| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 1,221,794 | 2,441,830 | +1,220,036 | 0.81 | 1.69 | +0.88 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,678,650 | 3,771,474 | +1,092,824 | 0.07 | 0.09 | +0.03 | buy |
| Deep Track Capital, LP | 1,411,402 | 1,800,000 | +388,598 | 1.36 | 1.82 | +0.46 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,915,708 | 2,105,608 | +189,900 | 3.14 | 3.34 | +0.20 | buy |
| Frazier Life Sciences Management, L.P. | 301,170 | 384,782 | +83,612 | 0.41 | 0.48 | +0.07 | buy |
| T. Rowe Price Investment Management, Inc. | 7,051,818 | 7,067,659 | +15,841 | 0.14 | 0.14 | +0.00 | buy |
| Fiera Capital Corp | 805,150 | 813,074 | +7,924 | 0.09 | 0.09 | +0.00 | buy |
| DIADEMA PARTNERS LP | 96,984 | 104,384 | +7,400 | 2.30 | 2.04 | -0.26 | buy |
| NEOS Investment Management LLC | 15,428 | 22,206 | +6,778 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 15,428 | 22,206 | +6,778 | 0.14 | 0.19 | +0.05 | buy |
| Hennion & Walsh Asset Management, Inc. | 62,555 | 66,780 | +4,225 | 0.08 | 0.08 | +0.00 | buy |
| Persistent Asset Partners Ltd | 22,330 | 24,038 | +1,708 | 0.58 | 0.66 | +0.08 | buy |
| Virtus Investment Advisers, LLC | 11,847 | 12,472 | +625 | 0.10 | 0.13 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 7,947 | 7,982 | +35 | 0.02 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 134,785 | 134,779 | -6 | 0.03 | 0.02 | -0.00 | sell |
| DnB Asset Management AS | 10,853 | 7,628 | -3,225 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 460,751 | 445,767 | -14,984 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 40,787 | 2,176 | -38,611 | 0.10 | 0.00 | -0.10 | sell |
| CANTOR FITZGERALD, L. P. | 100,000 | 25,001 | -74,999 | 0.06 | 0.01 | -0.05 | sell |
| Woodline Partners LP | 328,245 | 246,498 | -81,747 | 0.06 | 0.04 | -0.02 | sell |
| ARMISTICE CAPITAL, LLC | 978,000 | 678,000 | -300,000 | 0.43 | 0.37 | -0.07 | sell |
| Kynam Capital Management, LP | 1,695,576 | 976,267 | -719,309 | 4.30 | 3.30 | -1.01 | sell |