| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 6,499,835 | 6,700,208 | +200,373 | 0.12 | 0.12 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,048,833 | 6,617,055 | -431,778 | 0.04 | 0.04 | -0.00 | sell |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.19 | 2.17 | -0.02 | hold |
| FMR LLC | 4,836,040 | 4,817,699 | -18,341 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,472,020 | 2,668,550 | +196,530 | 0.06 | 0.06 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,157,698 | 2,187,530 | +29,832 | 0.01 | 0.01 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,105,600 | 1,555,600 | +450,000 | 2.46 | 3.04 | +0.58 | buy |
| BAKER BROS. ADVISORS LP | 1,515,318 | 1,515,318 | 0 | 0.49 | 0.48 | -0.01 | hold |
| GENERAL ATLANTIC, L.P. | 1,261,684 | 1,261,684 | 0 | 1.12 | 1.32 | +0.21 | hold |
| Kynam Capital Management, LP | 0 | 1,225,576 | +1,225,576 | 0.00 | 2.38 | +2.38 | buy |
| Bellevue Group AG | 1,205,464 | 1,205,464 | 0 | 0.61 | 0.68 | +0.08 | hold |
| ARMISTICE CAPITAL, LLC | 1,264,000 | 1,200,000 | -64,000 | 1.03 | 0.82 | -0.21 | sell |
| Fiera Capital Corp | 845,732 | 779,964 | -65,768 | 0.08 | 0.07 | -0.01 | sell |
| CITIGROUP INC | 16,032 | 632,944 | +616,912 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 757,700 | 604,900 | -152,800 | 0.06 | 0.04 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 676,631 | 573,362 | -103,269 | 0.02 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 0 | 519,376 | +519,376 | 0.00 | 0.57 | +0.57 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 546,318 | 502,857 | -43,461 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 498,221 | 459,045 | -39,176 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 403,304 | +403,304 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 597,142 | 390,800 | -206,342 | 0.04 | 0.03 | -0.02 | sell |
| Woodline Partners LP | 274,681 | 328,059 | +53,378 | 0.07 | 0.07 | -0.01 | buy |
| Hudson Bay Capital Management LP | 247,300 | 325,300 | +78,000 | 0.05 | 0.06 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 312,952 | 317,476 | +4,524 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 873,611 | 272,780 | -600,831 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 202,806 | 202,806 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 193,115 | +193,115 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 284,939 | 189,577 | -95,362 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 165,000 | +165,000 | 0.00 | 0.05 | +0.05 | buy |
| BNP Paribas Asset Management Holding S.A. | 427,152 | 161,292 | -265,860 | 0.03 | 0.01 | -0.02 | sell |
| UBS Group AG | 43,719 | 140,706 | +96,987 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 116,712 | 136,875 | +20,163 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 140,006 | 134,785 | -5,221 | 0.03 | 0.02 | -0.00 | sell |
| MORGAN STANLEY | 404,825 | 130,641 | -274,184 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 107,391 | 114,151 | +6,760 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 501,755 | 114,023 | -387,732 | 0.07 | 0.02 | -0.06 | sell |
| Frazier Life Sciences Management, L.P. | 108,762 | 108,762 | 0 | 0.14 | 0.13 | -0.00 | hold |
| Cubist Systematic Strategies, LLC | 0 | 106,600 | +106,600 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 276,200 | 96,570 | -179,630 | 0.01 | 0.00 | -0.01 | sell |
| AXA S.A. | 95,040 | 94,886 | -154 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 172,067 | 91,385 | -80,682 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 76,671 | 77,265 | +594 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 59,108 | 75,670 | +16,562 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 83,055 | 71,935 | -11,120 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 72,068 | 69,954 | -2,114 | 0.01 | 0.01 | -0.00 | sell |
| BIT Capital GmbH | 24,000 | 67,840 | +43,840 | 0.07 | 0.18 | +0.10 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 72,980 | 66,524 | -6,456 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 65,539 | 65,539 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rhenman & Partners Asset Management AB | 58,278 | 58,278 | 0 | 0.15 | 0.18 | +0.03 | hold |
| Hennion & Walsh Asset Management, Inc. | 22,010 | 49,608 | +27,598 | 0.03 | 0.07 | +0.03 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.28 | 0.33 | +0.06 | hold |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 35,112 | 45,274 | +10,162 | 0.03 | 0.03 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 860 | 40,551 | +39,691 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 38,350 | 40,454 | +2,104 | 0.01 | 0.01 | -0.00 | buy |
| Crossmark Global Holdings, Inc. | 27,803 | 38,020 | +10,217 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 226,341 | 36,039 | -190,302 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 35,072 | 35,492 | +420 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 60,622 | 32,600 | -28,022 | 0.04 | 0.02 | -0.02 | sell |
| ASSETMARK, INC | 30,555 | 32,171 | +1,616 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 44,970 | 30,322 | -14,648 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 199,443 | 28,610 | -170,833 | 0.01 | 0.00 | -0.01 | sell |
| Crestline Management, LP | 0 | 24,960 | +24,960 | 0.00 | 0.03 | +0.03 | buy |
| Qube Research & Technologies Ltd | 191,541 | 23,015 | -168,526 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 962 | 20,625 | +19,663 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 15,459 | 18,896 | +3,437 | 0.04 | 0.05 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 19,395 | 17,200 | -2,195 | 0.01 | 0.01 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 18,251 | 15,721 | -2,530 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Orion Porfolio Solutions, LLC | 20,692 | 13,017 | -7,675 | 0.01 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 8,298 | 11,536 | +3,238 | 0.12 | 0.14 | +0.02 | buy |
| NEOS Investment Management LLC | 10,092 | 11,194 | +1,102 | 0.01 | 0.01 | -0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 11,030 | 11,030 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AIGEN INVESTMENT MANAGEMENT, LP | 16,471 | 10,704 | -5,767 | 0.10 | 0.06 | -0.04 | sell |
| DnB Asset Management AS | 10,368 | 10,298 | -70 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 8,800 | 8,827 | +27 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,433 | 8,393 | +960 | 0.03 | 0.02 | -0.00 | buy |
| Snowden Capital Advisors LLC | 7,811 | 7,673 | -138 | 0.01 | 0.01 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 7,230 | 7,367 | +137 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 5,075 | 5,075 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 4,538 | 3,648 | -890 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 2,838 | 2,934 | +96 | 0.00 | 0.00 | -0.00 | buy |
| JTC Employer Solutions Trustee Ltd | 2,658 | 2,658 | 0 | 0.01 | 0.01 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 1,377 | 1,705 | +328 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 10,900 | 1,400 | -9,500 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 871 | 1,350 | +479 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,398 | 1,319 | -79 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 997 | 1,006 | +9 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 962 | 686 | -276 | 0.00 | 0.00 | -0.00 | sell |
| First Horizon Advisors, Inc. | 607 | 607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 423 | 559 | +136 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 415 | 415 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 500 | 350 | -150 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 348 | 348 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 313 | 310 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 244 | 201 | -43 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 1,111 | 179 | -932 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 112 | +12 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 72 | 96 | +24 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |