.00 | sell |
| Pier Capital, LLC | 88,054 | 81,306 | -6,748 | 0.79 | 0.41 | -0.38 | sell |
| Squarepoint Ops LLC | 3,118 | 73,766 | +70,648 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 69,965 | 70,571 | +606 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 28,866 | 62,205 | +33,339 | 0.05 | 0.04 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 79,778 | 58,278 | -21,500 | 0.49 | 0.19 | -0.30 | sell |
| Cubist Systematic Strategies, LLC | 57,630 | 53,687 | -3,943 | 0.04 | 0.03 | -0.01 | sell |
| STATE STREET CORP | 45,446 | 46,774 | +1,328 | 0.00 | 0.00 | -0.00 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.57 | 0.28 | -0.29 | hold |
| ROYAL BANK OF CANADA | 42,297 | 44,455 | +2,158 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 28,924 | 40,014 | +11,090 | 0.05 | 0.04 | -0.02 | buy |
| Eschler Asset Management LLP | 40,000 | 40,000 | 0 | 1.68 | 2.04 | +0.36 | hold |
| Engineers Gate Manager LP | 0 | 38,179 | +38,179 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 35,135 | 38,060 | +2,925 | 0.02 | 0.01 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 27,045 | 35,142 | +8,097 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 12,900 | 33,900 | +21,000 | 0.03 | 0.04 | +0.02 | buy |
| BIT Capital GmbH | 13,904 | 32,749 | +18,845 | 0.08 | 0.10 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 31,265 | +31,265 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 30,936 | +30,936 | 0.00 | 0.01 | +0.01 | buy |
| ASSETMARK, INC | 21,646 | 28,677 | +7,031 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 218,892 | 27,139 | -191,753 | 0.05 | 0.00 | -0.05 | sell |
| Atle Fund Management AB | 40,899 | 23,778 | -17,121 | 1.62 | 0.49 | -1.13 | sell |
| Orion Porfolio Solutions, LLC | 23,127 | 22,974 | -153 | 0.02 | 0.01 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 21,232 | 22,622 | +1,390 | 0.07 | 0.04 | -0.03 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 22,311 | +22,311 | 0.00 | 0.15 | +0.15 | buy |
| Tower Research Capital LLC (TRC) | 1,035 | 21,550 | +20,515 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 18,870 | 20,021 | +1,151 | 0.02 | 0.01 | -0.01 | buy |
| Robeco Institutional Asset Management B.V. | 72,841 | 19,869 | -52,972 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 140,094 | 19,515 | -120,579 | 0.01 | 0.00 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 19,643 | 19,453 | -190 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 116,295 | 18,550 | -97,745 | 0.01 | 0.00 | -0.01 | sell |
| Pentwater Capital Management LP | 15,000 | 15,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 13,280 | 13,199 | -81 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 0 | 11,408 | +11,408 | 0.00 | 0.18 | +0.18 | buy |
| JPMORGAN CHASE & CO | 7,708 | 11,275 | +3,567 | 0.00 | 0.00 | -0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 11,030 | 11,030 | 0 | 0.04 | 0.02 | -0.02 | hold |
| TORNO CAPITAL, LLC | 0 | 10,010 | +10,010 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 22,495 | 9,733 | -12,762 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 3,944 | 9,454 | +5,510 | 0.02 | 0.01 | -0.00 | buy |
| Tidal Investments LLC | 6,510 | 9,166 | +2,656 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 8,943 | +8,943 | 0.00 | 0.03 | +0.03 | buy |
| VIRTUS ADVISERS, LLC | 5,962 | 8,298 | +2,336 | 0.21 | 0.14 | -0.07 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 8,120 | 8,163 | +43 | 0.01 | 0.00 | -0.00 | buy |
| Snowden Capital Advisors LLC | 7,495 | 7,632 | +137 | 0.02 | 0.01 | -0.01 | buy |
| Baldwin Investment Management, LLC | 0 | 7,305 | +7,305 | 0.00 | 0.03 | +0.03 | buy |
| DnB Asset Management AS | 5,343 | 7,211 | +1,868 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 5,655 | 7,139 | +1,484 | 0.00 | 0.00 | -0.00 | buy |
| Nan Fung Group Holdings Ltd | 6,750 | 6,750 | 0 | 0.41 | 0.24 | -0.16 | hold |
| Graham Capital Management, L.P. | 4,305 | 6,258 | +1,953 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,621 | 4,380 | -2,241 | 0.05 | 0.02 | -0.03 | sell |
| JTC Employer Solutions Trustee Ltd | 3,908 | 3,908 | 0 | 0.02 | 0.01 | -0.01 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 4,738 | 3,614 | -1,124 | 0.01 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 3,062 | 3,035 | -27 | 0.01 | 0.00 | -0.00 | sell |