| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 19,850 | 976,054 | +956,204 | 0.02 | 1.02 | +1.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,521,284 | 2,944,574 | +423,290 | 0.02 | 0.03 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,913,410 | 4,312,611 | +399,201 | 0.04 | 0.05 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 374,561 | +374,561 | 0.00 | 0.02 | +0.02 | buy |
| Polar Capital Holdings Plc | 250,000 | 501,300 | +251,300 | 0.10 | 0.21 | +0.11 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 183,545 | +183,545 | 0.00 | 0.03 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 176,332 | +176,332 | 0.00 | 0.01 | +0.01 | buy |
| Fiera Capital Corp | 679,799 | 846,787 | +166,988 | 0.11 | 0.18 | +0.06 | buy |
| Woodline Partners LP | 0 | 100,328 | +100,328 | 0.00 | 0.07 | +0.07 | buy |
| Robeco Institutional Asset Management B.V. | 0 | 74,127 | +74,127 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 1,384,686 | 1,453,883 | +69,197 | 4.90 | 4.66 | -0.25 | buy |
| CITADEL ADVISORS LLC | 171,572 | 240,356 | +68,784 | 0.01 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 64,419 | +64,419 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 56,115 | 119,265 | +63,150 | 0.00 | 0.01 | +0.01 | buy |
| Eagle Health Investments LP | 0 | 46,300 | +46,300 | 0.00 | 0.64 | +0.64 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 198,641 | 244,439 | +45,798 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 301,920 | 346,930 | +45,010 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 64,782 | 101,082 | +36,300 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 126,162 | 157,082 | +30,920 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 19,230 | +19,230 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 113,487 | 132,491 | +19,004 | 0.00 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 16,837 | +16,837 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 28,555 | 44,900 | +16,345 | 0.06 | 0.10 | +0.04 | buy |
| JANE STREET GROUP, LLC | 44,449 | 60,792 | +16,343 | 0.00 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 54,269 | 68,574 | +14,305 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 82,785 | 96,785 | +14,000 | 0.01 | 0.01 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 13,754 | +13,754 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 70,445 | 84,143 | +13,698 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 12,384 | +12,384 | 0.00 | 0.05 | +0.05 | buy |
| Eschler Asset Management LLP | 30,000 | 40,000 | +10,000 | 1.82 | 2.17 | +0.35 | buy |
| TWO SIGMA INVESTMENTS, LP | 152,093 | 161,957 | +9,864 | 0.02 | 0.03 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 54,093 | 63,825 | +9,732 | 0.01 | 0.02 | +0.00 | buy |
| ROYAL BANK OF CANADA | 33,257 | 42,224 | +8,967 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 27,686 | 36,295 | +8,609 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 13,282 | 20,921 | +7,639 | 0.01 | 0.01 | +0.00 | buy |
| ASSETMARK, INC | 11,011 | 17,980 | +6,969 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 6,849 | 12,569 | +5,720 | 0.00 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 11,600 | 15,800 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 3,828 | +3,828 | 0.00 | 0.02 | +0.02 | buy |
| STIFEL FINANCIAL CORP | 14,462 | 18,238 | +3,776 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 12,529 | 16,152 | +3,623 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 3,371 | +3,371 | 0.00 | 0.14 | +0.14 | buy |
| China Universal Asset Management Co., Ltd. | 836 | 3,900 | +3,064 | 0.01 | 0.05 | +0.04 | buy |
| Integrated Wealth Concepts LLC | 0 | 2,957 | +2,957 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 290,917 | 293,000 | +2,083 | 2.84 | 3.41 | +0.57 | buy |
| FRED ALGER MANAGEMENT, LLC | 4,205 | 6,207 | +2,002 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 39,804 | 41,627 | +1,823 | 0.96 | 1.03 | +0.08 | buy |
| Trexquant Investment LP | 26,799 | 28,545 | +1,746 | 0.03 | 0.04 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 24,390 | 26,029 | +1,639 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 42,366 | 43,526 | +1,160 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,991 | 4,139 | +1,148 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 4,331 | 5,290 | +959 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 7,491 | 8,251 | +760 | 0.01 | 0.01 | +0.00 | buy |
| IFP Advisors, Inc | 2,397 | 3,079 | +682 | 0.01 | 0.01 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 1,982 | 2,656 | +674 | 0.00 | 0.00 | +0.00 | buy |
| Snowden Capital Advisors LLC | 7,248 | 7,537 | +289 | 0.02 | 0.02 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 312,347 | 312,608 | +261 | 0.01 | 0.01 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 492 | 607 | +115 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 104 | 138 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 47 | 58 | +11 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 46 | 56 | +10 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 950,000 | 950,000 | 0 | 0.76 | 0.93 | +0.17 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 405,600 | 405,600 | 0 | 2.97 | 2.56 | -0.41 | hold |
| BAKER BROS. ADVISORS LP | 2,520,731 | 2,520,731 | 0 | 0.75 | 1.96 | +1.21 | hold |
| Dalton Investments, Inc. | 10,000 | 10,000 | 0 | 0.40 | 0.45 | +0.05 | hold |
| Parkside Financial Bank & Trust | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 6,096,387 | 6,096,387 | 0 | 6.68 | 6.51 | -0.17 | hold |
| Parallel Advisors, LLC | 950 | 950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Robertson Stephens Wealth Management, LLC | 13,780 | 13,780 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Navera Investment Management Ltd. | 575 | 575 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 3,908 | 3,908 | 0 | 0.02 | 0.02 | +0.01 | hold |
| BIT Capital GmbH | 4,003 | 4,003 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Larson Financial Group LLC | 13 | 10 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Park Place Capital Corp | 17 | 0 | -17 | 0.00 | 0.00 | -0.00 | sell |
| Bell Investment Advisors, Inc | 41 | 18 | -23 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 273 | 243 | -30 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 321 | 259 | -62 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 2,763 | 2,680 | -83 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 23,742 | 23,642 | -100 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,265 | 5,104 | -161 | 0.17 | 0.22 | +0.06 | sell |
| Beacon Capital Management, LLC | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Pier Capital, LLC | 87,422 | 86,202 | -1,220 | 0.73 | 0.84 | +0.11 | sell |
| UBS Group AG | 1,478 | 0 | -1,478 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 107,262 | 105,685 | -1,577 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 1,793 | 0 | -1,793 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 97,227 | 94,929 | -2,298 | 0.02 | 0.02 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 485,886 | 483,336 | -2,550 | 0.02 | 0.02 | +0.00 | sell |
| ALPS ADVISORS INC | 36,168 | 33,390 | -2,778 | 0.02 | 0.02 | +0.00 | sell |
| Artisan Partners Limited Partnership | 129,649 | 126,610 | -3,039 | 0.01 | 0.01 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,388 | 311 | -3,077 | 0.01 | 0.00 | -0.01 | sell |
| Orion Porfolio Solutions, LLC | 20,549 | 17,301 | -3,248 | 0.01 | 0.01 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 215,925 | 211,831 | -4,094 | 0.03 | 0.03 | +0.00 | sell |