| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 0 | 11,000,000 | +11,000,000 | 0.05 | 0.05 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,305,608 | 2,628,538 | +322,930 | 3.22 | 4.51 | +1.28 | buy |
| ARMISTICE CAPITAL, LLC | 824,000 | 1,098,000 | +274,000 | 0.44 | 0.45 | +0.01 | buy |
| Fiera Capital Corp | 795,157 | 1,044,831 | +249,674 | 0.09 | 0.12 | +0.02 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,754,560 | 3,961,880 | +207,320 | 0.10 | 0.10 | -0.00 | buy |
| Deep Track Capital, LP | 1,800,000 | 2,003,978 | +203,978 | 1.82 | 1.59 | -0.24 | buy |
| Rhenman & Partners Asset Management AB | 28,278 | 153,278 | +125,000 | 0.11 | 0.50 | +0.38 | buy |
| Eschler Asset Management LLP | 40,000 | 80,000 | +40,000 | 1.08 | 1.89 | +0.81 | buy |
| Susquehanna Portfolio Strategies, LLC | 10,538 | 27,607 | +17,069 | 0.01 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 7,021 | 15,109 | +8,088 | 0.02 | 0.04 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 12,472 | 18,569 | +6,097 | 0.13 | 0.18 | +0.05 | buy |
| DnB Asset Management AS | 8,116 | 13,066 | +4,950 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 21,370 | 22,599 | +1,229 | 0.01 | 0.00 | -0.00 | buy |
| R Squared Ltd | 8,243 | 8,849 | +606 | 0.13 | 0.14 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 862 | 857 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 28,615 | 27,932 | -683 | 0.75 | 0.47 | -0.29 | sell |
| Hennion & Walsh Asset Management, Inc. | 62,662 | 48,585 | -14,077 | 0.08 | 0.06 | -0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 442,398 | 407,404 | -34,994 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 124,384 | 70,300 | -54,084 | 3.15 | 1.45 | -1.69 | sell |
| BVF INC/IL | 1,574,288 | 1,488,975 | -85,313 | 2.32 | 1.69 | -0.63 | sell |
| Kynam Capital Management, LP | 1,009,267 | 856,462 | -152,805 | 2.73 | 1.94 | -0.79 | sell |
| T. Rowe Price Investment Management, Inc. | 7,063,896 | 5,961,227 | -1,102,669 | 0.16 | 0.13 | -0.03 | sell |