| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 0 | 11,000,000 | +11,000,000 | 0.05 | 0.05 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 7,063,896 | 5,961,227 | -1,102,669 | 0.16 | 0.13 | -0.03 | sell |
| RTW INVESTMENTS, LP | 4,869,798 | 4,869,798 | 0 | 2.18 | 1.69 | -0.49 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 4,780,889 | 4,693,643 | -87,246 | 0.03 | 0.03 | -0.00 | sell |
| FMR LLC | 4,420,403 | 4,539,225 | +118,822 | 0.01 | 0.01 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,754,560 | 3,961,880 | +207,320 | 0.10 | 0.10 | -0.00 | buy |
| Bellevue Group AG | 2,796,803 | 2,796,803 | 0 | 2.11 | 1.84 | -0.27 | hold |
| TANG CAPITAL MANAGEMENT LLC | 2,305,608 | 2,628,538 | +322,930 | 3.22 | 4.51 | +1.28 | buy |
| BAKER BROS. ADVISORS LP | 2,322,656 | 2,322,656 | 0 | 0.61 | 0.47 | -0.14 | hold |
| Deep Track Capital, LP | 1,800,000 | 2,003,978 | +203,978 | 1.82 | 1.59 | -0.24 | buy |
| BVF INC/IL | 1,574,288 | 1,488,975 | -85,313 | 2.32 | 1.69 | -0.63 | sell |
| ARMISTICE CAPITAL, LLC | 824,000 | 1,098,000 | +274,000 | 0.94 | 0.93 | -0.01 | buy |
| Fiera Capital Corp | 795,157 | 1,044,831 | +249,674 | 0.09 | 0.12 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,016,771 | 968,784 | -47,987 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,265,965 | 911,597 | -354,368 | 0.04 | 0.02 | -0.01 | sell |
| Kynam Capital Management, LP | 1,009,267 | 856,462 | -152,805 | 2.73 | 1.94 | -0.79 | sell |
| Logos Global Management LP | 850,000 | 850,000 | 0 | 3.05 | 1.97 | -1.08 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 411,409 | 658,436 | +247,027 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 585,000 | +585,000 | 0.00 | 0.74 | +0.74 | buy |
| Point72 Asset Management, L.P. | 535,831 | 504,151 | -31,680 | 0.04 | 0.03 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 199,497 | 461,830 | +262,333 | 0.01 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 454,404 | +454,404 | 0.00 | 0.01 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 442,398 | 407,404 | -34,994 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 384,782 | 384,782 | 0 | 0.42 | 0.36 | -0.06 | hold |
| Hudson Bay Capital Management LP | 333,558 | 383,558 | +50,000 | 0.07 | 0.08 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 220,696 | 359,293 | +138,597 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 245,205 | 329,099 | +83,894 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 330,000 | 322,300 | -7,700 | 0.02 | 0.02 | -0.00 | sell |
| Woodline Partners LP | 207,438 | 316,685 | +109,247 | 0.04 | 0.04 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 288,860 | 292,764 | +3,904 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 269,204 | 287,125 | +17,921 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 269,729 | 269,729 | 0 | 0.05 | 0.05 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 211,825 | 234,737 | +22,912 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 42,198 | 234,268 | +192,070 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 211,140 | 211,140 | 0 | 0.01 | 0.01 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 0 | 183,940 | +183,940 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 28,278 | 153,278 | +125,000 | 0.11 | 0.50 | +0.38 | buy |
| Legal & General Group Plc | 125,756 | 149,333 | +23,577 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 142,770 | 140,900 | -1,870 | 0.01 | 0.01 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 135,207 | +135,207 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 109,849 | 109,849 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 107,043 | 103,253 | -3,790 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 40,270 | 100,940 | +60,670 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 95,904 | +95,904 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 463,662 | 94,384 | -369,278 | 0.98 | 0.14 | -0.84 | sell |
| STATE STREET CORP | 91,233 | 93,556 | +2,323 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,877 | 85,169 | +6,292 | 0.00 | 0.00 | +0.00 | buy |
| Eschler Asset Management LLP | 40,000 | 80,000 | +40,000 | 1.08 | 1.89 | +0.81 | buy |
