| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 19,850 | 976,054 | +956,204 | 0.02 | 1.02 | +1.00 | buy |
| Polar Capital Holdings Plc | 250,000 | 501,300 | +251,300 | 0.10 | 0.21 | +0.11 | buy |
| Fiera Capital Corp | 679,799 | 846,787 | +166,988 | 0.11 | 0.18 | +0.06 | buy |
| Paradigm Biocapital Advisors LP | 1,384,686 | 1,453,883 | +69,197 | 4.90 | 4.66 | -0.25 | buy |
| Eschler Asset Management LLP | 30,000 | 40,000 | +10,000 | 1.82 | 2.17 | +0.35 | buy |
| China Universal Asset Management Co., Ltd. | 836 | 3,900 | +3,064 | 0.01 | 0.05 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 290,917 | 293,000 | +2,083 | 2.75 | 3.41 | +0.66 | buy |
| FRED ALGER MANAGEMENT, LLC | 4,205 | 6,207 | +2,002 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 39,804 | 41,627 | +1,823 | 0.96 | 1.03 | +0.08 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 312,347 | 312,608 | +261 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,265 | 5,104 | -161 | 0.17 | 0.22 | +0.06 | sell |
| Pier Capital, LLC | 87,422 | 86,202 | -1,220 | 0.73 | 0.84 | +0.11 | sell |
| ALPS ADVISORS INC | 36,168 | 33,390 | -2,778 | 0.02 | 0.02 | +0.00 | sell |
| Artisan Partners Limited Partnership | 129,649 | 126,610 | -3,039 | 0.01 | 0.01 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 89,278 | 84,278 | -5,000 | 0.50 | 0.58 | +0.08 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 8,069 | 2,950 | -5,119 | 0.08 | 0.04 | -0.04 | sell |
| Zimmer Partners, LP | 35,600 | 14,900 | -20,700 | 0.05 | 0.04 | -0.01 | sell |
| Avidity Partners Management LP | 348,200 | 300,200 | -48,000 | 0.73 | 0.78 | +0.06 | sell |
| Logos Global Management LP | 450,000 | 400,000 | -50,000 | 3.33 | 3.04 | -0.29 | sell |
| ARMISTICE CAPITAL, LLC | 400,000 | 312,000 | -88,000 | 0.32 | 0.29 | -0.03 | sell |
| Candriam S.C.A. | 293,011 | 144,006 | -149,005 | 0.11 | 0.07 | -0.04 | sell |
| Rock Springs Capital Management LP | 2,943,710 | 2,661,507 | -282,203 | 4.09 | 4.48 | +0.38 | sell |
| BRAIDWELL LP | 906,973 | 611,365 | -295,608 | 1.49 | 1.53 | +0.05 | sell |
| Nicholas Investment Partners, LP | 512,855 | 52,159 | -460,696 | 1.99 | 0.42 | -1.57 | sell |