| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 4,994,728 | 5,945,488 | +950,760 | 2.38 | 0.99 | -1.39 | buy |
| Soleus Capital Management, L.P. | 2,534,565 | 4,354,501 | +1,819,936 | 3.28 | 1.77 | -1.51 | buy |
| MORGAN STANLEY | 3,459,453 | 4,227,634 | +768,181 | 0.01 | 0.00 | -0.00 | buy |
| Sands Capital Alternatives, LLC | 3,570,113 | 3,708,043 | +137,930 | 20.98 | 8.82 | -12.16 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,313,920 | 3,607,920 | -706,000 | 0.68 | 0.21 | -0.47 | sell |
| BlackRock, Inc. | 2,913,920 | 3,038,595 | +124,675 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 987,351 | 2,525,040 | +1,537,689 | 0.05 | 0.04 | -0.00 | buy |
| Vestal Point Capital, LP | 600,000 | 2,211,518 | +1,611,518 | 0.67 | 0.62 | -0.05 | buy |
| RTW INVESTMENTS, LP | 2,500,000 | 2,000,000 | -500,000 | 0.76 | 0.20 | -0.56 | sell |
| Eversept Partners, LP | 678,262 | 1,414,838 | +736,576 | 1.16 | 0.93 | -0.22 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 938,308 | 1,324,000 | +385,692 | 0.37 | 0.16 | -0.21 | buy |
| Omega Fund Management, LLC | 1,316,183 | 1,316,183 | 0 | 14.00 | 8.08 | -5.91 | hold |
| STATE STREET CORP | 863,133 | 946,087 | +82,954 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 921,464 | 932,678 | +11,214 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 945,461 | 860,866 | -84,595 | 0.02 | 0.01 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 602,944 | 842,944 | +240,000 | 0.34 | 0.17 | -0.17 | buy |
| UBS Group AG | 251,438 | 623,253 | +371,815 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 84,973 | 617,915 | +532,942 | 0.00 | 0.01 | +0.01 | buy |
| Bruce & Co., Inc. | 0 | 550,700 | +550,700 | 0.00 | 1.58 | +1.58 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1,327,100 | 546,132 | -780,968 | 0.07 | 0.01 | -0.06 | sell |
| Y-Intercept (Hong Kong) Ltd | 11,203 | 485,854 | +474,651 | 0.01 | 0.09 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 331,623 | 322,467 | -9,156 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 348,671 | 307,229 | -41,442 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 284,453 | 295,818 | +11,365 | 0.00 | 0.00 | -0.00 | buy |
| PURA VIDA INVESTMENTS, LLC | 281,250 | 281,250 | 0 | 32.03 | 18.94 | -13.09 | hold |
| Granahan Investment Management, LLC | 121,246 | 248,449 | +127,203 | 0.16 | 0.12 | -0.04 | buy |
| First Eagle Investment Management, LLC | 253,702 | 242,000 | -11,702 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 115,761 | 241,601 | +125,840 | 0.03 | 0.02 | -0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 259,632 | 218,094 | -41,538 | 0.04 | 0.01 | -0.03 | sell |
| RAYMOND JAMES FINANCIAL INC | 197,939 | 188,883 | -9,056 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGER MANAGEMENT, LLC | 0 | 163,124 | +163,124 | 0.00 | 1.28 | +1.28 | buy |
| Engineers Gate Manager LP | 8,247 | 136,343 | +128,096 | 0.00 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 432,340 | 136,215 | -296,125 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 405,408 | 121,334 | -284,074 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 37,374 | 114,719 | +77,345 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 99,783 | 98,804 | -979 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 85,379 | 85,928 | +549 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 86,504 | 85,800 | -704 | 0.03 | 0.01 | -0.02 | sell |
| Bellevue Group AG | 72,285 | 72,152 | -133 | 0.04 | 0.02 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 71,905 | +71,905 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,541 | 71,211 | +16,670 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 227,956 | 69,470 | -158,486 | 0.01 | 0.00 | -0.01 | sell |
| Quantinno Capital Management LP | 31,883 | 67,879 | +35,996 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 410,603 | 65,495 | -345,108 | 0.02 | 0.00 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 50,405 | 60,287 | +9,882 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 59,624 | +59,624 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 17,378 | 58,156 | +40,778 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 56,616 | +56,616 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 0 | 56,082 | +56,082 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 320,880 | 52,142 | -268,738 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 43,990 | 48,063 | +4,073 | 0.04 | 0.01 | -0.03 | buy |
| Values First Advisors, Inc. | 35,191 | 47,551 | +12,360 | 0.56 | 0.25 | -0.31 | buy |
| RHUMBLINE ADVISERS | 42,858 | 46,430 | +3,572 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 39,300 | 43,701 | +4,401 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 0 | 42,046 | +42,046 | 0.00 | 0.05 | +0.05 | buy |
| Quantbot Technologies LP | 89,405 | 41,295 | -48,110 | 0.09 | 0.02 | -0.07 | sell |
| Man Group plc | 11,321 | 39,267 | +27,946 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 39,157 | +39,157 | 0.00 | 0.02 | +0.02 | buy |
| DRW Securities, LLC | 0 | 36,735 | +36,735 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 532,749 | 35,472 | -497,277 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,400 | 35,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 6,698 | 31,988 | +25,290 | 0.00 | 0.00 | +0.00 | buy |
| Evanson Asset Management, LLC | 31,272 | 31,272 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Bridgefront Capital, LLC | 0 | 25,909 | +25,909 | 0.00 | 0.06 | +0.06 | buy |
| Verition Fund Management LLC | 82,862 | 25,427 | -57,435 | 0.01 | 0.00 | -0.01 | sell |
| Graham Capital Management, L.P. | 0 | 24,437 | +24,437 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,024 | 23,904 | +11,880 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 205,837 | 23,681 | -182,156 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 22,720 | 22,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 50,312 | 21,522 | -28,790 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 117,360 | 19,464 | -97,896 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 65,876 | 19,274 | -46,602 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 48,100 | 17,972 | -30,128 | 0.00 | 0.00 | -0.00 | sell |
| Gladstone Institutional Advisory LLC | 14,200 | 14,200 | 0 | 0.02 | 0.01 | -0.01 | hold |
| BANK OF MONTREAL /CAN/ | 12,861 | 13,522 | +661 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,200 | 12,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN ADVISORY INC | 11,946 | 11,946 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 49 WEALTH MANAGEMENT, LLC | 0 | 11,906 | +11,906 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,439 | 10,610 | -35,829 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 10,346 | 10,346 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bayesian Capital Management, LP | 0 | 10,017 | +10,017 | 0.00 | 0.12 | +0.12 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 201,892 | 8,495 | -193,397 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 60,664 | 7,344 | -53,320 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 6,534 | 6,036 | -498 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 3,430 | 5,514 | +2,084 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,202 | 3,202 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 17,111 | 3,199 | -13,912 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 2,024 | 3,003 | +979 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,474 | 2,991 | -4,483 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,397 | 2,107 | -290 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 1,944 | 2,013 | +69 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 381 | 1,489 | +1,108 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 625 | 1,300 | +675 | 0.00 | 0.00 | -0.00 | buy |
| Western Wealth Management, LLC | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 2,503 | 1,151 | -1,352 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 837 | 1,054 | +217 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 43 | 673 | +630 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 779 | 594 | -185 | 0.00 | 0.00 | -0.00 | sell |
| Larson Financial Group LLC | 277 | 557 | +280 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1,987 | 389 | -1,598 | 0.01 | 0.00 | -0.01 | sell |