| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 4,928,019 | 4,932,351 | +4,332 | 1.20 | 1.26 | +0.06 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,332,220 | 4,203,920 | +871,700 | 0.22 | 0.28 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,901,599 | 3,901,599 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Soleus Capital Management, L.P. | 3,395,341 | 3,820,158 | +424,817 | 3.26 | 3.84 | +0.58 | buy |
| Sands Capital Alternatives, LLC | 3,103,782 | 3,570,113 | +466,331 | 9.29 | 10.24 | +0.95 | buy |
| RTW INVESTMENTS, LP | 3,299,870 | 3,299,191 | -679 | 0.62 | 0.68 | +0.07 | sell |
| MORGAN STANLEY | 1,401,653 | 2,949,365 | +1,547,712 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 1,988,287 | 1,988,287 | 0 | 14.36 | 18.75 | +4.38 | hold |
| PERCEPTIVE ADVISORS LLC | 1,593,608 | 1,593,608 | 0 | 0.69 | 0.87 | +0.18 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,016,000 | 1,168,415 | +152,415 | 0.25 | 0.31 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 882,277 | 1,159,737 | +277,460 | 0.10 | 0.14 | +0.03 | buy |
| Divisadero Street Capital Management, LP | 0 | 948,965 | +948,965 | 0.00 | 0.92 | +0.92 | buy |
| ArrowMark Colorado Holdings LLC | 932,128 | 925,363 | -6,765 | 0.16 | 0.24 | +0.09 | sell |
| BlackRock, Inc. | 1,427,150 | 858,359 | -568,791 | 0.00 | 0.00 | -0.00 | sell |
| Holocene Advisors, LP | 1,107,812 | 770,851 | -336,961 | 0.04 | 0.03 | -0.01 | sell |
| VANGUARD GROUP INC | 709,255 | 706,968 | -2,287 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 665,653 | 665,653 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 673,658 | 614,965 | -58,693 | 0.01 | 0.01 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 550,000 | +550,000 | 0.00 | 0.42 | +0.42 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 542,198 | +542,198 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 946,350 | 539,963 | -406,387 | 0.01 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 500,000 | 500,000 | 0 | 0.10 | 0.12 | +0.02 | hold |
| LORD, ABBETT & CO. LLC | 228,160 | 419,398 | +191,238 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 636,204 | 317,943 | -318,261 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 306,017 | 312,930 | +6,913 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 58,422 | 311,001 | +252,579 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 369,225 | 249,734 | -119,491 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 0 | 244,202 | +244,202 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 105,972 | 229,995 | +124,023 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 148,105 | 218,189 | +70,084 | 0.02 | 0.03 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 216,349 | +216,349 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 275,825 | 196,607 | -79,218 | 1.91 | 0.69 | -1.22 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,097,263 | 193,325 | -903,938 | 0.00 | 0.00 | -0.00 | sell |
| First Turn Management, LLC | 0 | 157,194 | +157,194 | 0.00 | 0.43 | +0.43 | buy |
| Woodline Partners LP | 125,000 | 125,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 101,614 | 102,225 | +611 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 124,340 | 96,061 | -28,279 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 111,487 | 95,253 | -16,234 | 0.00 | 0.00 | -0.00 | sell |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 0 | 89,105 | +89,105 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 75,000 | 75,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 61,558 | 72,245 | +10,687 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 137,322 | 70,175 | -67,147 | 0.01 | 0.01 | -0.00 | sell |
| Bellevue Group AG | 66,825 | 66,825 | 0 | 0.02 | 0.02 | +0.00 | hold |
| JENNISON ASSOCIATES LLC | 67,611 | 59,185 | -8,426 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 55,433 | +55,433 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 50,000 | 50,000 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Verition Fund Management LLC | 27,217 | 45,476 | +18,259 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 37,585 | 42,563 | +4,978 | 0.27 | 0.34 | +0.07 | buy |
| TD ASSET MANAGEMENT INC | 39,876 | 39,876 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Evanson Asset Management, LLC | 38,772 | 38,772 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Palumbo Wealth Management LLC | 0 | 29,579 | +29,579 | 0.00 | 0.13 | +0.13 | buy |
| Bank of New York Mellon Corp | 25,793 | 27,353 | +1,560 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 25,968 | 25,000 | -968 | 0.01 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,353 | 23,558 | +2,205 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 17,425 | 22,680 | +5,255 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 20,751 | 21,296 | +545 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 54,025 | 20,771 | -33,254 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 0 | 19,770 | +19,770 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 12,880 | 18,439 | +5,559 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,318 | +18,318 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 17,044 | 17,044 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 16,500 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 11,817 | 16,485 | +4,668 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,883 | 16,377 | +9,494 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,464 | 16,296 | -168 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 15,820 | 15,020 | -800 | 0.00 | 0.00 | +0.00 | sell |
| Centiva Capital, LP | 20,131 | 14,546 | -5,585 | 0.01 | 0.01 | -0.00 | sell |
| Gladstone Institutional Advisory LLC | 0 | 14,200 | +14,200 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 12,079 | 13,659 | +1,580 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 8,370 | 8,370 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,772 | 7,460 | -312 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 6,260 | 6,170 | -90 | 0.00 | 0.00 | +0.00 | sell |
| Sandia Investment Management LP | 6,000 | 6,000 | 0 | 0.21 | 0.22 | +0.01 | hold |
| CITIGROUP INC | 9,339 | 4,605 | -4,734 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 0 | 4,011 | +4,011 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,337 | 3,976 | +2,639 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,751 | 2,751 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PURA VIDA INVESTMENTS, LLC | 429,120 | 2,500 | -426,620 | 38.36 | 37.57 | -0.79 | sell |
| Tower Research Capital LLC (TRC) | 1,097 | 2,384 | +1,287 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,700 | 1,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,115 | 1,515 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,339 | 1,339 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 720 | 1,228 | +508 | 0.00 | 0.00 | +0.00 | buy |
| GPS Wealth Strategies Group, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 0 | 872 | +872 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 560 | 869 | +309 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 830 | 830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 0 | 815 | +815 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 644 | 783 | +139 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 237 | 687 | +450 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New Hampshire | 0 | 680 | +680 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 625 | 625 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caitong International Asset Management Co., Ltd | 0 | 545 | +545 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 13 | 537 | +524 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 456 | 456 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 0 | 290 | +290 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 150 | 209 | +59 | 0.00 | 0.00 | +0.00 | buy |
| WPG Advisers, LLC | 28 | 186 | +158 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 106 | +106 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 74 | 92 | +18 | 0.00 | 0.00 | +0.00 | buy |