| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 276,502 | 1,265,965 | +989,463 | 0.01 | 0.04 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,213,575 | 4,780,889 | +567,314 | 0.02 | 0.03 | +0.01 | buy |
| BVF INC/IL | 1,024,288 | 1,574,288 | +550,000 | 1.15 | 2.32 | +1.17 | buy |
| Bellevue Group AG | 2,441,830 | 2,796,803 | +354,973 | 1.69 | 2.11 | +0.42 | buy |
| Caption Management, LLC | 179,503 | 463,662 | +284,159 | 0.52 | 0.98 | +0.46 | buy |
| Logos Global Management LP | 575,000 | 850,000 | +275,000 | 2.41 | 3.05 | +0.64 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,105,608 | 2,305,608 | +200,000 | 3.34 | 3.22 | -0.12 | buy |
| ARMISTICE CAPITAL, LLC | 678,000 | 824,000 | +146,000 | 0.81 | 0.94 | +0.13 | buy |
| Candriam S.C.A. | 134,779 | 269,729 | +134,950 | 0.02 | 0.05 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 90,798 | 199,497 | +108,699 | 0.01 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 19,289 | 100,580 | +81,291 | 0.01 | 0.04 | +0.03 | buy |
| Kynam Capital Management, LP | 976,267 | 1,009,267 | +33,000 | 3.30 | 2.73 | -0.57 | buy |
| MORGAN STANLEY | 237,879 | 269,204 | +31,325 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 25,163 | +25,163 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 221,379 | 245,205 | +23,826 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 104,384 | 124,384 | +20,000 | 2.04 | 3.15 | +1.11 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 19,922 | +19,922 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 22,552 | 41,234 | +18,682 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 193,200 | 211,825 | +18,625 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 9,295 | 25,886 | +16,591 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 44,956 | 58,977 | +14,021 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,005,592 | 1,016,771 | +11,179 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 10,538 | +10,538 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 10,193 | +10,193 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 61,646 | 71,030 | +9,384 | 0.03 | 0.04 | +0.01 | buy |
| STATE STREET CORP | 82,142 | 91,233 | +9,091 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 202,806 | 211,140 | +8,334 | 0.01 | 0.01 | +0.00 | buy |
| R Squared Ltd | 0 | 8,243 | +8,243 | 0.00 | 0.13 | +0.13 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 0 | 8,180 | +8,180 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 7,321 | +7,321 | 0.00 | 0.10 | +0.10 | buy |
| Engineers Gate Manager LP | 14,760 | 20,864 | +6,104 | 0.01 | 0.01 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 0 | 6,030 | +6,030 | 0.00 | 0.01 | +0.01 | buy |
| JT Stratford LLC | 0 | 5,782 | +5,782 | 0.00 | 0.03 | +0.03 | buy |
| Persistent Asset Partners Ltd | 24,038 | 28,615 | +4,577 | 0.66 | 0.75 | +0.09 | buy |
| SG Americas Securities, LLC | 3,267 | 7,592 | +4,325 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 4,121 | +4,121 | 0.00 | 0.02 | +0.02 | buy |
| Quadrature Capital Ltd | 14,975 | 19,013 | +4,038 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 31,334 | 34,985 | +3,651 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 80,761 | 83,681 | +2,920 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 286,264 | 288,860 | +2,596 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 123,239 | 125,756 | +2,517 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 2,090 | +2,090 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 2,022 | +2,022 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 645 | +645 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,663 | 3,205 | +542 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 7,628 | 8,116 | +488 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 371 | +371 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 603 | 914 | +311 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 106,862 | 107,043 | +181 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,148 | 3,295 | +147 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 446 | 540 | +94 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 302 | 344 | +42 | 0.00 | 0.00 | -0.00 | buy |
| CVA Family Office, LLC | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,535 | 1,548 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Crossmark Global Holdings, Inc. | 36,345 | 36,348 | +3 | 0.02 | 0.02 | +0.00 | buy |
| PALISADE CAPITAL MANAGEMENT, LP | 0 | 0 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 0 | 0 | 0.47 | 0.41 | -0.05 | hold |
| GROUPAMA ASSET MANAGMENT | 0 | 0 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 109,849 | 109,849 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADVENT CAPITAL MANAGEMENT /DE/ | 0 | 0 | 0 | 0.00 | 0.04 | +0.04 | hold |
| WEBSTER BANK, N. A. | 51 | 51 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 116 | 116 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 2,322,656 | 2,322,656 | 0 | 0.71 | 0.61 | -0.10 | hold |
| LINDEN ADVISORS LP | 0 | 0 | 0 | 0.45 | 0.54 | +0.09 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.25 | 0.03 | -0.23 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 2.31 | 1.96 | -0.35 | hold |
| SG Americas Securities, LLC | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nicholas Investment Partners, LP | 0 | 0 | 0 | 0.15 | 0.13 | -0.01 | hold |
| Kohlberg Kravis Roberts & Co. L.P. | 0 | 0 | 0 | 0.40 | 0.36 | -0.05 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 17,200 | 17,200 | 0 | 0.00 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.18 | 2.18 | +0.00 | hold |
| Wellesley Asset Management | 0 | 0 | 0 | 0.27 | 0.33 | +0.06 | hold |
| J.Safra Asset Management Corp | 75 | 75 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lowe Wealth Advisors, LLC | 330 | 330 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alpine Global Management, LLC | 0 | 0 | 0 | 0.00 | 0.33 | +0.33 | hold |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 0 | 0 | 0.00 | 0.25 | +0.25 | hold |
| Rhenman & Partners Asset Management AB | 28,278 | 28,278 | 0 | 0.11 | 0.11 | +0.00 | hold |
| Russell Investments Group, Ltd. | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| M&G Plc | 0 | 0 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Polar Capital Holdings Plc | 0 | 0 | 0 | 0.00 | 0.05 | +0.05 | hold |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.36 | 0.44 | +0.08 | hold |
| Deep Track Capital, LP | 1,800,000 | 1,800,000 | 0 | 1.82 | 1.82 | +0.01 | hold |
| JTC Employer Solutions Trustee Ltd | 2,658 | 2,658 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Bell Investment Advisors, Inc | 39 | 39 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 384,782 | 384,782 | 0 | 0.48 | 0.42 | -0.06 | hold |
| READYSTATE ASSET MANAGEMENT LP | 0 | 0 | 0 | 0.56 | 0.55 | -0.01 | hold |
| Eschler Asset Management LLP | 40,000 | 40,000 | 0 | 0.95 | 1.08 | +0.13 | hold |
| BRAIDWELL LP | 0 | 0 | 0 | 0.80 | 0.18 | -0.61 | hold |
| Cape Investment Advisory, Inc. | 57 | 57 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 12,472 | 12,472 | 0 | 0.13 | 0.13 | -0.00 | hold |
| JPMORGAN CHASE & CO | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Park Place Capital Corp | 26 | 26 | 0 | 0.00 | 0.00 | +0.00 | hold |