| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 7,067,659 | 7,063,896 | -3,763 | 0.14 | 0.16 | +0.02 | sell |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.18 | 2.18 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 4,213,575 | 4,780,889 | +567,314 | 0.02 | 0.03 | +0.01 | buy |
| FMR LLC | 4,855,772 | 4,420,403 | -435,369 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,771,474 | 3,754,560 | -16,914 | 0.09 | 0.10 | +0.01 | sell |
| Bellevue Group AG | 2,441,830 | 2,796,803 | +354,973 | 1.69 | 2.11 | +0.42 | buy |
| BAKER BROS. ADVISORS LP | 2,322,656 | 2,322,656 | 0 | 0.71 | 0.61 | -0.10 | hold |
| TANG CAPITAL MANAGEMENT LLC | 2,105,608 | 2,305,608 | +200,000 | 3.34 | 3.22 | -0.12 | buy |
| Deep Track Capital, LP | 1,800,000 | 1,800,000 | 0 | 1.82 | 1.82 | +0.01 | hold |
| BVF INC/IL | 1,024,288 | 1,574,288 | +550,000 | 1.15 | 2.32 | +1.17 | buy |
| MILLENNIUM MANAGEMENT LLC | 276,502 | 1,265,965 | +989,463 | 0.01 | 0.04 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,005,592 | 1,016,771 | +11,179 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 976,267 | 1,009,267 | +33,000 | 3.30 | 2.73 | -0.57 | buy |
| Logos Global Management LP | 575,000 | 850,000 | +275,000 | 2.41 | 3.05 | +0.64 | buy |
| ARMISTICE CAPITAL, LLC | 678,000 | 824,000 | +146,000 | 0.81 | 0.94 | +0.13 | buy |
| Fiera Capital Corp | 813,074 | 795,157 | -17,917 | 0.09 | 0.09 | +0.01 | sell |
| Point72 Asset Management, L.P. | 820,425 | 535,831 | -284,594 | 0.06 | 0.04 | -0.02 | sell |
| Caption Management, LLC | 179,503 | 463,662 | +284,159 | 0.52 | 0.98 | +0.46 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 445,767 | 442,398 | -3,369 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 454,919 | 411,409 | -43,510 | 0.01 | 0.01 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 384,782 | 384,782 | 0 | 0.48 | 0.42 | -0.06 | hold |
| Hudson Bay Capital Management LP | 345,952 | 333,558 | -12,394 | 0.07 | 0.07 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 512,430 | 330,000 | -182,430 | 0.03 | 0.02 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 286,264 | 288,860 | +2,596 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 134,779 | 269,729 | +134,950 | 0.02 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 237,879 | 269,204 | +31,325 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 221,379 | 245,205 | +23,826 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 634,501 | 225,310 | -409,191 | 0.01 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 433,065 | 220,696 | -212,369 | 0.02 | 0.01 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 193,200 | 211,825 | +18,625 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 202,806 | 211,140 | +8,334 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 246,498 | 207,438 | -39,060 | 0.04 | 0.04 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 90,798 | 199,497 | +108,699 | 0.01 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 222,052 | 142,770 | -79,282 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 123,239 | 125,756 | +2,517 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 104,384 | 124,384 | +20,000 | 2.04 | 3.15 | +1.11 | buy |
| MARSHALL WACE, LLP | 146,610 | 123,242 | -23,368 | 0.01 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 109,849 | 109,849 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 106,862 | 107,043 | +181 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 19,289 | 100,580 | +81,291 | 0.01 | 0.04 | +0.03 | buy |
| STATE STREET CORP | 82,142 | 91,233 | +9,091 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 80,761 | 83,681 | +2,920 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,738 | 78,877 | -3,861 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 61,646 | 71,030 | +9,384 | 0.03 | 0.04 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 142,757 | 68,572 | -74,185 | 0.05 | 0.04 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 66,780 | 62,662 | -4,118 | 0.08 | 0.08 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 63,287 | 60,435 | -2,852 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 44,956 | 58,977 | +14,021 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.36 | 0.44 | +0.08 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 52,001 | 45,969 | -6,032 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 46,566 | 45,657 | -909 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 51,663 | 45,331 | -6,332 | 0.04 | 0.04 | -0.00 | sell |