| WELLS FARGO & COMPANY/MN | 83,681 | 77,228 | -6,453 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 76,750 | +76,750 | 0.00 | 1.32 | +1.32 | buy |
| DIADEMA PARTNERS LP | 124,384 | 70,300 | -54,084 | 3.15 | 1.45 | -1.69 | sell |
| MARSHALL WACE, LLP | 123,242 | 61,163 | -62,079 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 71,030 | 61,150 | -9,880 | 0.04 | 0.03 | -0.01 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 60,435 | 55,190 | -5,245 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 34,985 | 50,337 | +15,352 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 62,662 | 48,585 | -14,077 | 0.08 | 0.06 | -0.02 | sell |
| Y-Intercept (Hong Kong) Ltd | 45,331 | 48,187 | +2,856 | 0.04 | 0.04 | -0.00 | buy |
| Eagle Health Investments LP | 46,300 | 46,300 | 0 | 0.44 | 0.35 | -0.09 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 45,969 | 43,026 | -2,943 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 45,657 | 42,486 | -3,171 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 42,000 | +42,000 | 0.00 | 0.35 | +0.35 | buy |
| ALPS ADVISORS INC | 24,339 | 41,487 | +17,148 | 0.00 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 19,013 | 38,608 | +19,595 | 0.01 | 0.01 | +0.01 | buy |
| Crossmark Global Holdings, Inc. | 36,348 | 36,406 | +58 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,193 | 35,188 | +24,995 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 33,579 | +33,579 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 32,998 | +32,998 | 0.00 | 0.29 | +0.29 | buy |
| HRT FINANCIAL LP | 8,796 | 32,596 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 58,977 | 32,390 | -26,587 | 0.00 | 0.00 | -0.00 | sell |
| ASSETMARK, INC | 34,069 | 31,676 | -2,393 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 28,164 | +28,164 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 28,615 | 27,932 | -683 | 0.75 | 0.47 | -0.29 | sell |
| State of New Jersey Common Pension Fund D | 25,886 | 27,663 | +1,777 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 19,922 | 27,648 | +7,726 | 0.01 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 10,538 | 27,607 | +17,069 | 0.01 | 0.01 | +0.01 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 25,163 | 25,163 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aquatic Capital Management LLC | 0 | 24,975 | +24,975 | 0.00 | 0.02 | +0.02 | buy |
| NEOS Investment Management LLC | 21,370 | 22,599 | +1,229 | 0.01 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 21,139 | 22,231 | +1,092 | 0.00 | 0.00 | -0.00 | buy |
| Orion Porfolio Solutions, LLC | 23,276 | 22,000 | -1,276 | 0.01 | 0.01 | -0.00 | sell |
| XTX Topco Ltd | 0 | 21,991 | +21,991 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 19,737 | 20,182 | +445 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 12,472 | 18,569 | +6,097 | 0.13 | 0.18 | +0.05 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 16,507 | +16,507 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 15,388 | +15,388 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,021 | 15,109 | +8,088 | 0.02 | 0.04 | +0.02 | buy |
| DekaBank Deutsche Girozentrale | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DnB Asset Management AS | 8,116 | 13,066 | +4,950 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 13,986 | 11,661 | -2,325 | 0.00 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 0 | 9,952 | +9,952 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 13,125 | 9,703 | -3,422 | 0.02 | 0.01 | -0.01 | sell |
| R Squared Ltd | 8,243 | 8,849 | +606 | 0.13 | 0.14 | +0.01 | buy |
| SG Americas Securities, LLC | 7,592 | 8,659 | +1,067 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 8,180 | 8,180 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Snowden Capital Advisors LLC | 7,548 | 6,970 | -578 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 225,310 | 6,900 | -218,410 | 0.01 | 0.00 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 6,839 | 6,839 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OPPENHEIMER ASSET MANAGEMENT INC. | 6,934 | 6,582 | -352 | 0.00 | 0.00 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,455 | +6,455 | 0.00 | 0.03 | +0.03 | buy |