| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 7,837,074 | 7,865,253 | +28,179 | 0.11 | 0.09 | -0.02 | buy |
| ARK Investment Management LLC | 8,157,028 | 7,778,536 | -378,492 | 3.85 | 3.73 | -0.12 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 3,268,785 | 3,151,514 | -117,271 | 0.15 | 0.13 | -0.03 | sell |
| Nikko Asset Management Americas, Inc. | 3,268,785 | 3,151,514 | -117,271 | 2.21 | 1.96 | -0.25 | sell |
| T. Rowe Price Investment Management, Inc. | 2,704,331 | 2,730,652 | +26,321 | 0.11 | 0.09 | -0.02 | buy |
| STATE STREET CORP | 1,495,208 | 2,393,684 | +898,476 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 2,239,683 | 2,353,091 | +113,408 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 1,636,799 | 1,748,513 | +111,714 | 0.00 | 0.00 | -0.00 | buy |
| NEA Management Company, LLC | 1,587,854 | 1,587,854 | 0 | 11.20 | 6.45 | -4.75 | hold |
| EcoR1 Capital, LLC | 1,389,276 | 1,389,276 | 0 | 2.40 | 2.30 | -0.11 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 1,048,951 | 1,048,951 | 0 | 19.64 | 17.74 | -1.90 | hold |
| LOOMIS SAYLES & CO L P | 1,025,243 | 1,006,213 | -19,030 | 0.10 | 0.07 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 909,298 | 973,018 | +63,720 | 0.01 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 931,055 | 950,149 | +19,094 | 0.02 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 863,214 | 941,550 | +78,336 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 669,192 | 717,606 | +48,414 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,465 | 693,958 | +583,493 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 590,268 | 650,208 | +59,940 | 0.01 | 0.01 | -0.00 | buy |
| Bellevue Group AG | 619,950 | 617,649 | -2,301 | 0.64 | 0.54 | -0.10 | sell |
| MORGAN STANLEY | 1,085,924 | 597,679 | -488,245 | 0.01 | 0.00 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 530,000 | +530,000 | 0.00 | 0.17 | +0.17 | buy |
| Versant Venture Management, LLC | 498,558 | 498,558 | 0 | 32.95 | 34.84 | +1.89 | hold |
| FEDERATED HERMES, INC. | 447,606 | 447,606 | 0 | 0.07 | 0.06 | -0.01 | hold |
| UBS Group AG | 320,377 | 424,216 | +103,839 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 600,234 | 420,695 | -179,539 | 0.01 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 395,915 | 405,425 | +9,510 | 0.02 | 0.02 | -0.00 | buy |
| JANE STREET GROUP, LLC | 175,072 | 349,931 | +174,859 | 0.02 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 392,750 | 329,069 | -63,681 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 116,500 | 316,500 | +200,000 | 0.83 | 1.74 | +0.91 | buy |
| CAPITAL ADVISORS INC/OK | 263,986 | 278,006 | +14,020 | 0.39 | 0.31 | -0.08 | buy |
| Squarepoint Ops LLC | 274,030 | 268,823 | -5,207 | 0.08 | 0.05 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 132,697 | 265,347 | +132,650 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,238 | 260,821 | +187,583 | 0.01 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 243,278 | 233,411 | -9,867 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 216,394 | 227,599 | +11,205 | 0.00 | 0.00 | -0.00 | buy |
| Cutter Capital Management, LP | 120,185 | 201,497 | +81,312 | 3.16 | 3.32 | +0.16 | buy |
| ARMISTICE CAPITAL, LLC | 192,000 | 198,357 | +6,357 | 0.35 | 0.28 | -0.07 | buy |
| Vestmark Advisory Solutions, Inc. | 249,544 | 197,614 | -51,930 | 0.73 | 0.45 | -0.29 | sell |
| Pictet Asset Management Holding SA | 320,523 | 190,408 | -130,115 | 0.02 | 0.01 | -0.01 | sell |
| MARSHALL WACE, LLP | 0 | 186,591 | +186,591 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 123,574 | 182,561 | +58,987 | 0.03 | 0.04 | +0.01 | buy |
| Spear Holdings RSC Ltd | 165,000 | 165,000 | 0 | 1.95 | 6.29 | +4.34 | hold |
| AMERIPRISE FINANCIAL INC | 156,781 | 162,877 | +6,096 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 166,794 | 159,644 | -7,150 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 148,900 | 158,700 | +9,800 | 0.01 | 0.01 | -0.00 | buy |
| Integral Health Asset Management, LLC | 220,000 | 150,000 | -70,000 | 1.47 | 0.81 | -0.67 | sell |
| Capital International Sarl | 141,908 | 149,393 | +7,485 | 0.32 | 0.25 | -0.07 | buy |
