| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 10,522,057 | 11,313,623 | +791,566 | 3.66 | 4.19 | +0.52 | buy |
| BlackRock, Inc. | 7,508,178 | 7,680,073 | +171,895 | 0.01 | 0.01 | -0.00 | buy |
| Orbis Allan Gray Ltd | 5,950,145 | 6,106,011 | +155,866 | 1.31 | 1.23 | -0.08 | buy |
| Capital World Investors | 0 | 4,725,037 | +4,725,037 | 0.00 | 0.03 | +0.03 | buy |
| Ghisallo Capital Management LLC | 0 | 4,000,000 | +4,000,000 | 0.00 | 0.11 | +0.11 | buy |
| STATE STREET CORP | 3,753,440 | 3,982,500 | +229,060 | 0.01 | 0.01 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,226,595 | 2,952,595 | -274,000 | 0.11 | 0.10 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,249,223 | 2,377,164 | +127,941 | 0.01 | 0.01 | -0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 2,038,763 | 2,038,763 | 0 | 15.14 | 10.59 | -4.54 | hold |
| FMR LLC | 1,953,957 | 1,954,694 | +737 | 0.01 | 0.00 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,958,111 | 1,853,875 | -104,236 | 0.06 | 0.06 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 1,958,111 | 1,853,875 | -104,236 | 1.19 | 1.25 | +0.06 | sell |
| UBS Group AG | 2,524,144 | 1,762,530 | -761,614 | 0.03 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 470,621 | 1,483,051 | +1,012,430 | 0.04 | 0.06 | +0.02 | buy |
| EcoR1 Capital, LLC | 1,389,276 | 1,389,276 | 0 | 3.33 | 2.82 | -0.50 | hold |
| Capital International Investors | 5,892,745 | 1,186,794 | -4,705,951 | 0.05 | 0.01 | -0.04 | sell |
| NEA Management Company, LLC | 1,058,570 | 1,058,570 | 0 | 2.83 | 2.86 | +0.03 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,030,182 | 1,039,349 | +9,167 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,096,887 | 983,072 | -113,815 | 0.00 | 0.00 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 899,331 | 968,135 | +68,804 | 0.06 | 0.06 | +0.01 | buy |
| NORTHERN TRUST CORP | 755,105 | 802,181 | +47,076 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 667,060 | 668,142 | +1,082 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 853,971 | 593,406 | -260,565 | 0.06 | 0.04 | -0.02 | sell |
| CITADEL ADVISORS LLC | 267,685 | 516,352 | +248,667 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 907,107 | 494,218 | -412,889 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 542,954 | 457,639 | -85,315 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 275,632 | 414,220 | +138,588 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 389,519 | 400,877 | +11,358 | 1.41 | 1.45 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,492 | 377,178 | +346,686 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 310,954 | 311,383 | +429 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 297,244 | 286,839 | -10,405 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 318,878 | 280,709 | -38,169 | 0.00 | 0.00 | -0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 249,548 | 256,779 | +7,231 | 0.18 | 0.14 | -0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 167,148 | 220,274 | +53,126 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 183,384 | 190,766 | +7,382 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 161,500 | 169,700 | +8,200 | 0.01 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 165,565 | 163,720 | -1,845 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 158,416 | 158,416 | 0 | 0.01 | 0.01 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 148,901 | 157,396 | +8,495 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 167,464 | 154,007 | -13,457 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 581,108 | 153,575 | -427,533 | 0.06 | 0.02 | -0.05 | sell |
| LPL Financial LLC | 170,831 | 152,042 | -18,789 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.42 | +0.42 | buy |
| Versant Venture Management, LLC | 148,831 | 148,831 | 0 | 5.17 | 5.01 | -0.16 | hold |
| ExodusPoint Capital Management, LP | 0 | 135,129 | +135,129 | 0.00 | 0.06 | +0.06 | buy |
| Marex Group plc | 127,546 | 134,097 | +6,551 | 0.07 | 0.07 | -0.01 | buy |
| Trexquant Investment LP | 0 | 127,181 | +127,181 | 0.00 | 0.04 | +0.04 | buy |