| CITADEL ADVISORS LLC | 204,217 | 42,198 | -162,019 | 0.01 | 0.00 | -0.00 | sell |
| UBS Group AG | 22,552 | 41,234 | +18,682 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 182,179 | 40,270 | -141,909 | 0.01 | 0.00 | -0.01 | sell |
| Eschler Asset Management LLP | 40,000 | 40,000 | 0 | 0.95 | 1.08 | +0.13 | hold |
| Crossmark Global Holdings, Inc. | 36,345 | 36,348 | +3 | 0.02 | 0.02 | +0.00 | buy |
| SEI INVESTMENTS CO | 31,334 | 34,985 | +3,651 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 34,958 | 34,069 | -889 | 0.00 | 0.00 | +0.00 | sell |
| Persistent Asset Partners Ltd | 24,038 | 28,615 | +4,577 | 0.66 | 0.75 | +0.09 | buy |
| Rhenman & Partners Asset Management AB | 28,278 | 28,278 | 0 | 0.11 | 0.11 | +0.00 | hold |
| State of New Jersey Common Pension Fund D | 9,295 | 25,886 | +16,591 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 25,163 | +25,163 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 27,076 | 24,339 | -2,737 | 0.00 | 0.00 | +0.00 | sell |
| Orion Porfolio Solutions, LLC | 23,965 | 23,276 | -689 | 0.01 | 0.01 | +0.00 | sell |
| NEOS Investment Management LLC | 22,206 | 21,370 | -836 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 22,206 | 21,370 | -836 | 0.19 | 0.06 | -0.12 | sell |
| TUDOR INVESTMENT CORP ET AL | 21,139 | 21,139 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 14,760 | 20,864 | +6,104 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 19,922 | +19,922 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 38,176 | 19,737 | -18,439 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 14,975 | 19,013 | +4,038 | 0.01 | 0.01 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 17,200 | 17,200 | 0 | 0.00 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STIFEL FINANCIAL CORP | 16,830 | 13,986 | -2,844 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 14,696 | 13,125 | -1,571 | 0.01 | 0.02 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 12,472 | 12,472 | 0 | 0.13 | 0.13 | -0.00 | hold |
| OXFORD ASSET MANAGEMENT LLP | 21,058 | 11,354 | -9,704 | 0.22 | 0.14 | -0.08 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 10,538 | +10,538 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 10,193 | +10,193 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 15,044 | 8,796 | -6,248 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 0 | 8,243 | +8,243 | 0.00 | 0.13 | +0.13 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 0 | 8,180 | +8,180 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 7,628 | 8,116 | +488 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 3,267 | 7,592 | +4,325 | 0.00 | 0.00 | +0.00 | buy |
| Snowden Capital Advisors LLC | 7,674 | 7,548 | -126 | 0.01 | 0.01 | +0.00 | sell |
| EntryPoint Capital, LLC | 0 | 7,321 | +7,321 | 0.00 | 0.10 | +0.10 | buy |
| China Universal Asset Management Co., Ltd. | 7,982 | 7,021 | -961 | 0.02 | 0.02 | -0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 7,035 | 6,934 | -101 | 0.00 | 0.00 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 88,887 | 6,839 | -82,048 | 0.00 | 0.00 | -0.00 | sell |
| Robertson Stephens Wealth Management, LLC | 0 | 6,030 | +6,030 | 0.00 | 0.01 | +0.01 | buy |
| JT Stratford LLC | 0 | 5,782 | +5,782 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 4,121 | +4,121 | 0.00 | 0.02 | +0.02 | buy |
| OSAIC HOLDINGS, INC. | 3,148 | 3,295 | +147 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 2,663 | 3,205 | +542 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 2,782 | 2,776 | -6 | 0.00 | 0.00 | +0.00 | sell |
| JTC Employer Solutions Trustee Ltd | 2,658 | 2,658 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 0 | 2,090 | +2,090 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 2,022 | +2,022 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 2,176 | 1,771 | -405 | 0.00 | 0.00 | -0.00 | sell |