| TWINBEECH CAPITAL LP | 0 | 146,473 | +146,473 | 0.00 | 0.16 | +0.16 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,729 | 143,140 | +35,411 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 237,100 | 142,562 | -94,538 | 0.02 | 0.01 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 148,942 | 136,333 | -12,609 | 0.01 | 0.01 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 147,890 | 134,969 | -12,921 | 0.03 | 0.02 | -0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 148,700 | 126,900 | -21,800 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 163,577 | 126,839 | -36,738 | 0.10 | 0.07 | -0.04 | sell |
| CAPITAL INTERNATIONAL LTD /CA/ | 126,770 | 126,131 | -639 | 0.41 | 0.31 | -0.10 | sell |
| LPL Financial LLC | 105,920 | 116,091 | +10,171 | 0.00 | 0.00 | -0.00 | buy |
| Reynders McVeigh Capital Management, LLC | 96,979 | 114,673 | +17,694 | 0.38 | 0.35 | -0.03 | buy |
| Capital International, Inc./CA/ | 91,661 | 102,178 | +10,517 | 0.08 | 0.07 | -0.01 | buy |
| Carnegie Investment Counsel | 67,612 | 102,112 | +34,500 | 0.14 | 0.17 | +0.03 | buy |
| Handelsbanken Fonder AB | 16,700 | 100,300 | +83,600 | 0.00 | 0.02 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 0 | 100,000 | +100,000 | 0.00 | 0.07 | +0.07 | buy |
| Baker Chad R | 98,520 | 98,520 | 0 | 1.43 | 1.11 | -0.32 | hold |
| Legal & General Group Plc | 82,910 | 94,092 | +11,182 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 79,120 | 94,027 | +14,907 | 0.02 | 0.01 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 90,664 | +90,664 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 91,051 | 88,401 | -2,650 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 84,775 | 86,403 | +1,628 | 0.00 | 0.00 | -0.00 | buy |
| VAN ECK ASSOCIATES CORP | 71,944 | 79,774 | +7,830 | 0.01 | 0.01 | -0.00 | buy |
| Slow Capital, Inc. | 67,569 | 79,216 | +11,647 | 0.74 | 0.69 | -0.05 | buy |
| Bank of New York Mellon Corp | 75,314 | 78,692 | +3,378 | 0.00 | 0.00 | -0.00 | buy |
| Private Advisor Group, LLC | 13,551 | 77,627 | +64,076 | 0.01 | 0.03 | +0.02 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 69,015 | 77,542 | +8,527 | 0.35 | 0.30 | -0.06 | buy |
| LAZARD ASSET MANAGEMENT LLC | 86,140 | 74,203 | -11,937 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,901 | 72,903 | +5,002 | 0.01 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 23,553 | 68,490 | +44,937 | 0.06 | 0.12 | +0.06 | buy |
| BARCLAYS PLC | 256,331 | 65,620 | -190,711 | 0.01 | 0.00 | -0.01 | sell |
| CONGRESS ASSET MANAGEMENT CO | 64,605 | 63,980 | -625 | 0.03 | 0.02 | -0.01 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 53,999 | 61,559 | +7,560 | 0.01 | 0.01 | -0.00 | buy |
| McGuire Investment Group, LLC | 57,988 | 57,870 | -118 | 0.58 | 0.45 | -0.13 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 54,721 | 55,271 | +550 | 0.01 | 0.01 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 49,968 | 53,353 | +3,385 | 0.02 | 0.02 | -0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 102,098 | 53,277 | -48,821 | 0.07 | 0.03 | -0.04 | sell |
| STIFEL FINANCIAL CORP | 59,432 | 50,412 | -9,020 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 17,406 | 50,060 | +32,654 | 0.11 | 0.26 | +0.14 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 31,172 | 47,223 | +16,051 | 0.00 | 0.01 | +0.00 | buy |
| GTS SECURITIES LLC | 19,277 | 41,211 | +21,934 | 0.04 | 0.05 | +0.01 | buy |
| Granite Bay Wealth Management, LLC | 0 | 41,096 | +41,096 | 0.00 | 0.08 | +0.08 | buy |
| DekaBank Deutsche Girozentrale | 40,745 | 40,745 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 41,317 | 40,646 | -671 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 42,573 | 39,665 | -2,908 | 0.00 | 0.00 | -0.00 | sell |
| Curi Capital, LLC | 34,314 | 39,118 | +4,804 | 0.05 | 0.05 | -0.00 | buy |
| CITIGROUP INC | 101,469 | 38,104 | -63,365 | 0.01 | 0.00 | -0.01 | sell |
| WESTWOOD HOLDINGS GROUP INC | 14,859 | 37,375 | +22,516 | 0.01 | 0.01 | +0.00 | buy |
| Del-Sette Capital Management, LLC | 0 | 36,841 | +36,841 | 0.00 | 1.63 | +1.63 | buy |
| B & T Capital Management DBA Alpha Capital Management | 44,246 | 36,636 | -7,610 | 0.59 | 0.39 | -0.20 | sell |
| Asset Management One Co., Ltd. | 27,100 | 35,986 | +8,886 | 0.01 | 0.01 | +0.00 | buy |
| West Family Investments, Inc. | 35,500 | 35,500 | 0 | 0.75 | 0.57 | -0.18 | hold |
| Hennion & Walsh Asset Management, Inc. | 16,876 | 35,001 | +18,125 | 0.06 | 0.10 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 34,774 | 34,774 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of New Jersey Common Pension Fund D | 44,755 | 34,538 | -10,217 | 0.01 | 0.01 | -0.00 | sell |