| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,203,840 | 1,593,608 | +610,232 | 0.95 | 0.87 | 0.00 | sell |
| Sands Capital Alternatives, LLC | 3,103,782 | 3,570,113 | +466,331 | 9.29 | 10.24 | +0.95 | buy |
| Soleus Capital Management, L.P. | 3,395,341 | 3,820,158 | +424,817 | 3.26 | 3.84 | +0.58 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 882,277 | 1,159,737 | +277,460 | 0.10 | 0.14 | +0.03 | buy |
| LORD, ABBETT & CO. LLC | 228,160 | 419,398 | +191,238 | 0.01 | 0.02 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,016,000 | 1,168,415 | +152,415 | 0.25 | 0.31 | +0.06 | buy |
| Values First Advisors, Inc. | 37,585 | 42,563 | +4,978 | 0.27 | 0.34 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 4,928,019 | 4,932,351 | +4,332 | 1.20 | 1.26 | +0.06 | buy |
| RTW INVESTMENTS, LP | 3,299,870 | 3,299,191 | -679 | 0.62 | 0.68 | +0.07 | sell |
| SOROS FUND MANAGEMENT LLC | 25,968 | 25,000 | -968 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 932,128 | 925,363 | -6,765 | 0.16 | 0.24 | +0.09 | sell |
| JENNISON ASSOCIATES LLC | 67,611 | 59,185 | -8,426 | 0.00 | 0.00 | -0.00 | sell |
| Longaeva Partners L.P. | 275,825 | 196,607 | -79,218 | 1.91 | 0.58 | -1.33 | sell |
| Clearbridge Investments, LLC | 369,225 | 249,734 | -119,491 | 0.00 | 0.00 | -0.00 | sell |
| Holocene Advisors, LP | 1,107,812 | 770,851 | -336,961 | 0.04 | 0.03 | -0.01 | sell |
| PURA VIDA INVESTMENTS, LLC | 429,120 | 2,500 | -426,620 | 38.36 | 37.57 | -0.79 | sell |