| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 4,932,351 | 4,957,252 | +24,901 | 1.26 | 1.62 | +0.36 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,203,920 | 4,313,920 | +110,000 | 0.28 | 0.48 | +0.21 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,901,599 | 3,901,599 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Soleus Capital Management, L.P. | 3,820,158 | 3,870,158 | +50,000 | 3.84 | 4.11 | +0.27 | buy |
| MORGAN STANLEY | 2,949,365 | 3,761,583 | +812,218 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 3,570,113 | 3,570,113 | 0 | 10.24 | 15.54 | +5.31 | hold |
| RTW INVESTMENTS, LP | 3,299,191 | 3,299,191 | 0 | 0.68 | 0.81 | +0.12 | hold |
| BlackRock, Inc. | 858,359 | 2,781,331 | +1,922,972 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 706,968 | 2,216,185 | +1,509,217 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 1,988,287 | 1,920,125 | -68,162 | 18.75 | 17.16 | -1.59 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,168,415 | 1,168,415 | 0 | 0.31 | 0.36 | +0.05 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,159,737 | 1,058,975 | -100,762 | 0.14 | 0.15 | +0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 312,930 | 917,553 | +604,623 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 229,995 | 826,302 | +596,307 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 542,198 | 796,964 | +254,766 | 0.01 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 665,653 | 650,825 | -14,828 | 0.00 | 0.01 | +0.00 | sell |
| Vestal Point Capital, LP | 550,000 | 600,000 | +50,000 | 0.42 | 0.54 | +0.12 | buy |
| MARSHALL WACE, LLP | 614,965 | 594,902 | -20,063 | 0.01 | 0.01 | +0.00 | sell |
| Walleye Capital LLC | 218,189 | 591,187 | +372,998 | 0.03 | 0.10 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 317,943 | 487,658 | +169,715 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 311,001 | 399,253 | +88,252 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 419,398 | 364,448 | -54,950 | 0.02 | 0.02 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 102,225 | 330,692 | +228,467 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 95,253 | 298,060 | +202,807 | 0.00 | 0.00 | +0.00 | buy |
| PURA VIDA INVESTMENTS, LLC | 2,500 | 281,250 | +278,750 | 37.57 | 34.05 | -3.52 | buy |
| PERCEPTIVE ADVISORS LLC | 1,593,608 | 277,944 | -1,315,664 | 0.87 | 0.16 | -0.71 | sell |
| First Eagle Investment Management, LLC | 0 | 233,202 | +233,202 | 0.00 | 0.01 | +0.01 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 222,615 | +222,615 | 0.00 | 0.68 | +0.68 | buy |
| JPMORGAN CHASE & CO | 6,170 | 205,955 | +199,785 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 216,349 | 204,292 | -12,057 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 72,245 | 197,707 | +125,462 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 249,734 | 197,052 | -52,682 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 70,175 | 183,663 | +113,488 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 21,296 | 163,764 | +142,468 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 244,202 | 162,649 | -81,553 | 0.04 | 0.03 | -0.00 | sell |
| UBS Group AG | 96,061 | 127,905 | +31,844 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 196,607 | 125,483 | -71,124 | 0.69 | 0.53 | -0.16 | sell |
| Kent Lake PR LLC | 0 | 125,000 | +125,000 | 0.00 | 1.27 | +1.27 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 89,105 | 114,666 | +25,561 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 815 | 94,227 | +93,412 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 27,353 | 90,118 | +62,765 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 85,741 | +85,741 | 0.00 | 0.07 | +0.07 | buy |
| ROYAL BANK OF CANADA | 0 | 75,775 | +75,775 | 0.00 | 0.00 | +0.00 | buy |
| Meridiem Capital Partners LP | 0 | 73,386 | +73,386 | 0.00 | 0.10 | +0.10 | buy |
| Bellevue Group AG | 66,825 | 64,283 | -2,542 | 0.02 | 0.03 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 39,876 | 60,076 | +20,200 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 56,259 | +56,259 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,460 | 55,266 | +47,806 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 22,680 | 54,414 | +31,734 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 17,044 | 53,490 | +36,446 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 55,433 | 52,010 | -3,423 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 16,296 | 48,720 | +32,424 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 45,476 | 47,299 | +1,823 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 18,439 | 47,117 | +28,678 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,558 | 42,404 | +18,846 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 42,563 | 40,465 | -2,098 | 0.34 | 0.43 | +0.09 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 38,991 | +38,991 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 38,593 | +38,593 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,659 | 38,004 | +24,345 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 20,771 | 35,490 | +14,719 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 34,614 | +34,614 | 0.00 | 0.00 | +0.00 | buy |
| Evanson Asset Management, LLC | 38,772 | 33,772 | -5,000 | 0.04 | 0.04 | +0.00 | sell |
| Calamos Advisors LLC | 0 | 32,302 | +32,302 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,020 | 31,954 | +16,934 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 30,200 | +30,200 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 19,770 | 26,610 | +6,840 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 50,000 | 25,000 | -25,000 | 0.02 | 0.02 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 193,325 | 24,500 | -168,825 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 23,346 | +23,346 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 8,370 | 22,720 | +14,350 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 16,500 | 22,500 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 21,388 | +21,388 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 16,485 | 21,030 | +4,545 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 14,546 | 19,903 | +5,357 | 0.01 | 0.04 | +0.02 | buy |
| FMR LLC | 16,377 | 16,810 | +433 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 14,856 | +14,856 | 0.00 | 0.02 | +0.02 | buy |
| Quantbot Technologies LP | 0 | 14,394 | +14,394 | 0.00 | 0.01 | +0.01 | buy |
| Gladstone Institutional Advisory LLC | 14,200 | 14,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Virtu Financial LLC | 0 | 13,620 | +13,620 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,700 | 12,200 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 0 | 11,946 | +11,946 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 11,726 | +11,726 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,751 | 10,346 | +7,595 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 10,225 | +10,225 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,228 | 7,815 | +6,587 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,976 | 6,634 | +2,658 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 4,011 | 3,407 | -604 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,339 | 3,202 | +1,863 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 830 | 2,540 | +1,710 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 91 | 2,515 | +2,424 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 783 | 2,377 | +1,594 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 1,515 | 1,515 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 4,605 | 1,481 | -3,124 | 0.00 | 0.00 | -0.00 | sell |
| GPS Wealth Strategies Group, LLC | 1,000 | 1,450 | +450 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,384 | 1,265 | -1,119 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 872 | 1,143 | +271 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 30 | 925 | +895 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 687 | 687 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New Hampshire | 680 | 680 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 625 | 625 | 0 | 0.00 | 0.00 | +0.00 | hold |