| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nicholas Investment Partners, LP | 4,700 | 512,855 | +508,155 | 0.02 | 1.99 | +1.97 | buy |
| BRAIDWELL LP | 468,027 | 906,973 | +438,946 | 0.92 | 1.49 | +0.57 | buy |
| Polar Capital Holdings Plc | 42,336 | 250,000 | +207,664 | 0.02 | 0.10 | +0.08 | buy |
| Fiera Capital Corp | 521,297 | 679,799 | +158,502 | 0.09 | 0.11 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 1,270,124 | 1,384,686 | +114,562 | 6.16 | 4.90 | -1.26 | buy |
| RTW INVESTMENTS, LP | 6,029,633 | 6,096,387 | +66,754 | 6.88 | 6.68 | -0.21 | buy |
| Pier Capital, LLC | 68,287 | 87,422 | +19,135 | 0.59 | 0.73 | +0.14 | buy |
| ADVISORY RESEARCH INC | 24,464 | 25,276 | +812 | 0.19 | 0.18 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 410 | 836 | +426 | 0.01 | 0.01 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 14,200 | 13,780 | -420 | 0.06 | 0.05 | -0.01 | sell |
| Campbell & CO Investment Adviser LLC | 8,640 | 7,965 | -675 | 0.09 | 0.05 | -0.04 | sell |
| VIRTUS ADVISERS, LLC | 5,949 | 5,265 | -684 | 0.21 | 0.17 | -0.05 | sell |
| ALPS ADVISORS INC | 37,155 | 36,168 | -987 | 0.02 | 0.02 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 6,564 | 4,205 | -2,359 | 0.00 | 0.00 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 11,817 | 8,069 | -3,748 | 0.10 | 0.08 | -0.03 | sell |
| Eschler Asset Management LLP | 34,000 | 30,000 | -4,000 | 2.89 | 1.82 | -1.07 | sell |
| HighVista Strategies LLC | 44,094 | 39,804 | -4,290 | 1.21 | 0.96 | -0.25 | sell |
| GREAT POINT PARTNERS LLC | 297,082 | 290,917 | -6,165 | 3.57 | 2.84 | -0.73 | sell |
| ARMISTICE CAPITAL, LLC | 428,000 | 400,000 | -28,000 | 0.64 | 0.62 | -0.03 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 361,963 | 312,347 | -49,616 | 0.01 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 500,000 | 450,000 | -50,000 | 4.14 | 3.33 | -0.81 | sell |
| Candriam S.C.A. | 350,014 | 293,011 | -57,003 | 0.15 | 0.11 | -0.04 | sell |
| Rock Springs Capital Management LP | 3,028,410 | 2,943,710 | -84,700 | 4.32 | 4.09 | -0.23 | sell |
| Avidity Partners Management LP | 575,000 | 348,200 | -226,800 | 1.20 | 0.73 | -0.48 | sell |
| Holocene Advisors, LP | 693,963 | 165,357 | -528,606 | 0.18 | 0.04 | -0.14 | sell |