| Reynders McVeigh Capital Management, LLC | 116,514 | 123,438 | +6,924 | 0.29 | 0.30 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,021 | 120,488 | +102,467 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 2,850 | 116,847 | +113,997 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,104 | 116,107 | +3 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 118,778 | 114,822 | -3,956 | 0.01 | 0.00 | -0.00 | sell |
| PEAK6 LLC | 27,574 | 108,604 | +81,030 | 0.04 | 0.15 | +0.11 | buy |
| CONGRESS ASSET MANAGEMENT CO | 63,336 | 108,371 | +45,035 | 0.02 | 0.04 | +0.01 | buy |
| Jump Financial, LLC | 6,478 | 107,439 | +100,961 | 0.00 | 0.08 | +0.07 | buy |
| Private Advisor Group, LLC | 107,259 | 106,662 | -597 | 0.03 | 0.02 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 31,015 | 105,373 | +74,358 | 0.03 | 0.07 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 84,940 | 105,000 | +20,060 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Sarl | 94,769 | 102,278 | +7,509 | 0.08 | 0.08 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,123 | 101,232 | +23,109 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 102,850 | 96,820 | -6,030 | 0.08 | 0.07 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 96,357 | 96,357 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 93,954 | 96,001 | +2,047 | 0.15 | 0.15 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 95,770 | +95,770 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 89,708 | 94,716 | +5,008 | 0.01 | 0.01 | -0.00 | buy |
| Baker Chad R | 93,270 | 93,300 | +30 | 0.89 | 0.84 | -0.05 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 84,390 | 92,481 | +8,091 | 0.27 | 0.34 | +0.06 | buy |
| Slow Capital, Inc. | 76,630 | 91,223 | +14,593 | 0.48 | 0.56 | +0.08 | buy |
| Rafferty Asset Management, LLC | 101,014 | 90,336 | -10,678 | 0.02 | 0.02 | -0.00 | sell |
| Man Group plc | 8,589 | 90,061 | +81,472 | 0.00 | 0.01 | +0.01 | buy |
| EverSource Wealth Advisors, LLC | 57,465 | 89,683 | +32,218 | 0.11 | 0.13 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 32,039 | 86,029 | +53,990 | 0.00 | 0.01 | +0.01 | buy |
| VAN ECK ASSOCIATES CORP | 85,831 | 85,294 | -537 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 70,492 | 83,356 | +12,864 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 56,572 | 82,206 | +25,634 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 78,113 | 78,488 | +375 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 87,911 | 75,640 | -12,271 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 112,667 | 73,325 | -39,342 | 0.01 | 0.01 | -0.00 | sell |
| HRT FINANCIAL LP | 27,972 | 70,532 | +42,560 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 60,796 | 64,117 | +3,321 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 57,489 | 63,666 | +6,177 | 0.00 | 0.00 | -0.00 | buy |
| Concurrent Investment Advisors, LLC | 26,341 | 62,423 | +36,082 | 0.02 | 0.03 | +0.02 | buy |
| OSAIC HOLDINGS, INC. | 59,211 | 60,056 | +845 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 63,913 | 59,245 | -4,668 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 55,737 | 57,022 | +1,285 | 2.68 | 2.67 | -0.01 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 55,519 | 56,066 | +547 | 0.10 | 0.10 | -0.00 | buy |
| BENJAMIN EDWARDS INC | 54,636 | 55,506 | +870 | 0.03 | 0.03 | -0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,172 | 52,546 | +4,374 | 0.01 | 0.01 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 1.29 | +1.29 | buy |
| Curi Capital, LLC | 50,591 | 49,706 | -885 | 0.05 | 0.04 | -0.00 | sell |
| MetLife Investment Management, LLC | 48,011 | 49,636 | +1,625 | 0.01 | 0.01 | -0.00 | buy |
| Quantinno Capital Management LP | 6,726 | 47,989 | +41,263 | 0.00 | 0.00 | +0.00 | buy |
| Patriot Financial Group Insurance Agency, LLC | 23,234 | 47,550 | +24,316 | 0.15 | 0.13 | -0.02 | buy |
| Russell Investments Group, Ltd. | 30,444 | 47,448 | +17,004 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 50,246 | 47,065 | -3,181 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,530 | 43,777 | +2,247 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 39,468 | 43,411 | +3,943 | 0.01 | 0.01 | -0.00 | buy |
| Privium Fund Management B.V. | 42,874 | 42,874 | 0 | 0.41 | 0.42 | +0.01 | hold |
| PROFUND ADVISORS LLC | 38,110 | 41,009 | +2,899 | 0.06 | 0.07 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 34,774 | 40,274 | +5,500 | 0.00 | 0.00 | +0.00 | buy |