| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 5,945,488 | 6,253,673 | +308,185 | 0.99 | 1.31 | +0.33 | buy |
| Soleus Capital Management, L.P. | 4,354,501 | 4,393,714 | +39,213 | 1.77 | 2.37 | +0.61 | buy |
| MORGAN STANLEY | 4,227,634 | 4,266,822 | +39,188 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 3,708,043 | 3,708,043 | 0 | 8.82 | 9.47 | +0.65 | hold |
| BlackRock, Inc. | 3,038,595 | 3,340,171 | +301,576 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,525,040 | 2,254,683 | -270,357 | 0.04 | 0.05 | +0.01 | sell |
| Vestal Point Capital, LP | 2,211,518 | 1,600,000 | -611,518 | 0.62 | 0.59 | -0.03 | sell |
| RTW INVESTMENTS, LP | 2,000,000 | 1,500,000 | -500,000 | 0.20 | 0.20 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,324,000 | 1,324,000 | 0 | 0.16 | 0.22 | +0.06 | hold |
| Omega Fund Management, LLC | 1,316,183 | 1,316,183 | 0 | 8.08 | 11.11 | +3.02 | hold |
| Eversept Partners, LP | 1,414,838 | 1,249,441 | -165,397 | 0.93 | 1.07 | +0.13 | sell |
| Divisadero Street Capital Management, LP | 0 | 1,113,802 | +1,113,802 | 0.00 | 0.41 | +0.41 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 932,678 | 1,073,452 | +140,774 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 946,087 | 970,192 | +24,105 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 860,866 | 956,244 | +95,378 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 617,915 | 855,682 | +237,767 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 842,944 | 832,944 | -10,000 | 0.17 | 0.20 | +0.04 | sell |
| JPMORGAN CHASE & CO | 307,229 | 703,356 | +396,127 | 0.00 | 0.00 | +0.00 | buy |
| Bruce & Co., Inc. | 550,700 | 665,700 | +115,000 | 1.58 | 2.82 | +1.25 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,607,920 | 595,000 | -3,012,920 | 0.21 | 0.05 | -0.16 | sell |
| BANK OF AMERICA CORP /DE/ | 136,215 | 546,650 | +410,435 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 121,334 | 537,105 | +415,771 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 241,601 | 494,435 | +252,834 | 0.02 | 0.05 | +0.03 | buy |
| Tri Locum Partners LP | 0 | 493,344 | +493,344 | 0.00 | 0.95 | +0.95 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 546,132 | 409,300 | -136,832 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 623,253 | 386,623 | -236,630 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 350,873 | +350,873 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 322,467 | 350,873 | +28,406 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 295,818 | 331,956 | +36,138 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 60,287 | 308,468 | +248,181 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 248,449 | 299,632 | +51,183 | 0.12 | 0.17 | +0.05 | buy |
| PURA VIDA INVESTMENTS, LLC | 281,250 | 281,164 | -86 | 18.94 | 11.91 | -7.03 | sell |
| Mariner, LLC | 0 | 220,359 | +220,359 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 56,616 | 172,584 | +115,968 | 0.01 | 0.03 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 161,098 | +161,098 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 98,804 | 122,897 | +24,093 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 71,905 | 95,554 | +23,649 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 85,928 | 91,371 | +5,443 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,013 | 74,055 | +72,042 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 72,152 | 72,152 | 0 | 0.02 | 0.02 | +0.01 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,211 | 69,959 | -1,252 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 218,094 | 63,809 | -154,285 | 0.01 | 0.00 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 485,854 | 63,039 | -422,815 | 0.09 | 0.02 | -0.07 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,400 | 56,600 | +21,200 | 0.00 | 0.00 | -0.00 | buy |
| Archon Capital Management LLC | 0 | 53,873 | +53,873 | 0.00 | 0.34 | +0.34 | buy |
| RHUMBLINE ADVISERS | 46,430 | 51,254 | +4,824 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 47,551 | 50,900 | +3,349 | 0.25 | 0.36 | +0.12 | buy |
| DEUTSCHE BANK AG\ | 43,701 | 48,222 | +4,521 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 31,988 | 46,353 | +14,365 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,472 | 43,450 | +7,978 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 41,254 | +41,254 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 21,522 | 35,577 | +14,055 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 33,654 | +33,654 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 0 | 27,372 | +27,372 | 0.00 | 0.10 | +0.10 | buy |
| Man Group plc | 39,267 | 26,770 | -12,497 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 22,720 | 26,148 | +3,428 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 67,879 | 24,064 | -43,815 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 23,599 | +23,599 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 114,719 | 22,843 | -91,876 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 19,464 | 21,021 | +1,557 | 0.00 | 0.00 | +0.00 | buy |
| Curated Wealth Partners LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 17,972 | 16,893 | -1,079 | 0.00 | 0.00 | +0.00 | sell |
| Quantbot Technologies LP | 41,295 | 16,819 | -24,476 | 0.02 | 0.01 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 23,904 | 15,360 | -8,544 | 0.00 | 0.00 | -0.00 | sell |
| INTREPID FAMILY OFFICE LLC | 0 | 15,000 | +15,000 | 0.00 | 0.22 | +0.22 | buy |
| BARCLAYS PLC | 7,344 | 14,936 | +7,592 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 14,597 | +14,597 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 13,522 | 14,278 | +756 | 0.00 | 0.00 | +0.00 | buy |
| Gladstone Institutional Advisory LLC | 14,200 | 14,201 | +1 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 10,346 | 13,388 | +3,042 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,200 | 12,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 11,946 | 11,946 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Engineers Gate Manager LP | 136,343 | 11,808 | -124,535 | 0.02 | 0.00 | -0.01 | sell |
| Russell Investments Group, Ltd. | 23,681 | 11,605 | -12,076 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 0 | 11,428 | +11,428 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 11,300 | +11,300 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,610 | 10,981 | +371 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 48,063 | 10,895 | -37,168 | 0.01 | 0.00 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 8,495 | 10,323 | +1,828 | 0.00 | 0.00 | +0.00 | buy |
| IAMS WEALTH MANAGEMENT, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 8,811 | +8,811 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 6,993 | +6,993 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 6,262 | +6,262 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,036 | 3,955 | -2,081 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,202 | 3,697 | +495 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,199 | 3,512 | +313 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 1,151 | 3,356 | +2,205 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,991 | 3,129 | +138 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 3,003 | 3,003 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 62 | 1,406 | +1,344 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 1,370 | +1,370 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 673 | 1,305 | +632 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 1,489 | 1,095 | -394 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 1,054 | 1,054 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 378 | 821 | +443 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 238 | 709 | +471 | 0.00 | 0.00 | +0.00 | buy |
| ADIRONDACK TRUST CO | 0 | 603 | +603 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,107 | 546 | -1,561 | 0.00 | 0.00 | -0.00 | sell |
| Larson Financial Group LLC | 557 | 538 | -19 | 0.00 | 0.00 | +0.00 | sell |
| GAMMA Investing LLC | 594 | 486 | -108 | 0.00 | 0.00 | +0.00 | sell |