| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 7,051,818 | 7,067,659 | +15,841 | 0.14 | 0.14 | +0.00 | buy |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.21 | 2.18 | -0.03 | hold |
| FMR LLC | 4,840,496 | 4,855,772 | +15,276 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,131,720 | 4,213,575 | -1,918,145 | 0.03 | 0.02 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,678,650 | 3,771,474 | +1,092,824 | 0.07 | 0.09 | +0.03 | buy |
| Bellevue Group AG | 1,221,794 | 2,441,830 | +1,220,036 | 0.81 | 1.69 | +0.88 | buy |
| BAKER BROS. ADVISORS LP | 2,322,656 | 2,322,656 | 0 | 0.76 | 0.71 | -0.06 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,915,708 | 2,105,608 | +189,900 | 3.14 | 3.34 | +0.20 | buy |
| Deep Track Capital, LP | 1,411,402 | 1,800,000 | +388,598 | 1.36 | 1.82 | +0.46 | buy |
| BVF INC/IL | 0 | 1,024,288 | +1,024,288 | 0.00 | 1.15 | +1.15 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,887,940 | 1,005,592 | -882,348 | 0.01 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 1,695,576 | 976,267 | -719,309 | 4.30 | 3.30 | -1.01 | sell |
| Point72 Asset Management, L.P. | 628,292 | 820,425 | +192,133 | 0.05 | 0.06 | +0.01 | buy |
| Fiera Capital Corp | 805,150 | 813,074 | +7,924 | 0.09 | 0.09 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 978,000 | 678,000 | -300,000 | 0.78 | 0.81 | +0.03 | sell |
| CITIGROUP INC | 639,288 | 634,501 | -4,787 | 0.01 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 0 | 575,000 | +575,000 | 0.00 | 2.41 | +2.41 | buy |
| TWO SIGMA ADVISERS, LP | 523,400 | 512,430 | -10,970 | 0.03 | 0.03 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 478,864 | 454,919 | -23,945 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 460,751 | 445,767 | -14,984 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 305,364 | 433,065 | +127,701 | 0.02 | 0.02 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 301,170 | 384,782 | +83,612 | 0.41 | 0.48 | +0.07 | buy |
| Hudson Bay Capital Management LP | 395,334 | 345,952 | -49,382 | 0.07 | 0.07 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 295,854 | 286,264 | -9,590 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 285,270 | 276,502 | -8,768 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 328,245 | 246,498 | -81,747 | 0.06 | 0.04 | -0.02 | sell |
| MORGAN STANLEY | 173,861 | 237,879 | +64,018 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 90,570 | 222,052 | +131,482 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 225,545 | 221,379 | -4,166 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 53,636 | 204,217 | +150,581 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 202,806 | 202,806 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 295,408 | 193,200 | -102,208 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 52,662 | 182,179 | +129,517 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 29,393 | 179,503 | +150,110 | 0.04 | 0.52 | +0.48 | buy |
| MARSHALL WACE, LLP | 27,882 | 146,610 | +118,728 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 68,629 | 142,757 | +74,128 | 0.03 | 0.05 | +0.02 | buy |
| Candriam S.C.A. | 134,785 | 134,779 | -6 | 0.03 | 0.02 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 161,292 | 129,410 | -31,882 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 141,675 | 123,239 | -18,436 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 65,539 | 109,849 | +44,310 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 107,090 | 106,862 | -228 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 96,984 | 104,384 | +7,400 | 2.30 | 2.04 | -0.26 | buy |
| AXA S.A. | 94,762 | 94,919 | +157 | 0.01 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 18,443 | 90,798 | +72,355 | 0.00 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 88,887 | +88,887 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 94,919 | 82,738 | -12,181 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 81,159 | 82,142 | +983 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 83,670 | 80,761 | -2,909 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 62,555 | 66,780 | +4,225 | 0.08 | 0.08 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 67,259 | 63,287 | -3,972 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 11,669 | 61,646 | +49,977 | 0.01 | 0.03 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,196 | 53,343 | +8,147 | 0.03 | 0.05 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 37,124 | 52,001 | +14,877 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 51,663 | +51,663 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 44,011 | 46,566 | +2,555 | 0.00 | 0.00 | -0.00 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.36 | 0.36 | +0.00 | hold |
| GOLDMAN SACHS GROUP INC | 31,257 | 44,956 | +13,699 | 0.00 | 0.00 | +0.00 | buy |
| Eschler Asset Management LLP | 0 | 40,000 | +40,000 | 0.00 | 0.95 | +0.95 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 40,321 | 38,176 | -2,145 | 0.00 | 0.00 | +0.00 | sell |
| Crossmark Global Holdings, Inc. | 38,147 | 36,345 | -1,802 | 0.02 | 0.02 | -0.00 | sell |
| ASSETMARK, INC | 33,710 | 34,958 | +1,248 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 10,736 | 31,334 | +20,598 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 28,278 | 28,278 | 0 | 0.10 | 0.11 | +0.02 | hold |
| ALPS ADVISORS INC | 35,836 | 27,076 | -8,760 | 0.01 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 100,000 | 25,001 | -74,999 | 0.11 | 0.02 | -0.09 | sell |
| Persistent Asset Partners Ltd | 22,330 | 24,038 | +1,708 | 0.58 | 0.66 | +0.08 | buy |
| Orion Porfolio Solutions, LLC | 22,934 | 23,965 | +1,031 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 176,132 | 22,552 | -153,580 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 15,428 | 22,206 | +6,778 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 15,428 | 22,206 | +6,778 | 0.14 | 0.19 | +0.05 | buy |
| OMERS ADMINISTRATION Corp | 0 | 21,800 | +21,800 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 54,493 | 21,139 | -33,354 | 0.01 | 0.01 | -0.01 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 21,058 | +21,058 | 0.00 | 0.22 | +0.22 | buy |
| XTX Topco Ltd | 18,192 | 20,873 | +2,681 | 0.03 | 0.03 | -0.00 | buy |
| Trexquant Investment LP | 0 | 19,289 | +19,289 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 17,200 | 17,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 16,890 | 16,830 | -60 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 15,044 | +15,044 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 15,032 | +15,032 | 0.00 | 0.02 | +0.02 | buy |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 0 | 14,975 | +14,975 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 14,760 | +14,760 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 14,696 | +14,696 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 11,847 | 12,472 | +625 | 0.10 | 0.13 | +0.04 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,849 | +11,849 | 0.00 | 0.06 | +0.06 | buy |
| Squarepoint Ops LLC | 0 | 10,714 | +10,714 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 9,295 | +9,295 | 0.00 | 0.00 | +0.00 | buy |
| Blueshift Asset Management, LLC | 0 | 8,195 | +8,195 | 0.00 | 0.08 | +0.08 | buy |
| Lido Advisors, LLC | 0 | 8,126 | +8,126 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,947 | 7,982 | +35 | 0.02 | 0.02 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 7,918 | +7,918 | 0.00 | 0.00 | +0.00 | buy |
| Snowden Capital Advisors LLC | 7,476 | 7,674 | +198 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 10,853 | 7,628 | -3,225 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 7,574 | 7,035 | -539 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,900 | 6,450 | +3,550 | 0.00 | 0.00 | +0.00 | buy |
| State of Tennessee, Department of Treasury | 0 | 4,214 | +4,214 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 3,267 | +3,267 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,448 | 3,148 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 2,798 | 2,782 | -16 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 3,205 | 2,663 | -542 | 0.00 | 0.00 | -0.00 | sell |