| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,992,273 | 6,499,835 | +3,507,562 | 0.06 | 0.12 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 405,600 | 1,105,600 | +700,000 | 1.40 | 2.46 | +1.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,380,451 | 7,048,833 | +668,382 | 0.04 | 0.04 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 1,951,070 | 2,472,020 | +520,950 | 0.05 | 0.06 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 457,500 | 757,700 | +300,200 | 0.03 | 0.06 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 976,000 | 1,264,000 | +288,000 | 0.87 | 1.03 | +0.16 | buy |
| TWO SIGMA INVESTMENTS, LP | 439,453 | 597,142 | +157,689 | 0.04 | 0.04 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 90,184 | 226,341 | +136,157 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 112,199 | +112,199 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 175,668 | 284,939 | +109,271 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 437,112 | 546,318 | +109,206 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 390,565 | 498,221 | +107,656 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,224 | 92,257 | +91,033 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 600,954 | 676,631 | +75,677 | 0.02 | 0.02 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 65,539 | +65,539 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 193,179 | 247,300 | +54,121 | 0.05 | 0.05 | +0.00 | buy |
| Bellevue Group AG | 1,154,654 | 1,205,464 | +50,810 | 0.64 | 0.61 | -0.03 | buy |
| TD ASSET MANAGEMENT INC | 264,896 | 312,952 | +48,056 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 132,613 | 172,067 | +39,454 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 13,199 | 43,719 | +30,520 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 23,778 | 54,060 | +30,282 | 0.49 | 0.79 | +0.30 | buy |
| STATE STREET CORP | 46,774 | 76,671 | +29,897 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 397,463 | 427,152 | +29,689 | 0.03 | 0.03 | -0.00 | buy |
| Crossmark Global Holdings, Inc. | 0 | 27,803 | +27,803 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 23,755 | +23,755 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 4,812,604 | 4,836,040 | +23,436 | 0.01 | 0.01 | -0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 18,922 | +18,922 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 18,288 | +18,288 | 0.00 | 0.02 | +0.02 | buy |
| Alpha DNA Investment Management LLC | 0 | 13,213 | +13,213 | 0.00 | 0.22 | +0.22 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 13,039 | +13,039 | 0.00 | 0.03 | +0.03 | buy |
| Bridgefront Capital, LLC | 0 | 8,707 | +8,707 | 0.00 | 0.10 | +0.10 | buy |
| Connective Portfolio Management, LLC | 0 | 7,000 | +7,000 | 0.00 | 2.03 | +2.03 | buy |
| XTX Topco Ltd | 8,943 | 15,459 | +6,516 | 0.03 | 0.04 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 6,479 | +6,479 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 882 | 7,230 | +6,348 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 9,733 | 16,032 | +6,299 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 6,258 | 11,345 | +5,087 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 7,211 | 10,368 | +3,157 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,380 | 7,433 | +3,053 | 0.02 | 0.03 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 70,571 | 72,980 | +2,409 | 0.00 | 0.00 | -0.00 | buy |
| ASSETMARK, INC | 28,677 | 30,555 | +1,878 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 3,614 | 5,075 | +1,461 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 81,782 | 83,055 | +1,273 | 0.00 | 0.00 | -0.00 | buy |
| Pier Capital, LLC | 81,306 | 82,480 | +1,174 | 0.41 | 0.36 | -0.05 | buy |
| SIMPLEX TRADING, LLC | 0 | 871 | +871 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 860 | +860 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 274,038 | 274,681 | +643 | 0.09 | 0.07 | -0.02 | buy |
| NEOS Investment Management LLC | 9,454 | 10,092 | +638 | 0.01 | 0.01 | -0.00 | buy |
| Coppell Advisory Solutions LLC | 0 | 617 | +617 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 44,455 | 44,970 | +515 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,071 | 1,377 | +306 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 38,060 | 38,350 | +290 | 0.01 | 0.01 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,113 | 1,398 | +285 | 0.00 | 0.00 | +0.00 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 0 | 269 | +269 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 158 | 423 | +265 | 0.00 | 0.00 | +0.00 | buy |
| Snowden Capital Advisors LLC | 7,632 | 7,811 | +179 | 0.01 | 0.01 | -0.00 | buy |
| Blue Trust, Inc. | 78 | 236 | +158 | 0.00 | 0.00 | +0.00 | buy |
| WOLFF WIESE MAGANA LLC | 0 | 94 | +94 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 355 | 415 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Elequin Capital, LP | 0 | 43 | +43 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 27 | 67 | +40 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 95,012 | 95,040 | +28 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 935 | 962 | +27 | 0.00 | 0.00 | -0.00 | buy |
| CI INVESTMENTS INC. | 1,293 | 1,303 | +10 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 1,261,684 | 1,261,684 | 0 | 1.34 | 1.12 | -0.23 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 18,550 | 18,550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,515,318 | 1,515,318 | 0 | 0.66 | 0.49 | -0.17 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 55 | 55 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.56 | 2.19 | -0.36 | hold |
| VIRTUS ADVISERS, LLC | 8,298 | 8,298 | 0 | 0.14 | 0.12 | -0.02 | hold |
| First Horizon Advisors, Inc. | 607 | 607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rhenman & Partners Asset Management AB | 58,278 | 58,278 | 0 | 0.19 | 0.15 | -0.04 | hold |
| Parallel Advisors, LLC | 997 | 997 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 167 | 167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Robertson Stephens Wealth Management, LLC | 11,030 | 11,030 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Avidity Partners Management LP | 200,000 | 200,000 | 0 | 0.29 | 0.32 | +0.03 | hold |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.28 | 0.28 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 108,762 | 108,762 | 0 | 0.17 | 0.14 | -0.04 | hold |
| Park Place Capital Corp | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 348 | 348 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 248 | 244 | -4 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 81 | 72 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Bell Investment Advisors, Inc | 27 | 14 | -13 | 0.00 | 0.00 | -0.00 | sell |
| CVA Family Office, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 35,142 | 35,072 | -70 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 99 | 0 | -99 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 8,163 | 8,045 | -118 | 0.00 | 0.00 | -0.00 | sell |
| Ashton Thomas Private Wealth, LLC | 168 | 0 | -168 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 3,035 | 2,838 | -197 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 1,527 | 1,111 | -416 | 0.00 | 0.00 | -0.00 | sell |
| Navera Investment Management Ltd. | 575 | 0 | -575 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 22,622 | 22,010 | -612 | 0.04 | 0.03 | -0.01 | sell |